Brain ischemic preconditioning does not require PARP-1

Stroke

Volumn 41, Issue 1, 2010, Pages 181-183

  Faraco, Giuseppe ^a   Blasi, Francesco ^a   Min, Wookee ^b   Wang, Zhao Qi ^b,c   Moroni, Flavio ^a   Chiarugi, Alberto ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

ATP; NAD; Neuroprotectants; PARP; Poly(ADP ribose)

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BRAIN ISCHEMIA; ISCHEMIC PRECONDITIONING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLY(ADP-RIBOSE) POLYMERASES;

EID: 74049162413     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.109.567826     Document Type: Article

References (14)

1. Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol. 2009;8:398-412.
2. Moroni F, Chiarugi A. Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment. FEBS J. 2009;276:36-45.
3. Liaudet L, Yang Z, Al Affar EB, Szabo C. Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase. Mol Med. 2001;7:406-417.
4. Garnier P, Ying W, Swanson RA. Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1. J Neurosci. 2003;23: 7967-7973.
5. Lee JY, Kim YJ, Kim TY, Koh JY, Kim YH. Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection. J Neurosci. 2008;28:10919-10927.
6. Zhang C, Rosenbaum DM, Shaikh AR, Li Q, Rosenbaum PS, Pelham DJ, Roth S. Ischemic preconditioning attenuates apoptotic cell death in the rat retina. Invest Ophthalmol Vis Sci. 2002;43:3059-3066.
7. Cho S, Park EM, Zhou P, Frys K, Ross ME, Iadecola C. Obligatory role of inducible nitric oxide synthase in ischemic preconditioning. J Cereb Blood Flow Metab. 2005;25:493-501.
8. Eliasson MJ, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J, Pieper A, Wang ZQ, Dawson TM, Snyder SH, Dawson VL. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med. 1997;3:1089-1095.
9. Cozzi A, Cipriani G, Fossati S, Faraco G, Formentini L, Min W, Cortes U, Wang ZQ, Moroni F, Chiarugi A. Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice. J Cereb Blood Flow Metab. 2006;26: 684-695.
10. Jagtap P, Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005;4:421-440. (Pubitemid 40704125)
11. Abdelkarim GE, Gertz K, Harms C, Katchanov J, Dirnagl U, Szabo C, Endres M. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int J Mol Med. 2001;7:255-260.
12. Wang Y, Dawson VL, Dawson TM. Poly(ADP-ribose) signals to mito-chondrial AIF: A key event in parthanatos. Exp Neurol. 2009.
13. McLaughlin B, Hartnett KA, Erhardt JA, Legos JJ, White RF, Barone FC, Aizenman E. Caspase 3 activation is essential for neuroprotection in preconditioning. Proc Natl Acad Sci U S A. 2003;100:715-720.
14. Shieh VM, Ame JC, Wilson MV, Wang ZQ, Kho DW, Jacobson MK, Jacobson EL. Poly(ADP-ribose)polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem. 1998;273:30069-30072.