-
1
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann, I.; Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 1990, 347, 645-650.
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
2
-
-
33751533892
-
Wahli International Union of Pharmacology LXI. Peroxisome proliferator-activated receptors
-
Michalik, L.; Auwerx, J.; Berger, J.P.; Chatterjee, V.K.; Glass, C.K.; Gonzalez, F.J.; Grimaldi, P.A.; Kadowaki, T.; Lazar, M.A.; O'Rahilly, S.; Palmer, C.N.; Plutzky, J.; Reddy, J.K.; Spiegelman, B.M.; Staels, B.; Wahli, W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol. Rev., 2006, 58, 726-741.
-
(2006)
Pharmacol. Rev
, vol.58
, pp. 726-741
-
-
Michalik, L.1
Auwerx, J.2
Berger, J.P.3
Chatterjee, V.K.4
Glass, C.K.5
Gonzalez, F.J.6
Grimaldi, P.A.7
Kadowaki, T.8
Lazar, M.A.9
O'Rahilly, S.10
Palmer, C.N.11
Plutzky, J.12
Reddy, J.K.13
Spiegelman, B.M.14
Staels, B.15
-
3
-
-
70349664475
-
Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta
-
Ehrenborg, E.; Krook, A. Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta. Pharmacol. Rev., 2009, 61, 373-393.
-
(2009)
Pharmacol. Rev
, vol.61
, pp. 373-393
-
-
Ehrenborg, E.1
Krook, A.2
-
4
-
-
8844276054
-
Regulation of muscle fiber type and running endurance by ppardelta
-
Wang, Y.X.; Zhang, C.L.; Yu, R.T.; Cho, H.K.; Nelson, M.C.; Bayuga-Ocampo, C.R.; Ham, J.; Kang, H.; Evans, R.M. Regulation of muscle fiber type and running endurance by ppardelta. PLoS Biol., 2004, 2, e294.
-
(2004)
PLoS Biol
, vol.2
-
-
Wang, Y.X.1
Zhang, C.L.2
Yu, R.T.3
Cho, H.K.4
Nelson, M.C.5
Bayuga-Ocampo, C.R.6
Ham, J.7
Kang, H.8
Evans, R.M.9
-
5
-
-
0142116239
-
Transcriptional repression of atherogenic inflammation: Modulation by PPARdelta
-
Lee, C.H.; Chawla, A.; Urbiztondo, N.; Liao, D.; Boisvert, W.A.; Evans, R.M.; Curtiss, L.K. Transcriptional repression of atherogenic inflammation: Modulation by PPARdelta. Science, 2003, 302, 453-457.
-
(2003)
Science
, vol.302
, pp. 453-457
-
-
Lee, C.H.1
Chawla, A.2
Urbiztondo, N.3
Liao, D.4
Boisvert, W.A.5
Evans, R.M.6
Curtiss, L.K.7
-
6
-
-
41949138804
-
PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis
-
Barish, G.D.; Atkins, A.R.; Downes, M.; Olson, P.; Chong, L.W.; Nelson, M.; Zou, Y.; Hwang, H.; Kang, H.; Curtiss, L.; Evans, R.M.; Lee, C.H. PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc. Natl. Acad. Sci. USA, 2008, 105, 4271-4276.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 4271-4276
-
-
Barish, G.D.1
Atkins, A.R.2
Downes, M.3
Olson, P.4
Chong, L.W.5
Nelson, M.6
Zou, Y.7
Hwang, H.8
Kang, H.9
Curtiss, L.10
Evans, R.M.11
Lee, C.H.12
-
7
-
-
0038210248
-
Nuclear receptors and the control of metabolism
-
Francis, G.A.; Fayard, E.; Picard, F.; Auwerx, J. Nuclear receptors and the control of metabolism. Annu. Rev. Physiol., 2003, 65, 261-311.
-
(2003)
Annu. Rev. Physiol
, vol.65
, pp. 261-311
-
-
Francis, G.A.1
Fayard, E.2
Picard, F.3
Auwerx, J.4
-
8
-
-
0032568261
-
Hepatic dysfunction associated with troglitazone
-
Watkins, P.B.; Whitcomb, R.W. Hepatic dysfunction associated with troglitazone. N. Engl. J. Med., 1998, 338, 916-917.
-
(1998)
N. Engl. J. Med
, vol.338
, pp. 916-917
-
-
Watkins, P.B.1
Whitcomb, R.W.2
-
9
-
-
33846424676
-
Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: A review
-
Masubuchi, Y. Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: A review. Drug Metab. Pharmacokinet., 2006, 21, 347-356.
-
(2006)
Drug Metab. Pharmacokinet
, vol.21
, pp. 347-356
-
-
Masubuchi, Y.1
-
10
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
Nissen, S.E.; Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med., 2007, 356, 2457-2471.
-
(2007)
N. Engl. J. Med
, vol.356
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
11
-
-
77951601655
-
Thiazolidinedione drugs and cardiovascular risks: A science advisory from the american heart association and american college of cardiology foundation
-
Kaul, S.; Bolger, A.F.; Herrington D.; Giugliano R.P.; Eckel R.H. Thiazolidinedione drugs and cardiovascular risks: A science advisory from the american heart association and american college of cardiology foundation. Circulation, 2010, 121, 1868-1877.
-
(2010)
Circulation
, vol.121
, pp. 1868-1877
-
-
Kaul, S.1
Bolger, A.F.2
Herrington, D.3
Giugliano, R.P.4
Eckel, R.H.5
-
12
-
-
0036771776
-
PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis
-
Panigrahy, D.; Singer, S.; Shen, L.Q.; Butterfield, C.E.; Freedman, D.A.; Chen, E.J.; Moses, M.A.; Kilroy, S.; Duensing, S.; Fletcher, C.; Fletcher, J.A.; Hlatky, L.; Hahnfeldt, P., Folkman, J.; Kaipainen, A. PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J. Clin. Invest., 2002, 110, 923-932.
-
(2002)
J. Clin. Invest
, vol.110
, pp. 923-932
-
-
Panigrahy, D.1
Singer, S.2
Shen, L.Q.3
Butterfield, C.E.4
Freedman, D.A.5
Chen, E.J.6
Moses, M.A.7
Kilroy, S.8
Duensing, S.9
Fletcher, C.10
Fletcher, J.A.11
Hlatky, L.12
Hahnfeldt, P.13
Folkman, J.14
Kaipainen, A.15
-
13
-
-
0031888958
-
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
-
Jiang, C.; Ting, A.T.; Seed, B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 1998, 391, 82-86.
-
(1998)
Nature
, vol.391
, pp. 82-86
-
-
Jiang, C.1
Ting, A.T.2
Seed, B.3
-
14
-
-
0031886864
-
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
-
Ricote, M.; Li, A.C.; Willson, T.M.; Kelly, C.J.; Glass, C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature, 1998, 391, 79-82.
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
15
-
-
0034010651
-
Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mrna expression in a murine model of non-insulin-dependent diabetes
-
Sigrist, S.; Bedoucha, M.; Boelsterli, U.A. Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mrna expression in a murine model of non-insulin-dependent diabetes. Biochem. Pharmacol., 2000, 60, 67-75.
-
(2000)
Biochem. Pharmacol
, vol.60
, pp. 67-75
-
-
Sigrist, S.1
Bedoucha, M.2
Boelsterli, U.A.3
-
16
-
-
0011446750
-
Enhanced hepatocarcinogenicity due to agonists of peroxisome proliferator-activated receptors in senescent rats: Role of peroxisome proliferation, cell proliferation, and apoptosis
-
Youssef, J.; Badr, M. Enhanced hepatocarcinogenicity due to agonists of peroxisome proliferator-activated receptors in senescent rats: Role of peroxisome proliferation, cell proliferation, and apoptosis. ScientificWorldJournal, 2002, 2, 1491-1500.
