메뉴 건너뛰기




Volumn 19, Issue 4, 2012, Pages 292-298

The role of activation-induced cytidine deaminase in lymphomagenesis

Author keywords

activation induced cytidine deaminase; chromosome translocations; class switch recombination; lymphoma; somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; DOUBLE STRANDED DNA;

EID: 84862123066     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e328353da3a     Document Type: Review
Times cited : (32)

References (52)
  • 1
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M, Kinoshita K, Fagarasan S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3
  • 2
    • 79955632686 scopus 로고    scopus 로고
    • Complex regulation and function of activation-induced cytidine deaminase
    • Stavnezer J. Complex regulation and function of activation-induced cytidine deaminase. Trends Immunol 2011; 32:194-201.
    • (2011) Trends Immunol , vol.32 , pp. 194-201
    • Stavnezer, J.1
  • 3
    • 77951057068 scopus 로고    scopus 로고
    • 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
    • Bothmer A, Robbiani DF, Feldhahn N, et al. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med 2010; 207:855-865.
    • (2010) J Exp Med , vol.207 , pp. 855-865
    • Bothmer, A.1    Robbiani, D.F.2    Feldhahn, N.3
  • 4
    • 62849104777 scopus 로고    scopus 로고
    • Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
    • Vuong BQ, Lee M, Kabir S, et al. Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol 2009; 10:420-426.
    • (2009) Nat Immunol , vol.10 , pp. 420-426
    • Vuong, B.Q.1    Lee, M.2    Kabir, S.3
  • 5
    • 77957239251 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
    • Pavri R, Gazumyan A, Jankovic M, et al. Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 2010; 143:122-133.
    • (2010) Cell , vol.143 , pp. 122-133
    • Pavri, R.1    Gazumyan, A.2    Jankovic, M.3
  • 6
    • 78751608734 scopus 로고    scopus 로고
    • The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
    • Nowak U, Matthews AJ, Zheng S, et al. The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat Immunol 2010; 12:160-166.
    • (2010) Nat Immunol , vol.12 , pp. 160-166
    • Nowak, U.1    Matthews, A.J.2    Zheng, S.3
  • 7
    • 49349112190 scopus 로고    scopus 로고
    • Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1
    • Conticello SG, Ganesh K, Xue K, et al. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell 2008; 31:474-484.
    • (2008) Mol Cell , vol.31 , pp. 474-484
    • Conticello, S.G.1    Ganesh, K.2    Xue, K.3
  • 8
    • 84863012447 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1
    • Kanehiro Y, Todo K, Negishi M, et al. Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1. Proc Natl Acad Sci USA 2012; 109:1216-1221.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 1216-1221
    • Kanehiro, Y.1    Todo, K.2    Negishi, M.3
  • 9
    • 77954901696 scopus 로고    scopus 로고
    • GANP-mediated recruitment of activationinduced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA
    • Maeda K, Singh SK, Eda K, et al. GANP-mediated recruitment of activationinduced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA. J Biol Chem 2010; 285:23945-23953.
    • (2010) J Biol Chem , vol.285 , pp. 23945-23953
    • Maeda, K.1    Singh, S.K.2    Eda, K.3
  • 10
    • 79551681406 scopus 로고    scopus 로고
    • The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
    • Basu U, Meng F-L, Keim C, et al. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell 2011; 144:353-363.
    • (2011) Cell , vol.144 , pp. 353-363
    • Basu, U.1    Meng, F.-L.2    Keim, C.3
  • 11
    • 79960145089 scopus 로고    scopus 로고
    • Analysis of a single-stranded DNAscanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversity
    • Pham P, Calabrese P, Park SJ, et al. Analysis of a single-stranded DNAscanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversity. J Biol Chem 2011; 286:24931-24942.
