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Volumn 11, Issue 1, 2012, Pages 113-125

Biological and chemical properties of Zingiber zerumbet Smith: A review

Author keywords

Anti HIV; Anti AD (Alzheimer's disease); Anti cancer; Anti inflammation; Multipotential Bioactivities

Indexed keywords

ANTIINFECTIVE AGENT; MORPHINE; PLANT EXTRACT; UNCLASSIFIED DRUG; ZEDERONE; ZERUMBONE; ZINGIBER ZERUMBET EXTRACT;

EID: 84861235699     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-011-9222-4     Document Type: Review
Times cited : (34)

References (105)
  • 2
    • 60249090960 scopus 로고    scopus 로고
    • Anticancer activity natural compound (zerumbone) extracted from Zingiber zerumbet in human HeLa cervical cancer cells
    • Abdul AB, Adel SA, Nirmala DT, Siddig SI, Zetty ZN, Sharin R et al (2008) Anticancer activity natural compound (zerumbone) extracted from Zingiber zerumbet in human HeLa cervical cancer cells. Int J Pharmacol 4:160-168
    • (2008) Int J Pharmacol , vol.4 , pp. 160-168
    • Abdul, A.B.1    Adel, S.A.2    Nirmala, D.T.3    Siddig, S.I.4    Zetty, Z.N.5    Sharin, R.6
  • 4
    • 76449122521 scopus 로고    scopus 로고
    • Chondroprotective effect zerumboneiodo acetate induced osteoarthritis in rats
    • Al-Saffar FJ, Ganabadi S, Fakurazi S, Yaakub H, Lip M (2010) Chondroprotective effect zerumboneiodo acetate induced osteoarthritis in rats. J Appl Sci 10(4):248-260
    • (2010) J Appl Sci , vol.10 , Issue.4 , pp. 248-260
    • Al-Saffar, F.J.1    Ganabadi, S.2    Fakurazi, S.3    Yaakub, H.4    Lip, M.5
  • 6
    • 72449201059 scopus 로고    scopus 로고
    • Molecular characterization of an oomycete-responsive PR- 5 protein gene from Zingiber zerumbet
    • Aswati Nair R, Kiran AG, Sivakumar KC, Thomas G (2010) Molecular characterization of an oomycete-responsive PR- 5 protein gene from Zingiber zerumbet. Plant Mol Biol Rep 28:128-135
    • (2010) Plant Mol Biol Rep , vol.28 , pp. 128-135
    • Aswati Nair, R.1    Kiran, A.G.2    Sivakumar, K.C.3    Thomas, G.4
  • 7
    • 26944462056 scopus 로고    scopus 로고
    • Ten years of AFLP in ecology and evolution: Why so few animals?
    • Bensch S, AkessonM(2005) Ten years of AFLP in ecology and evolution: why so few animals? Mol Ecol 14:2899-2914
    • (2005) Mol Ecol , vol.14 , pp. 2899-2914
    • Bensch, S.1    Akesson, M.2
  • 8
    • 55349099143 scopus 로고    scopus 로고
    • Zerumbone downregulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells
    • Bokyung S, Sonia J, Kwang SA, Yoichi M, Tingfang Y, Sushovan G, Mingyao L, Bhara BB (2008) Zerumbone downregulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. Cancer Res 68:21
    • (2008) Cancer Res , vol.68 , pp. 21
    • Bokyung, S.1    Sonia, J.2    Kwang, S.A.3    Yoichi, M.4    Tingfang, Y.5    Sushovan, G.6    Mingyao, L.7    Bhara, B.B.8
  • 9
    • 0030978825 scopus 로고    scopus 로고
    • Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease
    • Bordia A, Verma SK, Srivastava KC (1997) Effect of ginger (Zingiber officinale Rosc) and fenugreek (Trigomella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 56:379-384 (Pubitemid 27208438)
    • (1997) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.56 , Issue.5 , pp. 379-384
    • Bordia, A.1    Verma, S.K.2    Srivastava, K.C.3
  • 11
    • 0242366201 scopus 로고    scopus 로고
    • Chemical composition of the essential oil from rhizomes, leaves and flowers of Zingiber zerumbet Smith from Reunion Island
    • Chane-Ming J, Robert V, Chalchat JC (2003) Chemical composition of the essential oil from rhizomes, leaves and flowers of Zingiber zerumbet Smith from Reunion Island. J Essent Oil Res15(3):202-205
    • (2003) J Essent Oil Res , vol.15 , Issue.3 , pp. 202-205
    • Chane-Ming, J.1    Robert, V.2    Chalchat, J.C.3
