Boosting serotonin in the brain: Is it time to revamp the treatment of depression?

Journal of Psychopharmacology

Volumn 26, Issue 5, 2012, Pages 629-635

  Torrente, Mariana P ^a   Gelenberg, Alan J ^a   Vrana, Kent E ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Antidepressants; depression; serotonin; tryptophan hydroxylase 2

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE MALEATE; PAROXETINE; SEROTONIN; SERTRALINE; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 2;

CHEMICAL STRUCTURE; DEPRESSION; DISEASE ASSOCIATION; DRUG EFFECT; DRUG TARGETING; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; HUMAN; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; SEROTONIN BRAIN LEVEL; SEROTONIN METABOLISM; SEROTONIN RELEASE; SEROTONINERGIC TRANSMISSION; TREATMENT DURATION;

ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSIVE DISORDER; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 84861792389     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881111430744     Document Type: Review

References (64)

1. Alenina N, Kikic D, Todiras M, et al. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A. 2009 ; 106: 10332-10337
2. Andersen OA, Stokka AJ, Flatmark T, et al. 2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding. J Mol Biol. 2003 ; 333: 747-757
3. Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 ; 3: 271-280
4. Calvo AC, Scherer T, Pey AL, et al. Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2. J Neurochem. 2010 ; 114: 853-863
5. Carkaci-Salli N, Flanagan JM, Martz MK, et al. Functional domains of human tryptophan hydroxylase 2 (hTPH2). J Biol Chem. 2006 ; 281: 28105-28112
6. Cichon S, Winge I, Mattheisen M, et al. Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5′-region are associated with bipolar affective disorder. Hum Mol Genet. 2008 ; 17: 87-97
7. Covington HE, Maze I, LaPlant QC, et al. Antidepressant actions of histone deacetylase inhibitors. J Neurosci. 2009 ; 29: 11451-11460
8. de Bodinat C, Guardiola-Lemaitre B, Mocaer E, et al. Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discov. 2010a ; 9: 628-642
9. Dunkley PR, Bobrovskaya L, Graham ME, et al. Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem. 2004 ; 91: 1025-1043
10. Eckman EA, Eckman CB. Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention. Biochem Soc Trans. 2005 ; 33: 1101-1105
11. Evans DL, Charney DS, Lewis L, et al. Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry. 2005 ; 58: 175-189
12. Fernstrom JD, Wurtman RJ. Brain serotonin content: physiological dependence on plasma tryptophan levels. Science. 1971 ; 173: 149-152
13. Fitzpatrick PF. Tetrahydropterin-dependent amino acid hydroxylases. Annu Rev Biochem. 1999 ; 68: 355-381
14. Gildengers AG, Whyte EM, Drayer RA, et al. Medical burden in late-life bipolar and major depressive disorders. Am J Geriatr Psychiatry. 2008 ; 16: 194-200
15. Gnad F, Ren S, Cox J, et al. PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites. Genome Biol. 2007 ; 8: R250
16. Greenberg PE, Kessler RC, Birnbaum HG, et al. The economic burden of depression in the United States: how did it change between 1990 and 2000?. J Clin Psychiatry. 2003 ; 64: 1465-1475
17. Gutknecht L, Waider J, Kraft S, et al. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm. 2008 ; 115: 1127-1132
18. Haavik J, Blau N, Thony B. Mutations in human monoamine-related neurotransmitter pathway genes. Hum Mutat. 2008 ; 29: 891-902
19. Honore E. The neuronal background K2P channels: focus on TREK1. Nat Rev Neurosci. 2007 ; 8: 251-261
20. Huang Z, Liu T, Chattoraj A, et al. Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. J Pineal Res. 2008 ; 45: 506-514
21. Kennedy SH. Agomelatine: efficacy at each phase of antidepressant treatment. CNS Drugs. 2009 ; 23: 41-47
22. Knol MJ, Twisk JW, Beekman AT, et al. Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia. 2006 ; 49: 837-845
23. Kobe B, Jennings IG, House CM, et al. Structural basis of autoregulation of phenylalanine hydroxylase. Nat Struct Biol. 1999 ; 6: 442-448
24. Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature. 2008 ; 455: 894-902
25. Kuhn DM, Sakowski SA, Geddes TJ, et al. Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II. J Neurochem. 2007 ; 103: 1567-1573
26. Kumer SC, Vrana KE. Intricate regulation of tyrosine hydroxylase activity and gene expression. J Neurochem. 1996 ; 67: 443-462
27. Li J, Dangott LJ, Fitzpatrick PF. Regulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometry. Biochemistry. 2010 ; 49: 3327-3335
28. Licinio J, Wong ML. Depression, antidepressants and suicidality: a critical appraisal. Nat Rev Drug Discov. 2005 ; 4: 165-171