    • (2011) J Biol Chem , vol.286 , pp. 24931-24942
    • Pham, P.1    Calabrese, P.2    Park, S.J.3
  • 12
    • 79960990878 scopus 로고    scopus 로고
    • Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination
    • Han L, Masani S, Yu K. Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination. Proc Natl Acad Sci USA 2011; 108:11584-11589.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11584-11589
    • Han, L.1    Masani, S.2    Yu, K.3
  • 13
    • 34447617375 scopus 로고    scopus 로고
    • Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors
    • DOI 10.1016/j.immuni.2007.05.018, PII S1074761307003305
    • Han JH, Akira S, Calame K, et al. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity 2007; 27:64-75. (Pubitemid 47089025)
    • (2007) Immunity , vol.27 , Issue.1 , pp. 64-75
    • Han, J.-H.1    Akira, S.2    Calame, K.3    Beutler, B.4    Selsing, E.5    Imanishi-Kari, T.6
  • 14
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
    • Popp C, Dean W, Feng S, et al. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 2010; 463:1101-1105.
    • (2010) Nature , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.3
  • 16
    • 75649096381 scopus 로고    scopus 로고
    • B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
    • Tran TH, Nakata M, Suzuki K, et al. B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nat Immunol 2010; 11:148-154.
    • (2010) Nat Immunol , vol.11 , pp. 148-154
    • Tran, T.H.1    Nakata, M.2    Suzuki, K.3
  • 17
    • 43049178852 scopus 로고    scopus 로고
    • MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
    • Teng G, Hakimpour P, Landgraf P, et al. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity 2008; 28:621-629.
    • (2008) Immunity , vol.28 , pp. 621-629
    • Teng, G.1    Hakimpour, P.2    Landgraf, P.3
  • 18
    • 53349129731 scopus 로고    scopus 로고
    • MiR-181b negatively regulates activation-induced cytidine deaminase in B cells
    • de Yebenes VG, Belver L, Pisano DG, et al. miR-181b negatively regulates activation-induced cytidine deaminase in B cells. J Exp Med 2008; 205:2199-2206.
    • (2008) J Exp Med , vol.205 , pp. 2199-2206
    • De Yebenes, V.G.1    Belver, L.2    Pisano, D.G.3
  • 19
    • 66149126655 scopus 로고    scopus 로고
    • Active nuclear import and cytoplasmic retention of activation-induced deaminase
    • Patenaude AM, Orthwein A, Hu Y, et al. Active nuclear import and cytoplasmic retention of activation-induced deaminase. Nat Struct Mol Biol 2009; 16:517-527.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 517-527
    • Patenaude, A.M.1    Orthwein, A.2    Hu, Y.3
  • 21
    • 8844219645 scopus 로고    scopus 로고
    • AID is expressed in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas and is not correlated with intraclonal heterogeneity
    • DOI 10.1038/sj.leu.2403488
    • Lossos IS, Levy R, Alizadeh AA. AID is expressed in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas and is not correlated with intraclonal heterogeneity. Leukemia 2004; 18:1775-1779. (Pubitemid 39530006)
    • (2004) Leukemia , vol.18 , Issue.11 , pp. 1775-1779
    • Lossos, I.S.1    Levy, R.2    Alizadeh, A.A.3
  • 23
    • 84859709743 scopus 로고    scopus 로고
    • Role of activation-induced cytidine deaminase in the progression of follicular lymphoma
    • Shikata H, Yakushijin Y, Matsushita N, et al. Role of activation-induced cytidine deaminase in the progression of follicular lymphoma. Cancer Sci 2011; 103:415-421.
    • (2011) Cancer Sci , vol.103 , pp. 415-421
    • Shikata, H.1    Yakushijin, Y.2    Matsushita, N.3
  • 25
    • 77953955599 scopus 로고    scopus 로고
    • High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: Link with an activated microenvironment in CLL disease
    • Palacios F, Moreno P, Morande P, et al. High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Blood 2010; 115:4488-4496.
    • (2010) Blood , vol.115 , pp. 4488-4496
    • Palacios, F.1    Moreno, P.2    Morande, P.3
  • 26
    • 0038300728 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation
    • DOI 10.1182/blood-2002-10-3175
    • Oppezzo P, Vuillier F, Vasconcelos Y, et al. Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation. Blood 2003; 101:4029-4032. (Pubitemid 36857882)
    • (2003) Blood , vol.101 , Issue.10 , pp. 4029-4032
    • Oppezzo, P.1    Vuillier, F.2    Vasconcelos, Y.3    Dumas, G.4    Magnac, C.5    Payelle-Brogard, B.6    Pritsch, O.7    Dighiero, G.8
  • 27
    • 84863229246 scopus 로고    scopus 로고
    • Dendritic cell-mediated activationinduced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma
    • Koduru S, Wong E, Strowig T, et al. Dendritic cell-mediated activationinduced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. Blood 2012; 119:2302-2309.
