-
1
-
-
0033529704
-
Stat3 as an oncogene
-
Bromberg J.F., Wrzeszczynska M.H., Devgan G., Zhao Y., Pestell R.G., Albanese C., and Darnell Jr. J.E. Stat3 as an oncogene. Cell 98 (1999) 295-303
-
(1999)
Cell
, vol.98
, pp. 295-303
-
-
Bromberg, J.F.1
Wrzeszczynska, M.H.2
Devgan, G.3
Zhao, Y.4
Pestell, R.G.5
Albanese, C.6
Darnell Jr., J.E.7
-
2
-
-
0032772912
-
STAT signaling in the pathogenesis and treatment of cancer
-
Frank D.A. STAT signaling in the pathogenesis and treatment of cancer. Mol Med 5 (1999) 432-456
-
(1999)
Mol Med
, vol.5
, pp. 432-456
-
-
Frank, D.A.1
-
3
-
-
0031953831
-
Stat3 activation by Src induces specific gene regulation and is required for cell transformation
-
Turkson J., Bowman T., Garcia R., Caldenhoven E., De Groot R.P., and Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 18 (1998) 2545-2552
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2545-2552
-
-
Turkson, J.1
Bowman, T.2
Garcia, R.3
Caldenhoven, E.4
De Groot, R.P.5
Jove, R.6
-
4
-
-
0031893214
-
Stat3 activation is required for cellular transformation by v-src
-
Bromberg J.F., Horvath C.M., Besser D., Lathem W.W., and Darnell Jr. J.E. Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol 18 (1998) 2553-2558
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2553-2558
-
-
Bromberg, J.F.1
Horvath, C.M.2
Besser, D.3
Lathem, W.W.4
Darnell Jr., J.E.5
-
5
-
-
0030292721
-
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130. involvement of STAT3 in anti-apoptosis
-
Fukada T., Hibi M., Yamanaka Y., Takahashi-Tezuka M., Fujitani Y., Yamaguchi T., Nakajima K., and Hirano T. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130. involvement of STAT3 in anti-apoptosis. Immunity 5 (1996) 449-460
-
(1996)
Immunity
, vol.5
, pp. 449-460
-
-
Fukada, T.1
Hibi, M.2
Yamanaka, Y.3
Takahashi-Tezuka, M.4
Fujitani, Y.5
Yamaguchi, T.6
Nakajima, K.7
Hirano, T.8
-
6
-
-
0032711250
-
IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway
-
Puthier D., Bataille R., and Amiot M. IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway. Eur J Immunol 29 (1999) 3945-3950
-
(1999)
Eur J Immunol
, vol.29
, pp. 3945-3950
-
-
Puthier, D.1
Bataille, R.2
Amiot, M.3
-
7
-
-
0033584297
-
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
-
Karni R., Jove R., and Levitzki A. Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors. Oncogene 18 (1999) 4654-4662
-
(1999)
Oncogene
, vol.18
, pp. 4654-4662
-
-
Karni, R.1
Jove, R.2
Levitzki, A.3
-
8
-
-
0035265830
-
Cooperation between STAT3 and c-jun suppresses Fas transcription
-
Ivanov V.N., Bhoumik A., Krasilnikov M., Raz R., Owen-Schaub L.B., Levy D., Horvath C.M., and Ronai Z. Cooperation between STAT3 and c-jun suppresses Fas transcription. Mol Cell 7 (2001) 517-528
-
(2001)
Mol Cell
, vol.7
, pp. 517-528
-
-
Ivanov, V.N.1
Bhoumik, A.2
Krasilnikov, M.3
Raz, R.4
Owen-Schaub, L.B.5
Levy, D.6
Horvath, C.M.7
Ronai, Z.8
-
9
-
-
0034676267
-
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts. role of activated STAT3 signaling
-
Sinibaldi D., Wharton W., Turkson J., Bowman T., Pledger W.J., and Jove R. Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts. role of activated STAT3 signaling. Oncogene 19 (2000) 5419-5427
-
(2000)
Oncogene
, vol.19
, pp. 5419-5427
-
-
Sinibaldi, D.1
Wharton, W.2
Turkson, J.3
Bowman, T.4
Pledger, W.J.5
Jove, R.6
-
10
-
-
0030024443
-
IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s)
-
Kojima H., Nakajima K., and Hirano T. IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s). Oncogene 12 (1996) 547-554
-
(1996)
Oncogene
, vol.12
, pp. 547-554
-
-
Kojima, H.1