  • 12
    • 45849117255 scopus 로고    scopus 로고
    • Anti-hypersensitive and anti-inflammatory activities of water extract of Zingiber zerumbet (L.)
    • Chaungab HC, Chi-Tang H, Tzou-Chi H (2008) Anti-hypersensitive and anti-inflammatory activities of water extract of Zingiber zerumbet (L.). Food Agric Immunol 19(2): 117-129
    • (2008) Food Agric Immunol , vol.19 , Issue.2 , pp. 117-129
    • Chaungab, H.C.1    Chi-Tang, H.2    Tzou-Chi, H.3
  • 14
    • 0030770498 scopus 로고    scopus 로고
    • Chinnese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices
    • Chiou LC, Ling JY, Chang CC (1997) Chinnese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices. Neurosci Lett 15:171-174
    • (1997) Neurosci Lett , vol.15 , pp. 171-174
    • Chiou, L.C.1    Ling, J.Y.2    Chang, C.C.3
  • 16
    • 34250354277 scopus 로고    scopus 로고
    • Modulation of P-glycoprotein-mediated resistance by kaemferol derivatives isolated from Zingiber zerumbet
    • Chung SY, Jang DS, Han AR, Jang JO, Youngjoo K, Lee HJ, Seo EK (2007) Modulation of P-glycoprotein-mediated resistance by kaemferol derivatives isolated from Zingiber zerumbet. Phytother Res 21:565
    • (2007) Phytother Res , vol.21 , pp. 565
    • Chung, S.Y.1    Jang, D.S.2    Han, A.R.3    Jang, J.O.4    Youngjoo, K.5    Lee, H.J.6    Seo, E.K.7
  • 17
    • 0030812283 scopus 로고    scopus 로고
    • Zerumbone, an HIV-inhibitory and cytotoxic sesquiterpene of Zingiber aromaticum and Z. zerumbet
    • Dai JR, Cardellina JH, McMohan JB, Boyd MR (1997) Zerumbone, an HIV-inhibiotory cytotoxic sesquiterpene of Zingiber aromaticum and Zingiber zerumbet. Nat Prod Lett 10:115-118 (Pubitemid 27292336)
    • (1997) Natural Product Letters , vol.10 , Issue.2 , pp. 115-118
    • Dai, J.-R.1    Cardellina II, J.H.2    McMahon, J.B.3    Boyd, M.R.4
  • 18
    • 0029417273 scopus 로고
    • Effects L-NG-nitro arginine methyl ester (L-NAME), L-NG monomethyl arginine (L-NMMA) and Larginione on the antinociceptive effects of morphine in mice
    • Dambisiya YM, Lee LT (1995) Effects L-NG-nitro arginine methyl ester (L-NAME), L-NG monomethyl arginine (L-NMMA) and Larginione on the antinociceptive effects of morphine in mice. Exp Clin Pharmacol 17:577-582
    • (1995) Exp Clin Pharmacol , vol.17 , pp. 577-582
    • Dambisiya, Y.M.1    Lee, L.T.2
  • 19
    • 0006386556 scopus 로고
    • Attractive reactivity of a Natural product, zerumbone
    • Damodaran NP, Dev S (1965) Attractive reactivity of a Natural product, zerumbone. Tetrahedr Lett 6:1977-1981
    • (1965) Tetrahedr Lett , vol.6 , pp. 1977-1981
    • Damodaran, N.P.1    Dev, S.2
  • 20
    • 0001345983 scopus 로고
    • Studies in sesquiterpenes - XXXVII: Sesquiterpenoids from the essential oil of Zingiber zerumbet smith
    • Damodaran NP, Dev S (1968a) Studies in sesquiterpenes - XXXVII: sesquiterpenoids from the essential oil of Zingiber zerumbet smith. Tetrahedr Lett 24:4113-4122
    • (1968) Tetrahedr Lett , vol.24 , pp. 4113-4122
    • Damodaran, N.P.1    Dev, S.2
  • 21
    • 0001025750 scopus 로고
    • Studies in sesquiterpenes - XXXVIII: Structure of humuleneepoxide-I and humulene epoxide-II
    • Damodaran NP, Dev S (1968b) Studies in sesquiterpenes - XXXVIII: structure of humuleneepoxide-I and humulene epoxide-II. Tetrahedr Lett 24:4123-4132
    • (1968) Tetrahedr Lett , vol.24 , pp. 4123-4132
    • Damodaran, N.P.1    Dev, S.2
  • 22
    • 0242326547 scopus 로고
    • Studies in sesquiterpenes - XXXIX: Structure of humulenols
    • Damodaran NP, Dev S (1968c) Studies in sesquiterpenes - XXXIX: structure of humulenols. Tetrahedr Lett 24: 4133-4142
    • (1968) Tetrahedr Lett , vol.24 , pp. 4133-4142
    • Damodaran, N.P.1    Dev, S.2
  • 25
    • 0041897612 scopus 로고
