T-helper cells in the etiopathogenesis of periodontal disease: A mini review

Journal of Indian Society of Periodontology

Volumn 15, Issue 1, 2011, Pages 4-10

  Arun, K V ^a   Talwar, Avaneendra ^a   Kumar, T S S ^a  

^a RAGAS DENTAL COLLEGE AND HOSPITAL   (India)

Author keywords

Th1; Th17; Th2; Th22 cells; Th9; Treg

Indexed keywords

EID: 84861922001     PISSN: 0972124X     EISSN: 09751580     Source Type: Journal    
DOI: 10.4103/0972-124X.82255     Document Type: Article

References (84)

1. Ivanyi L, Lehner T. Stimulation of lymphocyte transformation by bacterial antigens in patients with periodontal disease. Arch Oral Biol 1970;15:1089-96.
2. Gemell E, Yamazak K, Gregory J. The role of T cells in periodontal disease: Homeostasis and autoimmunity. Periodontology 2000 2007;43:14-40.
3. Azuma M. Fundamental mechanisms of host immune responses to infection. J Periodont Res 2006;41:361-73.
4. Teng YT, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, et al. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest 2000;106:R59.
5. th Edition. USA, Mosby-Year Book, Inc., 1999. p. 1-12.
6. Parish CR, Liew FY. Immune response to chemically modified flagellin. 3. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J Exp Med 1972;135: 298-311.
7. Mossman TR, Coffman RL. TH1 and TH2 cells: Different patterns of lymphokine secretion leads to different functional properties. Annu Rev Immunol 1989;7:145-73.
8. Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are determined by the nature of the lymphocyte response. Crit Rev Oral Biol Med 2002;13:17-34.
9. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA. Immunopathogenesis of chronic inflammatory periodontal disease: Cellular and molecular mechanisms. J Periodontol Res 1993;28:478-86.
10. Ebersole JL, Taubman MA. The proactive nature of host response in periodontal disease. Periodontol 2000 1994;5:112-41.
11. Fujihashi K, Yamamoto m, McGhee JR, Kiyono H. Type1/type 2 cytokine production by CD4+ T cells in adult periodontitis. J Dent Res 1994;73:204.
12. Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, Van-Dyke T, Banchereau J. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J immunol 2001;167:5067-76.
13. Takeichi O, Haber J, Kawai T, Smith DJ, Taubman MA. Cytokine profiles of T lymphocytes from gingival tissues with pathological pocketing. J Dent Res 2000;79:1548-55.
14. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin-17 producting CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1069-70.
15. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha chain(CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
16. Yssel H, Pene J. Interleukin-22 producing T cells: A specialized population involved in skin inflammation. Immunol and Cell Biol 2009;87:574-6.
17. -) effector T cells. Nat Immunol 2008;9:1347-55.
18. Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, et al. Transforming growth factor beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008;9:1341-6.
19. Zhou L, Mark MW, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity 2009;30:646-55.
20. Locksley RM. Nine lives: Plasticity among T helper cell subsets. J Exp Med 2009;206:1643-6.
21. Romagnani S. Biology of human TH1 and TH2 cells. J Clin Immunol 1995;15:121-9.
22. Manetti R, Annunziato F, Tomasevic L, Gianno V, Parronchi P, Romagnani S, et al. Polyinosinic acid: Polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12. Eur J Immunol 1995;25:2656-60.
23. Jotwani R, Palucka AK, Al-Quotub M, Nauri-Shizazi M, Kim J, Bell D, et al. Mature dendritic cells infiltrate the T-cell rich region of oral mucosa in chronic periodontitis: In situ, in vivo and in vitro studies. J Immunol 2001;167:4693-700.
24. Amanuma R, Nakajima T, Yoshie H, Yamazaki K. Increased infiltration of CD1d and natural killer T cells in periodontal disease tissues. J Periodontol Res 2006;41:73-9.
25. Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)- 12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 1997;185:817-24.
26. Smeltz RB, Chen J, Ehrhardt R, Shevach EM. Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of Il-4 and by inducing/maintaining Il-12 receptor beta 2 expression. J Immunol 2002;168:6165-72.