-
(2002)
ScientificWorldJournal
, vol.2
, pp. 1491-1500
-
-
Youssef, J.1
Badr, M.2
-
17
-
-
78650286735
-
The nuclear hormone receptor ppargamma as a therapeutic target in major diseases
-
Schmidt, M.V.; Brune, B.; von Knethen, A. The nuclear hormone receptor ppargamma as a therapeutic target in major diseases. ScientificWorldJournal, 2010, 10, 2181-2197.
-
(2010)
ScientificWorldJournal
, vol.10
, pp. 2181-2197
-
-
Schmidt, M.V.1
Brune, B.2
von Knethen, A.3
-
19
-
-
34548182594
-
PPAR dual agonists: Are they opening pandora's box?
-
Balakumar, P.; Rose, M.; Ganti, S.S.; Krishan, P.; Singh, M. PPAR dual agonists: Are they opening pandora's box? Pharmacol. Res., 2007, 56, 91-98.
-
(2007)
Pharmacol. Res
, vol.56
, pp. 91-98
-
-
Balakumar, P.1
Rose, M.2
Ganti, S.S.3
Krishan, P.4
Singh, M.5
-
20
-
-
2442451618
-
Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
-
Schupp, M.; Janke, J.; Clasen, R.; Unger, T.; Kintscher, U. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation., 2004, 109, 2054-2057.
-
(2004)
Circulation
, vol.109
, pp. 2054-2057
-
-
Schupp, M.1
Janke, J.2
Clasen, R.3
Unger, T.4
Kintscher, U.5
-
21
-
-
33644672013
-
Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity
-
Schupp, M.; Clemenz, M.; Gineste, R., Witt, H.; Janke, J.; Helleboid, S.; Hennuyer, N.; Ruiz, P.; Unger, T.; Staels, B.; Kintscher, U. Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes, 2005, 54, 3442-3452.
-
(2005)
Diabetes
, vol.54
, pp. 3442-3452
-
-
Schupp, M.1
Clemenz, M.2
Gineste, R.3
Witt, H.4
Janke, J.5
Helleboid, S.6
Hennuyer, N.7
Ruiz, P.8
Unger, T.9
Staels, B.10
Kintscher, U.11
-
23
-
-
77954478333
-
Effect of rosiglitazone in sodium arsenite-induced experimental vascular endothelial dysfunction
-
Kaur, T.; Goel, R.K.; Balakumar, P. Effect of rosiglitazone in sodium arsenite-induced experimental vascular endothelial dysfunction. Arch. Pharm. Res., 2010, 33, 611-618.
-
(2010)
Arch. Pharm. Res
, vol.33
, pp. 611-618
-
-
Kaur, T.1
Goel, R.K.2
Balakumar, P.3
-
24
-
-
57549117258
-
Targeting cerebrovascular rhokinase in stroke
-
Shin, H.K.; Salomone, S.; Ayata, C. Targeting cerebrovascular rhokinase in stroke. Expert Opin. Ther. Targets, 2008, 12, 547-1564.
-
(2008)
Expert Opin. Ther. Targets
, vol.12
, pp. 547-1564
-
-
Shin, H.K.1
Salomone, S.2
Ayata, C.3
-
25
-
-
0027509176
-
Antihypertensive effects of CS-045 treatment in obese zucker rats
-
Yoshioka, S.; Nishino, H.; Shiraki, T.; Ikeda, K.; Koike, H.; Okuno, A.; Wada, M.; Fujiwara, T.; Horikoshi, H. Antihypertensive effects of CS-045 treatment in obese zucker rats. Metabolism, 1993, 42, 75-80.
-
(1993)
Metabolism
, vol.42
, pp. 75-80
-
-
Yoshioka, S.1
Nishino, H.2
Shiraki, T.3
Ikeda, K.4
Koike, H.5
Okuno, A.6
Wada, M.7
Fujiwara, T.8
Horikoshi, H.9
-
26
-
-
70349387354
-
Functional implications of genetic variation in human PPARgamma
-
Jeninga, E.H.; Gurnell, M.; Kalkhoven, E. Functional implications of genetic variation in human PPARgamma. Trends Endocrinol. Metab., 2009, 20, 380-387.
-
(2009)
Trends Endocrinol. Metab
, vol.20
, pp. 380-387
-
-
Jeninga, E.H.1
Gurnell, M.2
Kalkhoven, E.3
-
27
-
-
4344563444
-
Genetic variation in PPARg encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis
-
Al-Shali, K.Z.; House, A.A.; Hanley, A.J.; Khan, H.M.; Harris, S.B.; Zinman, B.; Mamakeesick, M.; Fenster, A.; Spence, J.D.; Hegele, R.A. Genetic variation in PPARg encoding peroxisome proliferator-activated receptor gamma associated with carotid atherosclerosis. Stroke, 2004, 35, 2036-2040.
-
(2004)
Stroke
, vol.35
, pp. 2036-2040
-
-
Al-Shali, K.Z.1
House, A.A.2
Hanley, A.J.3
Khan, H.M.4
Harris, S.B.5
Zinman, B.6
Mamakeesick, M.7
Fenster, A.8
Spence, J.D.9
Hegele, R.A.10
-
28
-
-
77954398507
-
Association of the PPARgamma2 gene pro12ala variant with primary hypertension and metabolic lipid disorders in han chinese of inner mongolia
-
Gao, L.; Wang, L.; Yun, H.; Su, L.; Su, X. Association of the PPARgamma2 gene pro12ala variant with primary hypertension and metabolic lipid disorders in han chinese of inner mongolia. Genet. Mol. Res., 2010, 9, 1312-1320.
-
(2010)
Genet. Mol. Res
, vol.9
, pp. 1312-1320
-
-
Gao, L.1
Wang, L.2
Yun, H.3
Su, L.4
Su, X.5
-
29
-
-
77956582828
-
The relationship between peroxisome proliferator-activated receptorgamma and renin: A human genetics study
-
Underwood, P.C.; Sun, B.; Williams, J.S.; Pojoga, L.H.; Chamarthi, B.; Lasky-Su, J.; Raby, B.A.; Hopkins, P.N.; Jeunemaitre, X.; Brown, N.J.; Adler, G.K.; Williams, G.H. The relationship between peroxisome proliferator-activated receptorgamma and renin: A human genetics study. J. Clin. Endocrinol. Metab., 2010, 95, E75-79.
-
(2010)
J. Clin. Endocrinol. Metab
, vol.95
-
-
Underwood, P.C.1
Sun, B.2
Williams, J.S.3
Pojoga, L.H.4
Chamarthi, B.5
Lasky-Su, J.6
Raby, B.A.7
Hopkins, P.N.8
Jeunemaitre, X.9
Brown, N.J.10
Adler, G.K.11
Williams, G.H.12
-
30
-
-
17044430286
-
PPARgamma in endothelial cells influences high fat diet-induced hypertension
-
Nicol, C.J.; Adachi, M.; Akiyama, T.E.; Gonzalez, F.J. PPARgamma in endothelial cells influences high fat diet-induced hypertension. Am. J. Hypertens., 2005, 18, 549-556.
