메뉴 건너뛰기




Volumn 7, Issue 5, 2012, Pages

1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DEFEROXAMINE; DIVALENT METAL TRANSPORTER 1 ISOFORM 1B; HISTONE H3; IRON; LYSINE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; CATION TRANSPORT PROTEIN; GLUCOSE; HISTONE; ISOPROTEIN; OXYGEN; SOLUTE CARRIER FAMILY 11 (PROTON COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

EID: 84861561342     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038019     Document Type: Article
Times cited : (42)

References (63)
  • 1
    • 66449106912 scopus 로고    scopus 로고
    • The impact of host iron homeostasis on disease
    • Connor JR, Ghio AJ, (2009) The impact of host iron homeostasis on disease. Biochim Biophys Acta 1790 (7): 581-2.
    • (2009) Biochim Biophys Acta , vol.1790 , Issue.7 , pp. 581-582
    • Connor, J.R.1    Ghio, A.J.2
  • 3
    • 1842608744 scopus 로고    scopus 로고
    • Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, deferoxamine and VK-28
    • Youdim MB, Stephenson G, Ben Shachar D, (2004) Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, deferoxamine and VK-28. Ann NY Acad Sci 1012: 306-325.
    • (2004) Ann NY Acad Sci , vol.1012 , pp. 306-325
    • Youdim, M.B.1    Stephenson, G.2    Ben Shachar, D.3
  • 5
    • 67349112729 scopus 로고    scopus 로고
    • Iron, the substantia nigra and related neurological disorders
    • Snyder AM, Connor JR, (2009) Iron, the substantia nigra and related neurological disorders. Biochim Biophys Acta 1790 (7): 606-14.
    • (2009) Biochim Biophys Acta , vol.1790 , Issue.7 , pp. 606-614
    • Snyder, A.M.1    Connor, J.R.2
  • 6
    • 1842504357 scopus 로고    scopus 로고
    • The methabolism of neuronal iron and its pathogenic role in neurological disease
    • Moos T, Morgan EH, (2004) The methabolism of neuronal iron and its pathogenic role in neurological disease. Ann NY Acad Sci 1012: 14-26.
    • (2004) Ann NY Acad Sci , vol.1012 , pp. 14-26
    • Moos, T.1    Morgan, E.H.2
  • 7
    • 0033373789 scopus 로고    scopus 로고
    • The pivotal role of Iron in NF-κB activation and nigrostriatal Dopaminergic Neurodegeneration
    • Youdim MB, Grünblatt E, Mandel S, (1999) The pivotal role of Iron in NF-κB activation and nigrostriatal Dopaminergic Neurodegeneration. Ann NY Acad Sci 890: 7-25.
    • (1999) Ann NY Acad Sci , vol.890 , pp. 7-25
    • Youdim, M.B.1    Grünblatt, E.2    Mandel, S.3
  • 8
    • 33749506725 scopus 로고    scopus 로고
    • Neuroprotective effects of iron chelator Deferoxamine on dopaminergic neurons in the substantia nigra of rats with iron-overload
    • Jiang H, Luan Z, Wang J, Xie J, (2006) Neuroprotective effects of iron chelator Deferoxamine on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochem Int 49 (6): 605-9.
    • (2006) Neurochem Int , vol.49 , Issue.6 , pp. 605-609
    • Jiang, H.1    Luan, Z.2    Wang, J.3    Xie, J.4
  • 9
    • 34249337528 scopus 로고    scopus 로고
    • Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents
    • Mandel S, Amit T, Bar-Am O, Youdim MB, (2007) Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. Prog Neurobiol 82: 348-360.
    • (2007) Prog Neurobiol , vol.82 , pp. 348-360
    • Mandel, S.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.4
  • 10
    • 67650474704 scopus 로고    scopus 로고
    • Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells
    • Zhang S, Wang J, Song N, Xie J, Jiang H, (2009) Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells. 9 Neurobiol Aging pp. 1466-76.