29. Lin YM, Chao SC, Chen TM, et al. Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Arch Gen Psychiatry. 2007 ; 64: 1015-1024
30. Lin YM, Ko HC, Chang FM, et al. Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Arch Womens Ment Health. 2009 ; 12: 401-408
31. Markus CR. Dietary amino acids and brain serotonin function; implications for stress-related affective changes. Neuromolecular Med. 2008 ; 10: 247-258
32. Marr RA, Rockenstein E, Mukherjee A, et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci. 2003 ; 23: 1992-1996
33. Matthes S, Mosienko V, Bashammakh S, et al. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology. 2010 ; 85: 95-109
34. McKinney J, Knappskog PM, Haavik J. Different properties of the central and peripheral forms of human tryptophan hydroxylase. J Neurochem. 2005 ; 92: 311-320
35. Meltzer H. Serotonergic dysfunction in depression. Br J Psychiatry Suppl. 1989 ; 8: 25-31
36. Mockus SM, Vrana KE. Advances in the molecular characterization of tryptophan hydroxylase. J Mol Neurosci. 1998 ; 10: 163-179
37. Moens AL, Kass DA. Tetrahydrobiopterin and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2006 ; 26: 2439-2444
38. Murphy KL, Zhang X, Gainetdinov RR, et al. A regulatory domain in the N terminus of tryptophan hydroxylase 2 controls enzyme expression. J Biol Chem. 2008 ; 283: 13216-13224
39. Musselman DL, Betan E, Larsen H, et al. Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biol Psychiatry. 2003 ; 54: 317-329
40. Nutt DJ. The role of dopamine and norepinephrine in depression and antidepressant treatment. J Clin Psychiatry. 2006 ; 67: 3-8
41. Patel PD, Pontrello C, Burke S. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry. 2004 ; 55: 428-433
42. Pincus HA, Pettit AR. The societal costs of chronic major depression. J Clin Psychiatry. 2001 ; 62: 5-9
43. Plazas-Mayorca MD, Vrana KE. Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior?. J Proteome Res. 2010 ; 10: 58-65
44. Rakofsky JJ, Holtzheimer PE, Nemeroff CB. Emerging targets for antidepressant therapies. Curr Opin Chem Biol. 2009 ; 13: 291-302
45. Savelieva KV, Zhao S, Pogorelov VM, et al. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 2008 ; 3: e3301
46. Spedding M, Jay T, Costa e, Silva J, et al. A pathophysiological paradigm for the therapy of psychiatric disease. Nat Rev Drug Discov. 2005 ; 4: 467-476
47. Turner EH, Loftis JM, Blackwell AD. Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther. 2006 ; 109: 325-338
48. van Wijngaarden B, Koeter M, Knapp M, et al. Caring for people with depression or with schizophrenia: are the consequences different?. Psychiatry Res. 2009 ; 169: 62-69
49. Veenstra-VanderWeele J, Cook EH. Molecular genetics of autism spectrum disorder. Mol Psychiatry. 2004 ; 9: 819-832
50. Walther DJ, Peter JU, Bashammakh S, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science. 2003 ; 299: 76
51. Wang L, Erlandsen H, Haavik J, et al. Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. Biochemistry. 2002 ; 41: 12569-12574
52. Windahl MS, Petersen CR, Christensen HE, et al. Crystal structure of tryptophan hydroxylase with bound amino acid substrate. Biochemistry. 2008 ; 47: 12087-12094
53. Winge I, McKinney JA, Knappskog PM, et al. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007 ; 100: 1648-1657
54. Winge I, McKinney JA, Ying M, et al. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochem J. 2008 ; 410: 195-204
55. Wong DT, Perry KW, Bymaster FP. Case history: the discovery of fluoxetine hydrochloride (Prozac). Nat Rev Drug Discov. 2005 ; 4: 764-774
56. Wong ML, Licinio J. From monoamines to genomic targets: a paradigm shift for drug discovery in depression. Nat Rev Drug Discov. 2004 ; 3: 136-151
57. Wurtman RJ. Ways that foods can affect the brain. Nutr Rev. 1986 ; 44: 2-6
58. Wurtman RJ. Presynaptic control of Release of Amine Neurotransmitters by Precursor Levels. News Physiol Sci. 1988 ; 3: 158-163
59. Young NL, Plazas-Mayorca MD, Garcia BA. Systems-wide proteomic characterization of combinatorial post-translational modification patterns. Expert Rev Proteomics. 2010 ; 7: 79-92
60. Young SN, Leyton M. The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels. Pharmacol Biochem Behav. 2002 ; 71: 857-865
61. Zhang X, Beaulieu JM, Gainetdinov RR, et al. Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. Cell Mol Life Sci. 2006 ; 63: 6-11
62. Zhang X, Beaulieu JM, Sotnikova TD, et al. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science. 2004 ; 305: 217
63. Zhang X, Gainetdinov RR, Beaulieu JM, et al. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron. 2005 ; 45: 11-16
64. Zorn JA, Wells JA. Turning enzymes ON with small molecules. Nat Chem Biol. 2010 ; 6: 179-188