-
1
-
-
37549048249
-
The BCL-2 protein family: opposing activities that mediate cell death
-
Youle R.J., Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9:47-59.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
2
-
-
0034975774
-
Mouse models of cell death
-
Ranger A.M., et al. Mouse models of cell death. Nat. Genet. 2001, 28:113-118.
-
(2001)
Nat. Genet.
, vol.28
, pp. 113-118
-
-
Ranger, A.M.1
-
3
-
-
82255192310
-
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
-
Ni Chonghaile T., et al. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 2011, 334:1129-1133.
-
(2011)
Science
, vol.334
, pp. 1129-1133
-
-
Ni Chonghaile, T.1
-
4
-
-
79952291173
-
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
-
Gandhi L., et al. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J. Clin. Oncol. 2011, 29:909-916.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 909-916
-
-
Gandhi, L.1
-
5
-
-
77957141008
-
Still embedded together binding to membranes regulates Bcl-2 protein interactions
-
Leber B., et al. Still embedded together binding to membranes regulates Bcl-2 protein interactions. Oncogene 2010, 29:5221-5230.
-
(2010)
Oncogene
, vol.29
, pp. 5221-5230
-
-
Leber, B.1
-
6
-
-
0033258120
-
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?
-
Vander Heiden M.G., Thompson C.B. Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?. Nat. Cell Biol. 1999, 1:E209-E216.
-
(1999)
Nat. Cell Biol.
, vol.1
-
-
Vander Heiden, M.G.1
Thompson, C.B.2
-
7
-
-
64749114270
-
Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons
-
Berman S.B., et al. Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons. J. Cell Biol. 2009, 184:707-719.
-
(2009)
J. Cell Biol.
, vol.184
, pp. 707-719
-
-
Berman, S.B.1
-
9
-
-
80051970600
-
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival
-
Yi C.H., et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell 2011, 146:607-620.
-
(2011)
Cell
, vol.146
, pp. 607-620
-
-
Yi, C.H.1
-
10
-
-
0037418843
-
2+: a control point for apoptosis
-
2+: a control point for apoptosis. Science 2003, 300:135-139.
-
(2003)
Science
, vol.300
, pp. 135-139
-
-
Scorrano, L.1
-
11
-
-
77958124651
-
Homeostatic functions of BCL-2 proteins beyond apoptosis
-
Danial N.N., et al. Homeostatic functions of BCL-2 proteins beyond apoptosis. Adv. Exp. Med. Biol. 2010, 687:1-32.
-
(2010)
Adv. Exp. Med. Biol.
, vol.687
, pp. 1-32
-
-
Danial, N.N.1
-
12
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang X.H., et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
-
13
-
-
0347091260
-
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development
-
Fannjiang Y., et al. BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development. Dev. Cell 2003, 4:575-585.
-
(2003)
Dev. Cell
, vol.4
, pp. 575-585
-
-
Fannjiang, Y.1
-
14
-
-
70449107007
-
Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis
-
Autret A., Martin S.J. Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. Mol. Cell 2009, 36:355-363.
-
(2009)
Mol. Cell
, vol.36
, pp. 355-363
-
-
Autret, A.1
Martin, S.J.2
-
15
-
-
78650679999
-
An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates
-
Guo T., et al. An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat. Neurosci. 2011, 14:31-36.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 31-36
-
-
Guo, T.1
-
16
-
-
24144493694
-
Actions of BAX on mitochondrial channel activity and on synaptic transmission
-
Jonas E.A., et al. Actions of BAX on mitochondrial channel activity and on synaptic transmission. Antioxid. Redox Signal. 2005, 7:1092-1100.
-
(2005)
Antioxid. Redox Signal.
, vol.7
, pp. 1092-1100
-
-
Jonas, E.A.1
-
17
-
-
84055212651
-
Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: the next step forward or two steps back?
-
Beverly L.J. Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: the next step forward or two steps back?. J. Cell. Biochem. 2012, 113:3-12.