27. Zhang K. Immunoglobin class switch recombination machinery: Progress and challenges. Clin Immunol 2000;95:1-8.
28. Berglundh T, Donat M, Zitzmann N. B cells in periodontitis-friends or enemies? Periodontol 2000 2007;45:51-66.
29. Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T cell fates by different notch ligands on antigen-presenting cells. Cell 2004;117:515-26.
30. Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 2006;203:843-9.
31. Yamazaki K, Nakajima T, Aoyagi T, Hara K. Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease. J Periodont Res 1993;28:324-34.
32. Steinsvoll S, Helgeland K, Schenck K. Mast cells: A role in periodontal diseases? J Clin Periodontol 2004;31:413-9.
33. Zhu J, Guo L, Watson CJ, Hu-Li J, Paul WE. Stat6 is necessary and suffcient for IL4's role in Th2 differentiation and cell expansion. J Immunol 2001;166:7276-81.
34. Zhu J, Yamane H, Cote-Sierra J, Guo L, Paul WE. GATA-3 promotes Th2 responses through three different mechanisms: Induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factor. Cell Res 2006; 16:3-10.
35. Usui T, Nishikomori R, Kitani A, Strober W. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rβ2 chain or t-bet. Immunity 2003;18:415-28.
36. Zhu J, Cote-Sierra J, Guo L, Paul WE. Stat5 activation plays a critical role in Th2 differentiation. Immunity 2003;19:739-48.
37. Gemmel E, Seymour GJ. Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease. Periodontol 2000 2004;35:21-4.
38. Gemmell E, Seymour GJ. Modulation of immune responses to periodontal bacteria. Curr Opin Periodontol 1994;94:28-38.
39. Gemmell E, Seymour GJ. Modulation of immune responses to periodontal bacteria. Curr Opin Periodontol 1994;94:28-38.
40. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA. Immunopathogenesis of chronic inflammatory periodontal disease: Cellular and molecular mechanisms. J Periodontol Res 1993;28:478-86.
41. Gemmell E, Marshall RI, Seymour GJ. Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease. Periodontol 2000 1997;14:112-43.
42. Gaffen SL, Hajishengallis G. A new inflammatory cytokine on the block: Re-thinking periodontal disease and the Th1/Th2 paradigm in the context of the Th17 cells and IL-17. J Dent Res 2008;87:817-25.
43. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003;421:744-8.
44. Dubin PJ, Kolls JK. Th17 cytokines and mucosal immunity. Immunol Rev 2008;226:160-71.
45. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007;25:821-52.
46. Ghilardi N, Ouyang W. Targeting the development and effector functions of Th17 cells. Semin Immunol 2007;19:383-93.
47. Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, et al. Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003;198:1951-7.
48. Roberts FA, McCafferyl KA, Michalek SM. Profile of cytokine mRNA expression in chronic adult periodontitis. J Dent Res 1997;76;1833-9.
49. Chen Z, Laurence A, O'Shea JJ. Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol 2007;19:400-8.
50. Takahashi K, Azuma T, Motohira H, Kinane DF, Kitetsu S. The potential role of interleukin-17 in the immunopathology of periodontal disease. J Clin Periodontol 2005;32:369-74.
51. Vernal R, Dutzan N, Chaparro A, Puente J, Antonieta Valenzuela M, Gamonal J. Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. J Clin Periodontol 2005;32:383-9.
52. Cardoso CR, Garlet GP, Crippa GE, Rosa AL, Júnior WM, Rossi MA, et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol Immunol 2009;24:1-6.
53. Romagani S. Human Th17 cells. Arthritis Res Ther 2008;10:206-19.
54. Oda T, Yoshie H, Yamazaki K. Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-κB ligand in vitro. Oral Microbiol Immunol 2003;18:30-6.
55. Fossiez F, Djoussou O, Chomarat P, Flores-Remo L, Ait-Yahia S, Maat C, et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and heamtopoeitic cytokines. J Exp Med 1996;183:2593-603.
56. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999;103:1345-52.
57. Van bezooijen RL, Farih-Sips HC, Papapoulos SE, Löwik CW. Interleukin-17: A new bone acting cytokine in vitro. J Bone Min Res 1999;14:1513-21.