-
(2005)
Am. J. Hypertens
, vol.18
, pp. 549-556
-
-
Nicol, C.J.1
Adachi, M.2
Akiyama, T.E.3
Gonzalez, F.J.4
-
31
-
-
62749196172
-
Distinct functions of vascular endothelial and smooth muscle ppargamma in regulation of blood pressure and vascular tone
-
Wang, N.; Symons, J.D.; Zhang, H.; Jia, Z.; Gonzalez, F.J.; Yang, T. Distinct functions of vascular endothelial and smooth muscle ppargamma in regulation of blood pressure and vascular tone. Toxicol. Pathol., 2009, 37, 21-27.
-
(2009)
Toxicol. Pathol
, vol.37
, pp. 21-27
-
-
Wang, N.1
Symons, J.D.2
Zhang, H.3
Jia, Z.4
Gonzalez, F.J.5
Yang, T.6
-
32
-
-
56449089574
-
Vascular PPARgamma controls circadian variation in blood pressure and heart rate through bmal1
-
Wang, N.; Yang, G.; Jia, Z.; Zhang, H.; Aoyagi, T.; Soodvilai, S.; Symons, J.D.; Schnermann, J.B.; Gonzalez, F.J.; Litwin, S.E.; Yang, T. Vascular PPARgamma controls circadian variation in blood pressure and heart rate through bmal1. Cell Metab., 2008, 8, 482-491.
-
(2008)
Cell Metab
, vol.8
, pp. 482-491
-
-
Wang, N.1
Yang, G.2
Jia, Z.3
Zhang, H.4
Aoyagi, T.5
Soodvilai, S.6
Symons, J.D.7
Schnermann, J.B.8
Gonzalez, F.J.9
Litwin, S.E.10
Yang, T.11
-
33
-
-
70350433697
-
Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production
-
Kleinhenz, J.M.; Kleinhenz, D.J.; You, S.; Ritzenthaler, J.D.; Hansen, J.M.; Archer, D.R.; Sutliff, R.L.; Hart, C.M. Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. Am. J. Physiol. Heart Circ. Physiol., 2009, 297, H1647-1654.
-
(2009)
Am. J. Physiol. Heart Circ. Physiol
, vol.297
-
-
Kleinhenz, J.M.1
Kleinhenz, D.J.2
You, S.3
Ritzenthaler, J.D.4
Hansen, J.M.5
Archer, D.R.6
Sutliff, R.L.7
Hart, C.M.8
-
34
-
-
53249111805
-
Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet
-
Beyer, A.M.; de Lange, W.J.; Halabi, C.M.; Modrick, M.L.; Keen, H.L.; Faraci, F.M.; Sigmund, C.D. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ. Res., 2008, 103, 654-661.
-
(2008)
Circ. Res
, vol.103
, pp. 654-661
-
-
Beyer, A.M.1
de Lange, W.J.2
Halabi, C.M.3
Modrick, M.L.4
Keen, H.L.5
Faraci, F.M.6
Sigmund, C.D.7
-
35
-
-
39649100393
-
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension
-
Halabi, C.M., Beyer, A.M.; de Lange, W.J.; Keen, H.L.; Baumbach, G.L.; Faraci, F.M.; Sigmund, C.D. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab., 2008, 7, 215-226.
-
(2008)
Cell Metab
, vol.7
, pp. 215-226
-
-
Halabi, C.M.1
Beyer, A.M.2
de Lange, W.J.3
Keen, H.L.4
Baumbach, G.L.5
Faraci, F.M.6
Sigmund, C.D.7
-
36
-
-
66549127391
-
Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension
-
Chang, L.; Villacorta, L.; Zhang, J.; Garcia-Barrio, M.T.; Yang, K.; Hamblin, M.; Whitesall, S.E.; D'Alecy, L.G.; Chen, Y.E. Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension. Circulation, 2009, 119, 2161-2169.
-
(2009)
Circulation
, vol.119
, pp. 2161-2169
-
-
Chang, L.1
Villacorta, L.2
Zhang, J.3
Garcia-Barrio, M.T.4
Yang, K.5
Hamblin, M.6
Whitesall, S.E.7
D'Alecy, L.G.8
Chen, Y.E.9
-
37
-
-
77954570367
-
Theoretical study on the molecular and electronic properties of some substances used for diabetes mellitus treatment
-
Maltarollo, V.G.; Homem-de-Mello, P.; Honorio, K.M. Theoretical study on the molecular and electronic properties of some substances used for diabetes mellitus treatment. J. Mol. Model., 2010, 16, 799-804.
-
(2010)
J. Mol. Model
, vol.16
, pp. 799-804
-
-
Maltarollo, V.G.1
Homem-de-Mello, P.2
Honorio, K.M.3
-
38
-
-
35648972677
-
Selective modulation of promoter recruitment and transcriptional activity of PPARgamma
-
Sears, D.D.; Hsiao, A.; Ofrecio, J.M.; Chapman, J.; He, W.; Olefsky, J.M. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem. Biophys. Res. Commun., 2007, 364, 515-521.
-
(2007)
Biochem. Biophys. Res. Commun
, vol.364
, pp. 515-521
-
-
Sears, D.D.1
Hsiao, A.2
Ofrecio, J.M.3
Chapman, J.4
He, W.5
Olefsky, J.M.6
-
39
-
-
33745662579
-
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma
-
Pomel, V.; Klicic, J.; Covini, D.; Church, D.D.; Shaw, J.P.; Roulin, K.; Burgat-Charvillon, F.; Valognes, D.; Camps, M.; Chabert, C.; Gillieron, C.; Francon, B.; Perrin, D.; Leroy, D.; Gretener, D.; Nichols, A.; Vitte, P.A.; Carboni, S.; Rommel, C.; Schwarz, M.K.; Ruckle, T. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J. Med. Chem. 2006, 49, 3857-3871.
-
(2006)
J. Med. Chem
, vol.49
, pp. 3857-3871
-
-
Pomel, V.1
Klicic, J.2
Covini, D.3
Church, D.D.4
Shaw, J.P.5
Roulin, K.6
Burgat-Charvillon, F.7
Valognes, D.8
Camps, M.9
Chabert, C.10
Gillieron, C.11
Francon, B.12
Perrin, D.13
Leroy, D.14
Gretener, D.15
Nichols, A.16
Vitte, P.A.17
Carboni, S.18
Rommel, C.19
Schwarz, M.K.20
Ruckle, T.21
more..
-
40
-
-
3242698804
-
The role of phosphoinositide-3 kinase and pten in cardiovascular physiology and disease
-
Oudit, G.Y.; Sun, H.; Kerfant, B.G.; Crackower, M.A.; Penninger, J.M.; Backx, P.H. The role of phosphoinositide-3 kinase and pten in cardiovascular physiology and disease. J. Mol. Cell. Cardiol., 2004, 37, 449-471.
-
(2004)
J. Mol. Cell. Cardiol
, vol.37
, pp. 449-471
-
-
Oudit, G.Y.1
Sun, H.2
Kerfant, B.G.3
Crackower, M.A.4
Penninger, J.M.5
Backx, P.H.6
-
41
-
-
2342537099
-
Phosphoinositide 3-kinase gamma: Kinase-dependent and-independent activities in cardiovascular function and disease
-
Alloatti, G.; Montrucchio, G.; Lembo, G.; Hirsch, E. Phosphoinositide 3-kinase gamma: Kinase-dependent and-independent activities in cardiovascular function and disease. Biochem. Soc. Trans., 2004, 32, 383-386.
-
(2004)
Biochem. Soc. Trans
, vol.32
, pp. 383-386
-
-
Alloatti, G.1
Montrucchio, G.2
Lembo, G.3
Hirsch, E.4
-
42
-
-
34447116875
-
The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo
-
Atochin, D.N.; Wang, A.; Liu, V.W.; Critchlow, J.D.; Dantas, A.P.; Looft-Wilson, R.; Murata, T.; Salomone, S.; Shin, H.K.; Ayata, C.; Moskowitz, M.A.; Michel, T.; Sessa, W.C.; Huang, P.L. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J. Clin. Invest., 2007, 117, 1961-1967.
