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Volumn 30, Issue 9, 2009, Pages 1466-1476

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

Author keywords

Apoptosis; Divalent metal transporter 1 (DMT1); Iron; Iron chelator; Iron regulatory protein (IRP); Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CASPASE 3; DEFEROXAMINE MESYLATE; FERROUS ION; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; REACTIVE OXYGEN METABOLITE;

EID: 67650474704     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.11.025     Document Type: Article
Times cited : (91)

References (50)
  • 1
    • 13444274645 scopus 로고    scopus 로고
    • Iron dysregulation and Parkinson's disease
    • Andersen J.K. Iron dysregulation and Parkinson's disease. J. Alzheimers Dis. 6 (2004) S47-S52
    • (2004) J. Alzheimers Dis. , vol.6
    • Andersen, J.K.1
  • 2
    • 0033044583 scopus 로고    scopus 로고
    • Iron transport across biologic membranes
    • Andrews N.C., Fleming M.D., and Gunshin H. Iron transport across biologic membranes. Nutr. Rev. 57 (1999) 114-123
    • (1999) Nutr. Rev. , vol.57 , pp. 114-123
    • Andrews, N.C.1    Fleming, M.D.2    Gunshin, H.3
  • 4
    • 33750320296 scopus 로고    scopus 로고
    • Iron metabolism in Parkinsonian syndromes
    • Berg D., and Hochstrasser H. Iron metabolism in Parkinsonian syndromes. Mov. Disord. 21 (2006) 1299-1310
    • (2006) Mov. Disord. , vol.21 , pp. 1299-1310
    • Berg, D.1    Hochstrasser, H.2
  • 5
    • 33750292972 scopus 로고    scopus 로고
    • Cell death in the nervous system
    • Bredesen D.E., Rao R.V., and Mehlen P. Cell death in the nervous system. Nature 443 (2006) 796-802
    • (2006) Nature , vol.443 , pp. 796-802
    • Bredesen, D.E.1    Rao, R.V.2    Mehlen, P.3
  • 6
    • 0028834446 scopus 로고
    • Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II)
    • Breuer W., Epsztejn S., and Cabantchik Z.I. Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II). J. Biol. Chem. 270 (1995) 24209-24215
    • (1995) J. Biol. Chem. , vol.270 , pp. 24209-24215
    • Breuer, W.1    Epsztejn, S.2    Cabantchik, Z.I.3
  • 8
    • 0026781572 scopus 로고
    • A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin
    • Crawford Jr. G.D., Le W.D., Smith R.G., Xie W.J., Stefani E., and Appel S.H. A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J. Neurosci. 12 (1992) 3392-3398
    • (1992) J. Neurosci. , vol.12 , pp. 3392-3398
    • Crawford Jr., G.D.1    Le, W.D.2    Smith, R.G.3    Xie, W.J.4    Stefani, E.5    Appel, S.H.6
  • 9
    • 34447337779 scopus 로고    scopus 로고
    • Neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) in MPP(+)-induced alteration of translational control in Neuro-2a neuroblastoma cells
    • Deguil J., Jailloux D., Page G., Fauconneau B., Houeto J.L., Philippe M., Muller J.M., and Pain S. Neuroprotective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) in MPP(+)-induced alteration of translational control in Neuro-2a neuroblastoma cells. J. Neurosci. Res. 85 (2007) 2017-2025
    • (2007) J. Neurosci. Res. , vol.85 , pp. 2017-2025
    • Deguil, J.1    Jailloux, D.2    Page, G.3    Fauconneau, B.4    Houeto, J.L.5    Philippe, M.6    Muller, J.M.7    Pain, S.8
  • 10
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • Dexter D.T., Wells F.R., Lees A.J., Agid F., Agid Y., Jenner P., and Marsden C.D. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52 (1989) 1830-1836
    • (1989) J. Neurochem. , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3    Agid, F.4    Agid, Y.5    Jenner, P.6    Marsden, C.D.7
  • 11
    • 0027343942 scopus 로고
    • Implications of alterations in trace element levels in brain in Parkinson's disease and other neurological disorders affecting the basal ganglia
    • Dexter D.T., Sian J., Jenner P., and Marsden C.D. Implications of alterations in trace element levels in brain in Parkinson's disease and other neurological disorders affecting the basal ganglia. Adv. Neurol. 60 (1993) 273-281
    • (1993) Adv. Neurol. , vol.60 , pp. 273-281
    • Dexter, D.T.1    Sian, J.2    Jenner, P.3    Marsden, C.D.4
  • 12
    • 25644452043 scopus 로고    scopus 로고
    • Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion
    • Gal S., Zheng H., Fridkin M., and Youdim M.B. Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion. J. Neurochem. 95 (2005) 79-88