    • (2009) Neurobiol Aging , Issue.9 , pp. 1466-1476
    • Zhang, S.1    Wang, J.2    Song, N.3    Xie, J.4    Jiang, H.5
  • 11
    • 79960895695 scopus 로고    scopus 로고
    • Novel molecular targets of the multi-functional brain-permeable iron chelating drug M30 in mouse brain
    • Kupershmidt L, Weinreb O, Amit T, Mandel S, Bar-Am O, et al. (2011) Novel molecular targets of the multi-functional brain-permeable iron chelating drug M30 in mouse brain. Neuroscience 189: 345-58.
    • (2011) Neuroscience , vol.189 , pp. 345-358
    • Kupershmidt, L.1    Weinreb, O.2    Amit, T.3    Mandel, S.4    Bar-Am, O.5
  • 12
    • 0030891276 scopus 로고    scopus 로고
    • The potential role of iron chelators in the treatment of Parkinson's disease and related neurological disorders. Pharmacol Toxicol
    • Gassen M, Youdim MB, (1997) The potential role of iron chelators in the treatment of Parkinson's disease and related neurological disorders. Pharmacol Toxicol. 80 (4): 159-66.
    • (1997) , vol.80 , Issue.4 , pp. 159-166
    • Gassen, M.1    Youdim, M.B.2
  • 13
    • 79951621372 scopus 로고    scopus 로고
    • Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats
    • Yang L, Zhang B, Yin L, Cai B, Shan H, et al. (2011) Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats. Cell Physiol Biochem 27 (1): 23-30.
    • (2011) Cell Physiol Biochem , vol.27 , Issue.1 , pp. 23-30
    • Yang, L.1    Zhang, B.2    Yin, L.3    Cai, B.4    Shan, H.5
  • 14
    • 67650481882 scopus 로고    scopus 로고
    • Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways
    • Siddiq A, Aminova LR, Troy CM, Suh K, Messer Z, et al. (2009) Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways. J Neurosci 29 (27): 8828-38.
    • (2009) J Neurosci , vol.29 , Issue.27 , pp. 8828-8838
    • Siddiq, A.1    Aminova, L.R.2    Troy, C.M.3    Suh, K.4    Messer, Z.5
  • 15
    • 77449128889 scopus 로고    scopus 로고
    • Deferoxamine treatment for intracerebral hemorrhage in aged rats: therapeutic time window and optimal duration
    • Okauchi M, Hua Y, Keep RF, Morgenstern LB, Schallert T, et al. (2010) Deferoxamine treatment for intracerebral hemorrhage in aged rats: therapeutic time window and optimal duration. Stroke 41 (2): 375-82.
    • (2010) Stroke , vol.41 , Issue.2 , pp. 375-382
    • Okauchi, M.1    Hua, Y.2    Keep, R.F.3    Morgenstern, L.B.4    Schallert, T.5
  • 16
    • 0000819723 scopus 로고
    • Transferrin receptors in rat brain: Neuropeptide-like pattern and relationship to iron distribution
    • Hill JM, Ruff MR, Weber RJ, Pert CB, (1985) Transferrin receptors in rat brain: Neuropeptide-like pattern and relationship to iron distribution. Proc Natl Acad Sci USA 82: 4553-4557.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 4553-4557
    • Hill, J.M.1    Ruff, M.R.2    Weber, R.J.3    Pert, C.B.4
  • 17
    • 0030615199 scopus 로고    scopus 로고
    • The density of [125I]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease
    • Faucheux BA, Hauw JJ, Agid Y, Hirsch EC, (1997) The density of [125I]-transferrin binding sites on perikarya of melanized neurons of the substantia nigra is decreased in Parkinson's disease. Brain Res 749: 170-174.
    • (1997) Brain Res , vol.749 , pp. 170-174
    • Faucheux, B.A.1    Hauw, J.J.2    Agid, Y.3    Hirsch, E.C.4
  • 18
    • 71849117649 scopus 로고    scopus 로고
    • Iron transport in Parkinson's disease
    • Hirsch EC, (2009) Iron transport in Parkinson's disease. Parkinsonism Relat Disord (Suppl 3): S209-11.
    • (2009) Parkinsonism Relat Disord , Issue.SUPPL. 3
    • Hirsch, E.C.1
  • 19
    • 0030755366 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    • Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, et al. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (6641): 482-8.
    • (1997) Nature , vol.388 , Issue.6641 , pp. 482-488
    • Gunshin, H.1    Mackenzie, B.2    Berger, U.V.3    Gunshin, Y.4    Romero, M.F.5
  • 20
    • 33846197505 scopus 로고    scopus 로고
    • A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity
    • Hidalgo C, Carrasco MA, Muñoz P, Núñez MT, (2007) A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity. Antioxid Redox Signal 9 (2): 245-55.
    • (2007) Antioxid Redox Signal , vol.9 , Issue.2 , pp. 245-255
    • Hidalgo, C.1    Carrasco, M.A.2    Muñoz, P.3    Núñez, M.T.4
  • 21
    • 0032805575 scopus 로고    scopus 로고
    • Cellular distribution of iron in the brain of the Belgrade rat
    • Burdo JR, Martin J, Menzies SL, Dolan KG, Romano MA, et al. (1999) Cellular distribution of iron in the brain of the Belgrade rat. Neuroscience 93 (3): 1189-96.
    • (1999) Neuroscience , vol.93 , Issue.3 , pp. 1189-1196
    • Burdo, J.R.1    Martin, J.2    Menzies, S.L.3    Dolan, K.G.4    Romano, M.A.5
  • 22
    • 0037491244 scopus 로고    scopus 로고
    • Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury
    • Wang XS, Ong WY, Connor JR, (2003) Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury. Neuroscience 120 (1): 21-9.
    • (2003) Neuroscience , vol.120 , Issue.1 , pp. 21-29
    • Wang, X.S.1    Ong, W.Y.2    Connor, J.R.3
  • 23
    • 4644365735 scopus 로고    scopus 로고
    • Distribution of divalent metal transporter-1 in the monkey basal ganglia
    • Huang E, Ong WY, Connor JR, (2004) Distribution of divalent metal transporter-1 in the monkey basal ganglia. Neuroscience 128 (3): 487-96.
    • (2004) Neuroscience , vol.128 , Issue.3 , pp. 487-496
    • Huang, E.1    Ong, W.Y.2    Connor, J.R.3
  • 24
    • 0029278789 scopus 로고
    • Cloning and characterization of a second human NRAMP gene on chromosome 12q13
    • Vidal S, Belouchi AM, Cellier M, Beatty B, Gros P, (1995) Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mamm Genome 6 (4): 224-30.
    • (1995) Mamm Genome , vol.6 , Issue.4 , pp. 224-230
    • Vidal, S.1    Belouchi, A.M.2    Cellier, M.3    Beatty, B.4    Gros, P.5
  • 25
    • 0037126002 scopus 로고    scopus 로고
    • Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function
    • Hubert N, Hentze MW, (2002) Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci USA 99 (19): 12345-50.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.19 , pp. 12345-12350
    • Hubert, N.1    Hentze, M.W.2
  • 26
    • 0033506728 scopus 로고    scopus 로고
    • Regulation of genes of iron metabolism by the iron response proteins
    • Haile J, (1999) Regulation of genes of iron metabolism by the iron response proteins. American Journal of the Medical Sciences 318, 230-240.
    • (1999) American Journal of the Medical Sciences , vol.318 , pp. 230-240
    • Haile, J.1
  • 27
    • 1842608845 scopus 로고    scopus 로고
    • Iron metabolism and the IRE/IRP regulatory system: an update
    • Pantopoulos K, (2004) Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci 1012: 1-13.
    • (2004) Ann N Y Acad Sci , vol.1012 , pp. 1-13
    • Pantopoulos, K.1
  • 28
    • 0036906608 scopus 로고    scopus 로고
    • Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms
    • Tabuchi M, Tanaka N, Nishida-Kitayama J, Ohno H, Kishi F, (2002) Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms. Mol Biol Cell 13 (12): 4371-87.
    • (2002) Mol Biol Cell , vol.13 , Issue.12 , pp. 4371-4387
    • Tabuchi, M.1    Tanaka, N.2    Nishida-Kitayama, J.3    Ohno, H.4    Kishi, F.5
  • 29
    • 57449092273 scopus 로고    scopus 로고
    • Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
    • Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, et al. (2008) Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A 105 (47): 18578-83.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.47 , pp. 18578-18583
    • Salazar, J.1    Mena, N.2    Hunot, S.3    Prigent, A.4    Alvarez-Fischer, D.5
  • 30
    • 0035892632 scopus 로고    scopus 로고
    • Distribution of divalent metal transporter-1 and metal transport protein 1 in the normal and Belgrade rat
    • Burdo JR, Menzies SL, Simpson IA, Garrick LM, Garrick MD, et al. (2001) Distribution of divalent metal transporter-1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res 66: 1198-1207.
    • (2001) J Neurosci Res , vol.66 , pp. 1198-1207
    • Burdo, J.R.1    Menzies, S.L.2    Simpson, I.A.3    Garrick, L.M.4    Garrick, M.D.5
  • 31
    • 84887212418 scopus 로고    scopus 로고
    • L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression
    • Du F, Qian ZM, Zhu L, Wu XM, Yung WH, et al. (2009) L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression. PLoS One 4 (2): e4593.
    • (2009) PLoS One , vol.4 , Issue.2
    • Du, F.1    Qian, Z.M.2    Zhu, L.3    Wu, X.M.4    Yung, W.H.5
  • 32
    • 19344376879 scopus 로고    scopus 로고
    • Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells
    • Lis A, Paradkar PN, Singleton S, Kuo HC, Garrick MD, et al. (2005) Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells. Biochem Pharmacol 69 (11): 1647-55.
    • (2005) Biochem Pharmacol , vol.69 , Issue.11 , pp. 1647-1655
    • Lis, A.1    Paradkar, P.N.2    Singleton, S.3    Kuo, H.C.4    Garrick, M.D.5
  • 33
    • 42349092684 scopus 로고    scopus 로고
    • Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells
    • Li Z, Lai Z, Ya K, Fang D, Ho YW, et al. (2008) Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J Cell Mol Med 12 (2): 569-79.
    • (2008) J Cell Mol Med , vol.12 , Issue.2 , pp. 569-579
    • Li, Z.1    Lai, Z.2    Ya, K.3    Fang, D.4    Ho, Y.W.5
  • 34
    • 58749094789 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
    • Shah, YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ, (2009) Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metabolism 9: 152-164.
    • (2009) Cell Metabolism , vol.9 , pp. 152-164
    • Shah, Y.M.1    Matsubara, T.2    Ito, S.3    Yim, S.H.4    Gonzalez, F.J.5
  • 35
    • 77955872792 scopus 로고    scopus 로고
    • Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia-inducible factor-1
    • Wang D, Wang LH, Zhao Y, Lu YP, Zhu L, (2010) Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia-inducible factor-1. IUBMB Life 62 (8): 629-36.
    • (2010) IUBMB Life , vol.62 , Issue.8 , pp. 629-636
    • Wang, D.1    Wang, L.H.2    Zhao, Y.3    Lu, Y.P.4    Zhu, L.5
  • 36
    • 79952714265 scopus 로고    scopus 로고
    • Divalent metal transporter 1 is a hypoxia-inducible gene
    • Qian ZM, Wu XM, Fan M, Yang L, Du F, et al. (2011) Divalent metal transporter 1 is a hypoxia-inducible gene. J Cell Physiol 226 (6): 1596-603.
    • (2011) J Cell Physiol , vol.226 , Issue.6 , pp. 1596-1603
    • Qian, Z.M.1    Wu, X.M.2    Fan, M.3    Yang, L.4    Du, F.5
  • 37
    • 32944477219 scopus 로고    scopus 로고
    • Post-translational and transcriptional regulation of DMT1 during P19 embryonic carcinoma cell differentiation by Retinoic acid
    • Paradkar PN, Roth JA, (2006) Post-translational and transcriptional regulation of DMT1 during P19 embryonic carcinoma cell differentiation by Retinoic acid. Biochemical J 394: 173-183.
    • (2006) Biochemical J , vol.394 , pp. 173-183
    • Paradkar, P.N.1    Roth, J.A.2
  • 38
    • 32944457363 scopus 로고    scopus 로고
    • Nitric oxide transcriptionally down-regulates specific isoforms of divalent metal transporter (DMT1) via NF-kappaB
    • Paradkar PN, Roth JA, (2006) Nitric oxide transcriptionally down-regulates specific isoforms of divalent metal transporter (DMT1) via NF-kappaB. J Neurochem 96 (6): 1768-77.
    • (2006) J Neurochem , vol.96 , Issue.6 , pp. 1768-1777
    • Paradkar, P.N.1    Roth, J.A.2
  • 39
    • 72049117894 scopus 로고    scopus 로고
    • Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake
    • Xu H, Jiang H, Wang J, Xie J, (2010) Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake. Neuropharmacology 58 (2): 488-94.
    • (2010) Neuropharmacology , vol.58 , Issue.2 , pp. 488-494
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4
  • 40
    • 33745997334 scopus 로고    scopus 로고
    • Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways
    • Jang SI, Kim HJ, Kim YJ, Jeong SI, You YO, (2006) Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways. Eur J Pharmacol 542 (1-3): 1-7.
    • (2006) Eur J Pharmacol , vol.542 , Issue.1-3 , pp. 1-7
    • Jang, S.I.1    Kim, H.J.2    Kim, Y.J.3    Jeong, S.I.4    You, Y.O.5
  • 41
    • 33747284324 scopus 로고    scopus 로고
    • Pizzi M, Spano P (2006) Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms
    • Pizzi M, Spano P (2006) Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms. Eur J Pharmacol 545 (1): 22-8.
    • Eur J Pharmacol , vol.545 , Issue.1 , pp. 22-28
  • 42
    • 57549112366 scopus 로고    scopus 로고
    • NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischemia
    • Sarnico I, Lanzillotta A, Boroni F, Benarese M, Alghisi M, et al. (2009) NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischemia. J Neurochem 108 (2): 475-85.
    • (2009) J Neurochem , vol.108 , Issue.2 , pp. 475-485
    • Sarnico, I.1    Lanzillotta, A.2    Boroni, F.3    Benarese, M.4    Alghisi, M.5
  • 43
    • 79958719815 scopus 로고    scopus 로고
    • The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
    • Lanzillotta A, Sarnico I, Ingrassia R, Boroni F, Branca C, et al. (2010) The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury. Cell Death Dis 1 (11): e96.
    • (2010) Cell Death Dis , vol.1 , Issue.11
    • Lanzillotta, A.1    Sarnico, I.2    Ingrassia, R.3    Boroni, F.4    Branca, C.5
  • 44
    • 77950642805 scopus 로고    scopus 로고
    • Functional interplay between acetylation and methylation of the RelA subunit of NF-κB
    • Yang XD, Tajkorshis E, Chen LF, (2010) Functional interplay between acetylation and methylation of the RelA subunit of NF-κB. Mol Cell Biol 30 (9): 2170-80.
    • (2010) Mol Cell Biol , vol.30 , Issue.9 , pp. 2170-2180
    • Yang, X.D.1    Tajkorshis, E.2    Chen, L.F.3
  • 45
    • 0036925411 scopus 로고    scopus 로고
    • Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line
    • Pizzi M, Boroni F, Bianchetti A, Moraitis C, Sarnico I, et al. (2002) Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line. Eur J Neurosci 16 (12): 2342-50.
    • (2002) Eur J Neurosci , vol.16 , Issue.12 , pp. 2342-2350
    • Pizzi, M.1    Boroni, F.2    Bianchetti, A.3    Moraitis, C.4    Sarnico, I.5
  • 46
    • 33845609294 scopus 로고    scopus 로고
    • Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. 50
    • Inta I, Paxian S, Maegele I, Zhang W, Pizzi M, et al. (2006) Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. 50 J Neurosci 26 pp. 12896-903.
    • (2006) J Neurosci , vol.26 , pp. 12896-12903
    • Inta, I.1    Paxian, S.2    Maegele, I.3    Zhang, W.4    Pizzi, M.5
  • 47
    • 74049162413 scopus 로고    scopus 로고
    • Brain ischemic preconditioning does not require PARP-1
    • Faraco G, Blasi F, Min W, Wang ZQ, Moroni F, et al. (2010) Brain ischemic preconditioning does not require PARP-1. Stroke 41 (1): 181-3.
    • (2010) Stroke , vol.41 , Issue.1 , pp. 181-183
    • Faraco, G.1    Blasi, F.2    Min, W.3    Wang, Z.Q.4    Moroni, F.5
  • 48
    • 0027409751 scopus 로고
    • The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene
    • Crenon I, Béraud C, Simard P, Montagne J, Veschambre P, et al. (1993) The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene. Oncogene 8 (4): 867-75.
    • (1993) Oncogene , vol.8 , Issue.4 , pp. 867-875
    • Crenon, I.1    Béraud, C.2    Simard, P.3    Montagne, J.4    Veschambre, P.5
  • 49
    • 33748751193 scopus 로고    scopus 로고
    • Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion
    • Garrick MD, Kuo HC, Vargas F, Singleton S, Zhao L, et al. (2006) Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. Biochem J 398 (3): 539-46.
    • (2006) Biochem J , vol.398 , Issue.3 , pp. 539-546
    • Garrick, M.D.1    Kuo, H.C.2    Vargas, F.3    Singleton, S.4    Zhao, L.5
  • 50
    • 0034667698 scopus 로고    scopus 로고
    • Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells
    • Roth JA, Horbinski C, Feng L, Dolan KG, Higgins D, et al. (2000) Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. J Neurosci 20 (20): 7595-601.
    • (2000) J Neurosci , vol.20 , Issue.20 , pp. 7595-7601
    • Roth, J.A.1    Horbinski, C.2    Feng, L.3    Dolan, K.G.4    Higgins, D.5
  • 51
    • 2342574313 scopus 로고    scopus 로고
    • Computer-identified nuclear localization signal in exon 1A of the transporter DMT1 is essentially ineffective in nuclear targeting
    • Kuo HC, Smith JJ, Lis A, Zhao L, Gonsiorek EA, et al. (2004) Computer-identified nuclear localization signal in exon 1A of the transporter DMT1 is essentially ineffective in nuclear targeting. J Neurosci Res 76 (4): 497-511.
    • (2004) J Neurosci Res , vol.76 , Issue.4 , pp. 497-511
    • Kuo, H.C.1    Smith, J.J.2    Lis, A.3    Zhao, L.4    Gonsiorek, E.A.5
  • 52
    • 0037011056 scopus 로고    scopus 로고
    • Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-κB
    • Chen LF, Mu Y, Greene WC, (2002) Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-κB. EMBO J 21: 6539-6548.
    • (2002) EMBO J , vol.21 , pp. 6539-6548
    • Chen, L.F.1    Mu, Y.2    Greene, W.C.3
  • 53
    • 0036291808 scopus 로고    scopus 로고
    • Transferrin receptor gene expression and transferrin-bound iron uptake are increased during post-ischemic rat liver reperfusion
    • Tacchini L, Fusar Poli D, Bernelli-Zazzera A, Cairo G, (2002) Transferrin receptor gene expression and transferrin-bound iron uptake are increased during post-ischemic rat liver reperfusion. Hepatology 36 (1): 103-11.
    • (2002) Hepatology , vol.36 , Issue.1 , pp. 103-111
    • Tacchini, L.1    Fusar Poli, D.2    Bernelli-Zazzera, A.3    Cairo, G.4
  • 54
    • 0037354170 scopus 로고    scopus 로고
    • Brain iron uptake and homeostatic mechanisms: an overview
    • Burdo JR, Connor JR, (2003) Brain iron uptake and homeostatic mechanisms: an overview. Biometals 16 (1): 63-75.
    • (2003) Biometals , vol.16 , Issue.1 , pp. 63-75
    • Burdo, J.R.1    Connor, J.R.2
  • 55
    • 78049478172 scopus 로고    scopus 로고
    • Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury
    • Lee JY, Keep RF, He Y, Sagher O, Hua Y, et al. (2010) Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury. J Cereb Blood Flow Metab 30 (11): 1793-803.
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.11 , pp. 1793-1803
    • Lee, J.Y.1    Keep, R.F.2    He, Y.3    Sagher, O.4    Hua, Y.5
  • 56
    • 1342285558 scopus 로고    scopus 로고
    • Expression and localization of different forms of DMT1 in normal and tumor astroglial cells
    • Lis A, Barone TA, Paradkar PN, Plunkett RJ, Roth JA, (2004) Expression and localization of different forms of DMT1 in normal and tumor astroglial cells. Brain Res Mol Brain Res 122 (1): 62-70.
    • (2004) Brain Res Mol Brain Res , vol.122 , Issue.1 , pp. 62-70
    • Lis, A.1    Barone, T.A.2    Paradkar, P.N.3    Plunkett, R.J.4    Roth, J.A.5
  • 57
    • 70349100880 scopus 로고    scopus 로고
    • Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke
    • Hanson LR, Roeytenberg A, Martinez PM, Coppes VG, Sweet DC, et al. (2009) Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. J Pharmacol Exp Ther 330 (3): 679-86.
    • (2009) J Pharmacol Exp Ther , vol.330 , Issue.3 , pp. 679-686
    • Hanson, L.R.1    Roeytenberg, A.2    Martinez, P.M.3    Coppes, V.G.4    Sweet, D.C.5
  • 58
    • 79957948980 scopus 로고    scopus 로고
    • Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function
    • Zhao Y, Rempe DA, (2011) Prophylactic neuroprotection against stroke: low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function. J Cereb Blood Flow Metab 31 (6): 1412-23.
    • (2011) J Cereb Blood Flow Metab , vol.31 , Issue.6 , pp. 1412-1423
    • Zhao, Y.1    Rempe, D.A.2
  • 59
    • 79959669623 scopus 로고    scopus 로고
    • Iron toxicity in mice with collagenase-induced intracerebral hemorrhage
    • Wu H, Wu T, Xu X, Wang J, Wang J, (2011) Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J Cereb Blood Flow Metab 31 (5): 1243-50.
    • (2011) J Cereb Blood Flow Metab , vol.31 , Issue.5 , pp. 1243-1250
    • Wu, H.1    Wu, T.2    Xu, X.3    Wang, J.4    Wang, J.5
  • 60
    • 0025980955 scopus 로고
    • The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons
    • Ben-Shachar D, Eshel G, Finberg JP, Youdim MB, (1991) The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J Neurochem 56: 1441-1444.
    • (1991) J Neurochem , vol.56 , pp. 1441-1444
    • Ben-Shachar, D.1    Eshel, G.2    Finberg, J.P.3    Youdim, M.B.4
  • 61
    • 80051625243 scopus 로고    scopus 로고
    • Oxygen sensing, homeostasis, and disease.N Engl J Med
    • Semenza GL, (2011) Oxygen sensing, homeostasis, and disease.N Engl J Med 365 (6): 537-47.
    • (2011) , vol.365 , Issue.6 , pp. 537-547
    • Semenza, G.L.1
  • 62
    • 80052989037 scopus 로고    scopus 로고
    • Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications from neuronal cell death in Parkinson disease
    • Chew KC, ET, Tai YK, Tsang F, Lo SQ, et al. (2011) Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications from neuronal cell death in Parkinson disease. J Biol Chem 286 (38): 33380-9.
    • (2011) J Biol Chem , vol.286 , Issue.38 , pp. 33380-33389
    • Chew, K.C.E.T.1    Tai, Y.K.2    Tsang, F.3    Lo, S.Q.4
  • 63
    • 78649782421 scopus 로고    scopus 로고
    • Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells
    • Xu H, Jiang H, Wang J, Xie J, (2010) Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells. J Cell Biochem 111 (6): 1537-45.
    • (2010) J Cell Biochem , vol.111 , Issue.6 , pp. 1537-1545
    • Xu, H.1    Jiang, H.2    Wang, J.3    Xie, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.