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Volumn 5, Issue 2, 2012, Pages 282-291

Effects of PPARγ ligands on vascular tone

Author keywords

Pioglitazone; PPAR ; Rosiglitazone; Thiazolidinediones; Troglitazone; Vascular tone

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CALCIUM CHANNEL L TYPE; CALCIUM ION; CALMODULIN; CYCLIC GMP; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; MYOSIN LIGHT CHAIN KINASE; MYOSIN PHOSPHATASE TARGET SUBUNIT 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA LIGAND; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; POTASSIUM ION; ROSIGLITAZONE; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TROGLITAZONE; UNCLASSIFIED DRUG;

EID: 84861750793     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467211205020282     Document Type: Review
Times cited : (17)

References (105)
  • 1
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I.; Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 1990, 347, 645-650.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 3
    • 70349664475 scopus 로고    scopus 로고
    • Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta
    • Ehrenborg, E.; Krook, A. Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta. Pharmacol. Rev., 2009, 61, 373-393.
    • (2009) Pharmacol. Rev , vol.61 , pp. 373-393
    • Ehrenborg, E.1    Krook, A.2
  • 8
    • 0032568261 scopus 로고    scopus 로고
    • Hepatic dysfunction associated with troglitazone
    • Watkins, P.B.; Whitcomb, R.W. Hepatic dysfunction associated with troglitazone. N. Engl. J. Med., 1998, 338, 916-917.
    • (1998) N. Engl. J. Med , vol.338 , pp. 916-917
    • Watkins, P.B.1    Whitcomb, R.W.2
  • 9
    • 33846424676 scopus 로고    scopus 로고
    • Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: A review
    • Masubuchi, Y. Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: A review. Drug Metab. Pharmacokinet., 2006, 21, 347-356.
    • (2006) Drug Metab. Pharmacokinet , vol.21 , pp. 347-356
    • Masubuchi, Y.1
  • 10
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen, S.E.; Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med., 2007, 356, 2457-2471.
    • (2007) N. Engl. J. Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 11
    • 77951601655 scopus 로고    scopus 로고
    • Thiazolidinedione drugs and cardiovascular risks: A science advisory from the american heart association and american college of cardiology foundation
    • Kaul, S.; Bolger, A.F.; Herrington D.; Giugliano R.P.; Eckel R.H. Thiazolidinedione drugs and cardiovascular risks: A science advisory from the american heart association and american college of cardiology foundation. Circulation, 2010, 121, 1868-1877.
    • (2010) Circulation , vol.121 , pp. 1868-1877
    • Kaul, S.1    Bolger, A.F.2    Herrington, D.3    Giugliano, R.P.4    Eckel, R.H.5
  • 13
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C.; Ting, A.T.; Seed, B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 1998, 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 14
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote, M.; Li, A.C.; Willson, T.M.; Kelly, C.J.; Glass, C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature, 1998, 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 15
    • 0034010651 scopus 로고    scopus 로고
    • Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mrna expression in a murine model of non-insulin-dependent diabetes
    • Sigrist, S.; Bedoucha, M.; Boelsterli, U.A. Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mrna expression in a murine model of non-insulin-dependent diabetes. Biochem. Pharmacol., 2000, 60, 67-75.
    • (2000) Biochem. Pharmacol , vol.60 , pp. 67-75
    • Sigrist, S.1    Bedoucha, M.2    Boelsterli, U.A.3
  • 16
    • 0011446750 scopus 로고    scopus 로고
    • Enhanced hepatocarcinogenicity due to agonists of peroxisome proliferator-activated receptors in senescent rats: Role of peroxisome proliferation, cell proliferation, and apoptosis
    • Youssef, J.; Badr, M. Enhanced hepatocarcinogenicity due to agonists of peroxisome proliferator-activated receptors in senescent rats: Role of peroxisome proliferation, cell proliferation, and apoptosis. ScientificWorldJournal, 2002, 2, 1491-1500.
    • (2002) ScientificWorldJournal , vol.2 , pp. 1491-1500
    • Youssef, J.1    Badr, M.2
  • 17
    • 78650286735 scopus 로고    scopus 로고
    • The nuclear hormone receptor ppargamma as a therapeutic target in major diseases
    • Schmidt, M.V.; Brune, B.; von Knethen, A. The nuclear hormone receptor ppargamma as a therapeutic target in major diseases. ScientificWorldJournal, 2010, 10, 2181-2197.
    • (2010) ScientificWorldJournal , vol.10 , pp. 2181-2197
    • Schmidt, M.V.1    Brune, B.2    von Knethen, A.3
  • 20
    • 2442451618 scopus 로고    scopus 로고
    • Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    • Schupp, M.; Janke, J.; Clasen, R.; Unger, T.; Kintscher, U. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation., 2004, 109, 2054-2057.