Nakajima, K.2
Hirano, T.3
-
11
-
-
0033521595
-
STAT3 is required for the gp130-mediated full activation of the c-myc gene
-
Kiuchi N., Nakajima K., Ichiba M., Fukada T., Narimatsu M., Mizuno K., Hibi M., and Hirano T. STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med 189 (1999) 63-73
-
(1999)
J Exp Med
, vol.189
, pp. 63-73
-
-
Kiuchi, N.1
Nakajima, K.2
Ichiba, M.3
Fukada, T.4
Narimatsu, M.5
Mizuno, K.6
Hibi, M.7
Hirano, T.8
-
12
-
-
0035912763
-
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
-
Bowman T., Broome M.A., Sinibaldi D., Wharton W., Pledger W.J., Sedivy J.M., Irby R., Yeatman T., Courtneidge S.A., and Jove R. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc Natl Acad Sci U S A 98 (2001) 7319-7324
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 7319-7324
-
-
Bowman, T.1
Broome, M.A.2
Sinibaldi, D.3
Wharton, W.4
Pledger, W.J.5
Sedivy, J.M.6
Irby, R.7
Yeatman, T.8
Courtneidge, S.A.9
Jove, R.10
-
13
-
-
0037844864
-
Independent and cooperative activation of chromosomal c-fos promoter by STAT3
-
Yang E., Lerner L., Besser D., and Darnell Jr. J.E. Independent and cooperative activation of chromosomal c-fos promoter by STAT3. J Biol Chem 278 (2003) 15794-15799
-
(2003)
J Biol Chem
, vol.278
, pp. 15794-15799
-
-
Yang, E.1
Lerner, L.2
Besser, D.3
Darnell Jr., J.E.4
-
14
-
-
0032803530
-
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as the SH2 domain
-
Sasaki A., Yasukawa H., Suzuki A., Kamizono S., Syoda T., Kinjyo I., Sasaki M., Johnston J.A., and Yoshimura A. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as the SH2 domain. Genes Cells 4 (1999) 339-351
-
(1999)
Genes Cells
, vol.4
, pp. 339-351
-
-
Sasaki, A.1
Yasukawa, H.2
Suzuki, A.3
Kamizono, S.4
Syoda, T.5
Kinjyo, I.6
Sasaki, M.7
Johnston, J.A.8
Yoshimura, A.9
-
15
-
-
0034703097
-
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
-
Sasaki A., Yasukawa H., Shouda T., Kitamura T., Dikic I., and Yoshimura A. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem 275 (2000) 29338-29347
-
(2000)
J Biol Chem
, vol.275
, pp. 29338-29347
-
-
Sasaki, A.1
Yasukawa, H.2
Shouda, T.3
Kitamura, T.4
Dikic, I.5
Yoshimura, A.6
-
16
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo I., Hanada T., Inagaki-Ohara K., Mori H., Aki D., Ohishi M., Yoshida H., Kubo M., and Yoshimura A. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17 (2002) 583-591
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
Hanada, T.2
Inagaki-Ohara, K.3
Mori, H.4
Aki, D.5
Ohishi, M.6
Yoshida, H.7
Kubo, M.8
Yoshimura, A.9
-
17
-
-
0037938816
-
SOCS3 negatively regulates IL-6 signaling in vivo
-
Croker B.A., Krebs D.L., Zhang J.G., Wormald S., Willson T.A., Stanley E.G., Robb L., Greenhalgh C.J., Forster I., Clausen B.E., Nicola N.A., Metcalf D., Hilton D.J., Roberts A.W., and Alexander W.S. SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4 (2003) 540-545
-
(2003)
Nat Immunol
, vol.4
, pp. 540-545
-
-
Croker, B.A.1
Krebs, D.L.2
Zhang, J.G.3
Wormald, S.4
Willson, T.A.5
Stanley, E.G.6
Robb, L.7
Greenhalgh, C.J.8
Forster, I.9
Clausen, B.E.10
Nicola, N.A.11
Metcalf, D.12
Hilton, D.J.13
Roberts, A.W.14
Alexander, W.S.15
-
18
-
-
1342346569
-
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
-
Kimura A., Kinjyo I., Matsumura Y., Mori H., Mashima R., Harada M., Chien K.R., Yasukawa H., and Yoshimura A. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem 279 (2004) 6905-6910
-
(2004)
J Biol Chem
, vol.279
, pp. 6905-6910
-
-
Kimura, A.1
Kinjyo, I.2
Matsumura, Y.3
Mori, H.4
Mashima, R.5
Harada, M.6
Chien, K.R.7
Yasukawa, H.8
Yoshimura, A.9
-
19
-
-
