메뉴 건너뛰기




Volumn 136, Issue 2, 2009, Pages 275-283

The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death

Author keywords

Apoptosis; Bcl 2 genes; Cell death; Drosophila

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BINDING PROTEIN; CYTOCHROME C; MEMBRANE PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN DARK; PROTEIN DEBCL; UNCLASSIFIED DRUG; BAX PROTEIN, MOUSE; DEBCL PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; PRIMER DNA;

EID: 62349085960     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.019042     Document Type: Article
Times cited : (47)

References (56)
  • 2
    • 0037654554 scopus 로고    scopus 로고
    • Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila
    • Arama, E., Agapite, J. and Steller, H. (2003). Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev. Cell 4, 687-697.
    • (2003) Dev. Cell , vol.4 , pp. 687-697
    • Arama, E.1    Agapite, J.2    Steller, H.3
  • 3
    • 30444448684 scopus 로고    scopus 로고
    • The two Drosophila cytochrome C proteins can function in both respiration and caspase activation
    • Arama, E., Bader, M., Srivastava, M., Bergmann, A. and Steller, H. (2005). The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 25, 232-243.
    • (2005) EMBO J , vol.25 , pp. 232-243
    • Arama, E.1    Bader, M.2    Srivastava, M.3    Bergmann, A.4    Steller, H.5
  • 4
    • 0034193520 scopus 로고    scopus 로고
    • The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
    • Brachmann, C. B., Jassim, O. W., Wachsmuth, B. D. and Cagan, R. L. (2000). The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation. Curr. Biol. 10, 547-550.
    • (2000) Curr. Biol , vol.10 , pp. 547-550
    • Brachmann, C.B.1    Jassim, O.W.2    Wachsmuth, B.D.3    Cagan, R.L.4
  • 5
    • 0034695934 scopus 로고    scopus 로고
    • Drosophila apoptosis and Bcl-2 genes: Outliers fly in
    • Chen, P. and Abrams, J. M. (2000). Drosophila apoptosis and Bcl-2 genes: Outliers fly in. J. Cell Biol. 148, 625-627.
    • (2000) J. Cell Biol , vol.148 , pp. 625-627
    • Chen, P.1    Abrams, J.M.2
  • 6
    • 0032530359 scopus 로고    scopus 로고
    • Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
    • Chen, P., Rodriguez, A., Erskine, R., Thach, T. and Abrams, J. M. (1998). Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Dev. Biol. 201, 202-216.
    • (1998) Dev. Biol , vol.201 , pp. 202-216
    • Chen, P.1    Rodriguez, A.2    Erskine, R.3    Thach, T.4    Abrams, J.M.5
  • 8
    • 33745625059 scopus 로고    scopus 로고
    • Programmed cell death mechanisms of identifiable peptidergic neurons in Drosophila melanogaster
    • Choi, Y. J., Lee, G. and Park, J. H. (2006). Programmed cell death mechanisms of identifiable peptidergic neurons in Drosophila melanogaster. Development 133, 2223-2232.
    • (2006) Development , vol.133 , pp. 2223-2232
    • Choi, Y.J.1    Lee, G.2    Park, J.H.3
  • 9
    • 0034695914 scopus 로고    scopus 로고
    • Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery
    • Colussi, P. A., Quinn, L. M., Huang, D. C. S., Coombe, M., Read, S. H., Richardson, H. and Kumar, S. (2000). Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery. J. Cell Biol. 148, 703-714.
    • (2000) J. Cell Biol , vol.148 , pp. 703-714
    • Colussi, P.A.1    Quinn, L.M.2    Huang, D.C.S.3    Coombe, M.4    Read, S.H.5    Richardson, H.6    Kumar, S.7
  • 10
    • 0032524885 scopus 로고    scopus 로고
    • The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    • Conradt, B. and Horvitz, H. R. (1998). The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93, 519-529.
    • (1998) Cell , vol.93 , pp. 519-529
    • Conradt, B.1    Horvitz, H.R.2
  • 11
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: Regulators of the cellular life-or-death switch
    • Cory, S. and Adams, J. M. (2002). The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 12
    • 0037730217 scopus 로고    scopus 로고
    • A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis
    • Cox, R. T. and Spradling, A. C. (2003). A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis. Development 130, 1579-1590.
    • (2003) Development , vol.130 , pp. 1579-1590
    • Cox, R.T.1    Spradling, A.C.2
  • 13
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial, N. N. and Korsmeyer, S. J. (2004). Cell death: critical control points. Cell 116, 205-219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 14
