Regulation of phenylalanine hydroxylase: Conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometry

Biochemistry

Volumn 49, Issue 15, 2010, Pages 3327-3335

  Li, Jun ^a   Dangott, Lawrence J ^b   Fitzpatrick, Paul F ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC ACTIVATOR; CATALYTIC DOMAINS; CONFORMATIONAL CHANGE; EXCHANGE KINETICS; GAIN INSIGHT; HYDROGEN/DEUTERIUM EXCHANGE; INHIBITORY PEPTIDES; MUTANT ENZYMES; PHENYLALANINE HYDROXYLASE; REGULATORY DOMAIN; TWO DOMAINS;

BINDING ENERGY; CHEMICAL ACTIVATION; DEUTERIUM; ENZYMES; LAWS AND LEGISLATION; MASS SPECTROMETRY; ORGANIC ACIDS; PEPTIDES;

AMINO ACIDS;

PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVATION; ENZYME CONFORMATION; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; DEUTERIUM; HYDROGEN; KINETICS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PROTEIN CONFORMATION; RATS;

RATTUS;

EID: 77950946245     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1001294     Document Type: Article

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