PL-05 genetic pathways linking hemostasis and cancer

Thrombosis Research

Volumn 129, Issue SUPPL. 1, 2012, Pages

  Garnier, Delphine ^a   Magnus, Nathalie ^a   D'Asti, Esterina ^a   Hashemi, Maryam ^a   Meehan, Brian ^a   Milsom, Chloe ^b   Rak, Janusz ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiogenesis; Cancer; Cancer stem cell niche; Cancer stem cells; Coagulation; Oncogenes; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 7; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GUANOSINE TRIPHOSPHATASE; MICRORNA; MICRORNA 19B; MICRORNA 520; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; RAS PROTEIN; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; RETINOBLASTOMA PROTEIN; SCATTER FACTOR RECEPTOR; THROMBOPLASTIN; UNCLASSIFIED DRUG; BLOOD CLOTTING FACTOR;

ANGIOGENESIS; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CANCER GROWTH; CANCER STEM CELL; CANCER SUSCEPTIBILITY; COLON POLYPOSIS; CONFERENCE PAPER; GLIOBLASTOMA; HEMOSTASIS; HUMAN; HYPOXIA; MICROPARTICLE ENZYME IMMUNOASSAY; MORBIDITY; MORTALITY; NEOPLASM; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; THROMBOPHILIA; ANIMAL; ARTICLE; GENETICS; IMMUNOLOGY;

ANIMALS; BLOOD COAGULATION FACTORS; HEMOSTASIS; HUMANS; NEOPLASMS;

EID: 84862141451     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/S0049-3848(12)70012-9     Document Type: Conference Paper

References (128)

1. B Vogelstein, KW Kinzler Cancer genes and the pathways they control Nat Med 10 2004 789 799 (Pubitemid 39070849)
2. D Hanahan, RA Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
3. JL Yu, L May, V Lhotak, S Shahrzad, S Shirasawa, JI Weitz et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis Blood 105 2005 1734 1741 (Pubitemid 40223697)
4. S Shahrzad, L Quayle, C Stone, C Plumb, S Shirasawa, JW Rak et al. Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression Cancer Res 65 2005 8134 8141 (Pubitemid 41330576)
5. J Folkman Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6 2007 273 286 (Pubitemid 46505878)
6. FR Rickles Mechanisms of cancer-induced thrombosis in cancer Pathophysiol Haemost Thromb 35 2006 103 110
7. A Mantovani, P Allavena, A Sica, F Balkwill Cancer-related inflammation Nature 454 2008 436 444
8. M. De Palma, L. Naldini Role of haematopoietic cells and endothelial progenitors in tumour angiogenesis Biochim Biophys Acta 1766 2006 159 166 (Pubitemid 44175637)
9. RS Kerbel Tumor angiogenesis N Engl J Med 358 2008 2039 2049 (Pubitemid 351656458)
10. J Rak, J Filmus, RS Kerbel Reciprocal paracrine interactions between tumor cells and endothelial cells. The "angiogenesis progression" hypothesis Eur J Cancer 32A 1996 2438 2450
11. JM Butler, H Kobayashi, S Rafii Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors Nat Rev Cancer 10 2010 138 146
12. J Rak Ras oncogenes and tumour vascular interface A Thomas-Tikhonenko Cancer Genome and Tumor Microenvironment 2009 Springer New York 133 165
13. N Bouck, V Stellmach, SC Hsu How tumors become angiogenic Adv Cancer Res 69 1996 135 174 (Pubitemid 26274885)
14. P Carmeliet, RK Jain Molecular mechanisms and clinical applications of angiogenesis Nature 473 2011 298 307 19
15. XZ West, NL Malinin, AA Merkulova, M Tischenko, BA Kerr, EC Borden et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands Nature 467 2010 972 976
16. BB Ancrile, KM O'Hayer, CM Counter Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics Mol Interv 8 2008 22 27 (Pubitemid 351398449)
17. A Sparmann, D Bar-Sagi Ras oncogene and inflammation: partners in crime Cell Cycle 4 2005 735 736 (Pubitemid 41353818)