    • (2012) Blood , vol.119 , pp. 2302-2309
    • Koduru, S.1    Wong, E.2    Strowig, T.3
  • 30
    • 73349141714 scopus 로고    scopus 로고
    • Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities
    • Mottok A, Renne C, Seifert M, et al. Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities. Blood 2009; 114:4503-4506.
    • (2009) Blood , vol.114 , pp. 4503-4506
    • Mottok, A.1    Renne, C.2    Seifert, M.3
  • 31
    • 72249096210 scopus 로고    scopus 로고
    • Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
    • Cattoretti G, Mandelbaum J, Lee N, et al. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res 2009; 69:8686-8692.
    • (2009) Cancer Res , vol.69 , pp. 8686-8692
    • Cattoretti, G.1    Mandelbaum, J.2    Lee, N.3
  • 32
    • 84862016740 scopus 로고    scopus 로고
    • BCL2 mutations in diffuse large B-cell lymphoma
    • [Epub ahead of print]
    • Schuetz JM, Johnson NA, Morin RD, et al. BCL2 mutations in diffuse large B-cell lymphoma. Leukemia 2012. [Epub ahead of print]
    • (2012) Leukemia
    • Schuetz, J.M.1    Johnson, N.A.2    Morin, R.D.3
  • 33
    • 0038243177 scopus 로고    scopus 로고
    • Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma
    • DOI 10.1182/blood-2002-11-3387
    • Pasqualucci L, Migliazza A, Basso K, et al. Mutations of the BCL6 protooncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 2003; 101:2914-2923. (Pubitemid 36857975)
    • (2003) Blood , vol.101 , Issue.8 , pp. 2914-2923
    • Pasqualucci, L.1    Migliazza, A.2    Basso, K.3    Houldsworth, J.4    Chaganti, R.S.K.5    Dalla-Favera, R.6
  • 34
    • 57349114233 scopus 로고    scopus 로고
    • Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression
    • Gagyi E, Balogh Z, Bodor C, et al. Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression. Haematologica 2008; 93:1822-1828.
    • (2008) Haematologica , vol.93 , pp. 1822-1828
    • Gagyi, E.1    Balogh, Z.2    Bodor, C.3
  • 35
    • 33744503388 scopus 로고    scopus 로고
    • Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation
    • DOI 10.1038/sj.leu.2404183, PII 2404183
    • Reiniger L, Bodor C, Bognar A, et al. Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation. Leukemia 2006; 20:1089-1095. (Pubitemid 43797302)
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 1089-1095
    • Reiniger, L.1    Bodor, C.2    Bognar, A.3    Balogh, Z.4    Csomor, J.5    Szepesi, A.6    Kopper, L.7    Matolcsy, A.8
  • 36
    • 80052269038 scopus 로고    scopus 로고
    • Analysis of the coding genome of diffuse large B-cell lymphoma
    • Pasqualucci L, Trifonov V, Fabbri G, et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet 2011; 43:830-837.
    • (2011) Nat Genet , vol.43 , pp. 830-837
    • Pasqualucci, L.1    Trifonov, V.2    Fabbri, G.3
  • 37
    • 78650308767 scopus 로고    scopus 로고
    • Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
    • Yamane A, Resch W, Kuo N, et al. Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 2011; 12:62-69.
    • (2011) Nat Immunol , vol.12 , pp. 62-69
    • Yamane, A.1    Resch, W.2    Kuo, N.3
  • 38
    • 84857942952 scopus 로고    scopus 로고
    • Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
    • Lohr JG, Stojanov P, Lawrence MS, et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci USA 2012; 109:3879-3884.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 3879-3884
    • Lohr, J.G.1    Stojanov, P.2    Lawrence, M.S.3
  • 40
    • 57149146036 scopus 로고    scopus 로고
    • AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
    • Robbiani DF, Bothmer A, Callen E, et al. AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell 2008; 135:1028-1038.