    • (2004) Circulation , vol.109 , pp. 2054-2057
    • Schupp, M.1    Janke, J.2    Clasen, R.3    Unger, T.4    Kintscher, U.5
  • 21
    • 33644672013 scopus 로고    scopus 로고
    • Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity
    • Schupp, M.; Clemenz, M.; Gineste, R., Witt, H.; Janke, J.; Helleboid, S.; Hennuyer, N.; Ruiz, P.; Unger, T.; Staels, B.; Kintscher, U. Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes, 2005, 54, 3442-3452.
    • (2005) Diabetes , vol.54 , pp. 3442-3452
    • Schupp, M.1    Clemenz, M.2    Gineste, R.3    Witt, H.4    Janke, J.5    Helleboid, S.6    Hennuyer, N.7    Ruiz, P.8    Unger, T.9    Staels, B.10    Kintscher, U.11
  • 23
    • 77954478333 scopus 로고    scopus 로고
    • Effect of rosiglitazone in sodium arsenite-induced experimental vascular endothelial dysfunction
    • Kaur, T.; Goel, R.K.; Balakumar, P. Effect of rosiglitazone in sodium arsenite-induced experimental vascular endothelial dysfunction. Arch. Pharm. Res., 2010, 33, 611-618.
    • (2010) Arch. Pharm. Res , vol.33 , pp. 611-618
    • Kaur, T.1    Goel, R.K.2    Balakumar, P.3
  • 26
    • 70349387354 scopus 로고    scopus 로고
    • Functional implications of genetic variation in human PPARgamma
    • Jeninga, E.H.; Gurnell, M.; Kalkhoven, E. Functional implications of genetic variation in human PPARgamma. Trends Endocrinol. Metab., 2009, 20, 380-387.
    • (2009) Trends Endocrinol. Metab , vol.20 , pp. 380-387
    • Jeninga, E.H.1    Gurnell, M.2    Kalkhoven, E.3
  • 28
    • 77954398507 scopus 로고    scopus 로고
    • Association of the PPARgamma2 gene pro12ala variant with primary hypertension and metabolic lipid disorders in han chinese of inner mongolia
    • Gao, L.; Wang, L.; Yun, H.; Su, L.; Su, X. Association of the PPARgamma2 gene pro12ala variant with primary hypertension and metabolic lipid disorders in han chinese of inner mongolia. Genet. Mol. Res., 2010, 9, 1312-1320.
    • (2010) Genet. Mol. Res , vol.9 , pp. 1312-1320
    • Gao, L.1    Wang, L.2    Yun, H.3    Su, L.4    Su, X.5
  • 30
    • 17044430286 scopus 로고    scopus 로고
    • PPARgamma in endothelial cells influences high fat diet-induced hypertension
    • Nicol, C.J.; Adachi, M.; Akiyama, T.E.; Gonzalez, F.J. PPARgamma in endothelial cells influences high fat diet-induced hypertension. Am. J. Hypertens., 2005, 18, 549-556.
    • (2005) Am. J. Hypertens , vol.18 , pp. 549-556
    • Nicol, C.J.1    Adachi, M.2    Akiyama, T.E.3    Gonzalez, F.J.4
  • 31
    • 62749196172 scopus 로고    scopus 로고
    • Distinct functions of vascular endothelial and smooth muscle ppargamma in regulation of blood pressure and vascular tone
    • Wang, N.; Symons, J.D.; Zhang, H.; Jia, Z.; Gonzalez, F.J.; Yang, T. Distinct functions of vascular endothelial and smooth muscle ppargamma in regulation of blood pressure and vascular tone. Toxicol. Pathol., 2009, 37, 21-27.
    • (2009) Toxicol. Pathol , vol.37 , pp. 21-27
    • Wang, N.1    Symons, J.D.2    Zhang, H.3    Jia, Z.4    Gonzalez, F.J.5    Yang, T.6
  • 34
    • 53249111805 scopus 로고    scopus 로고
    • Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet
    • Beyer, A.M.; de Lange, W.J.; Halabi, C.M.; Modrick, M.L.; Keen, H.L.; Faraci, F.M.; Sigmund, C.D. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ. Res., 2008, 103, 654-661.
    • (2008) Circ. Res , vol.103 , pp. 654-661
    • Beyer, A.M.1    de Lange, W.J.2    Halabi, C.M.3    Modrick, M.L.4    Keen, H.L.5    Faraci, F.M.6    Sigmund, C.D.7
  • 37
    • 77954570367 scopus 로고    scopus 로고
    • Theoretical study on the molecular and electronic properties of some substances used for diabetes mellitus treatment
    • Maltarollo, V.G.; Homem-de-Mello, P.; Honorio, K.M. Theoretical study on the molecular and electronic properties of some substances used for diabetes mellitus treatment. J. Mol. Model., 2010, 16, 799-804.
