TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5414-5422

  Jeon, Yoon ^a   Ko, Eun ^b   Lee, Kyung Yong ^b   Ko, Min Ji ^b   Park, Seo Young ^a   Kang, Jeeheon ^b   Jeon, Chang Hwan ^a   Lee, Ho ^a   Hwang, Deog Su ^b  

^a National Cancer Center   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CANCER CELL LINES; CANCER CELLS; CELL-CYCLE PROGRESSION; CELLULAR SENESCENCE; CRE RECOMBINASE; DNA BREAKS; DNA DAMAGE RESPONSE; EMBRYONIC LETHALITY; INDUCED APOPTOSIS; KNOCK OUTS; MOUSE CELLS; MOUSE EMBRYONIC FIBROBLASTS; PHYSIOLOGICAL FUNCTIONS; PRIMARY CELLS; REGULATORY FUNCTIONS; RNA INTERFERENCE;

CELL CULTURE; CELL DEATH; CELL PROLIFERATION; DISEASES; GENES; PHOSPHORYLATION; RNA;

NUCLEIC ACIDS;

BINDING PROTEIN; CHECKPOINT KINASE 2; CRE RECOMBINASE; DNA TOPOISOMERASE II BINDING PROTEIN 1; HISTONE H2AX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLASTOCYST; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; FEMALE; FIBROBLAST; GENE DISRUPTION; GENE FREQUENCY; HETEROZYGOSITY; HOMOZYGOSITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SENESCENCE; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; APOPTOSIS; BLASTOCYST; CARRIER PROTEINS; CELL AGING; CELL CYCLE; CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; DNA BREAKS; DNA-BINDING PROTEINS; EMBRYO LOSS; EMBRYONIC DEVELOPMENT; GENE KNOCKDOWN TECHNIQUES; HISTONES; HUMANS; MICE; MICE, TRANSGENIC; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

MUS; VERTEBRATA;

EID: 79953139076     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.189704     Document Type: Article

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