    • (2008) Cell , vol.135 , pp. 1028-1038
    • Robbiani, D.F.1    Bothmer, A.2    Callen, E.3
  • 41
    • 70449641054 scopus 로고    scopus 로고
    • AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations
    • Robbiani DF, Bunting S, Feldhahn N, et al. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell 2009; 36:631-641.
    • (2009) Mol Cell , vol.36 , pp. 631-641
    • Robbiani, D.F.1    Bunting, S.2    Feldhahn, N.3
  • 42
    • 77955921194 scopus 로고    scopus 로고
    • Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination
    • Hasham MG, Donghia NM, Coffey E, et al. Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 2010; 11:820-826.
    • (2010) Nat Immunol , vol.11 , pp. 820-826
    • Hasham, M.G.1    Donghia, N.M.2    Coffey, E.3
  • 43
    • 76249134265 scopus 로고    scopus 로고
    • Role of the translocation partner in protection against AID-dependent chromosomal translocations
    • Jankovic M, Robbiani DF, Dorsett Y, et al. Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci USA 2010; 107:187-192.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 187-192
    • Jankovic, M.1    Robbiani, D.F.2    Dorsett, Y.3
  • 44
    • 78651468710 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
    • Staszewski O, Baker RE, Ucher AJ, et al. Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells. Mol Cell 2011; 41:232-242.
    • (2011) Mol Cell , vol.41 , pp. 232-242
    • Staszewski, O.1    Baker, R.E.2    Ucher, A.J.3
  • 45
    • 84857131585 scopus 로고    scopus 로고
    • Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
    • Kato L, Begum NA, Burroughs AM, et al. Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. Proc Natl Acad Sci USA 2012; 109:2479-2484.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2479-2484
    • Kato, L.1    Begum, N.A.2    Burroughs, A.M.3
  • 46
    • 80053558376 scopus 로고    scopus 로고
    • Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
    • Chiarle R, Zhang Y, Frock RL, et al. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell 2011; 147:107-119.
    • (2011) Cell , vol.147 , pp. 107-119
    • Chiarle, R.1    Zhang, Y.2    Frock, R.L.3
  • 47
    • 80053502216 scopus 로고    scopus 로고
    • Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes
    • Klein IA, Resch W, Jankovic M, et al. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell 2011; 147:95-106.
    • (2011) Cell , vol.147 , pp. 95-106
    • Klein, I.A.1    Resch, W.2    Jankovic, M.3
  • 48
    • 84859474968 scopus 로고    scopus 로고
    • DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
    • [Epub ahead of print]
    • Hakim O, Resch W, Yamane A, et al. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature 2012. [Epub ahead of print]
    • (2012) Nature
    • Hakim, O.1    Resch, W.2    Yamane, A.3
  • 50
    • 49149108257 scopus 로고    scopus 로고
    • AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice
    • Nepal RM, Zaheen A, Basit W, et al. AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice. Oncogene 2008; 27:4752-4756.
    • (2008) Oncogene , vol.27 , pp. 4752-4756
    • Nepal, R.M.1    Zaheen, A.2    Basit, W.3
  • 51
    • 37549068541 scopus 로고    scopus 로고
    • AID is required for germinal center-derived lymphomagenesis
    • Pasqualucci L, Bhagat G, Jankovic M, et al. AID is required for germinal center-derived lymphomagenesis. Nat Gen 2008; 40:108-112.
    • (2008) Nat Gen , vol.40 , pp. 108-112
    • Pasqualucci, L.1    Bhagat, G.2    Jankovic, M.3
  • 52
    • 77649104794 scopus 로고    scopus 로고
    • Reprogramming towards pluripotency requires AID-dependent DNA demethylation
    • Bhutani N, Brady JJ, Damian M, et al. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 2010; 463:1042-1047.
    • (2010) Nature , vol.463 , pp. 1042-1047
    • Bhutani, N.1    Brady, J.J.2    Damian, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.