-
(2012)
J. Cell. Biochem.
, vol.113
, pp. 3-12
-
-
Beverly, L.J.1
-
18
-
-
27944470616
-
Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-Only, and BNip families of apoptotic regulators
-
Aouacheria A., et al. Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-Only, and BNip families of apoptotic regulators. Mol. Biol. Evol. 2005, 22:2395-2416.
-
(2005)
Mol. Biol. Evol.
, vol.22
, pp. 2395-2416
-
-
Aouacheria, A.1
-
19
-
-
79952709680
-
Molecular biology of Bax and Bak activation and action
-
Westphal D., et al. Molecular biology of Bax and Bak activation and action. Biochim. Biophys. Acta 2011, 1813:521-531.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 521-531
-
-
Westphal, D.1
-
20
-
-
77955717344
-
The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins
-
Lasi M., et al. The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins. Cell Res. 2010, 20:812-825.
-
(2010)
Cell Res.
, vol.20
, pp. 812-825
-
-
Lasi, M.1
-
21
-
-
42949148784
-
Surprising complexity of the ancestral apoptosis network
-
Zmasek C.M., et al. Surprising complexity of the ancestral apoptosis network. Genome Biol. 2007, 8:R226.
-
(2007)
Genome Biol.
, vol.8
-
-
Zmasek, C.M.1
-
22
-
-
32044465724
-
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin
-
Ellermeier C.D., et al. A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin. Cell 2006, 124:549-559.
-
(2006)
Cell
, vol.124
, pp. 549-559
-
-
Ellermeier, C.D.1
-
23
-
-
80052313694
-
Gene-dependent cell death in yeast
-
Teng X., et al. Gene-dependent cell death in yeast. Cell Death Dis. 2011, 2:e188.
-
(2011)
Cell Death Dis.
, vol.2
-
-
Teng, X.1
-
24
-
-
52149113769
-
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
-
Kvansakul M., et al. Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands. Cell Death Differ. 2008, 15:1564-1571.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1564-1571
-
-
Kvansakul, M.1
-
25
-
-
0036171149
-
Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins
-
Bellows D.S., et al. Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins. J. Virol. 2002, 76:2469-2479.
-
(2002)
J. Virol.
, vol.76
, pp. 2469-2479
-
-
Bellows, D.S.1
-
26
-
-
50849109845
-
Vaccinia virus proteins A52 and B14 share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis
-
Graham S.C., et al. Vaccinia virus proteins A52 and B14 share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis. PLoS Pathog. 2008, 4:e1000128.
-
(2008)
PLoS Pathog.
, vol.4
-
-
Graham, S.C.1
-
27
-
-
33750619845
-
How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?
-
Antignani A., Youle R.J. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?. Curr. Opin. Cell Biol. 2006, 18:685-689.
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 685-689
-
-
Antignani, A.1
Youle, R.J.2
-
28
-
-
79953236969
-
Mechanism of Diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process
-
Murphy J.R. Mechanism of Diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process. Toxins (Basel) 2011, 3:294-308.
-
(2011)
Toxins (Basel)
, vol.3
, pp. 294-308
-
-
Murphy, J.R.1
-
29
-
-
33845486323
-
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
-
Hinds M.G., et al. Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. Cell Death Differ. 2007, 14:128-136.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 128-136
-
-
Hinds, M.G.1
-
30
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S., et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005, 122:927-939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
-
31
-
-
83455225635
-
The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis
-
Rubinstein A.D., et al. The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis. Mol. Cell 2011, 44:698-709.
-
(2011)
Mol. Cell
, vol.44
, pp. 698-709
-
-
Rubinstein, A.D.1
-
32
-
-
84862777560
-
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
-
Huang W., et al. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res. 2012, 22:473-489.
-
(2012)
Cell Res.