    • 1842816486 scopus 로고    scopus 로고
    • Drosophila myc regulates organ size by inducing cell competition
    • de la Cova, C., Abril, M., Bellosta, P., Gallant, P. and Johnston, L. A. (2004). Drosophila myc regulates organ size by inducing cell competition. Cell 117, 107-116.
    • (2004) Cell , vol.117 , pp. 107-116
    • de la Cova, C.1    Abril, M.2    Bellosta, P.3    Gallant, P.4    Johnston, L.A.5
  • 15
    • 33644859410 scopus 로고    scopus 로고
    • Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics
    • Delivani, P., Adrain, C., Taylor, R. C., Duriez, P. J. and Martin, S. J. (2006). Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. Mol. Cell 21, 761-773.
    • (2006) Mol. Cell , vol.21 , pp. 761-773
    • Delivani, P.1    Adrain, C.2    Taylor, R.C.3    Duriez, P.J.4    Martin, S.J.5
  • 16
    • 0037128924 scopus 로고    scopus 로고
    • The role of cytochrome c in caspase activation in Drosophila melanogaster cells
    • Dorstyn, L., Read, S., Cakouros, D., Huh, J. R., Hay, B. A. and Kumar, S. (2002). The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J. Cell Biol. 156, 1089-1098.
    • (2002) J. Cell Biol , vol.156 , pp. 1089-1098
    • Dorstyn, L.1    Read, S.2    Cakouros, D.3    Huh, J.R.4    Hay, B.A.5    Kumar, S.6
  • 17
    • 8444227809 scopus 로고    scopus 로고
    • The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells
    • Dorstyn, L., Mills, K., Lazebnik, Y. and Kumar, S. (2004). The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J. Cell Biol. 167, 405-410.
    • (2004) J. Cell Biol , vol.167 , pp. 405-410
    • Dorstyn, L.1    Mills, K.2    Lazebnik, Y.3    Kumar, S.4
  • 18
    • 0033824366 scopus 로고    scopus 로고
    • Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila
    • Gaumer, S., Guenal, I., Brun, S., Theodore, L. and Mignotte, B. (2000). Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila. Cell Death Differ. 7, 804-814.
    • (2000) Cell Death Differ , vol.7 , pp. 804-814
    • Gaumer, S.1    Guenal, I.2    Brun, S.3    Theodore, L.4    Mignotte, B.5
  • 19
    • 0037418177 scopus 로고    scopus 로고
    • Ends-out, or replacement, gene targeting in Drosophila
    • Gong, W. J. and Golic, K. G. (2003). Ends-out, or replacement, gene targeting in Drosophila. Proc. Natl. Acad. Sci. USA 100, 2556-2561.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2556-2561
    • Gong, W.J.1    Golic, K.G.2
  • 20
    • 34247603036 scopus 로고    scopus 로고
    • Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster
    • Goyal, G., Fell, B., Sarin, A., Youle, R. J. and Sriram, V. (2007). Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Dev. Cell 12, 807-816.
    • (2007) Dev. Cell , vol.12 , pp. 807-816
    • Goyal, G.1    Fell, B.2    Sarin, A.3    Youle, R.J.4    Sriram, V.5
  • 21
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and Apoptosis
    • Green, D. R. and Reed, J. C. (1998). Mitochondria and Apoptosis. Science 281, 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 22
    • 0033179760 scopus 로고
    • b (1999). BCL-2 family members and the mitochondria in apoptosis
    • Gross, A., McDonnell, J. M. and Korsmeyer, S. J. b (1999). BCL-2 family members and the mitochondria in apoptosis. Genes Dev. b 13, 1899-1911.
    • (1899) Genes Dev. b , vol.13
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 26
    • 0025317162 scopus 로고
    • Postmetamorphic cell death in the nervous and muscular systems of Drosophila melanogaster
    • Kimura, K. I. and Truman, J. W. (1990). Postmetamorphic cell death in the nervous and muscular systems of Drosophila melanogaster. J. Neurosci. 10, 403-411.
    • (1990) J. Neurosci , vol.10 , pp. 403-411
    • Kimura, K.I.1    Truman, J.W.2
  • 27
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria-a primary site for bcl-2 regulation of apoptosis
    • Kluck, R. M., Bossywetzel, E., Green, D. R. and Newmeyer, D. D. (1997). The release of cytochrome c from mitochondria-a primary site for bcl-2 regulation of apoptosis. Science 275, 1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossywetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 28
    • 0033571045 scopus 로고    scopus 로고
    • The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol
    • Kluck, R. M., Esposti, M. D., Perkins, G., Renken, C., Kuwana, T., Bossy-Wetzel, E., Goldberg, M., Allen, T., Barber, M. J., Green, D. R. et al. (1999). The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol. J. Cell Biol. 147, 809-822.
    • (1999) J. Cell Biol , vol.147 , pp. 809-822
    • Kluck, R.M.1    Esposti, M.D.2    Perkins, G.3    Renken, C.4    Kuwana, T.5    Bossy-Wetzel, E.6    Goldberg, M.7    Allen, T.8    Barber, M.J.9    Green, D.R.10
  • 29
    • 0031814029 scopus 로고    scopus 로고
    • Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    • Kosman, D., Small, S. and Reinitz, J. (1998). Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins. Dev. Genes Evol. 208, 290-294.
    • (1998) Dev. Genes Evol , vol.208 , pp. 290-294
    • Kosman, D.1    Small, S.2    Reinitz, J.3
  • 30
    • 0347361690 scopus 로고    scopus 로고
    • Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila
    • Laundrie, B., Peterson, J. S., Baum, J. S., Chang, J. C., Fileppo, D., Thompson, S. R. and McCall, K. (2003). Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila. Genetics 165, 1881-1888.
    • (2003) Genetics , vol.165 , pp. 1881-1888
    • Laundrie, B.1    Peterson, J.S.2    Baum, J.S.3    Chang, J.C.4    Fileppo, D.5    Thompson, S.R.6    McCall, K.7
  • 31
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of bid by caspase 8 mediates the mitochondrial damage in the fas pathway of apoptosis
    • Li, H. L., Zhu, H., Xu, C. J. and Yuan, J. Y. (1998). Cleavage of bid by caspase 8 mediates the mitochondrial damage in the fas pathway of apoptosis. Cell 94, 491-501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.L.1    Zhu, H.2    Xu, C.J.3    Yuan, J.Y.4
  • 32
    • 33751118533 scopus 로고    scopus 로고
    • MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila
    • Li, Y., Wang, F., Lee, J. A. and Gao, F. B. (2006). MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev. 20, 2793-2805.
    • (2006) Genes Dev , vol.20 , pp. 2793-2805
    • Li, Y.1    Wang, F.2    Lee, J.A.3    Gao, F.B.4
  • 33
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
    • Lindsten, T., Ross, A. J., King, A., Zong, W. X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K. et al. (2000). The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6, 1389-1399.
    • (2000) Mol. Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1    Ross, A.J.2    King, A.3    Zong, W.X.4    Rathmell, J.C.5    Shiels, H.A.6    Ulrich, E.7    Waymire, K.G.8    Mahar, P.9    Frauwirth, K.10
  • 36
    • 0034757896 scopus 로고    scopus 로고
    • A novel assay to study autophagy: Regulation of autophagosome vacuole size by amino acid deprivation
    • Munafo, D. B. and Colombo, M. I. (2001). A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J. Cell Sci. 114, 3619-3629.
    • (2001) J. Cell Sci , vol.114 , pp. 3619-3629
    • Munafo, D.B.1    Colombo, M.I.2
  • 37
    • 0041813273 scopus 로고    scopus 로고
    • Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions
    • Quinn, L., Coombe, M., Mills, K., Daish, T., Colussi, P., Kumar, S. and Richardson, H. (2003). Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. EMBO J. 22, 3568-3579.
    • (2003) EMBO J , vol.22 , pp. 3568-3579
    • Quinn, L.1    Coombe, M.2    Mills, K.3    Daish, T.4    Colussi, P.5    Kumar, S.6    Richardson, H.7
  • 38
    • 0027486314 scopus 로고
    • Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform
    • Robinow, S., Talbot, W. S., Hogness, D. S. and Truman, J. W. (1993). Programmed cell death in the Drosophila CNS is ecdysone-regulated and coupled with a specific ecdysone receptor isoform. Development 119, 1251-1259.
    • (1993) Development , vol.119 , pp. 1251-1259
    • Robinow, S.1    Talbot, W.S.2    Hogness, D.S.3    Truman, J.W.4
  • 39
    • 0033193863 scopus 로고    scopus 로고
    • Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
    • Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X. D. and Abrams, J. M. (1999). Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat. Cell Biol. 1, 272-279.
    • (1999) Nat. Cell Biol , vol.1 , pp. 272-279
    • Rodriguez, A.1    Oliver, H.2    Zou, H.3    Chen, P.4    Wang, X.D.5    Abrams, J.M.6
  • 40
    • 0036566395 scopus 로고    scopus 로고
    • Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark
    • Rodriguez, A., Chen, P., Oliver, H. and Abrams, J. M. (2002). Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark. EMBO J. 21, 2189-2197.