-
(2007)
J. Clin. Invest
, vol.117
, pp. 1961-1967
-
-
Atochin, D.N.1
Wang, A.2
Liu, V.W.3
Critchlow, J.D.4
Dantas, A.P.5
Looft-Wilson, R.6
Murata, T.7
Salomone, S.8
Shin, H.K.9
Ayata, C.10
Moskowitz, M.A.11
Michel, T.12
Sessa, W.C.13
Huang, P.L.14
-
43
-
-
0028043535
-
Signal transduction and regulation in smooth muscle
-
Somlyo, A.P.; Somlyo, A.V. Signal transduction and regulation in smooth muscle. Nature, 1994, 372, 231-236.
-
(1994)
Nature
, vol.372
, pp. 231-236
-
-
Somlyo, A.P.1
Somlyo, A.V.2
-
44
-
-
0022888328
-
Calcium antagonism and calcium entry blockade
-
Godfraind, T.; Miller, R.; Wibo, M. Calcium antagonism and calcium entry blockade. Pharmacol. Rev., 1986, 38, 321-416.
-
(1986)
Pharmacol. Rev
, vol.38
, pp. 321-416
-
-
Godfraind, T.1
Miller, R.2
Wibo, M.3
-
45
-
-
0029142479
-
Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect
-
Buchanan, T.A.; Meehan, W.P.; Jeng, Y.Y.; Yang, D.; Chan, T.M.; Nadler, J.L.; Scott, S.; Rude, R.K.; Hsueh, W.A. Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect. J. Clin. Invest., 1995, 96, 354-360.
-
(1995)
J. Clin. Invest
, vol.96
, pp. 354-360
-
-
Buchanan, T.A.1
Meehan, W.P.2
Jeng, Y.Y.3
Yang, D.4
Chan, T.M.5
Nadler, J.L.6
Scott, S.7
Rude, R.K.8
Hsueh, W.A.9
-
46
-
-
65949114415
-
Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons
-
Pancani, T.; Phelps, J.T.; Searcy, J.L.; Kilgore, M.W.; Chen, K.C.; Porter, N.M.; Thibault, O. Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. J. Neurochem., 2009, 109, 1800-1811.
-
(2009)
J. Neurochem
, vol.109
, pp. 1800-1811
-
-
Pancani, T.1
Phelps, J.T.2
Searcy, J.L.3
Kilgore, M.W.4
Chen, K.C.5
Porter, N.M.6
Thibault, O.7
-
47
-
-
84861733534
-
Rapid and contrasting effects of rosiglitazone on TRPM3 and TRPC5 channels
-
Majeed, Y.; Bahnasi, Y.; Seymour, V.A.; Wilson, L.A.; Milligan, C.J.; Agarwal, A.K.; Sukumar, P.; Naylor, J.; Beech, D.J. Rapid and contrasting effects of rosiglitazone on TRPM3 and TRPC5 channels. Mol. Pharmacol., 2011
-
(2011)
Mol. Pharmacol
-
-
Majeed, Y.1
Bahnasi, Y.2
Seymour, V.A.3
Wilson, L.A.4
Milligan, C.J.5
Agarwal, A.K.6
Sukumar, P.7
Naylor, J.8
Beech, D.J.9
-
48
-
-
0035967936
-
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle
-
Eto, K.; Ohya, Y.; Nakamura, Y.; Abe, I.; Fujishima, M. Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle. Eur. J. Pharmacol., 2001, 423, 1-7.
-
(2001)
Eur. J. Pharmacol
, vol.423
, pp. 1-7
-
-
Eto, K.1
Ohya, Y.2
Nakamura, Y.3
Abe, I.4
Fujishima, M.5
-
49
-
-
10844281766
-
Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries
-
Heppner, T.J.; Bonev, A.D.; Eckman, D.M.; Gomez, M.F.; Petkov, G.V.; Nelson, M.T. Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology, 2005, 73, 15-22.
-
(2005)
Pharmacology
, vol.73
, pp. 15-22
-
-
Heppner, T.J.1
Bonev, A.D.2
Eckman, D.M.3
Gomez, M.F.4
Petkov, G.V.5
Nelson, M.T.6
-
50
-
-
45749103308
-
Physiological roles of K+ channels in vascular smooth muscle cells
-
Ko, E.A.; Han, J.; Jung, I.D.; Park, W.S. Physiological roles of K+ channels in vascular smooth muscle cells. J. Smooth Muscle Res., 2008, 44, 65-81.
-
(2008)
J. Smooth Muscle Res
, vol.44
, pp. 65-81
-
-
Ko, E.A.1
Han, J.2
Jung, I.D.3
Park, W.S.4
-
51
-
-
68349127297
-
Pioglitazone induced gastric acid secretion
-
Rotte, A.; Mack, A.F.; Bhandaru, M.; Kempe, D.S.; Beier, N.; Scholz, W.; Dicks, E.; Potzsch, S.; Kuhl, D.; Lang, F. Pioglitazone induced gastric acid secretion. Cell Physiol. Biochem., 2009, 24, 193-200.
-
(2009)
Cell Physiol. Biochem
, vol.24
, pp. 193-200
-
-
Rotte, A.1
Mack, A.F.2
Bhandaru, M.3
Kempe, D.S.4
Beier, N.5
Scholz, W.6
Dicks, E.7
Potzsch, S.8
Kuhl, D.9
Lang, F.10
-
52
-
-
67650096546
-
Activation of PPARgamma by rosiglitazone attenuates intestinal Cl-secretion
-
Bajwa, P.J.; Lee, J.W.; Straus, D.S.; Lytle, C. Activation of PPARgamma by rosiglitazone attenuates intestinal Cl-secretion. Am. J. Physiol. Gastrointest. Liver. Physiol., 2009, 297, G82-89.
-
(2009)
Am. J. Physiol. Gastrointest. Liver. Physiol
, vol.297
-
-
Bajwa, P.J.1
Lee, J.W.2
Straus, D.S.3
Lytle, C.4
-
53
-
-
0033783407
-
Regulation of CA(2+)-activated K+ currents by ciglitazone in rat pituitary GH3 cells
-
Wu, S.N.; Ho, L.L.; Li, H.F.; Chiang, H.T. Regulation of CA(2+)-activated K+ currents by ciglitazone in rat pituitary GH3 cells. J. Investig. Med., 2000, 48, 259-269.
-
(2000)
J. Investig. Med
, vol.48
, pp. 259-269
-
-
Wu, S.N.1
Ho, L.L.2
Li, H.F.3
Chiang, H.T.4
-
54
-
-
4243173683
-
Fenofibrate, troglitazone, and 15-deoxydelta12,14-prostaglandin J2 close KATP channels and induce insulin secretion
-
Shimomura, K.; Shimizu, H.; Ikeda, M.; Okada, S.; Kakei, M.; Matsumoto, S.; Mori, M. Fenofibrate, troglitazone, and 15-deoxydelta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. J. Pharmacol. Exp. Ther., 2004, 310, 1273-1280.
-
(2004)
J. Pharmacol. Exp. Ther
, vol.310
, pp. 1273-1280
-
-
Shimomura, K.1
Shimizu, H.2
Ikeda, M.3
Okada, S.4
Kakei, M.5
Matsumoto, S.6
Mori, M.7
-
55
-
-
33846414323
-
Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: A combined virtual screening and biological assay approach
-
Scarsi, M.; Podvinec, M.; Roth, A.; Hug, H.; Kersten, S.; Albrecht, H.; Schwede, T.; Meyer, U.A.; Rucker, C. Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: A combined virtual screening and biological assay approach. Mol. Pharmacol., 2007, 71, 398-406.