18. W Kalas, JL Yu, C Milsom, J Rosenfeld, R Benezra, P Bornstein et al. Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras Cancer Res 65 2005 8878 8886 (Pubitemid 41377377)
19. K Al-Nedawi, B Meehan, J Micallef, V Lhotak, L May, A Guha et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Nat Cell Biol 10 2008 619 624 (Pubitemid 351627382)
20. J Rak Microparticles in cancer Semin Thromb Hemost 36 2010 888 906
21. S Gesierich, I Berezovskiy, E Ryschich, M Zoller Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029 Cancer Res 66 2006 7083 7094 (Pubitemid 44197685)
22. L Ricci-Vitiani, R Pallini, M Biffoni, M Todaro, G Invernici, T Cenci, G Maira, EA Parati, G Stassi, LM Larocca, MR De Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells Nature 468 2010 824 828
23. J Rak, G Klement Impact of oncogenes and tumor suppressor genes on deregulation of hemostasis and angiogenesis in cancer Cancer Metastasis Rev 19 2000 93 96 (Pubitemid 32004698)
24. Y Rong, DE Post, RO Pieper, DL Durden, EG Van Meir, DJ Brat PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma Cancer Res 65 2005 1406 1413 (Pubitemid 40270169)
25. C Boccaccio, G Sabatino, E Medico, F Girolami, A Follenzi, G Reato et al. The MET oncogene drives a genetic programme linking cancer to haemostasis Nature 434 2005 396 400 (Pubitemid 40469184)
26. FR Rickles, A Falanga Activation of clotting factors in cancer Cancer Treat Res 148 2009 31 41
27. AK Kakkar, MN Levine Thrombosis and cancer: implications beyond Trousseau J Thromb Haemost 2 2004 1261 1262 (Pubitemid 40186118)
28. AY Lee, JA Rickles FR Julian, M Gent, RI Baker, C Bowden et al. Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism J Clin Oncol 23 2005 2123 2129 (Pubitemid 46218703)
29. JI Weitz Potential of new anticoagulants in patients with cancer Thromb Res 125 Suppl 2 2010 S30 S35
30. HR Buller, FF van Doormaal, GL van Sluis, PW Kamphuisen Cancer and thrombosis: from molecular mechanisms to clinical presentations J Thromb Haemost 5 Suppl 1 2007 246 254 (Pubitemid 46958840)
31. P Goldin-Lang, K Pels, QV Tran, B Szotowski, F Wittchen, S Antoniak et al. Effect of ionizing radiation on cellular procoagulability and co-ordinated gene alterations Haematologica 92 2007 1091 1098 (Pubitemid 350144216)
32. F Elice, F Rodeghiero, A Falanga, FR Rickles Thrombosis associated with angiogenesis inhibitors Best Pract Res Clin Haematol 22 2009 115 128
33. T Wun, RH White Epidemiology of cancer-related venous thromboembolism Best Pract Res Clin Haematol 22 2009 9 23
34. W Ruf, J Disse, TC Carneiro-Lobo, N Yokota, F Schaffner Tissue factor and cell signalling in cancer progression and thrombosis J Thromb Haemost 9 Suppl 1 2011 306 315 10.1111/j.1538-7836.2011.04318.x
35. KA Steinbrecher, NA Horowitz, EA Blevins, KA Barney, MA Shaw, E Harmel-Laws et al. Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen Cancer Res 70 2010 2634 2643
36. ML Nierodzik, S Karpatkin Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype Cancer Cell 10 2006 355 362 (Pubitemid 44693468)
37. C Boccaccio, PM Comoglio Genetic link between cancer and thrombosis J Clin Oncol 27 2009 4827 4833
38. J Contrino, G Hair, DL Kreutzer, FR Rickles In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease Nat Med 2 1996 209 215 (Pubitemid 26054985)
39. HF Dvorak, NS Orenstein, AC Carvalho, WH Churchill, AM Dvorak, SJ Galli et al. Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor secreted products J Immunol 122 1979 166 174 (Pubitemid 9078536)
