AID and RAG1 do not contribute to lymphomagenesis in Eμ c-myc transgenic mice

Oncogene

Volumn 27, Issue 34, 2008, Pages 4752-4756

  Nepal, R M ^a   Zaheen, A ^a   Basit, W ^a   Li, L ^a   Berger, S A ^a,b   Martin, A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Activation induced cytidine deaminase; B cells; c myc; Hypermutation; Lymphoma; RAG

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CYTIDINE DEAMINASE; IMMUNOGLOBULIN G; RAG1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CANCER INCIDENCE; CARCINOGENESIS; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; GENE MUTATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENIC MOUSE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CYTIDINE DEAMINASE; GENETIC PREDISPOSITION TO DISEASE; HOMEODOMAIN PROTEINS; IMMUNOGLOBULIN MU-CHAINS; INCIDENCE; LYMPHOMA, B-CELL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-MYC; SURVIVAL ANALYSIS;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 49149108257     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.111     Document Type: Article

References (27)

1. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S et al. (1985). The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318: 533-538.
2. Crews S, Barth R, Hood L, Prehn J, Calame K. (1982). Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science 218: 1319-1321.
3. Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montano C et al. (2007). Regulation of AID expression in the immune response. J Exp Med 204: 1145-1156.
4. Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM. (1982). Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 79: 7824-7827.
5. Di Noia JM, Neuberger MS. (2007). Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem 76: 1-22.
6. Dorsett Y, Robbiani DF, Jankovic M, Reina-San-Martin B, Eisenreich TR, Nussenzweig MC. (2007). A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med 204: 2225-2232.
7. Egle A, Harris AW, Bouillet P, Cory S. (2004). Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci USA 101: 6164-6169.
8. Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. (1999). Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 13: 2658-2669.
9. Fang W, Weintraub BC, Dunlap B, Garside P, Pape KA, Jenkins MK et al. (1998). Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity 9: 35-45.
10. Franco S, Alt FW, Manis JP. (2006a). Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. DNA Repair (Amst) 5: 1030-1041.
11. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA et al. (2006b). H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell 21: 201-214.
12. Goodnow CC, Crosbie J, Adelstein S, Lavoie TB, Smith-Gill SJ, Brink RA et al. (1988). Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682.
13. Harris AW, Pinkert CA, Crawford M, Langdon WY, Brinster RL, Adams JM. (1988). The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J Exp Med 167: 353-371.
14. Korsmeyer SJ. (1992). Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu Rev Immunol 10: 785-807.
15. Kotani A, Kakazu N, Tsuruyama T, Okazaki IM, Muramatsu M, Kinoshita K et al. (2007). Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Proc Natl Acad Sci USA 104: 1616-1620.
16. Mason DY, Jones M, Goodnow CC. (1992). Development and follicular localization of tolerant B lymphocytes in lysozyme/antilysozyme IgM/IgD transgenic mice. Int Immunol 4: 163-175.
17. Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. (2000). Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553-563.
18. Muramatsu M, Sankaranand VS, Anant S, Sugai M, Kinoshita K, Davidson NO et al. (1999). Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 274: 18470-18476.
19. Muschen M, Re D, Jungnickel B, Diehl V, Rajewsky K, Kuppers R. (2000). Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J Exp Med 192: 1833-1840.
20. Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Kuppers R et al. (2001). Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412: 341-346.
21. Prasad VS, Temple MJ, Davisson MT, Akeson EC, Sidman CL. (1996). Heterogeneity of B-lymphoid tumors in E mu-myc transgenic mice. Cytometry 23: 131-139.
22. Raghavan SC, Swanson PC, Wu X, Hsieh CL, Lieber MR. (2004). A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature 428: 88-93.
23. Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM et al. (2006). Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440: 105-109.
24. Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M et al. (2004). AID is required for c-myc/IgH chromosome translocations in vivo. Cell 118: 431-438.
25. Shen HM, Peters A, Baron B, Zhu X, Storb U. (1998). Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280: 1750-1752.
26. Smith DP, Bath ML, Harris AW, Cory S. (2005). T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC. Oncogene 24: 3544-3553.
27. van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A. (1991). Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell 65: 737-752.