-
(2007)
Mol. Pharmacol
, vol.71
, pp. 398-406
-
-
Scarsi, M.1
Podvinec, M.2
Roth, A.3
Hug, H.4
Kersten, S.5
Albrecht, H.6
Schwede, T.7
Meyer, U.A.8
Rucker, C.9
-
56
-
-
33744958561
-
Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferator-activated receptor gammaactivated maxi-K channel opening in human umbilical vein endothelial cells
-
Kim, K.Y.; Cheon, H.G. Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferator-activated receptor gammaactivated maxi-K channel opening in human umbilical vein endothelial cells. J. Biol. Chem., 2006, 281, 13503-13512.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 13503-13512
-
-
Kim, K.Y.1
Cheon, H.G.2
-
57
-
-
33745243327
-
Synthetic peroxisome proliferatoractivated receptor-gamma agonists restore impaired vasorelaxation via ATP-sensitive K+ channels by high glucose
-
Kinoshita, H.; Azma, T.; Iranami, H.; Nakahata, K.; Kimoto, Y.; Dojo, M.; Yuge, O.; Hatano, Y. Synthetic peroxisome proliferatoractivated receptor-gamma agonists restore impaired vasorelaxation via ATP-sensitive K+ channels by high glucose. J. Pharmacol. Exp. Ther., 2006, 318, 312-318.
-
(2006)
J. Pharmacol. Exp. Ther
, vol.318
, pp. 312-318
-
-
Kinoshita, H.1
Azma, T.2
Iranami, H.3
Nakahata, K.4
Kimoto, Y.5
Dojo, M.6
Yuge, O.7
Hatano, Y.8
-
58
-
-
56649120697
-
Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel
-
Nomura, H.; Yamawaki, H.; Mukohda, M.; Okada, M.; Hara, Y. Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel. J. Pharmacol. Sci., 2008, 108, 258-265.
-
(2008)
J. Pharmacol. Sci
, vol.108
, pp. 258-265
-
-
Nomura, H.1
Yamawaki, H.2
Mukohda, M.3
Okada, M.4
Hara, Y.5
-
59
-
-
0141751697
-
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by g proteins, kinases, and myosin phosphatase
-
Somlyo, A.P.; Somlyo, A.V. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by g proteins, kinases, and myosin phosphatase. Physiol. Rev., 2003, 83, 1325-1358.
-
(2003)
Physiol. Rev
, vol.83
, pp. 1325-1358
-
-
Somlyo, A.P.1
Somlyo, A.V.2
-
60
-
-
29644432101
-
Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle
-
Wilson, D.P.; Sutherland, C.; Borman, M.A.; Deng, J.T.; Macdonald, J.A.; Walsh, M.P. Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. Biochem. J., 2005, 392, 641-648.
-
(2005)
Biochem. J
, vol.392
, pp. 641-648
-
-
Wilson, D.P.1
Sutherland, C.2
Borman, M.A.3
Deng, J.T.4
Macdonald, J.A.5
Walsh, M.P.6
-
61
-
-
0028354842
-
Smooth muscle: Excitationcontraction coupling, contractile regulation, and the cross-bridge cycle
-
Somlyo, A.P.; Somlyo, A.V. Smooth muscle: Excitationcontraction coupling, contractile regulation, and the cross-bridge cycle. Alcohol Clin. Exp. Res., 1994, 18, 138-143.
-
(1994)
Alcohol Clin. Exp. Res
, vol.18
, pp. 138-143
-
-
Somlyo, A.P.1
Somlyo, A.V.2
-
62
-
-
38849184196
-
The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction
-
Schubert, R.; Lidington, D.; Bolz, S.S. The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc. Res., 2008, 77, 8-18.
-
(2008)
Cardiovasc. Res
, vol.77
, pp. 8-18
-
-
Schubert, R.1
Lidington, D.2
Bolz, S.S.3
-
63
-
-
13144266902
-
Peroxisome proliferatoractivated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2
-
Wakino, S.; Hayashi, K.; Kanda, T.; Tatematsu, S.; Homma, K.; Yoshioka, K.; Takamatsu, I.; Saruta, T. Peroxisome proliferatoractivated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2. Circ. Res., 2004, 95, e45-55.
-
(2004)
Circ. Res
, vol.95
-
-
Wakino, S.1
Hayashi, K.2
Kanda, T.3
Tatematsu, S.4
Homma, K.5
Yoshioka, K.6
Takamatsu, I.7
Saruta, T.8
-
64
-
-
66149140549
-
A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT
-
Atkins, K.B.; Irey, B.; Xiang, N.; Brosius, F.C. 3rd. A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT. Am. J. Physiol. Cell Physiol., 2009, 296, C1151-1161.
-
(2009)
Am. J. Physiol. Cell Physiol
, vol.296
-
-
Atkins, K.B.1
Irey, B.2
Xiang, N.3
Brosius III, F.C.4
-
65
-
-
84861138368
-
Pleiotropic effects of glitazones: A double edge sword? Front
-
Salomone, S. Pleiotropic effects of glitazones: A double edge sword? Front. Pharmacol., 2011, 2, 14
-
(2011)
Pharmacol
, vol.2
, pp. 14
-
-
Salomone, S.1
-
66
-
-
1442288375
-
PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice
-
Ryan, M.J.; Didion, S.P.; Mathur, S.; Faraci, F.M.; Sigmund, C.D. PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension, 2004, 43, 661-666.
-
(2004)
Hypertension
, vol.43
, pp. 661-666
-
-
Ryan, M.J.1
Didion, S.P.2
Mathur, S.3
Faraci, F.M.4
Sigmund, C.D.5
-
67
-
-
67651146363
-
Inflammatory cytokines in vascular dysfunction and vascular disease
-
Sprague, A.H.; Khalil, R.A. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem. Pharmacol., 2009, 78, 539-552.
-
(2009)
Biochem. Pharmacol
, vol.78
, pp. 539-552
-
-
Sprague, A.H.1
Khalil, R.A.2
-
68
-
-
0032560545
-
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
-
Ricote, M.; Huang, J.; Fajas, L.; Li A.; Welch, J.; Najib, J.; Witztum, J.L.; Auwerx, J.; Palinski, W.; Glass, C.K. Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA, 1998, 95, 7614-7619.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7614-7619
-
-
Ricote, M.1
Huang, J.2
Fajas, L.3
Li, A.4
Welch, J.5
Najib, J.6
Witztum, J.L.7
Auwerx, J.8
Palinski, W.9
Glass, C.K.10
-
69
-
-
0001297403
-
Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT
-
Yang, X.Y.; Wang, L.H.; Chen, T.; Hodge, D.R.; Resau, J.H.; DaSilva, L.; Farrar, W.L. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT. J. Biol. Chem., 2000, 275, 4541-4544.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 4541-4544
-
-
Yang, X.Y.1
Wang, L.H.2
Chen, T.3
Hodge, D.R.4
Resau, J.H.5
DaSilva, L.6
Farrar, W.L.7
-
70
-
-
0037072826
-
Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses proinflammatory adhesion molecules in human vascular endothelial cells
-
Wang, N.; Verna, L.; Chen, N.G.; Chen, J.; Li, H.; Forman, B.M.; Stemerman, M.B. Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses proinflammatory adhesion molecules in human vascular endothelial cells. J. Biol. Chem., 2002, 277, 34176-34181.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 34176-34181
-
-
Wang, N.1
Verna, L.2
Chen, N.G.3
Chen, J.4
Li, H.5
Forman, B.M.6
Stemerman, M.B.7
-
71
-
-
0034660182
-
Peroxisome proliferator-activated receptor-gamma activators inhibit IFNgamma-induced expression of the T cell-active CXC chemokines IP-10, MIG, and I-TAC in human endothelial cells
-
Marx, N.; Mach, F.; Sauty, A.; Leung, J.H.; Sarafi, M.N.; Ransohoff, R.M.; Libby, P.; Plutzky, J.; Luster, A.D. Peroxisome proliferator-activated receptor-gamma activators inhibit IFNgamma-induced expression of the T cell-active CXC chemokines IP-10, MIG, and I-TAC in human endothelial cells. J. Immunol., 2000, 164, 6503-6508.