40. A Falanga, SG Gordon Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue Biochemistry 24 1985 5558 5567 (Pubitemid 16228838)
41. S Koizume, MS Jin, E Miyagi, F Hirahara, Y Nakamura, JH Piao et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII Cancer Res 66 2006 9453 9460 (Pubitemid 44623642)
42. EB Schulze, BD Hedley, D Goodale, CO Postenka, W Al-Katib, AB Tuck et al. The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms Breast Cancer Res Treat 112 2008 243 254
43. EE Cliffton, CE Grossi Fibrinolytic activity of human tumors as measured by the fibrin-plate method Cancer 8 1955 1146 1154
44. MB Donati Cancer and Thrombosis Haemostasis 24 1994 54 58
45. K Bajou, A Noel, RD Gerard, V Masson, N Brunner, C Holst-Hansen et al. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization Nature Med 4 1998 923 928 (Pubitemid 28364031)
46. C Boccaccio, PM Comoglio A functional role for hemostasis in early cancer development Cancer Res 65 2005 8579 8582 (Pubitemid 41377338)
47. M Bezuhly, R Cullen, CT Esmon, SF Morris, KA West, B Johnston et al. Role of activated protein C and its receptor in inhibition of tumor metastasis Blood 113 2009 3371 3374
48. HF Dvorak, SC Quay, NS Orenstein, AM Dvorak, P Hahn, AM Bitzer et al. Tumor shedding and coagulation Science 212 1981 923 924 (Pubitemid 11120474)
49. GJ Gasic, TB Gasic, CC Stewart Antimetastatic effects associated with platelet reduction Proc Natl Acad Sci U S A 61 1968 46 52
50. LL Swystun, S Mukherjee, PC Liaw Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus J Thromb Haemost 9 2011 2313 2321
51. N Mackman Triggers, targets and treatments for thrombosis Nature 451 2008 914 918
52. A Falanga Thrombophilia in cancer Semin Thromb Hemost 31 2005 104 110 (Pubitemid 40262144)
53. T Albrektsen, BB Sorensen, GM Hjorto, J Fleckner, LV Rao, LC Petersen Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells J Thromb Haemost 5 2007 1588 1597 (Pubitemid 47091396)
54. N Magnus, D Garnier, J Rak Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells Blood 116 2010 815 818
55. GA Petralia, NR Lemoine, AK Kakkar Mechanisms of disease: the impact of antithrombotic therapy in cancer patients Nat Clin Pract Oncol 2 2005 356 363 (Pubitemid 43118122)
56. GF Nash, DC Walsh, AK Kakkar The role of the coagulation system in tumour angiogenesis Lancet Oncol 2 2001 608 613 (Pubitemid 33009256)
57. MB Donati Cancer and thrombosis: from Phlegmasia alba dolens to transgenic mice Thromb Haemost 74 1995 278 281
58. ME Tesselaar, FP Romijn, IK van der Linden, FA Prins, RM Bertina, S Osanto Microparticle-associated tissue factor activity: a link between cancer and thrombosis? J Thromb Haemost 5 2007 520 527 (Pubitemid 46680685)
59. MT Sartori, PA Della, A Ballin, G Saggiorato, D Bernardi, A Padoan et al. Prothrombotic state in glioblastoma multiforme: an evaluation of the procoagulant activity of circulating microparticles J Neurooncol 104 2011 225 231
60. AA Khorana Venous thromboembolism and prognosis in cancer Thromb Res 125 2010 490 493
61. JI Zwicker, CC Trenor III, BC Furie, B Furie Tissue factor-bearing microparticles and thrombus formation Arterioscler Thromb Vasc Biol 31 2011 728 733
62. B Furie, BC Furie Mechanisms of thrombus formation N Engl J Med 359 2008 938 949
63. AK Kakkar, MN Levine, Z Kadziola, NR Lemoine, V Low, HK Patel, G Rustin et al. Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS) J Clin Oncol 22 2004 1944 1948 (Pubitemid 41095187)