, vol.22
, pp. 473-489
-
-
Huang, W.1
-
33
-
-
80355146535
-
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential
-
Chen Y.B., et al. Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. J. Cell Biol. 2011, 195:263-276.
-
(2011)
J. Cell Biol.
, vol.195
, pp. 263-276
-
-
Chen, Y.B.1
-
34
-
-
80053560844
-
Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase
-
Alavian K.N., et al. Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. Nat. Cell Biol. 2011, 13:1224-1233.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1224-1233
-
-
Alavian, K.N.1
-
35
-
-
73349128117
-
Genetic control of programmed cell death during animal development
-
Conradt B. Genetic control of programmed cell death during animal development. Annu. Rev. Genet. 2009, 43:493-523.
-
(2009)
Annu. Rev. Genet.
, vol.43
, pp. 493-523
-
-
Conradt, B.1
-
36
-
-
26844485563
-
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
-
Yan N., et al. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature 2005, 437:831-837.
-
(2005)
Nature
, vol.437
, pp. 831-837
-
-
Yan, N.1
-
37
-
-
4644249309
-
Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4
-
Yan N., et al. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Mol. Cell 2004, 15:999-1006.
-
(2004)
Mol. Cell
, vol.15
, pp. 999-1006
-
-
Yan, N.1
-
38
-
-
0033635266
-
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1
-
Chau B.N., et al. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. Mol. Cell 2000, 6:31-40.
-
(2000)
Mol. Cell
, vol.6
, pp. 31-40
-
-
Chau, B.N.1
-
39
-
-
13944278072
-
DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans
-
Jagasia R., et al. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 2005, 433:754-760.
-
(2005)
Nature
, vol.433
, pp. 754-760
-
-
Jagasia, R.1
-
40
-
-
69449104405
-
The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion
-
Rolland S.G., et al. The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion. J. Cell Biol. 2009, 186:525-540.
-
(2009)
J. Cell Biol.
, vol.186
, pp. 525-540
-
-
Rolland, S.G.1
-
41
-
-
80054765894
-
A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans
-
Lu Y., et al. A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:E813-E822.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
-
-
Lu, Y.1
-
42
-
-
41149111891
-
Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
-
Li H., et al. Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:2169-2174.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 2169-2174
-
-
Li, H.1
-
43
-
-
78651468702
-
The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes
-
Hoppins S., et al. The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol. Cell 2011, 41:150-160.
-
(2011)
Mol. Cell
, vol.41
, pp. 150-160
-
-
Hoppins, S.1
-
44
-
-
33749846225
-
Role of Bax and Bak in mitochondrial morphogenesis
-
Karbowski M., et al. Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006, 443:658-662.
-
(2006)
Nature
, vol.443
, pp. 658-662
-
-
Karbowski, M.1
-
45
-
-
79960621726
-
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
-
Zhao J., et al. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J. 2011, 30:2762-2778.
-
(2011)
EMBO J.
, vol.30
, pp. 2762-2778
-
-
Zhao, J.1
-
46
-
-
34447323097
-
Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease
-
Challa M., et al. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 2007, 26:3144-3156.
-
(2007)
EMBO J.
, vol.26
, pp. 3144-3156
-
-
Challa, M.1
-
47
-
-
34247564610
-
Mitochondrial disruption in Drosophila apoptosis
-
Abdelwahid E., et al. Mitochondrial disruption in Drosophila apoptosis. Dev. Cell 2007, 12:793-806.
-
(2007)
Dev. Cell
, vol.12
, pp. 793-806
-
-
Abdelwahid, E.1
-
48
-
-
79952740220
-
Mitochondrial involvement in cell death of non-mammalian eukaryotes
-
Abdelwahid E., et al. Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim. Biophys. Acta 2011, 1813:597-607.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 597-607
-
-
Abdelwahid, E.1
-
49
-
-
67249131118
-
A lepidopteran orthologue of reaper reveals functional conservation and evolution of IAP antagonists
-
Bryant B., et al. A lepidopteran orthologue of reaper reveals functional conservation and evolution of IAP antagonists. Insect Mol. Biol. 2009, 18:341-351.