    • (2005) J. Neurochem. , vol.95 , pp. 79-88
    • Gal, S.1    Zheng, H.2    Fridkin, M.3    Youdim, M.B.4
  • 15
    • 12744280693 scopus 로고    scopus 로고
    • Correlation of R2 with total iron concentration in the brains of rhesus monkeys
    • Hardy P.A., Gash D., Yokel R., Andersen A., Ai Y., and Zhang Z. Correlation of R2 with total iron concentration in the brains of rhesus monkeys. J. Magn. Reson. Imaging 21 (2005) 118-127
    • (2005) J. Magn. Reson. Imaging , vol.21 , pp. 118-127
    • Hardy, P.A.1    Gash, D.2    Yokel, R.3    Andersen, A.4    Ai, Y.5    Zhang, Z.6
  • 16
    • 4644365735 scopus 로고    scopus 로고
    • Distribution of divalent metal transporter-1 in the monkey basal ganglia
    • Huang E., Ong W.Y., and Connor J.R. Distribution of divalent metal transporter-1 in the monkey basal ganglia. Neuroscience 128 (2004) 487-496
    • (2004) Neuroscience , vol.128 , pp. 487-496
    • Huang, E.1    Ong, W.Y.2    Connor, J.R.3
  • 17
    • 0037126002 scopus 로고    scopus 로고
    • Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function
    • Hubert N., and Hentze M.W. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 12345-12350
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 12345-12350
    • Hubert, N.1    Hentze, M.W.2
  • 18
    • 33845219352 scopus 로고    scopus 로고
    • Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells
    • Jantova S., Cipak L., and Letasiova S. Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. Toxicol. In Vitro 21 (2007) 25-31
    • (2007) Toxicol. In Vitro , vol.21 , pp. 25-31
    • Jantova, S.1    Cipak, L.2    Letasiova, S.3
  • 19
    • 0242712032 scopus 로고    scopus 로고
    • Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice
    • Jiang H., Qian Z.M., and Xie J.X. Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice. Sheng Li Xue Bao. 55 (2003) 571-576
    • (2003) Sheng Li Xue Bao. , vol.55 , pp. 571-576
    • Jiang, H.1    Qian, Z.M.2    Xie, J.X.3
  • 20
    • 33749506725 scopus 로고    scopus 로고
    • Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload
    • Jiang H., Luan Z., Wang J., and Xie J. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochem. Int. 49 (2006) 605-609
    • (2006) Neurochem. Int. , vol.49 , pp. 605-609
    • Jiang, H.1    Luan, Z.2    Wang, J.3    Xie, J.4
  • 21
    • 34347251501 scopus 로고    scopus 로고
    • Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra
    • Jiang H., Song N., Wang J., Ren L.Y., and Xie J.X. Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochem. Int. (2007)
    • (2007) Neurochem. Int.
    • Jiang, H.1    Song, N.2    Wang, J.3    Ren, L.Y.4    Xie, J.X.5
  • 22
    • 0037394420 scopus 로고    scopus 로고
    • 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide
    • Kalivendi S.V., Kotamraju S., Cunningham S., Shang T., Hillard C.J., and Kalyanaraman B. 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. Biochem. J. 371 (2003) 151-164
    • (2003) Biochem. J. , vol.371 , pp. 151-164
    • Kalivendi, S.V.1    Kotamraju, S.2    Cunningham, S.3    Shang, T.4    Hillard, C.J.5    Kalyanaraman, B.6
  • 23
    • 4243403960 scopus 로고    scopus 로고
    • Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals
    • Kamp D.W., Panduri V., Weitzman S.A., and Chandel N. Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Mol. Cell Biochem. 234-235 (2002) 153-160
    • (2002) Mol. Cell Biochem. , vol.234-235 , pp. 153-160
    • Kamp, D.W.1    Panduri, V.2    Weitzman, S.A.3    Chandel, N.4
  • 24
    • 13644278965 scopus 로고    scopus 로고
    • Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain
    • Ke Y., Chang Y.Z., Duan X.L., Du J.R., Zhu L., Wang K., Yang X.D., Ho K.P., and Qian Z.M. Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain. Neurobiol. Aging 26 (2005) 739-748
    • (2005) Neurobiol. Aging , vol.26 , pp. 739-748
    • Ke, Y.1    Chang, Y.Z.2    Duan, X.L.3    Du, J.R.4    Zhu, L.5    Wang, K.6    Yang, X.D.7    Ho, K.P.8    Qian, Z.M.9
  • 25
    • 2542515348 scopus 로고    scopus 로고
    • Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain
    • Knutson M., Menzies S., Connor J., and Wessling-Resnick M. Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. J. Neurosci. Res. 76 (2004) 633-641
    • (2004) J. Neurosci. Res. , vol.76 , pp. 633-641