64. M Altinbas, HS Coskun, O Er, M Ozkan, B Eser, A Unal et al. A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer J Thromb Haemost 2 2004 1266 1271 (Pubitemid 40186120)
65. A Luttun, M Tjwa, L Moons, Y Wu, A Angelillo-Scherrer, F Liao et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 Nat Med 8 2002 831 840
66. HH Versteeg, F Schaffner, M Kerver, HH Petersen, J Ahamed, B Felding-Habermann et al. Inhibition of tissue factor signaling suppresses tumor growth Blood 111 2008 190 199
67. Y Zhang, Y Deng, T Luther, M Muller, R Ziegler, R Waldherr et al. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice J Clin Invest 94 1994 1320 1327 (Pubitemid 24286478)
68. TA Hembrough, GM Swartz, A Papathanassiu, GP Vlasuk, WE Rote, SJ Green, VS Pribluda Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism Cancer Res 63 2003 2997 3000 (Pubitemid 36667175)
69. J Zhao, G Aguilar, S Palencia, E Newton, A Abo rNAPc2 inhibits colorectal cancer in mice through tissue factor Clin Cancer Res 15 2009 208 216
70. Z Hu, A Garen Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer Proc Natl Acad Sci U S A 98 2001 12180 12185 (Pubitemid 32959847)
71. Y Liu, P Jiang, K Capkova, D Xue, L Ye, SC Sinha et al. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy Cancer Res 71 2011 6492 6502
72. CY Vossen, M Hoffmeister, JC Chang-Claude, FR Rosendaal, H Brenner Clotting factor gene polymorphisms and colorectal cancer risk J Clin Oncol 29 2011 1722 1727
73. Y Rong, VE Belozerov, C Tucker-Burden, G Chen, DL Durden, JJ Olson et al. Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity Cancer Res 69 2009 2540 2549
74. J Rak, C Milsom, J Yu Tissue factor in cancer Curr Opin Hematol 15 2008 522 528
75. JS Palumbo, JL Degen Mechanisms coupling the hemostatic system to colitis-associated cancer Thromb Res 125 Suppl 2 2010 S39 S43
76. HH Versteeg, F Schaffner, M Kerver, LG Ellies, P Andrade-Gordon, BM Mueller et al. Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice Cancer Res 68 2008 7219 7227
77. CC Milsom, JL Yu, N Mackman, J Micallef, GM Anderson, A Guha et al. Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis Cancer Res 68 2008 10068 10076
78. BM Mueller, RA Reisfeld, TS Edgington, W Ruf Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis Proc Natl Acad Sci U S A 89 1992 11832 11836 (Pubitemid 23004738)
79. K Abe, M Shoji, J Chen, A Bierhaus, I Danave, C Micko et al. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor Proc Natl Acad Sci U S A 96 1999 8663 8668 (Pubitemid 29354848)
80. CV Ngo, K Picha, F McCabe, H Millar, R Tawadros, SH Tam et al. CNTO 859, a humanized anti-tissue factor monoclonal antibody, is a potent inhibitor of breast cancer metastasis and tumor growth in xenograft models Int J Cancer 120 2007 1261 1267
81. JS Palumbo, KW Kombrinck, AF Drew, TS Grimes, JH Kiser, JL Degen et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells Blood 96 2000 3302 3309
82. JL Francis, A Amirkhosravi Effect of antihemostatic agents on experimental tumor dissemination Semin Thromb Hemost 28 2002 29 38 (Pubitemid 34194870)
83. J Yu, L May, C Milsom, GM Anderson, JI Weitz, JP Luyendyk et al. Contribution of host-derived tissue factor to tumor neovascularization Arterioscler Thromb Vasc Biol 28 2008 1975 1981
84. C Milsom, N Magnus, B Meehan, K Al-Nedawi, D Garnier, J Rak Tissue Factor and Cancer Stem Cells. Is There a Linkage? Arterioscler Thromb Vasc Biol 29 2009 2005 2014
85. T Reya, SJ Morrison, MF Clarke, IL Weissman Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111 (Pubitemid 33041634)