    • (2002) EMBO J , vol.21 , pp. 2189-2197
    • Rodriguez, A.1    Chen, P.2    Oliver, H.3    Abrams, J.M.4
  • 41
    • 33846480083 scopus 로고    scopus 로고
    • Programmed cell death in the embryonic central nervous system of Drosophila melanogaster
    • Rogulja-Ortmann, A., Luer, K., Seibert, J., Rickert, C. and Technau, G. M. (2007). Programmed cell death in the embryonic central nervous system of Drosophila melanogaster. Development 134, 105-116.
    • (2007) Development , vol.134 , pp. 105-116
    • Rogulja-Ortmann, A.1    Luer, K.2    Seibert, J.3    Rickert, C.4    Technau, G.M.5
  • 42
    • 0019945644 scopus 로고
    • Genetic transformation of Drosophila with transposable element vectors
    • Rubin, G. M. and Spradling, A. C. (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.
    • (1982) Science , vol.218 , pp. 348-353
    • Rubin, G.M.1    Spradling, A.C.2
  • 43
    • 4344608793 scopus 로고    scopus 로고
    • Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
    • Rusten, T. E., Lindmo, K., Juhasz, G., Sass, M., Seglen, P. O., Brech, A. and Stenmark, H. (2004). Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7, 179-192.
    • (2004) Dev. Cell , vol.7 , pp. 179-192
    • Rusten, T.E.1    Lindmo, K.2    Juhasz, G.3    Sass, M.4    Seglen, P.O.5    Brech, A.6    Stenmark, H.7
  • 44
    • 5044248528 scopus 로고    scopus 로고
    • Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways
    • Ryoo, H. D., Gorenc, T. and Steller, H. (2004). Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev. Cell 7, 491-501.
    • (2004) Dev. Cell , vol.7 , pp. 491-501
    • Ryoo, H.D.1    Gorenc, T.2    Steller, H.3
  • 45
    • 23044487272 scopus 로고    scopus 로고
    • Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila
    • Senoo-Matsuda, N., Igaki, T. and Miura, M. (2005). Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila. EMBO J. 24, 2700-2713.
    • (2005) EMBO J , vol.24 , pp. 2700-2713
    • Senoo-Matsuda, N.1    Igaki, T.2    Miura, M.3
  • 48
    • 0037447069 scopus 로고    scopus 로고
    • Drosophila p53 preserves genomic stability by regulating cell death
    • Sogame, N., Kim, M. and Abrams, J. M. (2003). Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl. Acad. Sci. USA 100, 4696-4701.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4696-4701
    • Sogame, N.1    Kim, M.2    Abrams, J.M.3
  • 51
    • 19444366944 scopus 로고    scopus 로고
    • The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
    • Xu, D., Li, Y., Arcaro, M., Lackey, M. and Bergmann, A. (2005). The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132, 2125-2134.
    • (2005) Development , vol.132 , pp. 2125-2134
    • Xu, D.1    Li, Y.2    Arcaro, M.3    Lackey, M.4    Bergmann, A.5
  • 53
    • 28944443033 scopus 로고    scopus 로고
    • Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer
    • Yu, X., Wang, L., Acehan, D., Wang, X. and Akey, C. W. (2005). Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer. J. Mol. Biol. 355, 577-589.
    • (2005) J. Mol. Biol , vol.355 , pp. 577-589
    • Yu, X.1    Wang, L.2    Acehan, D.3    Wang, X.4    Akey, C.W.5
  • 54
    • 0034282917 scopus 로고    scopus 로고
    • Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms
    • Zhang, H., Huang, Q., Ke, N., Matsuyama, S., Hammock, B., Godzik, A. and Reed, J. C. (2000). Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms. J. Biol. Chem 275, 27303-27306.
    • (2000) J. Biol. Chem , vol.275 , pp. 27303-27306
    • Zhang, H.1    Huang, Q.2    Ke, N.3    Matsuyama, S.4    Hammock, B.5    Godzik, A.6    Reed, J.C.7
  • 55
    • 0037128923 scopus 로고    scopus 로고
    • The role of ARK in stress-induced apoptosis in Drosophila cells
    • Zimmermann, K. C., Ricci, J. E., Droin, N. M. and Green, D. R. (2002). The role of ARK in stress-induced apoptosis in Drosophila cells. J. Cell Biol. 156, 1077-1087.
    • (2002) J. Cell Biol , vol.156 , pp. 1077-1087
    • Zimmermann, K.C.1    Ricci, J.E.2    Droin, N.M.3    Green, D.R.4
  • 56
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to c-elegans ced-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou, H., Henzel, W. J., Liu, X. S., Lutschg, A. and Wang, X. D. (1997). Apaf-1, a human protein homologous to c-elegans ced-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.S.3    Lutschg, A.4    Wang, X.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.