    • (2010) J. Mol. Model , vol.16 , pp. 799-804
    • Maltarollo, V.G.1    Homem-de-Mello, P.2    Honorio, K.M.3
  • 41
    • 2342537099 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase gamma: Kinase-dependent and-independent activities in cardiovascular function and disease
    • Alloatti, G.; Montrucchio, G.; Lembo, G.; Hirsch, E. Phosphoinositide 3-kinase gamma: Kinase-dependent and-independent activities in cardiovascular function and disease. Biochem. Soc. Trans., 2004, 32, 383-386.
    • (2004) Biochem. Soc. Trans , vol.32 , pp. 383-386
    • Alloatti, G.1    Montrucchio, G.2    Lembo, G.3    Hirsch, E.4
  • 43
    • 0028043535 scopus 로고
    • Signal transduction and regulation in smooth muscle
    • Somlyo, A.P.; Somlyo, A.V. Signal transduction and regulation in smooth muscle. Nature, 1994, 372, 231-236.
    • (1994) Nature , vol.372 , pp. 231-236
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 44
    • 0022888328 scopus 로고
    • Calcium antagonism and calcium entry blockade
    • Godfraind, T.; Miller, R.; Wibo, M. Calcium antagonism and calcium entry blockade. Pharmacol. Rev., 1986, 38, 321-416.
    • (1986) Pharmacol. Rev , vol.38 , pp. 321-416
    • Godfraind, T.1    Miller, R.2    Wibo, M.3
  • 46
    • 65949114415 scopus 로고    scopus 로고
    • Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons
    • Pancani, T.; Phelps, J.T.; Searcy, J.L.; Kilgore, M.W.; Chen, K.C.; Porter, N.M.; Thibault, O. Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. J. Neurochem., 2009, 109, 1800-1811.
    • (2009) J. Neurochem , vol.109 , pp. 1800-1811
    • Pancani, T.1    Phelps, J.T.2    Searcy, J.L.3    Kilgore, M.W.4    Chen, K.C.5    Porter, N.M.6    Thibault, O.7
  • 48
    • 0035967936 scopus 로고    scopus 로고
    • Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle
    • Eto, K.; Ohya, Y.; Nakamura, Y.; Abe, I.; Fujishima, M. Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle. Eur. J. Pharmacol., 2001, 423, 1-7.
    • (2001) Eur. J. Pharmacol , vol.423 , pp. 1-7
    • Eto, K.1    Ohya, Y.2    Nakamura, Y.3    Abe, I.4    Fujishima, M.5
  • 49
    • 10844281766 scopus 로고    scopus 로고
    • Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries
    • Heppner, T.J.; Bonev, A.D.; Eckman, D.M.; Gomez, M.F.; Petkov, G.V.; Nelson, M.T. Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology, 2005, 73, 15-22.
    • (2005) Pharmacology , vol.73 , pp. 15-22
    • Heppner, T.J.1    Bonev, A.D.2    Eckman, D.M.3    Gomez, M.F.4    Petkov, G.V.5    Nelson, M.T.6
  • 50
    • 45749103308 scopus 로고    scopus 로고
    • Physiological roles of K+ channels in vascular smooth muscle cells
    • Ko, E.A.; Han, J.; Jung, I.D.; Park, W.S. Physiological roles of K+ channels in vascular smooth muscle cells. J. Smooth Muscle Res., 2008, 44, 65-81.
    • (2008) J. Smooth Muscle Res , vol.44 , pp. 65-81
    • Ko, E.A.1    Han, J.2    Jung, I.D.3    Park, W.S.4
  • 53
    • 0033783407 scopus 로고    scopus 로고
    • Regulation of CA(2+)-activated K+ currents by ciglitazone in rat pituitary GH3 cells
    • Wu, S.N.; Ho, L.L.; Li, H.F.; Chiang, H.T. Regulation of CA(2+)-activated K+ currents by ciglitazone in rat pituitary GH3 cells. J. Investig. Med., 2000, 48, 259-269.
    • (2000) J. Investig. Med , vol.48 , pp. 259-269
    • Wu, S.N.1    Ho, L.L.2    Li, H.F.3    Chiang, H.T.4
  • 54
    • 4243173683 scopus 로고    scopus 로고
    • Fenofibrate, troglitazone, and 15-deoxydelta12,14-prostaglandin J2 close KATP channels and induce insulin secretion
    • Shimomura, K.; Shimizu, H.; Ikeda, M.; Okada, S.; Kakei, M.; Matsumoto, S.; Mori, M. Fenofibrate, troglitazone, and 15-deoxydelta12,14-prostaglandin J2 close KATP channels and induce insulin secretion. J. Pharmacol. Exp. Ther., 2004, 310, 1273-1280.