86. RJ Gilbertson, JN Rich Making a tumour's bed: glioblastoma stem cells and the vascular niche Nat Rev Cancer 7 2007 733 736 (Pubitemid 47463683)
87. C Milsom, GM Anderson, JI Weitz, J Rak Elevated tissue factor procoagulant activity in CD133-positive cancer cells J Thromb Haemost 5 2007 2550 2552 (Pubitemid 350154368)
88. SA Mani, W Guo, MJ Liao, EN Eaton, A Ayyanan, AY Zhou et al. The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715 (Pubitemid 351636299)
89. D Agostino, EE Cliffton Trauma as a cause of localization of blood-borne metastases: Preventive effect of heparin and fibrinolysin Ann Surg 161 1965 97 102
90. R. Auer, J Bell, R Seth Surgical Stress Promotes the Development of Cancer Metastases by a Coagulation-Dependent Mechanism in a Murine Model 2010 ICTHIC Stressa, IT
91. L Ma, G Francia, A Viloria-Petit, DJ Hicklin, MJ du, J Rak et al. In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy Cancer Res 65 2005 5365 5373 (Pubitemid 40827350)
92. WC Black, HG Welch Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy N Engl J Med 328 1993 1237 1243 (Pubitemid 23115703)
93. M Labelle, S Begum, RO Hynes Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis Cancer Cell 20 2011 576 590
94. J Rak, JL Yu, J Luyendyk, N Mackman Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans Cancer Res 66 2006 10643 10646 (Pubitemid 44876956)
95. FH Dvorak, FR Rickles Malignancy and Hemostasis RB Coleman VJ Marder AW Clowes JN George SZ Goldhaber Hemostasis and Thrombosis: Basic Principles and Clinical Practice 2006 Lippincott Company Williams & Wilkins Philadelphia 851 873
96. IJ Fidler The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited Nat Rev Cancer 3 2003 453 458 (Pubitemid 37328849)
97. MS Tallman, P Lefebvre, RM Baine, M Shoji, I Cohen, D Green et al. Effects of all-trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute promyelocytic leukemia J Thromb Haemost 2 2004 1341 1350 (Pubitemid 40186131)
98. GM Thomas, L Panicot-Dubois, R Lacroix, F Dignat-George, D Lombardo, C Dubois Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo J Exp Med 206 2009 1913 1927
99. T Koyama, S Hirosawa, N Kawamata, S Tohda, N Aoki All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells: distinct expression of thrombomodulin and tissue factor in human leukemic cells Blood 84 1994 3001 3009
100. T Tenno, F Oberg, N Mackman, K Nilsson, A Siegbahn PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells Thromb Haemost 90 2003 930 939 (Pubitemid 37427864)
101. J Yan, K Wang, L Dong, H Liu, W Chen, W Xi et al. PML/RARalpha fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association Proc Natl Acad Sci U S A 107 2010 3716 3721
102. FJ Kaye Mutation-associated fusion cancer genes in solid tumors Mol Cancer Ther 8 2009 1399 1408
103. JL Yu, L May, P Klement, JI Weitz, J Rak Oncogenes as regulators of tissue factor expression in cancer: implications for tumor angiogenesis and anti-cancer therapy Semin Thromb Hemost 30 2004 21 30 (Pubitemid 38457298)
104. JL Yu, R Xing, C Milsom, J Rak Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1 Thromb Res 126 2010 e6 e10
105. MT Wiiger, H Prydz The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells Thromb Haemost 92 2004 13 22 (Pubitemid 39010864)
106. R Avraham, Y Yarden Feedback regulation of EGFR signalling: decision making by early and delayed loops Nat Rev Mol Cell Biol 12 2011 104 117
107. M Provencal, N Berger-Thibault, D Labbe, R Veitch, D Boivin, GE Rivard et al. Tissue factor mediates the HGF/Met-induced anti-apoptotic pathway in DAOY medulloblastoma cells J Neurooncol 97 2010 365 372
