PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 8, 2010, Pages 3716-3721

  Yan, Jinsong ^a,d   Wang, Kankan ^a   Dong, Leiming ^a   Liu, Hongchen ^a   Chen, Weiqin ^a   Xi, Wenda ^b   Ding, Qiulan ^a   Kieffer, Nelly ^a   Caen, Jacques P ^c   Chen, Saijuan ^a   Chen, Zhu ^a   Xi, Aodong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY   (China)

^c Fondation Franco Chinoise pour la Science et ses Applications (FFCSA)   (France)

^d DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Acute promyelocytic leukemia; Coagulopathy; GAGC motif; Regulation; Transcription

Indexed keywords

HYBRID PROTEIN; LUCIFERASE; PROMYELOCYTIC LEUKEMIA PROTEIN; RETINOIC ACID RECEPTOR ALPHA; THROMBOPLASTIN; TRANSCRIPTION FACTOR; DNA; ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA RETINOIC ACID RECEPTOR ALPHA FUSION ONCOPROTEIN; PROMYELOCYTIC LEUKEMIA-RETINOIC ACID RECEPTOR ALPHA FUSION ONCOPROTEIN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; DNA SEQUENCE; GENE DELETION; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PLASMID; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION; UPREGULATION; BLOOD CLOTTING DISORDER; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROMOTER REGION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

MAMMALIA;

BASE SEQUENCE; CELL LINE, TUMOR; COAGULATION PROTEIN DISORDERS; DNA; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; ONCOGENE PROTEINS, FUSION; PROMOTER REGIONS, GENETIC; THROMBOPLASTIN; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION;

EID: 77649258369     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0915006107     Document Type: Article

References (31)

1. Chong BH, Lee SH (2007) Management of thromboembolism in hematologic malig nancies. Semin Thromb Hemost 33:435-448.
2. Rickles FR, et al. (2007) Bleeding and thrombosis in acute leukemia: What does the future of therapy look like? Thromb Res 120 (Suppl 2):S99-S106.
3. Tallman MS, Kwaan HC (2004) Intravascular clotting activation and bleeding in patients with hematologic malignancies. Rev Clin Exp Hematol 8:E1.
4. Kwaan HC,Wang J, Boggio LN (2002) Abnormalities in hemostasis in acute promyelocytic leukemia. Hematol Oncol 20:33-41.
5. Zhou GB, Zhang J, Wang ZY, Chen SJ, Chen Z (2007) Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: A paradigm of synergistic molecular targeting therapy. Philos Trans R Soc Lond B Biol Sci 362:959-971.
6. Arbuthnot C, Wilde JT (2006) Haemostatic problems in acute promyelocytic leukaemia. Blood Rev 20:289-297.
7. Barbui T, Finazzi G, Falanga A (1998) The impact of all-trans-retinoic acid on the coagulopathy of acute promyelocytic leukemia. Blood 91:3093-3102.
8. Zhao W, et al. (2001) Effects of all-trans-retinoic acid and arsenic trioxide on the hemo static disturbanceassociatedwithacutepromyelocytic leukemia.Thromb Res 102:197-204.
9. Zhu J, et al. (1999) Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. Leukemia 13:1062-1070.
10. Mackman N (2004) Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 24:1015-1022.
11. Guha M, et al. (2001) Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cellsmediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 98:1429-1439.
12. Krikun G, et al. (2000) Regulation of tissue factor gene expression in human endometrium by transcription factors Sp1 and Sp3. Mol Endocrinol 14:393-400.
13. Mackman N (1997) Regulation of the tissue factor gene. Thromb Haemost 78: 747-754.
14. Grignani F, et al. (1998) Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia. Nature 391:815-818.
15. Khan MM, et al. (2001) PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb. J Biol Chem 276:43491-43494.
16. Zhu J, et al. (2005) A sumoylation site in PML/RARA is essential for leukemic transformation. Cancer Cell 7:143-153.
17. Tenno T, Oberg F, Mackman N, Nilsson K, Siegbahn A (2003) PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells. Thromb Haemost 90:930-939.
18. Nervi C, et al. (1998) Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein. Blood 92:2244-2251.
19. Kamashev D, Vitoux D, De Thé H (2004) PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation. J Exp Med 199:1163-1174.
20. van Wageningen S, et al. (2008) Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha. Blood 111:1634-1643.
21. Métivier R, et al. (2003) Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115:751-763.
22. Nishizawa M, Kataoka K, Vogt PK (2003) MafA has strong cell transforming ability but is a weak transactivator. Oncogene 22:7882-7890.
23. Tenen DG, Hromas R, Licht JD, Zhang DE (1997) Transcription factors, normal myeloid development, and leukemia. Blood 90:489-519.
24. Hebbar PB, Archer TK (2008) Altered histone H1 stoichiometry and an absence of nucleosome positioning on transfected DNA. J Biol Chem 283:4595-4601.
25. Nicholson RC, et al. (1990) Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J 9:4443-4454.
26. Doucas V, Brockes JP, Yaniv M, de Thé H, Dejean A (1993) The PML-retinoic acid receptor αtranslocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1. Proc Natl Acad Sci USA 90:9345-9349.
27. Croston GE, Kerrigan LA, Lira LM, Marshak DR, Kadonaga JT (1991) Sequence-specific antirepressionof histoneH1-mediated inhibition ofbasalRNApolymerase II transcription. Science 251:643-649.
28. Kim SW, et al. (2005) A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter. J Biol Chem 280:14545-14555.
29. Bevilacqua A, Fiorenza MT, Mangia F (2000) A developmentally regulated GAGA boxbinding factor and Sp1 are required for transcription of the hsp70.1 gene at the onset of mouse zygotic genome activation. Development 127:1541-1551.
30. Zhu Q, et al. (2002) Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Blood 99:1014-1022.
31. Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.