    • Knutson, M.1    Menzies, S.2    Connor, J.3    Wessling-Resnick, M.4
  • 26
    • 0030864433 scopus 로고    scopus 로고
    • Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice
    • Lan J., and Jiang D.H. Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. 104 (1997) 469-481
    • (1997) J. Neural Transm. , vol.104 , pp. 469-481
    • Lan, J.1    Jiang, D.H.2
  • 27
    • 0032104739 scopus 로고    scopus 로고
    • The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms
    • Lee P.L., Gelbart T., West C., Halloran C., and Beutler E. The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol. Dis. 24 (1998) 199-215
    • (1998) Blood Cells Mol. Dis. , vol.24 , pp. 199-215
    • Lee, P.L.1    Gelbart, T.2    West, C.3    Halloran, C.4    Beutler, E.5
  • 28
    • 34147189116 scopus 로고    scopus 로고
    • Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)
    • Mackenzie B., Takanaga H., Hubert N., Rolfs A., and Hediger M.A. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem. J. 403 (2007) 59-69
    • (2007) Biochem. J. , vol.403 , pp. 59-69
    • Mackenzie, B.1    Takanaga, H.2    Hubert, N.3    Rolfs, A.4    Hediger, M.A.5
  • 29
    • 0033151523 scopus 로고    scopus 로고
    • Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells
    • May J.M., Qu Z.C., and Mendiratta S. Role of ascorbic acid in transferrin-independent reduction and uptake of iron by U-937 cells. Biochem. Pharmacol. 57 (1999) 1275-1282
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 1275-1282
    • May, J.M.1    Qu, Z.C.2    Mendiratta, S.3
  • 30
    • 1842504357 scopus 로고    scopus 로고
    • The metabolism of neuronal iron and its pathogenic role in neurological disease: review
    • Moos T., and Morgan E.H. The metabolism of neuronal iron and its pathogenic role in neurological disease: review. Ann. NY Acad. Sci. 1012 (2004) 14-26
    • (2004) Ann. NY Acad. Sci. , vol.1012 , pp. 14-26
    • Moos, T.1    Morgan, E.H.2
  • 31
    • 0034680828 scopus 로고    scopus 로고
    • Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool
    • Picard V., Govoni G., Jabado N., and Gros P. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J. Biol. Chem. 275 (2000) 35738-35745
    • (2000) J. Biol. Chem. , vol.275 , pp. 35738-35745
    • Picard, V.1    Govoni, G.2    Jabado, N.3    Gros, P.4
  • 32
    • 0022353536 scopus 로고
    • The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals
    • Poirier J., Donaldson J., and Barbeau A. The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals. Biochem. Biophys. Res. Commun. 128 (1985) 25-33
    • (1985) Biochem. Biophys. Res. Commun. , vol.128 , pp. 25-33
    • Poirier, J.1    Donaldson, J.2    Barbeau, A.3
  • 34
    • 0034935074 scopus 로고    scopus 로고
    • Iron on the brain
    • Rouault T.A. Iron on the brain. Nat. Genet. 28 (2001) 299-300
    • (2001) Nat. Genet. , vol.28 , pp. 299-300
    • Rouault, T.A.1
  • 35
    • 33746361251 scopus 로고    scopus 로고
    • The role of iron regulatory proteins in mammalian iron homeostasis and disease
    • Rouault T.A. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2 (2006) 406-414
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 406-414
    • Rouault, T.A.1
  • 37
    • 34147127042 scopus 로고    scopus 로고
    • Calcium mediated excitotoxicity in neurofilament aggregate-bearing neurons in vitro is NMDA receptor dependant
    • Sanelli T., Ge W., Leystra-Lantz C., and Strong M.J. Calcium mediated excitotoxicity in neurofilament aggregate-bearing neurons in vitro is NMDA receptor dependant. J. Neurol. Sci. 256 (2007) 39-51
    • (2007) J. Neurol. Sci. , vol.256 , pp. 39-51
    • Sanelli, T.1    Ge, W.2    Leystra-Lantz, C.3    Strong, M.J.4
  • 38
    • 35848961208 scopus 로고    scopus 로고
    • Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx
    • Song N., Jiang H., Wang J., and Xie J.X. Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx. J. Neurosci. Res. 85 (2007) 3118-3126
    • (2007) J. Neurosci. Res. , vol.85 , pp. 3118-3126
    • Song, N.1    Jiang, H.2    Wang, J.3    Xie, J.X.4
  • 39
    • 0028045734 scopus 로고
    • Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis
    • Temlett J.A., Landsberg J.P., Watt F., and Grime G.W. Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis. J. Neurochem. 62 (1994) 134-146