58. Pradeep AR, Parag Hadge P, Chowdhry S, Patel S, Happy D. Exploring the role of Th1 cytokines: Interleukin-17 and interleukin-18 in periodontal health and disease. J Oral Sci 2009;51:261-6.
59. Gershon RK, Kondo K. Cell interactions in the induction of tolerance: The Role of Thymic lymphocytes. Immunology 1970;18:723-37.
60. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha chain (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-64.
61. + regulatory T cell: A jack of all trades, master of regulation. Nat Immunol 2008;9:239-44.
62. Gonzalez-Garcia C, Martin-Saavedra F, Ballester A, Ballester S. The Th17 lineage: Answers to some immunological questions. Inmunologia 2009;28:32-45.
63. Zhou L, Litterman DR. Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol 2009;21:146-52.
64. Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4+CD25+ regulatory T cells is mediated by cell surface-bound transforming growth factorβ. J Exp Med 2001;194:629-44.
65. Lu DC, Quezada LF, Sakaguchi SA, Noelle R J. Cutting edge: Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin independent mechanism. J Immunol 2005;174:1783-6.
66. Ren X, Ye F, Jiang Z, Chu Y, Xiong S, Wang Y. Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+)regulatory T cells. Cell Death Differ 2007;14: 2076-84.
67. Da la Rosa M, Rutz S, Dorninger H, Scheffold A. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol 2004;34:2480-8.
68. Hubert P, Jacobs N, Caberg JH, Boniver J, Delvenne P. The crosstalk between dendritic and regulatory cells: Good or evil? J Leuk Bio 2007;82:781-94.
69. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Immunol 2008;8:523-32.
70. Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 2006;442:997-1002.
71. Nakajima T, Ueki-Maruyama K, Oda T, Ohasawa Y, Ito H, Seymour GJ, et al. Regulatory T-cells infiltrate periodontal disease tissues. J Dent Res 2005;84:639-43.
72. Cardoso CR, Garlet GP, Moreira AP, Junior WM, Rossi MA, Silva JS. Characterization of CD4(+)CD25(+) natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. J Leuk Biol 2008;84:311-8.
73. Ernst CW, Lee JE, Nakanishi T, Karimbux NY, Rezende TM, Stashenko P, et al. Diminished forkhead box P3/CD25 double positive T regulatory cells are associated with the increased nuclear factor - κB ligand (RANKL +) T cells in the bone resorption lesion of periodontal disease. Clin Exp Immunol 2007;148: 271-80.
74. Dutzan N, Gamonal J, Silva A, Sanz M, Vernal R. Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL)-17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. J Clin Periodontol 2009;36:396-403.
75. Okui T, Ito H, Honda T, Amanuma R, Yoshie H, Yamazaki K. Characterization of CD4+ FOXP3+ T-cell clones established from chronic inflammatory lesions. Oral Microbiol Immunol 2007;23:49-54.
76. Wolk K, Sabat R. Interleukin-22: A novel T- and NK cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev 2006;17:367-80.
77. Boniface K, Guigouard E, Pedretti N, Garcia M, Delwail A, Bernard FX, et al. A role for T cell-derived interleukin 22 in psoriatic skin inflammation. Clin Exp Immunol 2007;150:407-15.
78. Yssel H, Pene J. Interleukin-22 producing T cells: A specialized population involved in skin inflammation? Immunol Cell Biol 2009;87:574-6.
79. Gessner A, Blum H, Röllinghoff M. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiol 1993;189:419-35.
80. Ma CS, Tangye SG, Deenick EK. Human Th9 cells: Inflammatory cytokines modulate IL-9 production through the induction of IL-21. Immunol Cell Biol 2010;88:621-3.
81. Neill DR, Andrew NJ, McKenzie AN. TH9: The latest addition to the expanding repertoire of IL-25 targets. Immunol Cell Biol 2010;88:502-4.
82. + T cells and implications for autoimmunity. J Neuroimmune Pharmacol 2009;5:198-209.
83. Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, et al. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci USA 2009;106:12885-90.
84. Demoulin JB, Uyttenhove C, Roost EV, De Lestre B, Donckers D, Snick JV, et al. A single tyrosine of the Interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol 1996;16:4710-6.