3142723983
-
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
-
Mori H., Hanada R., Hanada T., Aki D., Mashima R., Nishinakamura H., Torisu T., Chien K.R., Yasukawa H., and Yoshimura A. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10 (2004) 739-743
-
(2004)
Nat Med
, vol.10
, pp. 739-743
-
-
Mori, H.1
Hanada, R.2
Hanada, T.3
Aki, D.4
Mashima, R.5
Nishinakamura, H.6
Torisu, T.7
Chien, K.R.8
Yasukawa, H.9
Yoshimura, A.10
-
20
-
-
0037600741
-
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
-
Yasukawa H., Ohishi M., Mori H., Murakami M., Chinen T., Aki D., Hanada T., Takeda K., Akira S., Hoshijima M., Hirano T., Chien K.R., and Yoshimura A. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 4 (2003) 551-556
-
(2003)
Nat Immunol
, vol.4
, pp. 551-556
-
-
Yasukawa, H.1
Ohishi, M.2
Mori, H.3
Murakami, M.4
Chinen, T.5
Aki, D.6
Hanada, T.7
Takeda, K.8
Akira, S.9
Hoshijima, M.10
Hirano, T.11
Chien, K.R.12
Yoshimura, A.13
-
21
-
-
10744223693
-
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
-
Croker B.A., Metcalf D., Robb L., Wei W., Mifsud S., DiRago L., Cluse L.A., Sutherland K.D., Hartley L., Williams E., Zhang J.G., Hilton D.J., Nicola N.A., Alexander W.S., and Roberts A.W. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20 (2004) 153-165
-
(2004)
Immunity
, vol.20
, pp. 153-165
-
-
Croker, B.A.1
Metcalf, D.2
Robb, L.3
Wei, W.4
Mifsud, S.5
DiRago, L.6
Cluse, L.A.7
Sutherland, K.D.8
Hartley, L.9
Williams, E.10
Zhang, J.G.11
Hilton, D.J.12
Nicola, N.A.13
Alexander, W.S.14
Roberts, A.W.15
-
22
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
Howard J.K., Cave B.J., Oksanen L.J., Tzameli I., Bjorbaek C., and Flier J.S. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10 (2004) 734-738
-
(2004)
Nat Med
, vol.10
, pp. 734-738
-
-
Howard, J.K.1
Cave, B.J.2
Oksanen, L.J.3
Tzameli, I.4
Bjorbaek, C.5
Flier, J.S.6
-
23
-
-
0034724677
-
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
-
Schmitz J., Weissenbach M., Haan S., Heinrich P.C., and Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275 (2000) 12848-12856
-
(2000)
J Biol Chem
, vol.275
, pp. 12848-12856
-
-
Schmitz, J.1
Weissenbach, M.2
Haan, S.3
Heinrich, P.C.4
Schaper, F.5
-
24
-
-
0034612271
-
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
-
Nicholson S.E., De Souza D., Fabri L.J., Corbin J., Willson T.A., Zhang J.G., Silva A., Asimakis M., Farley A., Nash A.D., Metcalf D., Hilton D.J., Nicola N.A., and Baca M. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci U S A 97 (2000) 6493-6498
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6493-6498
-
-
Nicholson, S.E.1
De Souza, D.2
Fabri, L.J.3
Corbin, J.4
Willson, T.A.5
Zhang, J.G.6
Silva, A.7
Asimakis, M.8
Farley, A.9
Nash, A.D.10
Metcalf, D.11
Hilton, D.J.12
Nicola, N.A.13
Baca, M.14
-
25
-
-
0035979275
-
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
-
Roberts A.W., Robb L., Rakar S., Hartley L., Cluse L., Nicola N.A., Metcalf D., Hilton D.J., and Alexander W.S. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A 98 (2001) 9324-9329
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9324-9329
-
-
Roberts, A.W.1
Robb, L.2
Rakar, S.3
Hartley, L.4
Cluse, L.5
Nicola, N.A.6
Metcalf, D.7
Hilton, D.J.8
Alexander, W.S.9
-
26
-
-
0037415694
-
SOCS3. an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
-
Takahashi Y., Carpino N., Cross J.C., Torres M., Parganas E., and Ihle J.N. SOCS3. an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J 22 (2003) 372-384
-
(2003)
EMBO J
, vol.22
, pp. 372-384
-
-
Takahashi, Y.1
Carpino, N.2
Cross, J.C.3
Torres, M.4
Parganas, E.5