    • (2004) J. Pharmacol. Exp. Ther , vol.310 , pp. 1273-1280
    • Shimomura, K.1    Shimizu, H.2    Ikeda, M.3    Okada, S.4    Kakei, M.5    Matsumoto, S.6    Mori, M.7
  • 55
    • 33846414323 scopus 로고    scopus 로고
    • Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: A combined virtual screening and biological assay approach
    • Scarsi, M.; Podvinec, M.; Roth, A.; Hug, H.; Kersten, S.; Albrecht, H.; Schwede, T.; Meyer, U.A.; Rucker, C. Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: A combined virtual screening and biological assay approach. Mol. Pharmacol., 2007, 71, 398-406.
    • (2007) Mol. Pharmacol , vol.71 , pp. 398-406
    • Scarsi, M.1    Podvinec, M.2    Roth, A.3    Hug, H.4    Kersten, S.5    Albrecht, H.6    Schwede, T.7    Meyer, U.A.8    Rucker, C.9
  • 56
    • 33744958561 scopus 로고    scopus 로고
    • Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferator-activated receptor gammaactivated maxi-K channel opening in human umbilical vein endothelial cells
    • Kim, K.Y.; Cheon, H.G. Antiangiogenic effect of rosiglitazone is mediated via peroxisome proliferator-activated receptor gammaactivated maxi-K channel opening in human umbilical vein endothelial cells. J. Biol. Chem., 2006, 281, 13503-13512.
    • (2006) J. Biol. Chem , vol.281 , pp. 13503-13512
    • Kim, K.Y.1    Cheon, H.G.2
  • 57
    • 33745243327 scopus 로고    scopus 로고
    • Synthetic peroxisome proliferatoractivated receptor-gamma agonists restore impaired vasorelaxation via ATP-sensitive K+ channels by high glucose
    • Kinoshita, H.; Azma, T.; Iranami, H.; Nakahata, K.; Kimoto, Y.; Dojo, M.; Yuge, O.; Hatano, Y. Synthetic peroxisome proliferatoractivated receptor-gamma agonists restore impaired vasorelaxation via ATP-sensitive K+ channels by high glucose. J. Pharmacol. Exp. Ther., 2006, 318, 312-318.
    • (2006) J. Pharmacol. Exp. Ther , vol.318 , pp. 312-318
    • Kinoshita, H.1    Azma, T.2    Iranami, H.3    Nakahata, K.4    Kimoto, Y.5    Dojo, M.6    Yuge, O.7    Hatano, Y.8
  • 58
    • 56649120697 scopus 로고    scopus 로고
    • Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel
    • Nomura, H.; Yamawaki, H.; Mukohda, M.; Okada, M.; Hara, Y. Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel. J. Pharmacol. Sci., 2008, 108, 258-265.
    • (2008) J. Pharmacol. Sci , vol.108 , pp. 258-265
    • Nomura, H.1    Yamawaki, H.2    Mukohda, M.3    Okada, M.4    Hara, Y.5
  • 59
    • 0141751697 scopus 로고    scopus 로고
    • Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by g proteins, kinases, and myosin phosphatase
    • Somlyo, A.P.; Somlyo, A.V. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: Modulated by g proteins, kinases, and myosin phosphatase. Physiol. Rev., 2003, 83, 1325-1358.
    • (2003) Physiol. Rev , vol.83 , pp. 1325-1358
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 60
    • 29644432101 scopus 로고    scopus 로고
    • Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle
    • Wilson, D.P.; Sutherland, C.; Borman, M.A.; Deng, J.T.; Macdonald, J.A.; Walsh, M.P. Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. Biochem. J., 2005, 392, 641-648.
    • (2005) Biochem. J , vol.392 , pp. 641-648
    • Wilson, D.P.1    Sutherland, C.2    Borman, M.A.3    Deng, J.T.4    Macdonald, J.A.5    Walsh, M.P.6
  • 61
    • 0028354842 scopus 로고
    • Smooth muscle: Excitationcontraction coupling, contractile regulation, and the cross-bridge cycle
    • Somlyo, A.P.; Somlyo, A.V. Smooth muscle: Excitationcontraction coupling, contractile regulation, and the cross-bridge cycle. Alcohol Clin. Exp. Res., 1994, 18, 138-143.
    • (1994) Alcohol Clin. Exp. Res , vol.18 , pp. 138-143
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 62
    • 38849184196 scopus 로고    scopus 로고
    • The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction
    • Schubert, R.; Lidington, D.; Bolz, S.S. The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc. Res., 2008, 77, 8-18.