-
(2009)
Insect Mol. Biol.
, vol.18
, pp. 341-351
-
-
Bryant, B.1
-
50
-
-
33749521656
-
Cytochrome c-d regulates developmental apoptosis in the Drosophila retina
-
Mendes C.S., et al. Cytochrome c-d regulates developmental apoptosis in the Drosophila retina. EMBO Rep. 2006, 7:933-939.
-
(2006)
EMBO Rep.
, vol.7
, pp. 933-939
-
-
Mendes, C.S.1
-
51
-
-
0037654554
-
Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila
-
Arama E., et al. Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev. Cell 2003, 4:687-697.
-
(2003)
Dev. Cell
, vol.4
, pp. 687-697
-
-
Arama, E.1
-
52
-
-
30444448684
-
The two Drosophila cytochrome C proteins can function in both respiration and caspase activation
-
Arama E., et al. The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 2006, 25:232-243.
-
(2006)
EMBO J.
, vol.25
, pp. 232-243
-
-
Arama, E.1
-
53
-
-
21144451097
-
Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis
-
Hao Z., et al. Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell 2005, 121:579-591.
-
(2005)
Cell
, vol.121
, pp. 579-591
-
-
Hao, Z.1
-
54
-
-
0041813273
-
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions
-
Quinn L., et al. Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. EMBO J. 2003, 22:3568-3579.
-
(2003)
EMBO J.
, vol.22
, pp. 3568-3579
-
-
Quinn, L.1
-
55
-
-
0028922885
-
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
-
Motoyama N., et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 1995, 267:1506-1510.
-
(1995)
Science
, vol.267
, pp. 1506-1510
-
-
Motoyama, N.1
-
56
-
-
0033954132
-
Mcl-1 deficiency results in peri-implantation embryonic lethality
-
Rinkenberger J.L., et al. Mcl-1 deficiency results in peri-implantation embryonic lethality. Genes Dev. 2000, 14:23-27.
-
(2000)
Genes Dev.
, vol.14
, pp. 23-27
-
-
Rinkenberger, J.L.1
-
57
-
-
0026582702
-
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
-
Hengartner M.O., et al. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 1992, 356:494-499.
-
(1992)
Nature
, vol.356
, pp. 494-499
-
-
Hengartner, M.O.1
-
58
-
-
34247599253
-
Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development
-
Sevrioukov E.A., et al. Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development. Genesis 2007, 45:184-193.
-
(2007)
Genesis
, vol.45
, pp. 184-193
-
-
Sevrioukov, E.A.1
-
59
-
-
62349085960
-
The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death
-
Galindo K.A., et al. The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death. Development (Cambridge, England) 2009, 136:275-283.
-
(2009)
Development (Cambridge, England)
, vol.136
, pp. 275-283
-
-
Galindo, K.A.1
-
60
-
-
79955526702
-
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
-
Sahay A., et al. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 2011, 472:466-470.
-
(2011)
Nature
, vol.472
, pp. 466-470
-
-
Sahay, A.1
-
61
-
-
0034508217
-
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
-
Lindsten T., et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 2000, 6:1389-1399.
-
(2000)
Mol. Cell
, vol.6
, pp. 1389-1399
-
-
Lindsten, T.1
-
62
-
-
77958121925
-
Noncanonical functions of BCL-2 proteins in the nervous system
-
Lamb H.M., Hardwick M. Noncanonical functions of BCL-2 proteins in the nervous system. Adv. Exp. Med. Biol. 2010, 687:115-129.
-
(2010)
Adv. Exp. Med. Biol.
, vol.687
, pp. 115-129
-
-
Lamb, H.M.1
Hardwick, M.2
-
63
-
-
77957201030
-
Grim promotes programmed cell death of Drosophila microchaete glial cells
-
Wu J.N., et al. grim promotes programmed cell death of Drosophila microchaete glial cells. Mech. Dev. 2010, 127:407-417.