108. C Alberti, P Pinciroli, B Valeri, R Ferri, A Ditto, K Umezawa et al. Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer Oncogene 2011 10
109. J Hu, M Jo, WK Cavenee, F Furnari, SR VandenBerg, SL Gonias Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells Proc Natl Acad Sci U S A 108 2011 15984 15989 20
110. M Sudol From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management Oncogene 30 2011 3003 3010
111. JA Aguirre-Ghiso, P Frankel, EF Farias, Z Lu, H Jiang, A Olsen et al. RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases Oncogene 18 1999 4718 4725 (Pubitemid 29417747)
112. SM Bell, DC Connolly, NJ Maihle, JL Degen Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases Mol Cell Biol 13 1993 5888 5897 (Pubitemid 23260688)
113. D Jahner, T Hunter The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes Oncogene 6 1991 1259 1268 (Pubitemid 21924216)
114. A Falanga, M Marchetti, A Vignoli, D Balducci, L Russo, V Guerini et al. V617F JAK-2 mutation in patients with essential thrombocythemia: relation to platelet, granulocyte, and plasma hemostatic and inflammatory molecules Exp Hematol 35 2007 702 711 (Pubitemid 46601748)
115. Y Pylayeva-Gupta, E Grabocka, D Bar-Sagi RAS oncogenes: weaving a tumorigenic web Nat Rev Cancer 11 2011 761 774
116. S Regina, J Rollin, C Blechet, S Iochmann, P Reverdiau, Y Gruel Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation J Thorac Oncol 3 2008 689 697
117. S Regina, JB Valentin, S Lachot, E Lemarie, J Rollin, Y Gruel Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN Clin Chem 55 2009 1834 1842
118. T Gaiser, MR Becker, J Meyer, A Habel, MD Siegelin p53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas Neurochem Int 54 2009 458 463
119. BJ Lee, JH Kim, SH Woo, JH Kim, DH Kim, YS Yu Tissue factor is involved in retinoblastoma cell proliferation via both the Akt and extracellular signalregulated kinase pathways Oncol Rep 26 2011 665 670
120. SL Liu, A Rand, RJ Kelm Jr., MJ Getz The retinoblastoma gene family members pRB and p107 coactivate the AP-1-dependent mouse tissue factor promoter in fibroblasts Oncogene 19 2000 3352 3362 (Pubitemid 30479330)
121. R Garzon, G Marcucci, CM Croce Targeting microRNAs in cancer: rationale, strategies and challenges Nat Rev Drug Discov 9 2010 775 789
122. R Teruel, J Corral, V Perez-Andreu, I Martinez-Martinez, V Vicente, C Martinez Potential role of miRNAs in developmental haemostasis PLoS ONE 6 2011 e17648
123. M Muth, K Theophile, K Hussein, C Jacobi, H Kreipe, O Bock Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression J Transl Med 8 2010 33
124. A Fort, C Borel, E Migliavacca, SE Antonarakis, RJ Fish, M Neerman-Arbez Regulation of fibrinogen production by microRNAs Blood 116 2010 2608 2615
125. R Teruel, C Perez-Sanchez, J Corral, MT Herranz, V Perez-Andreu, E Saiz et al. Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome J Thromb Haemost 9 2011 1985 1992
126. X Zhang, H Yu, JR Lou, J Zheng, H Zhu, NI Popescu et al. MicroRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells J Biol Chem 286 2011 1429 1435
127. HS Phillips, S Kharbanda, R Chen, WF Forrest, RH Soriano, TD Wu et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis Cancer Cell 9 2006 157 173 (Pubitemid 43357943)
128. D Faury, A Nantel, SE Dunn, MC Guiot, T Haque, P Hauser et al. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors J Clin Oncol 25 2007 1196 1208 (Pubitemid 46640565)