    • (2008) Cardiovasc. Res , vol.77 , pp. 8-18
    • Schubert, R.1    Lidington, D.2    Bolz, S.S.3
  • 63
    • 13144266902 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2
    • Wakino, S.; Hayashi, K.; Kanda, T.; Tatematsu, S.; Homma, K.; Yoshioka, K.; Takamatsu, I.; Saruta, T. Peroxisome proliferatoractivated receptor gamma ligands inhibit Rho/Rho kinase pathway by inducing protein tyrosine phosphatase SHP-2. Circ. Res., 2004, 95, e45-55.
    • (2004) Circ. Res , vol.95
    • Wakino, S.1    Hayashi, K.2    Kanda, T.3    Tatematsu, S.4    Homma, K.5    Yoshioka, K.6    Takamatsu, I.7    Saruta, T.8
  • 64
    • 66149140549 scopus 로고    scopus 로고
    • A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT
    • Atkins, K.B.; Irey, B.; Xiang, N.; Brosius, F.C. 3rd. A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT. Am. J. Physiol. Cell Physiol., 2009, 296, C1151-1161.
    • (2009) Am. J. Physiol. Cell Physiol , vol.296
    • Atkins, K.B.1    Irey, B.2    Xiang, N.3    Brosius III, F.C.4
  • 65
    • 84861138368 scopus 로고    scopus 로고
    • Pleiotropic effects of glitazones: A double edge sword? Front
    • Salomone, S. Pleiotropic effects of glitazones: A double edge sword? Front. Pharmacol., 2011, 2, 14
    • (2011) Pharmacol , vol.2 , pp. 14
    • Salomone, S.1
  • 66
    • 1442288375 scopus 로고    scopus 로고
    • PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice
    • Ryan, M.J.; Didion, S.P.; Mathur, S.; Faraci, F.M.; Sigmund, C.D. PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension, 2004, 43, 661-666.
    • (2004) Hypertension , vol.43 , pp. 661-666
    • Ryan, M.J.1    Didion, S.P.2    Mathur, S.3    Faraci, F.M.4    Sigmund, C.D.5
  • 67
    • 67651146363 scopus 로고    scopus 로고
    • Inflammatory cytokines in vascular dysfunction and vascular disease
    • Sprague, A.H.; Khalil, R.A. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem. Pharmacol., 2009, 78, 539-552.
    • (2009) Biochem. Pharmacol , vol.78 , pp. 539-552
    • Sprague, A.H.1    Khalil, R.A.2
  • 68
    • 0032560545 scopus 로고    scopus 로고
    • Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
    • Ricote, M.; Huang, J.; Fajas, L.; Li A.; Welch, J.; Najib, J.; Witztum, J.L.; Auwerx, J.; Palinski, W.; Glass, C.K. Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA, 1998, 95, 7614-7619.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7614-7619
    • Ricote, M.1    Huang, J.2    Fajas, L.3    Li, A.4    Welch, J.5    Najib, J.6    Witztum, J.L.7    Auwerx, J.8    Palinski, W.9    Glass, C.K.10
  • 69
    • 0001297403 scopus 로고    scopus 로고
    • Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT
    • Yang, X.Y.; Wang, L.H.; Chen, T.; Hodge, D.R.; Resau, J.H.; DaSilva, L.; Farrar, W.L. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT. J. Biol. Chem., 2000, 275, 4541-4544.
    • (2000) J. Biol. Chem , vol.275 , pp. 4541-4544
    • Yang, X.Y.1    Wang, L.H.2    Chen, T.3    Hodge, D.R.4    Resau, J.H.5    DaSilva, L.6    Farrar, W.L.7
  • 70
    • 0037072826 scopus 로고    scopus 로고
    • Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses proinflammatory adhesion molecules in human vascular endothelial cells
    • Wang, N.; Verna, L.; Chen, N.G.; Chen, J.; Li, H.; Forman, B.M.; Stemerman, M.B. Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses proinflammatory adhesion molecules in human vascular endothelial cells. J. Biol. Chem., 2002, 277, 34176-34181.
    • (2002) J. Biol. Chem , vol.277 , pp. 34176-34181
    • Wang, N.1    Verna, L.2    Chen, N.G.3    Chen, J.4    Li, H.5    Forman, B.M.6    Stemerman, M.B.7
  • 71
    • 0034660182 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activators inhibit IFNgamma-induced expression of the T cell-active CXC chemokines IP-10, MIG, and I-TAC in human endothelial cells
    • Marx, N.; Mach, F.; Sauty, A.; Leung, J.H.; Sarafi, M.N.; Ransohoff, R.M.; Libby, P.; Plutzky, J.; Luster, A.D. Peroxisome proliferator-activated receptor-gamma activators inhibit IFNgamma-induced expression of the T cell-active CXC chemokines IP-10, MIG, and I-TAC in human endothelial cells. J. Immunol., 2000, 164, 6503-6508.