-
(2010)
Mech. Dev.
, vol.127
, pp. 407-417
-
-
Wu, J.N.1
-
64
-
-
78751482244
-
Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary
-
Tanner E.A., et al. Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary. Development (Cambridge, England) 2011, 138:327-338.
-
(2011)
Development (Cambridge, England)
, vol.138
, pp. 327-338
-
-
Tanner, E.A.1
-
65
-
-
84859464590
-
Mitochondrial pathway of apoptosis is ancestral in metazoans
-
Bender C.E., et al. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:4904-4909.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 4904-4909
-
-
Bender, C.E.1
-
67
-
-
75749098116
-
The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism
-
Perkins G.A., et al. The micro-architecture of mitochondria at active zones: electron tomography reveals novel anchoring scaffolds and cristae structured for high-rate metabolism. J. Neurosci. 2010, 30:1015-1026.
-
(2010)
J. Neurosci.
, vol.30
, pp. 1015-1026
-
-
Perkins, G.A.1
-
68
-
-
0032563736
-
Ultrastructure of neurons and large synaptic terminals in the lateral nucleus of the trapezoid body of the cat
-
Spirou G.A., et al. Ultrastructure of neurons and large synaptic terminals in the lateral nucleus of the trapezoid body of the cat. J. Comp. Neurol. 1998, 398:257-272.
-
(1998)
J. Comp. Neurol.
, vol.398
, pp. 257-272
-
-
Spirou, G.A.1
-
69
-
-
77953271477
-
Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
-
Li Z., et al. Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell 2010, 141:859-871.
-
(2010)
Cell
, vol.141
, pp. 859-871
-
-
Li, Z.1
-
70
-
-
60549089207
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
-
Nikolaev A., et al. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457:981-989.
-
(2009)
Nature
, vol.457
, pp. 981-989
-
-
Nikolaev, A.1
-
71
-
-
79959929850
-
Mitochondrial regulation of cell death in the Drosophila ovary
-
Tanner E.A., McCall K. Mitochondrial regulation of cell death in the Drosophila ovary. Autophagy 2011, 7:793-794.
-
(2011)
Autophagy
, vol.7
, pp. 793-794
-
-
Tanner, E.A.1
McCall, K.2
-
72
-
-
0037421190
-
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
-
Kaufmann T., et al. Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J. Cell Biol. 2003, 160:53-64.
-
(2003)
J. Cell Biol.
, vol.160
, pp. 53-64
-
-
Kaufmann, T.1
-
73
-
-
0029760303
-
Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types
-
Zhu W., et al. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO J. 1996, 15:4130-4141.
-
(1996)
EMBO J.
, vol.15
, pp. 4130-4141
-
-
Zhu, W.1
-
74
-
-
0033535347
-
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
-
Griffiths G.J., et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J. Cell Biol. 1999, 144:903-914.
-
(1999)
J. Cell Biol.
, vol.144
, pp. 903-914
-
-
Griffiths, G.J.1
-
75
-
-
0033522391
-
Conformation of the Bax C-terminus regulates subcellular location and cell death
-
Nechushtan A., et al. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J. 1999, 18:2330-2341.
-
(1999)
EMBO J.
, vol.18
, pp. 2330-2341
-
-
Nechushtan, A.1
-
76
-
-
0030780106
-
Movement of Bax from the cytosol to mitochondria during apoptosis
-
Wolter K.G., et al. Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 1997, 139:1281-1292.
-
(1997)
J. Cell Biol.
, vol.139
, pp. 1281-1292
-
-
Wolter, K.G.1
-
77
-
-
70449091753
-
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis
-
Kim H., et al. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol. Cell 2009, 36:487-499.
