Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding

Biochemical Journal

Volumn 410, Issue 1, 2008, Pages 195-204

  Winge, Ingeborg ^a   McKinney, Jeffrey A ^a   Ying, Ming ^a   D'Santos, Clive S ^a   Kleppe, Rune ^a   Knappskog, Per M ^a,b   Haavik, Jan ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

14 3 3 protein; Human embryonic kidney (HEK) 293 cell; Phosphorylation; Protein kinase A; Serotonin; Tryptophan hydroxylase 2 (TPH2) regulation

Indexed keywords

BINDING SITES; ESCHERICHIA COLI; PHOSPHORYLATION; STOICHIOMETRY; TISSUE;

HUMAN EMBRYONIC KIDNEY; PROTEIN KINASE; SEROTONIN;

ENZYME ACTIVITY;

PROTEIN 14 3 3; TRYPTOPHAN HYDROXYLASE 2;

ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME KINETICS; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOICHIOMETRY;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; ENZYME ACTIVATION; ENZYME STABILITY; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; SURFACE PLASMON RESONANCE; TANDEM MASS SPECTROMETRY; TRYPTOPHAN HYDROXYLASE;

ESCHERICHIA COLI; MAMMALIA;

EID: 39749177631     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071033     Document Type: Article

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