Ihle, J.N.6
-
27
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
Howard J.K., Cave B.J., Oksanen L.J., Tzameli I., Bjorbaek C., and Flier J.S. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10 (2004) 734-738
-
(2004)
Nat Med
, vol.10
, pp. 734-738
-
-
Howard, J.K.1
Cave, B.J.2
Oksanen, L.J.3
Tzameli, I.4
Bjorbaek, C.5
Flier, J.S.6
-
28
-
-
10744223693
-
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
-
Croker B.A., Metcalf D., Robb L., Wei W., Mifsud S., DiRago L., Cluse L.A., Sutherland K.D., Hartley L., Williams E., Zhang J.G., Hilton D.J., Nicola N.A., Alexander W.S., and Roberts A.W. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20 (2004) 153-165
-
(2004)
Immunity
, vol.20
, pp. 153-165
-
-
Croker, B.A.1
Metcalf, D.2
Robb, L.3
Wei, W.4
Mifsud, S.5
DiRago, L.6
Cluse, L.A.7
Sutherland, K.D.8
Hartley, L.9
Williams, E.10
Zhang, J.G.11
Hilton, D.J.12
Nicola, N.A.13
Alexander, W.S.14
Roberts, A.W.15
-
29
-
-
28044463595
-
Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease
-
Robb L., Boyle K., Rakar S., Hartley L., Lochland J., Roberts A.W., Alexander W.S., and Metcalf D. Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease. Proc Natl Acad Sci U S A 102 (2005) 16333-16338
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16333-16338
-
-
Robb, L.1
Boyle, K.2
Rakar, S.3
Hartley, L.4
Lochland, J.5
Roberts, A.W.6
Alexander, W.S.7
Metcalf, D.8
-
30
-
-
0034059141
-
DNA excision in liver by an albumin-Cre transgene occurs progressively with age
-
Postic C., and Magnuson M.A. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 26 (2000) 149-150
-
(2000)
Genesis
, vol.26
, pp. 149-150
-
-
Postic, C.1
Magnuson, M.A.2
-
31
-
-
3042592451
-
SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis
-
Yoshida T., Ogata H., Kamio M., Joo A., Shiraishi H., Tokunaga Y., Sata M., Nagai H., and Yoshimura A. SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. J Exp Med 199 (2004) 1701-1707
-
(2004)
J Exp Med
, vol.199
, pp. 1701-1707
-
-
Yoshida, T.1
Ogata, H.2
Kamio, M.3
Joo, A.4
Shiraishi, H.5
Tokunaga, Y.6
Sata, M.7
Nagai, H.8
Yoshimura, A.9
-
32
-
-
0023134168
-
Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single small HCC
-
Kenmochi K., Sugihara S., and Kojiro M. Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single small HCC. Liver 7 (1987) 18-26
-
(1987)
Liver
, vol.7
, pp. 18-26
-
-
Kenmochi, K.1
Sugihara, S.2
Kojiro, M.3
-
33
-
-
0029159792
-
Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation
-
Bissell D.M., Wang S.S., Jarnagin W.R., and Roll F.J. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 96 (1995) 447-455
-
(1995)
J Clin Invest
, vol.96
, pp. 447-455
-
-
Bissell, D.M.1
Wang, S.S.2
Jarnagin, W.R.3
Roll, F.J.4
-
34
-
-
0036717295
-
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
-
Yoshida T., Hanada T., Tokuhisa T., Kosai K., Sata M., Kohara M., and Yoshimura A. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med 196 (2002) 641-653
-
(2002)
J Exp Med
, vol.196
, pp. 641-653
-
-
Yoshida, T.1
Hanada, T.2
Tokuhisa, T.3
Kosai, K.4
Sata, M.5
Kohara, M.6
Yoshimura, A.7
-
35
-
-
1842479907
-
Electric foot shock stress-induced exacerbation of alpha-galactosylceramide-triggered apoptosis in mouse liver
-
Chida Y., Sudo N., Sonoda J., Sogawa H., and Kubo C. Electric foot shock stress-induced exacerbation of alpha-galactosylceramide-triggered apoptosis in mouse liver. Hepatology 39 (2004) 1131-1140
-
(2004)
Hepatology
, vol.39
, pp. 1131-1140
-
-
Chida, Y.1
Sudo, N.2
Sonoda, J.3
Sogawa, H.4
Kubo, C.5
-
36
-
-
0035336183
-
Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice
-
Nakagawa R., Nagafune I., Tazunoki Y., Ehara H., Tomura H., Iijima R., Motoki K., Kamishohara M., and Seki S. Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice. J Immunol 166 (2001) 6578-6584
-
(2001)
J Immunol
, vol.166
, pp. 6578-6584
-
-
Nakagawa, R.1
Nagafune, I.2
Tazunoki, Y.3
Ehara, H.4
Tomura, H.5
Iijima, R.6
Motoki, K.7
Kamishohara, M.8
Seki, S.9
-
37
-
-
18744376897
-
Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine
-
Matsuda M., Nakamoto Y., Suzuki S., Kurata T., and Kaneko S. Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine. Lab Invest 85 (2005) 655-663
-
(2005)
Lab Invest
, vol.85
, pp. 655-663
-
-
Matsuda, M.1
Nakamoto, Y.2
Suzuki, S.3
Kurata, T.4
Kaneko, S.5
-
38
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
Niu G., Wright K.L., Huang M., Song L., Haura E., Turkson J., Zhang S., Wang T., Sinibaldi D., Coppola D., Heller R., Ellis L.M., Karras J., Bromberg J., Pardoll D., Jove R., and Yu H. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21 (2002) 2000-2008
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
Song, L.4
Haura, E.5
Turkson, J.6
Zhang, S.7
Wang, T.8
Sinibaldi, D.9
Coppola, D.10
Heller, R.11
Ellis, L.M.12
Karras, J.13
Bromberg, J.14
Pardoll, D.15
Jove, R.16
Yu, H.17
-
39
-
-
0033973631
-
NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines
-
Fiorucci S., Santucci L., Antonelli E., Distrutti E., Del Sero G., Morelli O., Romani L., Federici B., Del Soldato P., and Morelli A. NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines. Gastroenterology 118 (2000) 404-421
-
(2000)
Gastroenterology
, vol.118
, pp. 404-421
-
-
Fiorucci, S.1
Santucci, L.2
Antonelli, E.3
Distrutti, E.4
Del Sero, G.5
Morelli, O.6
Romani, L.7
Federici, B.8
Del Soldato, P.9
Morelli, A.10
-
40
-
-
0026643743
-
A T cell-dependent experimental liver injury in mice inducible by concanavalin A
-
Tiegs G., Hentschel J., and Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 90 (1992) 196-203
-
(1992)
J Clin Invest
, vol.90
, pp. 196-203
-
-
Tiegs, G.1
Hentschel, J.2
Wendel, A.3
-
41
-
-
0034624976
-
Critical contribution of liver natural killer T cells to a murine model of hepatitis
-
Takeda K., Hayakawa Y., Van Kaer L., Matsuda H., Yagita H., and Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 97 (2000) 5498-5503
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5498-5503
-
-
Takeda, K.1
Hayakawa, Y.2
Van Kaer, L.3
Matsuda, H.4
Yagita, H.5
Okumura, K.6
-
42
-
-
0036854891
-
Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis. regulation by SOCS
-
Hong F., Jaruga B., Kim W.H., Radaeva S., El-Assal O.N., Tian Z., Nguyen V.A., and Gao B. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis. regulation by SOCS. J Clin Invest 110 (2002) 1503-1513
-
(2002)
J Clin Invest
, vol.110
, pp. 1503-1513
-
-
Hong, F.1
Jaruga, B.2
Kim, W.H.3
Radaeva, S.4
El-Assal, O.N.5
Tian, Z.6
Nguyen, V.A.7
Gao, B.8
-
43
-
-
0033970969
-
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
-
Kovalovich K., DeAngelis R.A., Li W., Furth E.E., Ciliberto G., and Taub R. Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice. Hepatology 31 (2000) 149-159
-
(2000)
Hepatology
, vol.31
, pp. 149-159
-
-
Kovalovich, K.1
DeAngelis, R.A.2
Li, W.3
Furth, E.E.4
Ciliberto, G.5
Taub, R.6
-
44
-
-
21344435775
-
Mechanisms of disease. Insights into the emerging role of signal transducers and activators of transcription in cancer
-
Haura E.B., Turkson J., and Jove R. Mechanisms of disease. Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2 (2005) 315-324
-
(2005)
Nat Clin Pract Oncol
, vol.2