-
(2000)
J. Immunol
, vol.164
, pp. 6503-6508
-
-
Marx, N.1
Mach, F.2
Sauty, A.3
Leung, J.H.4
Sarafi, M.N.5
Ransohoff, R.M.6
Libby, P.7
Plutzky, J.8
Luster, A.D.9
-
72
-
-
2942670612
-
PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase c signaling pathway: Role of diacylglycerol kinase
-
Verrier, E.; Wang, L.; Wadham, C.; Albanese, N.; Hahn, C.; Gamble, J.R.; Chatterjee, V.K.; Vadas, M.A.; Xia, P. PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase c signaling pathway: Role of diacylglycerol kinase. Circ. Res., 2004, 94, 1515-1522.
-
(2004)
Circ. Res
, vol.94
, pp. 1515-1522
-
-
Verrier, E.1
Wang, L.2
Wadham, C.3
Albanese, N.4
Hahn, C.5
Gamble, J.R.6
Chatterjee, V.K.7
Vadas, M.A.8
Xia, P.9
-
73
-
-
68149178582
-
PPARgamma agonist, rosiglitazone, regulates angiotensin ii-induced vascular inflammation through the TLR4-dependent signaling pathway
-
Ji, Y.; Liu, J.; Wang, Z.; Liu, N.; Gou, W. PPARgamma agonist, rosiglitazone, regulates angiotensin ii-induced vascular inflammation through the TLR4-dependent signaling pathway. Lab. Invest., 2009, 89, 887-902.
-
(2009)
Lab. Invest
, vol.89
, pp. 887-902
-
-
Ji, Y.1
Liu, J.2
Wang, Z.3
Liu, N.4
Gou, W.5
-
74
-
-
42249089079
-
A new mechanism involving erk contributes to rosiglitazone inhibition of tumor necrosis factoralpha and interferon-gamma inflammatory effects in human endothelial cells
-
Lombardi, A.; Cantini, G.; Piscitelli, E.; Gelmini, S.; Francalanci, M.; Mello, T.; Ceni, E.; Varano, G.; Forti, G.; Rotondi, M.; Galli, A.; Serio, M.; Luconi, M. A new mechanism involving erk contributes to rosiglitazone inhibition of tumor necrosis factoralpha and interferon-gamma inflammatory effects in human endothelial cells. Arterioscler. Thromb. Vasc. Biol., 2008, 28, 718-724.
-
(2008)
Arterioscler. Thromb. Vasc. Biol
, vol.28
, pp. 718-724
-
-
Lombardi, A.1
Cantini, G.2
Piscitelli, E.3
Gelmini, S.4
Francalanci, M.5
Mello, T.6
Ceni, E.7
Varano, G.8
Forti, G.9
Rotondi, M.10
Galli, A.11
Serio, M.12
Luconi, M.13
-
75
-
-
0037076294
-
Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferatoractivated receptor-gamma
-
Diep, Q.N.; El Mabrouk, M.; Cohn, J.S.; Endemann, D.; Amiri, F.; Virdis, A.; Neves, M.F.; Schiffrin, E.L. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferatoractivated receptor-gamma. Circulation, 2002, 105, 2296-2302.
-
(2002)
Circulation
, vol.105
, pp. 2296-2302
-
-
Diep, Q.N.1
El Mabrouk, M.2
Cohn, J.S.3
Endemann, D.4
Amiri, F.5
Virdis, A.6
Neves, M.F.7
Schiffrin, E.L.8
-
76
-
-
67649516450
-
Rosiglitazone reduces the development and rupture of experimental aortic aneurysms
-
Jones, A.; Deb, R.; Torsney, E.; Howe, F.; Dunkley, M.; Gnaneswaran, Y.; Gaze, D.; Nasr, H.; Loftus, I.M.; Thompson, M.M.; Cockerill, G.W. Rosiglitazone reduces the development and rupture of experimental aortic aneurysms. Circulation, 2009, 119, 3125-3132.
-
(2009)
Circulation
, vol.119
, pp. 3125-3132
-
-
Jones, A.1
Deb, R.2
Torsney, E.3
Howe, F.4
Dunkley, M.5
Gnaneswaran, Y.6
Gaze, D.7
Nasr, H.8
Loftus, I.M.9
Thompson, M.M.10
Cockerill, G.W.11
-
77
-
-
0034711678
-
Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators
-
Pasceri, V.; Wu, H.D.; Willerson, J.T.; Yeh, E.T. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators. Circulation, 2000, 101, 235-238.
-
(2000)
Circulation
, vol.101
, pp. 235-238
-
-
Pasceri, V.1
Wu, H.D.2
Willerson, J.T.3
Yeh, E.T.4
-
78
-
-
0032847680
-
Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyteendothelial cell interaction
-
Jackson, S.M.; Parhami, F.; Xi, X.P.; Berliner, J.A.; Hsueh, W.A.; Law, R.E.; Demer, L.L. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyteendothelial cell interaction. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 2094-2104.
-
(1999)
Arterioscler. Thromb. Vasc. Biol
, vol.19
, pp. 2094-2104
-
-
Jackson, S.M.1
Parhami, F.2
Xi, X.P.3
Berliner, J.A.4
Hsueh, W.A.5
Law, R.E.6
Demer, L.L.7
-
79
-
-
0033546190
-
Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta12, 14-prostaglandin J2
-
Bishop-Bailey, D.; Hla, T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta12, 14-prostaglandin J2. J. Biol. Chem., 1999, 274, 17042-17048.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 17042-17048
-
-
Bishop-Bailey, D.1
Hla, T.2
-
80
-
-
0042009938
-
Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor gamma 1 (PPARgamma 1) and PPARalpha genes
-
Inoue, I.; Hayashi, K.; Yagasaki, F.; Nakamura, K.; Matsunaga, T.; Xu, H.; Inukai, K.; Awata, T.; Komoda, T.; Katayama, S. Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor gamma 1 (PPARgamma 1) and PPARalpha genes. J. Atheroscler. Thromb., 2003, 10, 99-108.
-
(2003)
J. Atheroscler. Thromb
, vol.10
, pp. 99-108
-
-
Inoue, I.1
Hayashi, K.2
Yagasaki, F.3
Nakamura, K.4
Matsunaga, T.5
Xu, H.6
Inukai, K.7
Awata, T.8
Komoda, T.9
Katayama, S.10
-
81
-
-
0038028546
-
Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta
-
Hannan, K.M.; Dilley, R.J.; de Dios, S.T.; Little, P.J. Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 762-768.