    • (2000) J. Immunol , vol.164 , pp. 6503-6508
    • Marx, N.1    Mach, F.2    Sauty, A.3    Leung, J.H.4    Sarafi, M.N.5    Ransohoff, R.M.6    Libby, P.7    Plutzky, J.8    Luster, A.D.9
  • 72
    • 2942670612 scopus 로고    scopus 로고
    • PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase c signaling pathway: Role of diacylglycerol kinase
    • Verrier, E.; Wang, L.; Wadham, C.; Albanese, N.; Hahn, C.; Gamble, J.R.; Chatterjee, V.K.; Vadas, M.A.; Xia, P. PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase c signaling pathway: Role of diacylglycerol kinase. Circ. Res., 2004, 94, 1515-1522.
    • (2004) Circ. Res , vol.94 , pp. 1515-1522
    • Verrier, E.1    Wang, L.2    Wadham, C.3    Albanese, N.4    Hahn, C.5    Gamble, J.R.6    Chatterjee, V.K.7    Vadas, M.A.8    Xia, P.9
  • 73
    • 68149178582 scopus 로고    scopus 로고
    • PPARgamma agonist, rosiglitazone, regulates angiotensin ii-induced vascular inflammation through the TLR4-dependent signaling pathway
    • Ji, Y.; Liu, J.; Wang, Z.; Liu, N.; Gou, W. PPARgamma agonist, rosiglitazone, regulates angiotensin ii-induced vascular inflammation through the TLR4-dependent signaling pathway. Lab. Invest., 2009, 89, 887-902.
    • (2009) Lab. Invest , vol.89 , pp. 887-902
    • Ji, Y.1    Liu, J.2    Wang, Z.3    Liu, N.4    Gou, W.5
  • 75
    • 0037076294 scopus 로고    scopus 로고
    • Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferatoractivated receptor-gamma
    • Diep, Q.N.; El Mabrouk, M.; Cohn, J.S.; Endemann, D.; Amiri, F.; Virdis, A.; Neves, M.F.; Schiffrin, E.L. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferatoractivated receptor-gamma. Circulation, 2002, 105, 2296-2302.
    • (2002) Circulation , vol.105 , pp. 2296-2302
    • Diep, Q.N.1    El Mabrouk, M.2    Cohn, J.S.3    Endemann, D.4    Amiri, F.5    Virdis, A.6    Neves, M.F.7    Schiffrin, E.L.8
  • 77
    • 0034711678 scopus 로고    scopus 로고
    • Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators
    • Pasceri, V.; Wu, H.D.; Willerson, J.T.; Yeh, E.T. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators. Circulation, 2000, 101, 235-238.
    • (2000) Circulation , vol.101 , pp. 235-238
    • Pasceri, V.1    Wu, H.D.2    Willerson, J.T.3    Yeh, E.T.4
  • 78
    • 0032847680 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyteendothelial cell interaction
    • Jackson, S.M.; Parhami, F.; Xi, X.P.; Berliner, J.A.; Hsueh, W.A.; Law, R.E.; Demer, L.L. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyteendothelial cell interaction. Arterioscler. Thromb. Vasc. Biol., 1999, 19, 2094-2104.
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , pp. 2094-2104
    • Jackson, S.M.1    Parhami, F.2    Xi, X.P.3    Berliner, J.A.4    Hsueh, W.A.5    Law, R.E.6    Demer, L.L.7
  • 79
    • 0033546190 scopus 로고    scopus 로고
    • Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta12, 14-prostaglandin J2
    • Bishop-Bailey, D.; Hla, T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta12, 14-prostaglandin J2. J. Biol. Chem., 1999, 274, 17042-17048.
    • (1999) J. Biol. Chem , vol.274 , pp. 17042-17048
    • Bishop-Bailey, D.1    Hla, T.2
  • 80
    • 0042009938 scopus 로고    scopus 로고
    • Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor gamma 1 (PPARgamma 1) and PPARalpha genes
    • Inoue, I.; Hayashi, K.; Yagasaki, F.; Nakamura, K.; Matsunaga, T.; Xu, H.; Inukai, K.; Awata, T.; Komoda, T.; Katayama, S. Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor gamma 1 (PPARgamma 1) and PPARalpha genes. J. Atheroscler. Thromb., 2003, 10, 99-108.
    • (2003) J. Atheroscler. Thromb , vol.10 , pp. 99-108
    • Inoue, I.1    Hayashi, K.2    Yagasaki, F.3    Nakamura, K.4    Matsunaga, T.5    Xu, H.6    Inukai, K.7    Awata, T.8    Komoda, T.9    Katayama, S.10
  • 81
    • 0038028546 scopus 로고    scopus 로고
    • Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta
    • Hannan, K.M.; Dilley, R.J.; de Dios, S.T.; Little, P.J. Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 762-768.