    • Highlights of the chemistry and pharmacology of wild ginger (Zingiber zerumbet Smith)
    • Duve RN (1980) Highlights of the chemistry and pharmacology of wild ginger (Zingiber zerumbet Smith) Fiji Agric J 42:41-43
    • (1980) Fiji Agric J , vol.42 , pp. 41-43
    • Duve, R.N.1
  • 26
    • 34247547489 scopus 로고    scopus 로고
    • Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells
    • DOI 10.1271/bbb.60596
    • Eguchi A, Kaneko Y, Murakami A, Ohigashi H (2007) Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. Biosci Biotechnol Biochem 71:935-945 (Pubitemid 46650943)
    • (2007) Bioscience, Biotechnology and Biochemistry , vol.71 , Issue.4 , pp. 935-945
    • Eguchi, A.1    Kaneko, Y.2    Murakami, A.3    Ohigashi, H.4
  • 27
    • 0023222245 scopus 로고
    • The medicinal plants of Gunung Leuser National Park, Indonesia
    • DOI 10.1016/0378-8741(87)90006-7
    • Elliot S, Brimacombe J (1987) The medicinal plants of Gunung Leusar National Park, Indonesia. J Ethnopharmacol 19: 285-317 (Pubitemid 17107425)
    • (1987) Journal of Ethnopharmacology , vol.19 , Issue.3 , pp. 285-317
    • Elliott, S.1    Brimacombe, J.2
  • 29
    • 39749180988 scopus 로고    scopus 로고
    • Isolation and functional characterization of a ß-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet
    • Fengnian Y, Harada H, Kazuhisa Y, Okamotoa Sh, Hirasec S, Tanaka Y, Norihiko M, Utsumia R (2008a) Isolation and functional characterization of a ß-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet. FEBS 582(5):565-572
    • (2008) FEBS , vol.582 , Issue.5 , pp. 565-572
    • Fengnian, Y.1    Harada, H.2    Kazuhisa, Y.3    Sh, O.4    Hirasec, S.5    Tanaka, Y.6    Norihiko, M.7    Utsumia, R.8
  • 30
    • 42149123319 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of a-humulenesynthase, a possible key enzyme on zerumbone biosynthesis in shampoo ginger Zingiber zerumbet Smith
    • Fengnian Y, Okamoto S, Nakasore K, Adachi K, Matsuda S, Harada H, Misawa N, Utumi R (2008b) Molecular cloning and functional characterization of a-humulenesynthase, a possible key enzyme on zerumbone biosynthesis in shampoo ginger Zingiber zerumbet Smith. Planta 227: 1291-1299
    • (2008) Planta , vol.227 , pp. 1291-1299
    • Fengnian, Y.1    Okamoto, S.2    Nakasore, K.3    Adachi, K.4    Matsuda, S.5    Harada, H.6    Misawa, N.7    Utumi, R.8
  • 31
    • 79953698422 scopus 로고    scopus 로고
    • Zingiber zerumbet CYP71BA1 catalyzes the conversion of a-humulene to 8-hydroxy-A-humulene in zerumbone biosynthesis
    • Fengnian Y, Okamoto Sh, Harada H, Kazuhisa Y, Norihiko M, Utsumi R (2010) Zingiber zerumbet CYP71BA1 catalyzes the conversion of a-humulene to 8-hydroxy-a-humulene in zerumbone biosynthesis. Cell Mol Life Sci 68:1033-1040
    • (2010) Cell Mol Life Sci , vol.68 , pp. 1033-1040
    • Fengnian, Y.1    Sh, O.2    Harada, H.3    Kazuhisa, Y.4    Norihiko, M.5    Utsumi, R.6
  • 34
    • 27744555241 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitory phenylbutenoids from the rhizomes of Zingiber cassumunar
    • DOI 10.1248/cpb.53.1466
    • Han AR, Kim MS, Jeong YH, Lee SK, Seo EK (2005) Cyclooxygenase- 2-inhibitory phenylbutanoids from the rhizomes of Zingiber cassumunar. Chem Phar Bull 53: 1466-1468 (Pubitemid 41634219)
    • (2005) Chemical and Pharmaceutical Bulletin , vol.53 , Issue.11 , pp. 1466-1468
    • Han, A.-R.1    Kim, M.-S.2    Jeong, Y.H.3    Lee, S.K.4    Seo, E.-K.5
  • 35
    • 58149151350 scopus 로고    scopus 로고
    • Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli
    • Harada H, Yu F, Okamoto S, Kuzuyama T, Utsumi R, Misawa N (2009) Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli. Appl Microbiol Biotechnol 81:915-925
    • (2009) Appl Microbiol Biotechnol , vol.81 , pp. 915-925