-
(2003)
Arterioscler. Thromb. Vasc. Biol
, vol.23
, pp. 762-768
-
-
Hannan, K.M.1
Dilley, R.J.2
de Dios, S.T.3
Little, P.J.4
-
82
-
-
0033605677
-
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo
-
Xin, X., Yang, S., Kowalski, J., Gerritsen, M.E. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J. Biol. Chem., 1999, 274, 9116-9121.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 9116-9121
-
-
Xin, X.1
Yang, S.2
Kowalski, J.3
Gerritsen, M.E.4
-
83
-
-
18444371741
-
PPAR activators inhibit endothelial cell migration by targeting Akt
-
Goetze, S.; Eilers, F.; Bungenstock, A.; Kintscher, U.; Stawowy, P.; Blaschke, F.; Graf, K.; Law, R.E.; Fleck, E; Grafe, M. PPAR activators inhibit endothelial cell migration by targeting Akt. Biochem. Biophys. Res. Commun., 2002, 293, 1431-1437.
-
(2002)
Biochem. Biophys Res. Commun
, vol.293
, pp. 1431-1437
-
-
Goetze, S.1
Eilers, F.2
Bungenstock, A.3
Kintscher, U.4
Stawowy, P.5
Blaschke, F.6
Graf, K.7
Law, R.E.8
Fleck, E.9
Grafe, M.10
-
84
-
-
0036840309
-
Leptin induces endothelial cell migration through akt, which is inhibited by PPARgamma-ligands
-
Goetze, S.; Bungenstock, A.; Czupalla, C.; Eilers, F.; Stawowy, P.; Kintscher, U.; Spencer-Hansch, C.; Graf K.; Nurnberg, B.; Law, R.E.; Fleck, E., Grafe, M. Leptin induces endothelial cell migration through akt, which is inhibited by PPARgamma-ligands. Hypertension, 2002, 40, 748-754.
-
(2002)
Hypertension
, vol.40
, pp. 748-754
-
-
Goetze, S.1
Bungenstock, A.2
Czupalla, C.3
Eilers, F.4
Stawowy, P.5
Kintscher, U.6
Spencer-Hansch, C.7
Graf, K.8
Nurnberg, B.9
Law, R.E.10
Fleck, E.11
Grafe, M.12
-
85
-
-
70449717330
-
Peroxisome proliferator-activated receptors and angiogenesis
-
Biscetti, F.; Straface, G.; Pitocco, D.; Zaccardi, F.; Ghirlanda, G.; Flex, A. Peroxisome proliferator-activated receptors and angiogenesis. Nutr. Metab. Cardiovasc. Dis., 2009, 19, 751-759.
-
(2009)
Nutr. Metab. Cardiovasc. Dis
, vol.19
, pp. 751-759
-
-
Biscetti, F.1
Straface, G.2
Pitocco, D.3
Zaccardi, F.4
Ghirlanda, G.5
Flex, A.6
-
86
-
-
45149096016
-
Rosiglitazone and delayed onset of proliferative diabetic retinopathy
-
Shen, L.Q.; Child, A.; Weber, G.M.; Folkman, J.; Aiello, L.P. Rosiglitazone and delayed onset of proliferative diabetic retinopathy. Arch. Ophthalmol., 2008, 126, 793-799.
-
(2008)
Arch. Ophthalmol
, vol.126
, pp. 793-799
-
-
Shen, L.Q.1
Child, A.2
Weber, G.M.3
Folkman, J.4
Aiello, L.P.5
-
87
-
-
77957241136
-
Anticancer role of ppargamma agonists in hematological malignancies found in the vasculature, marrow, and eyes
-
Simpson-Haidaris, P.J.; Pollock, S.J.; Ramon, S.; Guo, N.; Woeller, C.F.; Feldon, S.E.; Phipps, R.P. Anticancer role of ppargamma agonists in hematological malignancies found in the vasculature, marrow, and eyes. PPAR Res., 2010, 2010, 814609.
-
(2010)
PPAR Res
, vol.2010
, pp. 814609
-
-
Simpson-Haidaris, P.J.1
Pollock, S.J.2
Ramon, S.3
Guo, N.4
Woeller, C.F.5
Feldon, S.E.6
Phipps, R.P.7
-
88
-
-
79953774672
-
Molecular cross-regulation between PPARgamma and other signaling pathways: Implications for lung cancer therapy
-
Reka, A.K.; Goswami, M.T.; Krishnapuram, R.; Standiford, T.J.; Keshamouni, V.G. Molecular cross-regulation between PPARgamma and other signaling pathways: Implications for lung cancer therapy. Lung Cancer, 2011, 72, 154-159.
-
(2011)
Lung Cancer
, vol.72
, pp. 154-159
-
-
Reka, A.K.1
Goswami, M.T.2
Krishnapuram, R.3
Standiford, T.J.4
Keshamouni, V.G.5
-
89
-
-
80054761005
-
The peroxisome proliferator-activated receptors and atherosclerosis
-
Soskic, S.S.; Dobutovic, B.D.; Sudar, E.M.; Obradovic, M.M.; Nikolic, D.M., Zaric, BL; Stojanovic S.D.; Stokic E.J.; Mikhailidis D.P.; Isenovic E.R. The peroxisome proliferator-activated receptors and atherosclerosis. Angiology, 2011, 62(7), 523-534.
-
(2011)
Angiology
, vol.62
, Issue.7
, pp. 523-534
-
-
Soskic, S.S.1
Dobutovic, B.D.2
Sudar, E.M.3
Obradovic, M.M.4
Nikolic, D.M.5
Zaric, B.L.6
Stojanovic, S.D.7
Stokic, E.J.8
Mikhailidis, D.P.9
Isenovic, E.R.10
-
90
-
-
0033520304
-
Peroxisome proliferatoractivated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
-
Delerive, P.; Martin-Nizard, F.; Chinetti, G.; Trottein, F.; Fruchart, J.C.; Najib, J.; Duriez, P.; Staels, B. Peroxisome proliferatoractivated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ. Res., 1999, 85, 394-402.
-
(1999)
Circ. Res
, vol.85
, pp. 394-402
-
-
Delerive, P.1
Martin-Nizard, F.2
Chinetti, G.3
Trottein, F.4
Fruchart, J.C.5
Najib, J.6
Duriez, P.7
Staels, B.8
-
91
-
-
0037231474
-
Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells
-
Calnek, D.S.; Mazzella, L.; Roser, S.; Roman, J.; Hart, C.M. Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 52-57.
-
(2003)
Arterioscler. Thromb. Vasc. Biol
, vol.23
, pp. 52-57
-
-
Calnek, D.S.1
Mazzella, L.2
Roser, S.3
Roman, J.4
Hart, C.M.5
-
92
-
-
24144448954
-
Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms
-
Polikandriotis, J.A.; Mazzella, L.J.; Rupnow, H.L.; Hart, C.M. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. Arterioscler. Thromb. Vasc. Biol., 2005, 25, 1810-1816.
-
(2005)
Arterioscler. Thromb. Vasc. Biol
, vol.25
, pp. 1810-1816
-
-
Polikandriotis, J.A.1
Mazzella, L.J.2
Rupnow, H.L.3
Hart, C.M.4
-
93
-
-
15444367174
-
Peroxisome proliferator-activated receptorgamma ligands regulate endothelial membrane superoxide production
-
Hwang, J.; Kleinhenz, D.J.; Lassegue, B.; Griendling, K.K.; Dikalov, S.; Hart, C.M. Peroxisome proliferator-activated receptorgamma ligands regulate endothelial membrane superoxide production. Am. J. Physiol. Cell. Physiol., 2005, 288, C899-905.