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 762-768
    • Hannan, K.M.1    Dilley, R.J.2    de Dios, S.T.3    Little, P.J.4
  • 82
    • 0033605677 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo
    • Xin, X., Yang, S., Kowalski, J., Gerritsen, M.E. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J. Biol. Chem., 1999, 274, 9116-9121.
    • (1999) J. Biol. Chem , vol.274 , pp. 9116-9121
    • Xin, X.1    Yang, S.2    Kowalski, J.3    Gerritsen, M.E.4
  • 86
    • 45149096016 scopus 로고    scopus 로고
    • Rosiglitazone and delayed onset of proliferative diabetic retinopathy
    • Shen, L.Q.; Child, A.; Weber, G.M.; Folkman, J.; Aiello, L.P. Rosiglitazone and delayed onset of proliferative diabetic retinopathy. Arch. Ophthalmol., 2008, 126, 793-799.
    • (2008) Arch. Ophthalmol , vol.126 , pp. 793-799
    • Shen, L.Q.1    Child, A.2    Weber, G.M.3    Folkman, J.4    Aiello, L.P.5
  • 87
    • 77957241136 scopus 로고    scopus 로고
    • Anticancer role of ppargamma agonists in hematological malignancies found in the vasculature, marrow, and eyes
    • Simpson-Haidaris, P.J.; Pollock, S.J.; Ramon, S.; Guo, N.; Woeller, C.F.; Feldon, S.E.; Phipps, R.P. Anticancer role of ppargamma agonists in hematological malignancies found in the vasculature, marrow, and eyes. PPAR Res., 2010, 2010, 814609.
    • (2010) PPAR Res , vol.2010 , pp. 814609
    • Simpson-Haidaris, P.J.1    Pollock, S.J.2    Ramon, S.3    Guo, N.4    Woeller, C.F.5    Feldon, S.E.6    Phipps, R.P.7
  • 88
    • 79953774672 scopus 로고    scopus 로고
    • Molecular cross-regulation between PPARgamma and other signaling pathways: Implications for lung cancer therapy
    • Reka, A.K.; Goswami, M.T.; Krishnapuram, R.; Standiford, T.J.; Keshamouni, V.G. Molecular cross-regulation between PPARgamma and other signaling pathways: Implications for lung cancer therapy. Lung Cancer, 2011, 72, 154-159.
    • (2011) Lung Cancer , vol.72 , pp. 154-159
    • Reka, A.K.1    Goswami, M.T.2    Krishnapuram, R.3    Standiford, T.J.4    Keshamouni, V.G.5
  • 90
    • 0033520304 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
    • Delerive, P.; Martin-Nizard, F.; Chinetti, G.; Trottein, F.; Fruchart, J.C.; Najib, J.; Duriez, P.; Staels, B. Peroxisome proliferatoractivated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ. Res., 1999, 85, 394-402.
    • (1999) Circ. Res , vol.85 , pp. 394-402
    • Delerive, P.1    Martin-Nizard, F.2    Chinetti, G.3    Trottein, F.4    Fruchart, J.C.5    Najib, J.6    Duriez, P.7    Staels, B.8
  • 91
    • 0037231474 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells
    • Calnek, D.S.; Mazzella, L.; Roser, S.; Roman, J.; Hart, C.M. Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 52-57.
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 52-57
    • Calnek, D.S.1    Mazzella, L.2    Roser, S.3    Roman, J.4    Hart, C.M.5
  • 92
    • 24144448954 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms
    • Polikandriotis, J.A.; Mazzella, L.J.; Rupnow, H.L.; Hart, C.M. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. Arterioscler. Thromb. Vasc. Biol., 2005, 25, 1810-1816.
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , pp. 1810-1816
    • Polikandriotis, J.A.1    Mazzella, L.J.2    Rupnow, H.L.3    Hart, C.M.4
  • 94
    • 0037231532 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator-activated receptoralpha and-gamma activators on vascular remodeling in endothelindependent hypertension
    • Iglarz, M.; Touyz, R.M.; Amiri, F.; Lavoie, M.F.; Diep, Q.N.; Schiffrin, E.L. Effect of peroxisome proliferator-activated receptoralpha and-gamma activators on vascular remodeling in endothelindependent hypertension. Arterioscler. Thromb. Vasc. Biol., 2003, 23, 45-51.
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 45-51
    • Iglarz, M.1    Touyz, R.M.2    Amiri, F.3    Lavoie, M.F.4    Diep, Q.N.5    Schiffrin, E.L.6
  • 96
    • 0037047666 scopus 로고    scopus 로고
    • Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptorgamma ligand therapy
    • Bishop-Bailey, D.; Hla, T.; Warner, T.D. Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptorgamma ligand therapy. Circ. Res., 2002, 91, 210-217.
