Blockade of 5-HT1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission

Neuropharmacology

Volumn 54, Issue 7, 2008, Pages 1041-1050

  Eriksson, Therese M ^a   Madjid, Nather ^a   Elvander Tottie, Elin ^a   Stiedl, Oliver ^b   Svenningsson, Per ^a   Ögren, Sven Ove ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

5 HT1B receptor; Acetylcholine; Contextual learning; Glutamate; Memory; Passive avoidance

Indexed keywords

2 (3 MORPHOLINOMETHYL 2H CHROMEN 8 YL) OXYMETHYLMORPHOLINE METHANESULFONATE; ANPIRTOLINE; DIZOCILPINE; GLUTAMIC ACID; NAS 181; SCOPOLAMINE; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AVERSIVE BEHAVIOR; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; LEARNING; MALE; MEMORY CONSOLIDATION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; PROTEIN FUNCTION;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BENZOPYRANS; CHOLINERGIC ANTAGONISTS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; MALE; MICE; MORPHOLINES; PIPERIDINES; PYRIDINES; REACTION TIME; RECEPTOR, SEROTONIN, 5-HT1B; SCOPOLAMINE; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SYNAPTIC TRANSMISSION;

EID: 42749091882     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.02.007     Document Type: Article

References (58)

1. Adell A., Celada P., and Artigas F. The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain. Journal of Neurochemistry 79 (2001) 172-182
2. Åhlander-Lüttgen M., Madjid N., Schött P.A., Sandin J., and Ögren S.O. Analysis of the role of the 5-HT1B receptor in spatial and aversive learning in the rat. Neuropsychopharmacology 28 (2003) 1642-1655
3. Ait Amara D., Segu L., Naili S., and Buhot M.-C. Serotonin 1B receptor regulation after dorsal subiculum deafferentation. Brain Research Bulletin 38 (1995) 17-23
4. Ait Amara D., Segu L., and Buhot M.C. Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat. Neuroscience Letters 310 (2001) 25-28
5. Azmitia E.C., and Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. Journal of Comparative Neurology 179 (1978) 641-668
6. Baarendse P.J., van Grootheest G., Jansen R.F., Pieneman A.W., Ögren S.O., Verhage M., and Stiedl O. Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice. Hippocampus 18 (2008) 11-19
7. Bartus R.T., Dean III R.L., Beer B., and Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217 (1982) 408-414
8. Berg S., Larsson L.G., Renyi L., Ross S.B., Thorberg S.O., and Thorell-Svantesson G. R-(+)-2-(3-Morpholinomethyl-2H-chromen-8-yl)oxymethylmorpholine methanesulfonate), a new selective rat 5-hydroxytryptamine1B receptor antagonist. Journal of Medicinal Chemistry 41 (1998) 1934-1942
9. 1B receptors suppresses low but not high frequency synaptic transmission in the rat subicular cortex in vitro. Brain Research 721 (1996) 59-65
10. 1B presynaptic heteroreceptors inhibiting acetylcholine-release. Neuropharmacology 33 (1994) 77-81
11. Boschert U., Amara D.A., Segu L., and Hen R. The mouse 5-hydroxytryptamine1B receptor is localized predominantly on axon terminals. Neuroscience 58 (1994) 167-182
12. 1F, receptor messenger-RNA in rodent and primate brain. Neuropharmacology 33 (1994) 367-386
13. 1B knockout mice. Behavioral Neuroscience 113 (1999) 587-601
14. Buhot M.C., Patra S.K., and Naili S. Spatial memory deficits following stimulation of hippocampal 5-HT1B receptors in the rat. European Journal of Pharmacology 285 (1995) 221-228
15. 1A receptors. British Journal of Pharmacology 105 (1992) 720-726
16. 1B-mediated modulation of [3H]acetylcholine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts of septal origin. Brain Research 704 (1995) 153-166
17. Caulfield M.P. Muscarinic receptors-characterization, coupling and function. Pharmacology & Therapeutics 58 (1993) 319-379
18. Chadha A., Sur C., Atack J., and Duty S. The 5HT(1B) receptor agonist, CP-93129, inhibits [(3)H]-GABA release from rat globus pallidus slices and reverses akinesia following intrapallidal injection in the reserpine-treated rat. British Journal of Pharmacology 130 (2000) 1927-1932
19. 1B receptors. Proceedings of the National Academy of Sciences USA 94 (1997) 9899-9904
20. 1B receptors. Journal of Pharmacology & Experimental Therapeutics 277 (1996) 823-830
21. 1B receptor agonist. Neuropsychopharmacology 272 (2002) 171-181
22. Duguid I., and Sjostrom P.J. Novel presynaptic mechanisms for coincidence detection in synaptic plasticity. Current Opinion in Neurobiology 16 (2006) 312-322
23. Elvander-Tottie E., Eriksson T.M., Sandin J., and Ögren S.O. N-methyl-d-aspartate receptors in the medial septal area have a role in spatial and emotional learning in the rat. Neuroscience 142 (2006) 963-978
24. Engel G., Gothert M., Hoyer D., Schlicker E., and Hillenbrand K. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat-brain cortex with 5-HT1B binding-sites. Naunyn-Schmiedebergs Archives of Pharmacology 332 (1986) 1-7
25. de Groote L., Olivier B., and Westenberg H.G. Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice. Psychopharmacology (Berl) 162 (2002) 419-424
26. de Groote L., Klompmakers A.A., Olivier B., and Westenberg H.G. An evaluation of the effect of NAS-181, a new selective 5-HT(1B) receptor antagonist, on extracellular 5-HT levels in rat frontal cortex. Naunyn-Schmiedebergs Archives of Pharmacology 367 (2003) 89-94