-
(2009)
Mol. Cell
, vol.36
, pp. 487-499
-
-
Kim, H.1
-
78
-
-
34247533289
-
Bax activation and mitochondrial insertion during apoptosis
-
Lalier L., et al. Bax activation and mitochondrial insertion during apoptosis. Apoptosis 2007, 12:887-896.
-
(2007)
Apoptosis
, vol.12
, pp. 887-896
-
-
Lalier, L.1
-
79
-
-
8844235617
-
The mitochondrial death pathway and cardiac myocyte apoptosis
-
Crow M.T., et al. The mitochondrial death pathway and cardiac myocyte apoptosis. Circ. Res. 2004, 95:957-970.
-
(2004)
Circ. Res.
, vol.95
, pp. 957-970
-
-
Crow, M.T.1
-
80
-
-
34247506768
-
A tale of two mitochondrial channels, MAC and PTP, in apoptosis
-
Kinnally K.W., Antonsson B. A tale of two mitochondrial channels, MAC and PTP, in apoptosis. Apoptosis 2007, 12:857-868.
-
(2007)
Apoptosis
, vol.12
, pp. 857-868
-
-
Kinnally, K.W.1
Antonsson, B.2
-
81
-
-
79952708659
-
Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission
-
Landes T., Martinou J.C. Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission. Biochim. Biophys. Acta 2011, 1813:540-545.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 540-545
-
-
Landes, T.1
Martinou, J.C.2
-
82
-
-
0025204548
-
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
-
Hockenbery D., et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990, 348:334-336.
-
(1990)
Nature
, vol.348
, pp. 334-336
-
-
Hockenbery, D.1
-
83
-
-
0030610962
-
Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
-
Kharbanda S., et al. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:6939-6942.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 6939-6942
-
-
Kharbanda, S.1
-
84
-
-
0032575606
-
Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver
-
Motoyama S., et al. Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver. Biochem. Biophys. Res. Commun. 1998, 249:628-636.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.249
, pp. 628-636
-
-
Motoyama, S.1
-
85
-
-
0033939697
-
Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells
-
Gotow T., et al. Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells. Cell Death Differ. 2000, 7:666-674.
-
(2000)
Cell Death Differ.
, vol.7
, pp. 666-674
-
-
Gotow, T.1
-
86
-
-
0037439801
-
Bcl-2 and Bax modulate adenine nucleotide translocase activity
-
Belzacq A.S., et al. Bcl-2 and Bax modulate adenine nucleotide translocase activity. Cancer Res. 2003, 63:541-546.
-
(2003)
Cancer Res.
, vol.63
, pp. 541-546
-
-
Belzacq, A.S.1
-
87
-
-
0027453852
-
The bcl-2 protein is inserted into the outer membrane but not into the inner membrane of rat liver mitochondria in vitro
-
Nakai M., et al. The bcl-2 protein is inserted into the outer membrane but not into the inner membrane of rat liver mitochondria in vitro. Biochem. Biophys. Res. Commun. 1993, 196:233-239.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.196
, pp. 233-239
-
-
Nakai, M.1
-
88
-
-
0027525536
-
Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence
-
Nguyen M., et al. Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J. Biol. Chem. 1993, 268:25265-25268.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 25265-25268
-
-
Nguyen, M.1
-
89
-
-
0028289951
-
Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus
-
Nguyen M., et al. Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus. J. Biol. Chem. 1994, 269:16521-16524.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16521-16524
-
-
Nguyen, M.1
-
90
-
-
0032487582
-
Regulated targeting of BAX to mitochondria
-
Goping I.S., et al. Regulated targeting of BAX to mitochondria. J. Cell Biol. 1998, 143:207-215.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 207-215
-
-
Goping, I.S.1
-
91
-
-
0035844867
-
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis
-
Nechushtan A., et al. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J. Cell Biol. 2001, 153:1265-1276.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1265-1276
-
-
Nechushtan, A.1
-
92
-
-
0026480579
-
Ultrastructural localization of bcl-2 protein
-
Monaghan P., et al. Ultrastructural localization of bcl-2 protein. J. Histochem. Cytochem. 1992, 40:1819-1825.