, pp. 315-324
-
-
Haura, E.B.1
Turkson, J.2
Jove, R.3
-
45
-
-
27544476971
-
The role of IL-6 and STAT3 in inflammation and cancer
-
Hodge D.R., Hurt E.M., and Farrar W.L. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41 (2005) 2502-2512
-
(2005)
Eur J Cancer
, vol.41
, pp. 2502-2512
-
-
Hodge, D.R.1
Hurt, E.M.2
Farrar, W.L.3
-
46
-
-
23844445451
-
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling
-
Jenkins B.J., Grail D., Nheu T., Najdovska M., Wang B., Waring P., Inglese M., McLoughlin R.M., Jones S.A., Topley N., Baumann H., Judd L.M., Giraud A.S., Boussioutas A., Zhu H.J., and Ernst M. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med 11 (2005) 845-852
-
(2005)
Nat Med
, vol.11
, pp. 845-852
-
-
Jenkins, B.J.1
Grail, D.2
Nheu, T.3
Najdovska, M.4
Wang, B.5
Waring, P.6
Inglese, M.7
McLoughlin, R.M.8
Jones, S.A.9
Topley, N.10
Baumann, H.11
Judd, L.M.12
Giraud, A.S.13
Boussioutas, A.14
Zhu, H.J.15
Ernst, M.16
-
47
-
-
11144357779
-
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
-
Wang T., Niu G., Kortylewski M., Burdelya L., Shain K., Zhang S., Bhattacharya R., Gabrilovich D., Heller R., Coppola D., Dalton W., Jove R., Pardoll D., and Yu H. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 10 (2004) 48-54
-
(2004)
Nat Med
, vol.10
, pp. 48-54
-
-
Wang, T.1
Niu, G.2
Kortylewski, M.3
Burdelya, L.4
Shain, K.5
Zhang, S.6
Bhattacharya, R.7
Gabrilovich, D.8
Heller, R.9
Coppola, D.10
Dalton, W.11
Jove, R.12
Pardoll, D.13
Yu, H.14
-
48
-
-
20444446371
-
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
-
Alvarez J.V., Febbo P.G., Ramaswamy S., Loda M., Richardson A., and Frank D.A. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res 65 (2005) 5054-5062
-
(2005)
Cancer Res
, vol.65
, pp. 5054-5062
-
-
Alvarez, J.V.1
Febbo, P.G.2
Ramaswamy, S.3
Loda, M.4
Richardson, A.5
Frank, D.A.6
-
49
-
-
0035042611
-
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
-
Yoshikawa H., Matsubara K., Qian G.S., Jackson P., Groopman J.D., Manning J.E., Harris C.C., and Herman J.G. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 28 (2001) 29-35
-
(2001)
Nat Genet
, vol.28
, pp. 29-35
-
-
Yoshikawa, H.1
Matsubara, K.2
Qian, G.S.3
Jackson, P.4
Groopman, J.D.5
Manning, J.E.6
Harris, C.C.7
Herman, J.G.8
-
50
-
-
0345492424
-
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
-
He B., You L., Uematsu K., Zang K., Xu Z., Lee A.Y., Costello J.F., McCormick F., and Jablons D.M. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A 100 (2003) 14133-14138
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14133-14138
-
-
He, B.1
You, L.2
Uematsu, K.3
Zang, K.4
Xu, Z.5
Lee, A.Y.6
Costello, J.F.7
McCormick, F.8
Jablons, D.M.9
-
51
-
-
27144433826
-
Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma
-
Niwa Y., Kanda H., Shikauchi Y., Saiura A., Matsubara K., Kitagawa T., Yamamoto J., Kubo T., and Yoshikawa H. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene 24 (2005) 6406-6417
-
(2005)
Oncogene
, vol.24
, pp. 6406-6417
-
-
Niwa, Y.1
Kanda, H.2
Shikauchi, Y.3
Saiura, A.4
Matsubara, K.5
Kitagawa, T.6
Yamamoto, J.7
Kubo, T.8
Yoshikawa, H.9
-
52
-
-
27144540201
-
SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition
-
Weber A., Hengge U.R., Bardenheuer W., Tischoff I., Sommerer F., Markwarth A., Dietz A., Wittekind C., and Tannapfel A. SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition. Oncogene 24 (2005) 6699-6708
-
(2005)
Oncogene
, vol.24
, pp. 6699-6708
-
-
Weber, A.1
Hengge, U.R.2
Bardenheuer, W.3
Tischoff, I.4
Sommerer, F.5
Markwarth, A.6
Dietz, A.7
Wittekind, C.8
Tannapfel, A.9
|