    • (1994) J. Neurochem. , vol.62 , pp. 134-146
    • Temlett, J.A.1    Landsberg, J.P.2    Watt, F.3    Grime, G.W.4
  • 40
    • 18844425714 scopus 로고    scopus 로고
    • Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis
    • Tenopoulou M., Doulias P.T., Barbouti A., Brunk U., and Galaris D. Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis. Biochem. J. 387 (2005) 703-710
    • (2005) Biochem. J. , vol.387 , pp. 703-710
    • Tenopoulou, M.1    Doulias, P.T.2    Barbouti, A.3    Brunk, U.4    Galaris, D.5
  • 41
    • 0034070941 scopus 로고    scopus 로고
    • Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload
    • Trinder D., Oates P.S., Thomas C., Sadleir J., and Morgan E.H. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut 46 (2000) 270-276
    • (2000) Gut , vol.46 , pp. 270-276
    • Trinder, D.1    Oates, P.S.2    Thomas, C.3    Sadleir, J.4    Morgan, E.H.5
  • 42
    • 11144304136 scopus 로고    scopus 로고
    • Time dependent effects of 6-OHDA lesions on iron level and neuronal loss in rat nigrostriatal system
    • Wang J., Jiang H., and Xie J.X. Time dependent effects of 6-OHDA lesions on iron level and neuronal loss in rat nigrostriatal system. Neurochem. Res. 29 (2004) 2239-2243
    • (2004) Neurochem. Res. , vol.29 , pp. 2239-2243
    • Wang, J.1    Jiang, H.2    Xie, J.X.3
  • 43
    • 34250014148 scopus 로고    scopus 로고
    • Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats
    • Wang J., Jiang H., and Xie J.X. Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats. Eur. J. Neurosci. 25 (2007) 2766-2772
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 2766-2772
    • Wang, J.1    Jiang, H.2    Xie, J.X.3
  • 44
    • 0033167931 scopus 로고    scopus 로고
    • The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake
    • Wardrop S.L., and Richardson D.R. The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake. Eur. J. Biochem. 263 (1999) 41-49
    • (1999) Eur. J. Biochem. , vol.263 , pp. 41-49
    • Wardrop, S.L.1    Richardson, D.R.2
  • 45
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator
    • West M.J., Slomianka L., and Gundersen H.J. Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231 (1991) 482-497
    • (1991) Anat. Rec. , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 46
    • 33748548397 scopus 로고    scopus 로고
    • Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake
    • Wetli H.A., Buckett P.D., and Wessling-Resnick M. Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake. Chem. Biol. 13 (2006) 965-972
    • (2006) Chem. Biol. , vol.13 , pp. 965-972
    • Wetli, H.A.1    Buckett, P.D.2    Wessling-Resnick, M.3
  • 47
    • 0042164632 scopus 로고    scopus 로고
    • Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of Parkinson's disease
    • Xie J., Jiang H., Chen W.F., and Qian Z.M. Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of Parkinson's disease. Exp. Neurol. 182 (2003) 483-489
    • (2003) Exp. Neurol. , vol.182 , pp. 483-489
    • Xie, J.1    Jiang, H.2    Chen, W.F.3    Qian, Z.M.4
  • 48
    • 33947540523 scopus 로고    scopus 로고
    • Antioxidants tiron and N-acetyl-l-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway
    • Yang J., Su Y., and Richmond A. Antioxidants tiron and N-acetyl-l-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway. Free Radic. Biol. Med. 42 (2007) 1369-1380
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 1369-1380
    • Yang, J.1    Su, Y.2    Richmond, A.3
  • 49
    • 29144460927 scopus 로고    scopus 로고
    • Nonylphenol-induced thymocyte apoptosis involved caspase-3 activation and mitochondrial depolarization
    • Yao G., Yang L., Hu Y., Liang J., and Hou Y. Nonylphenol-induced thymocyte apoptosis involved caspase-3 activation and mitochondrial depolarization. Mol. Immunol. 43 (2006) 915-926
    • (2006) Mol. Immunol. , vol.43 , pp. 915-926
    • Yao, G.1    Yang, L.2    Hu, Y.3    Liang, J.4    Hou, Y.5
  • 50
    • 3042543657 scopus 로고    scopus 로고
    • Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism
    • Zhu H.J., and Liu G.Q. Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism. Life Sci. 75 (2004) 1313-1322
    • (2004) Life Sci. , vol.75 , pp. 1313-1322
    • Zhu, H.J.1    Liu, G.Q.2


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