-
(1992)
J. Histochem. Cytochem.
, vol.40
, pp. 1819-1825
-
-
Monaghan, P.1
-
93
-
-
0028793279
-
Localization of the Bcl-2 protein to the outer mitochondrial membrane by electron microscopy
-
Riparbelli M.G., et al. Localization of the Bcl-2 protein to the outer mitochondrial membrane by electron microscopy. Exp. Cell Res. 1995, 221:363-369.
-
(1995)
Exp. Cell Res.
, vol.221
, pp. 363-369
-
-
Riparbelli, M.G.1
-
94
-
-
0027977928
-
The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane
-
Lithgow T., et al. The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ. 1994, 5:411-417.
-
(1994)
Cell Growth Differ.
, vol.5
, pp. 411-417
-
-
Lithgow, T.1
-
95
-
-
0034306169
-
Cardiolipin provides specificity for targeting of tBid to mitochondria
-
Lutter M., et al. Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat. Cell Biol. 2000, 2:754-761.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 754-761
-
-
Lutter, M.1
-
96
-
-
20044370709
-
TBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak
-
Gonzalvez F., et al. tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak. Cell Death Differ. 2005, 12:614-626.
-
(2005)
Cell Death Differ.
, vol.12
, pp. 614-626
-
-
Gonzalvez, F.1
-
97
-
-
0036850312
-
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
-
Kuwana T., et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002, 111:331-342.
-
(2002)
Cell
, vol.111
, pp. 331-342
-
-
Kuwana, T.1
-
98
-
-
77956634444
-
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
-
Montessuit S., et al. Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell 2010, 142:889-901.
-
(2010)
Cell
, vol.142
, pp. 889-901
-
-
Montessuit, S.1
-
99
-
-
0036007116
-
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
-
Scorrano L., et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell 2002, 2:55-67.
-
(2002)
Dev. Cell
, vol.2
, pp. 55-67
-
-
Scorrano, L.1
-
100
-
-
0025013378
-
Mitochondrial contact sites. Lipid composition and dynamics
-
Ardail D., et al. Mitochondrial contact sites. Lipid composition and dynamics. J. Biol. Chem. 1990, 265:18797-18802.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 18797-18802
-
-
Ardail, D.1
-
101
-
-
77955271289
-
The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity
-
Huang C.R., Yang-Yen H.F. The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity. FEBS Lett. 2010, 584:3323-3330.
-
(2010)
FEBS Lett.
, vol.584
, pp. 3323-3330
-
-
Huang, C.R.1
Yang-Yen, H.F.2
-
102
-
-
79960148142
-
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site
-
Warr M.R., et al. Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. J. Biol. Chem. 2011, 286:25098-25107.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25098-25107
-
-
Warr, M.R.1
-
103
-
-
0033021064
-
Inhibition of virus-induced neuronal apoptosis by Bax
-
Lewis J., et al. Inhibition of virus-induced neuronal apoptosis by Bax. Nat. Med. 1999, 5:832-835.
-
(1999)
Nat. Med.
, vol.5
, pp. 832-835
-
-
Lewis, J.1
-
104
-
-
4744362784
-
BAD is a pro-survival factor prior to activation of its pro-apoptotic function
-
Seo S.Y., et al. BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 2004, 279:42240-42249.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 42240-42249
-
-
Seo, S.Y.1
-
105
-
-
0031465443
-
Conversion of Bcl-2 to a Bax-like death effector by caspases
-
Cheng E.H., et al. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 1997, 278:1966-1968.
