FXR ligands protect against hepatocellular inflammation via SOCS3 induction

Cellular Signalling

Volumn 24, Issue 8, 2012, Pages 1658-1664

  Xu, Zhizhen ^a   Huang, Gang ^a   Gong, Wei ^a   Zhou, Peng ^a   Zhao, Yuanyin ^a   Zhang, Yan ^a   Zeng, Yijun ^a   Gao, Min ^a   Pan, Zhisheng ^a   He, Fengtian ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

FXR; Hepatocyte; Inflammation; SOCS3; STAT3

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA ACTIN; BETA GALACTOSIDASE; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR AGONIST; HORMONE RECEPTOR STIMULATING AGENT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INACTIVATION; GENE; GENE TARGETING; HEPATITIS; HUMAN; HUMAN CELL; LIVER CELL; LIVER PROTECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; SUPPRESSOR OF CYTOKINE SIGNALING 3 GENE; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; HEP G2 CELLS; HUMANS; INFLAMMATION; LIGANDS; LIPOPOLYSACCHARIDES; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

ANIMALIA;

EID: 84861555163     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.04.015     Document Type: Article

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