27. Hertel P., Nomikos G.G., and Svensson T.H. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology 38 (1999) 1175-1184
28. Hjorth S., and Tao R. The putative 5-HT1B receptor agonist CP-93,129 suppresses rat hippocampal 5-HT release in vivo: comparison with RU 24969. European Journal of Pharmacology 209 (1991) 249-252
29. Hjorth S., Bengtsson H.J., Kullberg A., Carlzon D., Peilot H., and Auerbach S.B. Serotonin autoreceptor function and antidepressant drug action. Journal of Psychopharmacology 14 (2000) 177-185
30. Hoss W., Messer Jr. W.S., Monsma Jr. F.J., Miller M.D., Ellerbrock B.R., Scranton T., Ghodsi-Hovsepian S., Price M.A., Balan S., Mazloum Z., et al. Biochemical and behavioral evidence for muscarinic autoreceptors in the CNS. Brain Research 517 (1990) 195-201
31. Hoyer D., Hannon J.P., and Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology Biochemistry and Behavior 71 (2002) 533-554
32. Hu X.J., Wang F.H., Stenfors C., Ögren S.O., and Kehr J. Effects of the 5-HT(1B) receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats: a microdialysis study. European Neuropsychopharmacology 17 (2007) 580-586
33. 1A receptor enhances acetylcholine release in conscious rats. Journal of Neurochemistry 62 (1994) 1804-1808
34. Johnson S.W., Mercuri N.B., and North R.A. 5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons. Journal of Neuroscience 12 (1992) 2000-2006
35. 1B receptors of glutamatergic synaptic inputs onto serotonergic caudal raphe neurones in rat. Journal of Physiology-London 510 (1998) 121-134
36. 1A receptors in spatial and aversive learning in the rat. Neuropharmacology 48 (2005) 830-852
37. Madjid N., Tottie E.E., Lüttgen M., Meister B., Sandin J., Kuzmin A., Stiedl O., and Ögren S.O. 5-Hydroxytryptamine 1A receptor blockade facilitates aversive learning in mice: interactions with cholinergic and glutamatergic mechanisms. Journal of Pharmacology and Experimental Therapeutics 316 (2006) 581-591
38. Malleret G., Hen R., Guillou J.L., Segu L., and Buhot M.C. 5-HT1B receptor knock-out mice exhibit increased exploratory activity and enhanced spatial memory performance in the Morris water maze. Journal of Neuroscience 19 (1999) 6157-6168
39. Misane I., and Ögren S.O. Multiple 5-HT receptors in passive avoidance: comparative studies of p-chloroamphetamine and 8-OH-DPAT. Neuropsychopharmacology 22 (2000) 168-190
40. 1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat. Neuropsychopharmacology 28 (2003) 253-264
41. 1B receptor-mediated inhibition of local excitatory synaptic transmission in the CA1 region of rat hippocampus. British Journal of Pharmacology 138 (2003) 71-80
42. 1B auto- and heteroreceptors. Molecular Pharmacology 58 (2000) 1271-1278
43. 1B receptors. European Journal of Neuroscience 10 (1998) 2371-2379
44. Ögren S.O. Central serotonin neurones in avoidance learning: interactions with noradrenaline and dopamine neurones. Pharmacology Biochemistry and Behavior 23 (1985) 107-123
45. Ögren S.O. Evidence for a role of brain serotonergic neurotransmission in avoidance learning. Acta Physiologica Scandinavica 125 (1985) 1-71
46. Ramboz S., Saudou F., Amara D.A., Belzung C., Segu L., Misslin R., Buhot M.C., and Hen R. 5-HT1B receptor knock out-behavioral consequences. Behavioural Brain Research 73 (1996) 305-312
47. 1B-receptor knockout mice. Brain Research Bulletin 70 (2006) 81-93
48. Sari Y. Serotonin(1B) receptors: from protein to physiological function and behavior. Neuroscience and Biobehavioral Reviews 28 (2004) 565-582
49. 1B receptor agonist with antinociceptive/antidepressant-like actions in rodents. British Journal of Pharmacology 105 (1992) 732-738
50. Steckler T., and Sahgal A. The role of serotonergic-cholinergic interactions in the mediation of cognitive behaviour. Behavioural Brain Research 67 (1995) 165-199
51. Stenfors C., Yu H., and Ross S.B. Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. Naunyn-Schmiedeberg's Archives of Pharmacology 363 (2001) 222-232
52. Stiedl O., and Meyer M. Cardiac dynamics in corticotropin-releasing factor receptor subtype-2 deficient mice. Neuropeptides 37 (2003) 3-16
53. Stiedl O., Birkenfeld K., Palve M., and Spiess J. Impairment of conditioned contextual fear of C57BL/6J mice by intracerebral injections of the NMDA receptor antagonist APV. Behavioural Brain Research 116 (2000) 157-168
54. Stiedl O., Misane I., Spiess J., and Ögren S.O. Involvement of the 5-HT1A receptors in classical fear conditioning in C57BL/6J mice. Journal of Neuroscience 20 (2000) 8515-8527
55. 1B receptor function by p11 in depression-like states. Science 311 (2006) 77-80
56. Timmerman W., and Westerink B.H.C. Brain microdialysis of GABA and glutamate: what does it signify?. Synapse 27 (1997) 242-261
57. 1B receptors: in vivo microdialysis studies. Journal of Neurochemistry 69 (1997) 2019-2025
58. Wolff M., Benhassine N., Costet P., Hen R., Segu L., and Buhot M.C. Delay-dependent working memory impairment in young-adult and aged 5-HT1BKO mice as assessed in a radial-arm water maze. Learning & Memory 10 (2003) 401-409