    • (2002) Circ. Res , vol.91 , pp. 210-217
    • Bishop-Bailey, D.1    Hla, T.2    Warner, T.D.3
  • 97
    • 0034698074 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and g1--> s transition in vascular smooth muscle cells
    • Wakino, S., Kintscher, U., Kim, S., Yin, F., Hsueh, W.A., Law, R.E. Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and g1--> s transition in vascular smooth muscle cells. J. Biol. Chem., 2000, 275, 22435-22441.
    • (2000) J. Biol. Chem , vol.275 , pp. 22435-22441
    • Wakino, S.1    Kintscher, U.2    Kim, S.3    Yin, F.4    Hsueh, W.A.5    Law, R.E.6
  • 98
    • 0346668393 scopus 로고    scopus 로고
    • A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth
    • Bruemmer, D.; Berger, J.P.; Liu, J.; Kintscher, U.; Wakino, S.; Fleck, E.; Moller, D.E.; Law R.E. A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth. Eur. J. Pharmacol., 2003, 466, 225-234.
    • (2003) Eur. J. Pharmacol , vol.466 , pp. 225-234
    • Bruemmer, D.1    Berger, J.P.2    Liu, J.3    Kintscher, U.4    Wakino, S.5    Fleck, E.6    Moller, D.E.7    Law, R.E.8
  • 99
    • 0037674923 scopus 로고    scopus 로고
    • Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptorgamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation
    • de Dios, S.T.; Bruemmer, D.; Dilley, R.J.; Ivey, M.E.; Jennings, G.L.; Law, R.E.; Little, P.J. Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptorgamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation. Circulation, 2003, 107, 2548-2550.
    • (2003) Circulation , vol.107 , pp. 2548-2550
    • de Dios, S.T.1    Bruemmer, D.2    Dilley, R.J.3    Ivey, M.E.4    Jennings, G.L.5    Law, R.E.6    Little, P.J.7
  • 100
    • 0141886991 scopus 로고    scopus 로고
    • Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells
    • Bruemmer, D.; Yin, F.; Liu, J.; Berger, J.P.; Sakai, T.; Blaschke, F.; Fleck, E.; Van Herle, A.J.; Forman, B.M.; Law, R.E. Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells. Circ. Res., 2003, 93, e38-47.
    • (2003) Circ. Res , vol.93
    • Bruemmer, D.1    Yin, F.2    Liu, J.3    Berger, J.P.4    Sakai, T.5    Blaschke, F.6    Fleck, E.7    van Herle, A.J.8    Forman, B.M.9    Law, R.E.10
  • 101
    • 0034633847 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells
    • Takeda, K.; Ichiki, T.; Tokunou, T.; Funakoshi, Y.; Iino, N.; Hirano, K.; Kanaide, H.; Takeshita, A. Peroxisome proliferatoractivated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. Circulation, 2000, 102, 1834-1839.
    • (2000) Circulation , vol.102 , pp. 1834-1839
    • Takeda, K.1    Ichiki, T.2    Tokunou, T.3    Funakoshi, Y.4    Iino, N.5    Hirano, K.6    Kanaide, H.7    Takeshita, A.8
  • 102
    • 36049036174 scopus 로고    scopus 로고
    • An oxidized lipid-peroxisome proliferatoractivated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion
    • Barlic, J.; Murphy, P.M. An oxidized lipid-peroxisome proliferatoractivated receptor gamma-chemokine pathway in the regulation of macrophage-vascular smooth muscle cell adhesion. Trends Cardiovasc. Med., 2007, 17, 269-274.
    • (2007) Trends Cardiovasc. Med , vol.17 , pp. 269-274
    • Barlic, J.1    Murphy, P.M.2
  • 104
    • 33845633231 scopus 로고    scopus 로고
    • Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase c activation: Novel mechanism for PPARgamma agonist's effects on edema and weight gain
    • Sotiropoulos, K.B.; Clermont, A.; Yasuda, Y.; Rask-Madsen, C.; Mastumoto, M.; Takahashi, J.; Della Vecchia, K.; Kondo, T.; Aiello, L.P.; King, G.L. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase c activation: Novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J., 2006, 20, 1203-1205.
    • (2006) FASEB J , vol.20 , pp. 1203-1205
    • Sotiropoulos, K.B.1    Clermont, A.2    Yasuda, Y.3    Rask-Madsen, C.4    Mastumoto, M.5    Takahashi, J.6    Della Vecchia, K.7    Kondo, T.8    Aiello, L.P.9    King, G.L.10


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