-
(1997)
Science
, vol.278
, pp. 1966-1968
-
-
Cheng, E.H.1
-
106
-
-
0031930688
-
Modulation of cell death by Bcl-XL through caspase interaction
-
Clem R.J., et al. Modulation of cell death by Bcl-XL through caspase interaction. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:554-559.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 554-559
-
-
Clem, R.J.1
-
107
-
-
0033597785
-
Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
-
Kirsch D.G., et al. Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J. Biol. Chem. 1999, 274:21155-21161.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21155-21161
-
-
Kirsch, D.G.1
-
108
-
-
0034698878
-
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
-
Nakagawa T., Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 2000, 150:887-894.
-
(2000)
J. Cell Biol.
, vol.150
, pp. 887-894
-
-
Nakagawa, T.1
Yuan, J.2
-
109
-
-
84862777042
-
N-terminally cleaved Bcl-x(L) mediates ischemia-induced neuronal death
-
Ofengeim D., et al. N-terminally cleaved Bcl-x(L) mediates ischemia-induced neuronal death. Nat. Neurosci. 2012, 15:574-580.
-
(2012)
Nat. Neurosci.
, vol.15
, pp. 574-580
-
-
Ofengeim, D.1
-
110
-
-
0035478279
-
Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice
-
Oguro K., et al. Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice. J. Neurosci. 2001, 21:7534-7542.
-
(2001)
J. Neurosci.
, vol.21
, pp. 7534-7542
-
-
Oguro, K.1
-
111
-
-
0037147239
-
Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature
-
Basanez G., et al. Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature. J. Biol. Chem. 2002, 277:49360-49365.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49360-49365
-
-
Basanez, G.1
-
112
-
-
4544359229
-
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals
-
Jonas E.A., et al. Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:13590-13595.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 13590-13595
-
-
Jonas, E.A.1
-
113
-
-
84867416957
-
Integration of apoptosis and metabolism
-
Yi C.H., et al. Integration of apoptosis and metabolism. Cold Spring Harb. Symp. Quant. Biol. 2011, http://dx.doi.org/10.1101/sqb.2011.76.010777.
-
(2011)
Cold Spring Harb. Symp. Quant. Biol.
-
-
Yi, C.H.1
-
114
-
-
78650874294
-
Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells
-
Vento M.T., et al. Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. PLoS ONE 2010, 5:e15636.
-
(2010)
PLoS ONE
, vol.5
-
-
Vento, M.T.1
-
115
-
-
0034688175
-
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
-
Brenner C., et al. Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene 2000, 19:329-336.
-
(2000)
Oncogene
, vol.19
, pp. 329-336
-
-
Brenner, C.1
-
116
-
-
79952282995
-
Modular assembly of yeast mitochondrial ATP synthase
-
Rak M., et al. Modular assembly of yeast mitochondrial ATP synthase. EMBO J. 2011, 30:920-930.
-
(2011)
EMBO J.
, vol.30
, pp. 920-930
-
-
Rak, M.1
-
117
-
-
67649760168
-
Mitochondrial dynamics in Parkinson's disease
-
Van Laar V.S., Berman S.B. Mitochondrial dynamics in Parkinson's disease. Exp. Neurol. 2009, 218:247-256.
-
(2009)
Exp. Neurol.
, vol.218
, pp. 247-256
-
-
Van Laar, V.S.1
Berman, S.B.2
-
118
-
-
78649685455
-
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
-
Jin S.M., et al. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J. Cell Biol. 2010, 191:933-942.
-
(2010)
J. Cell Biol.
, vol.191
, pp. 933-942
-
-
Jin, S.M.1
-
119
-
-
84857032953
-
Role of PINK1 Binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin
-
Lazarou M., et al. Role of PINK1 Binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev. Cell 2012, 22:320-333.
-
(2012)
Dev. Cell
, vol.22
, pp. 320-333
-
-
Lazarou, M.1
-
120
-
-
84857059879
-
Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction
-
Pourkarimi E., et al. Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction. Cell Death Differ. 2012, 19:406-415.
-
(2012)
Cell Death Differ.
, vol.19
, pp. 406-415
-
-
Pourkarimi, E.1
|