-
(2005)
Am. J. Physiol. Cell. Physiol
, vol.288
-
-
Hwang, J.1
Kleinhenz, D.J.2
Lassegue, B.3
Griendling, K.K.4
Dikalov, S.5
Hart, C.M.6
-
94
-
-
0037231532
-
Effect of peroxisome proliferator-activated receptoralpha and-gamma activators on vascular remodeling in endothelindependent hypertension
-
Iglarz, M.; Touyz, R.M.; Amiri, F.; Lavoie, M.F.; Diep, Q.N.; Schiffrin, E.L. Effect of peroxisome proliferator-activated receptoralpha and-gamma activators on vascular remodeling in endothelindependent hypertension. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 45-51.
-
(2003)
Arterioscler. Thromb. Vasc. Biol
, vol.23
, pp. 45-51
-
-
Iglarz, M.1
Touyz, R.M.2
Amiri, F.3
Lavoie, M.F.4
Diep, Q.N.5
Schiffrin, E.L.6
-
95
-
-
0037342201
-
Gata-6 is involved in ppargamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells
-
Abe, M.; Hasegawa, K.; Wada, H.; Morimoto, T.; Yanazume, T.; Kawamura, T.; Hirai, M.; Furukawa, Y.; Kita, T. Gata-6 is involved in ppargamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 404-410.
-
(2003)
Arterioscler. Thromb. Vasc. Biol
, vol.23
, pp. 404-410
-
-
Abe, M.1
Hasegawa, K.2
Wada, H.3
Morimoto, T.4
Yanazume, T.5
Kawamura, T.6
Hirai, M.7
Furukawa, Y.8
Kita, T.9
-
96
-
-
0037047666
-
Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptorgamma ligand therapy
-
Bishop-Bailey, D.; Hla, T.; Warner, T.D. Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptorgamma ligand therapy. Circ. Res., 2002, 91, 210-217.
-
(2002)
Circ. Res
, vol.91
, pp. 210-217
-
-
Bishop-Bailey, D.1
Hla, T.2
Warner, T.D.3
-
97
-
-
0034698074
-
Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and g1--> s transition in vascular smooth muscle cells
-
Wakino, S., Kintscher, U., Kim, S., Yin, F., Hsueh, W.A., Law, R.E. Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and g1--> s transition in vascular smooth muscle cells. J. Biol. Chem., 2000, 275, 22435-22441.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 22435-22441
-
-
Wakino, S.1
Kintscher, U.2
Kim, S.3
Yin, F.4
Hsueh, W.A.5
Law, R.E.6
-
98
-
-
0346668393
-
A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth
-
Bruemmer, D.; Berger, J.P.; Liu, J.; Kintscher, U.; Wakino, S.; Fleck, E.; Moller, D.E.; Law R.E. A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth. Eur. J. Pharmacol., 2003, 466, 225-234.
-
(2003)
Eur. J. Pharmacol
, vol.466
, pp. 225-234
-
-
Bruemmer, D.1
Berger, J.P.2
Liu, J.3
Kintscher, U.4
Wakino, S.5
Fleck, E.6
Moller, D.E.7
Law, R.E.8
-
99
-
-
0037674923
-
Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptorgamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation
-
de Dios, S.T.; Bruemmer, D.; Dilley, R.J.; Ivey, M.E.; Jennings, G.L.; Law, R.E.; Little, P.J. Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptorgamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation. Circulation, 2003, 107, 2548-2550.
-
(2003)
Circulation
, vol.107
, pp. 2548-2550
-
-
de Dios, S.T.1
Bruemmer, D.2
Dilley, R.J.3
Ivey, M.E.4
Jennings, G.L.5
Law, R.E.6
Little, P.J.7
-
100
-
-
0141886991
-
Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells
-
Bruemmer, D.; Yin, F.; Liu, J.; Berger, J.P.; Sakai, T.; Blaschke, F.; Fleck, E.; Van Herle, A.J.; Forman, B.M.; Law, R.E. Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells. Circ. Res., 2003, 93, e38-47.
-
(2003)
Circ. Res
, vol.93
-
-
Bruemmer, D.1
Yin, F.2
Liu, J.3
Berger, J.P.4
Sakai, T.5
Blaschke, F.6
Fleck, E.7
van Herle, A.J.8
Forman, B.M.9
Law, R.E.10
-
101
-
-
0034633847
-
Peroxisome proliferatoractivated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells
-
Takeda, K.; Ichiki, T.; Tokunou, T.; Funakoshi, Y.; Iino, N.; Hirano, K.; Kanaide, H.; Takeshita, A. Peroxisome proliferatoractivated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. Circulation, 2000, 102, 1834-1839.
-
(2000)
Circulation
, vol.102
, pp. 1834-1839
-
-
Takeda, K.1
Ichiki, T.2
Tokunou, T.3
Funakoshi, Y.4
Iino, N.5
Hirano, K.6
Kanaide, H.7
Takeshita, A.8
-
102
-
-
36049036174
-
An oxidized lipid-peroxisome proliferatoractivated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion
-
Barlic, J.; Murphy, P.M. An oxidized lipid-peroxisome proliferatoractivated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion. Trends Cardiovasc. Med., 2007, 17, 269-274.
-
(2007)
Trends Cardiovasc. Med
, vol.17
, pp. 269-274
-
-
Barlic, J.1
Murphy, P.M.2
-
103
-
-
19944434103
-
Gi262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats
-
Chen, L., Yang, B., McNulty, J.A., Clifton, L.G., Binz, J.G., Grimes, A.M., Strum, J.C., Harrington, W.W., Chen, Z., Balon, T.W., Stimpson, S.A., Brown, K.K. Gi262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats. J. Pharmacol. Exp. Ther., 2005, 312, 718-725.
-
(2005)
J. Pharmacol. Exp. Ther
, vol.312
, pp. 718-725
-
-
Chen, L.1
Yang, B.2
McNulty, J.A.3
Clifton, L.G.4
Binz, J.G.5
Grimes, A.M.6
Strum, J.C.7
Harrington, W.W.8
Chen, Z.9
Balon, T.W.10
Stimpson, S.A.11
Brown, K.K.12
-
104
-
-
33845633231
-
Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase c activation: Novel mechanism for PPARgamma agonist's effects on edema and weight gain
-
Sotiropoulos, K.B.; Clermont, A.; Yasuda, Y.; Rask-Madsen, C.; Mastumoto, M.; Takahashi, J.; Della Vecchia, K.; Kondo, T.; Aiello, L.P.; King, G.L. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase c activation: Novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J., 2006, 20, 1203-1205.
-
(2006)
FASEB J
, vol.20
, pp. 1203-1205
-
-
Sotiropoulos, K.B.1
Clermont, A.2
Yasuda, Y.3
Rask-Madsen, C.4
Mastumoto, M.5
Takahashi, J.6
Della Vecchia, K.7
Kondo, T.8
Aiello, L.P.9
King, G.L.10
-
105
-
-
53549106595
-
Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists
-
Geese, W.J.; Achanzar, W.; Rubin, C.; Hariharan, N.; Cheng, P.; Tomlinson, L.; Ordway, N.; Dracopoli, N.C.; Delmonte, T.; Hui, L.; Krishnan, B.; Cosma, G.; Ranade, K. Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists. Pharmacogenet. Genomics, 2008, 18, 903-910.
-
(2008)
Pharmacogenet. Genomics
, vol.18
, pp. 903-910
-
-
Geese, W.J.1
Achanzar, W.2
Rubin, C.3
Hariharan, N.4
Cheng, P.5
Tomlinson, L.6
Ordway, N.7
Dracopoli, N.C.8
Delmonte, T.9
Hui, L.10
Krishnan, B.11
Cosma, G.12
Ranade, K.13
|