Phosphoinositide 3-kinase γ: Kinase-dependent and -independent activities in cardiovascular function and disease

Biochemical Society Transactions

Volumn 32, Issue 2, 2004, Pages 383-386

  Alloatti, G ^a   Montrucchio, G ^a   Lembo, G ^b   Hirsch, E ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b IRCCS NEUROMED   (Italy)

Author keywords

adrenergic receptor; Contractility; G protein coupled receptor (GPCR); Heart disease; Hypertrophy; Phosphoinositide 3 kinase (PI3K )

Indexed keywords

CALCIUM CHANNEL L TYPE; ENZYME; G PROTEIN COUPLED RECEPTOR KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE 3 KINASE GAMMA; PROTEIN KINASE B; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

BLOOD PRESSURE MONITORING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CONFERENCE PAPER; DELETION MUTANT; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HEART RATE AND RHYTHM; NONHUMAN; PHENOTYPE; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; THROMBOCYTE RELEASE REACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARDIOVASCULAR SYSTEM; CYCLIC AMP; DISEASE MODELS, ANIMAL; HEART DISEASES; HUMANS; ISOENZYMES; MICE; MICE, TRANSGENIC; MYOCARDIAL ISCHEMIA; NITRIC OXIDE; PHENOTYPE; PLATELET ACTIVATING FACTOR; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 2342537099     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0320383     Document Type: Conference Paper

References (22)

1. Go, Y.M., Park, H., Maland, M.C., Darley-Usmar, V.M., Stoyanov, B., Wetzker, R. and Jo, H. (1998) Am. J. Physiol. 275, H1898-H1904
2. Viard, P., Exner, T., Maier, U., Mironneau, J., Nurnberg, B. and Macrez, N. (1999) FASEB J. 13, 685-694
3. Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtchenkov, M., Malek, D., Stoyanova, S., Vanhaesebroeck, B., Dhand, R., Nurnberg, B. et al. (1995) Science 269, 690-693
4. Stephens, L.R., Eguinoa, A., Erdjument-Bromage, H., Lui, M., Cooke, F., Coadwell, J., Smrcka, A.S., Thelen, M., Cadwallader, K., Tempst, P. and Hawkins, P.T. (1997) Cell 89, 105-114
5. Hirsch, E., Katanaev, V.L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F. and Wymann, M.P. (2000) Science 287, 1049-1053
6. Sasaki, T., Irie-Sasaki, J., Jones, R.G., Oliveira-dos-Santos, A.J., Stanford, W.L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I. et al. (2000) Science 287, 1040-1046
7. Bony, C., Roche, S., Shuichi, U., Sasaki, T., Crackower, M.A., Penninger J., Mano, H. and Puceat, M. (2001) J. Cell Biol. 152, 717-728
8. Crackower, M.A., Oudit, G.Y., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J. et al. (2002) Cell 110, 737-749
9. Shioi, T., Kang, P.M., Douglas, P.S., Hampe, J., Yballe, C.M., Lawitts, J., Cantley, L.C. and Izumo, S. (2000) EMBO J. 19, 2537-2548
10. Rockman, H.A., Koch, W.J. and Lefkowitz, R.J. (2002) Nature (London) 415, 206-212
11. Prasad, S.V., Perrino, C. and Rockman, H.A. (2003) Trends Cardiovasc. Med. 13, 206-212
12. Naga Prasad, S.V., Laporte, S.A., Chamberlain, D., Caron, M.G., Barak, L. and Rockman, H.A. (2002) J. Cell Biol. 158, 563-575
13. Naga Prasad, S.V., Esposito, G., Mao, L., Koch, W.J. and Rockman, H.A. (2000) J. Biol. Chem. 275, 4693-4698
14. Oudit, G.Y., Crackower, M.A., Eriksson, U., Sarao, R., Kozieradzki, I., Sasaki, T., Irie-Sasaki, J., Gidrewicz, D., Rybin, V.O., Wada, T. et al. (2003) Circulation 108, 2147-2152
15. Xiao, R.P., Cheng, H., Zhou, Y.Y., Kuschel, M. and Lakatta, E.G. (1999) Circ. Res. 85, 1092-1100
16. Jo, S.H., Leblais, V., Wang, P.H., Crow, M.T. and Xiao, R.P. (2002) Circ. Res. 91, 46-53
17. Hunter, J.J. and Chien, K.R. (1999) N. Engl. J. Med. 341, 1276-1283
18. Prasad, S.V., Nienaber J. and Rockman, H.A. (2002) Cold Spring Harbor Symp. Quant. Biol. 67, 439-444
19. Naga Prasad, S.V., Nienaber J. and Rockman, H.A. (2001) Trends Genet. 17, 544-549
20. Barki-Harrington, L. and Rockman, H.A. (2003) Nat. Med. 9, 19-20
21. Stangl, V., Baumann, G., Stangl, K. and Felix, S.B. (2002) Cardiovasc. Res. 53, 12-30
22. Alloatti, G., Levi, R., Malan, O., Del Sorbo, L., Bosco, O., Barberis, L., Marcantoni, A., Bedendi, I., Penna, C., Azzolino, O. et al. (2003) Cardiovasc. Res. 60, 242-249