    • Harada, H.1    Yu, F.2    Okamoto, S.3    Kuzuyama, T.4    Utsumi, R.5    Misawa, N.6
  • 37
    • 75749086900 scopus 로고    scopus 로고
    • Phytochemical characterization and antimicrobial activity of shampoo ginger (Zingiber zerumbet) from Tamil Nadu
    • Helen MPA, Nizzy AM, Jegatheesh TR (2009) Phytochemical characterization and antimicrobial activity of shampoo ginger (Zingiber zerumbet) from Tamil Nadu. India Asian J Microbiol Biotechnol Environ Sci 11(3):625-628
    • (2009) India Asian J Microbiol Biotechnol Environ Sci , vol.11 , Issue.3 , pp. 625-628
    • Helen, M.P.A.1    Nizzy, A.M.2    Jegatheesh, T.R.3
  • 38
    • 0036849565 scopus 로고    scopus 로고
    • Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation
    • Hoffman AL, Spetner M, Burke M (2002) Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation. Carcinogenesis 23:1961
    • (2002) Carcinogenesis , vol.23 , pp. 1961
    • Hoffman, A.L.1    Spetner, M.2    Burke, M.3
  • 41
    • 16444363611 scopus 로고    scopus 로고
    • Antitrumour effects of zerumbone from Zingiber zerumbet in P-388D cells in vitro and in vivo
    • Huang GC, Chien TY, Chen LG, Wang CC (2005a) Antitrumour effects of zerumbone from Zingiber zerumbet in P-388D cells in vitro and in vivo. Plant Med 71:219-224
    • (2005) Plant Med , vol.71 , pp. 219-224
    • Huang, G.C.1    Chien, T.Y.2    Chen, L.G.3    Wang, C.C.4
  • 42
    • 16444363611 scopus 로고    scopus 로고
    • 1 cells in vitro and in vivo
    • DOI 10.1055/s-2005-837820
    • Huang G-C, Chien T-Y, Chen L-g, Wang C-C (2005b) Antitumour effects of zerumbone from Zingiber zerumbet in P-388D 1 cells in vitro and in vivo. Planta Med 71:219-224 (Pubitemid 40476777)
    • (2005) Planta Medica , vol.71 , Issue.3 , pp. 219-224
    • Huang, G.-C.1    Chien, T.-Y.2    Chen, L.-G.3    Wang, C.-C.4
  • 43
    • 0023223448 scopus 로고
    • Preliminary analysis of the antinociceptive activity of Zerumbone
    • Hunskaar S, Hole K (1987) Preliminary analysis of the antinociceptive activity of Zerumbone. Pain 30:103
    • (1987) Pain , vol.30 , pp. 103
    • Hunskaar, S.1    Hole, K.2
  • 45
    • 84861227306 scopus 로고    scopus 로고
    • Establishment of embryogenic cell suspension and field evaluation of regenerants of Zingiber zerumbet Smith
    • Idris FD, Jali M, Ibrahim H, Khalid N (2009) Establishment of embryogenic cell suspension and field evaluation of regenerants of Zingiber zerumbet Smith. Acta Horticulturae 829:p 6
    • (2009) Acta Horticulturae , vol.829 , pp. 6
    • Idris, F.D.1    Jali, M.2    Ibrahim, H.3    Khalid, N.4
  • 46
    • 23344451156 scopus 로고    scopus 로고
    • Potentially bioactive two new natural sesquiterpenoids from the rhizomes of Zingiber zerumbet
    • Jang DS, Seo EK (2005) Potentially bioactive two new natural sesquiterpenoids from the rhizomes of Zingiber zerumbet. Arch Pharm Res 28(3):294-296
    • (2005) Arch Pharm Res , vol.28 , Issue.3 , pp. 294-296
    • Jang, D.S.1    Seo, E.K.2
  • 49
    • 84861235117 scopus 로고    scopus 로고
    • Platelet activating factor (PAF) receptor binding antagonist activity of Malaysian medicinal plants
    • Jantan I, Rafi IAA, Alil J (2005) Platelet activating factor (PAF) receptor binding antagonist activity of Malaysian medicinal plants. Phyto Med 27:799-812
    • (2005) Phyto Med , vol.27 , pp. 799-812
    • Jantan, I.1    Rafi, I.A.A.2    Alil, J.3
  • 53
    • 77953215652 scopus 로고    scopus 로고
    • Screening of selected Zingiberaceae extracts for Dengue-2 virus protease inhibitory activities
    • Kiat TS, Richard P (2006) Screening of selected Zingiberaceae extracts for Dengue-2 virus protease inhibitory activities. Sun Acad J 3:1-7
    • (2006) Sun Acad J , vol.3 , pp. 1-7
    • Kiat, T.S.1    Richard, P.2
  • 55
    • 0041510434 scopus 로고    scopus 로고
    • