Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: Implications for neuronal cell death in parkinson disease

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 33380-33389

  Chew, Katherine C M ^a   Ang, Eng Tat ^a   Tai, Yee Kit ^a   Tsang, Fai ^a   Lo, Shun Qiang ^a   Ong, Elijah ^a   Ong, Wei Yi ^a   Shen, Han Ming ^a   Lim, Kah Leong ^a,b,c   Dawson, Valina L ^d   Dawson, Ted M ^d   Soong, Tuck Wah ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY; CHRONIC TOXICITY; DIVALENT METAL ION; DNA DAMAGES; DOPAMINERGIC NEURONS; IRON HOMEOSTASIS; LEWY BODIES; MIDBRAIN; NEURODEGENERATIVE; NEURONAL CELL; OVER-EXPRESSION; PARKINSON DISEASE; PHARMACOLOGICAL INHIBITION; SUBSTANTIA NIGRA; SYNUCLEIN; WILD TYPES;

DISEASES; IRON; METAL IONS; NEURONS; TOXICITY;

CELL DEATH;

ALPHA SYNUCLEIN; FERROUS ION; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; GENE OVEREXPRESSION; IRON OVERLOAD; IRON TRANSPORT; NERVE CELL NECROSIS; NEUROPATHOLOGY; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WILD TYPE;

ALPHA-SYNUCLEIN; APOPTOSIS; AUTOPHAGY; CELL LINE; CYTOCHROMES C; HUMANS; IRON; MUTANT PROTEINS; NEURONS; OXIDATIVE STRESS; PARKINSON DISEASE; PHAGOSOMES; PROTEASOME ENDOPEPTIDASE COMPLEX; TRANSCRIPTION FACTORS; UBIQUITIN;

EID: 80052989037     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.268409     Document Type: Article

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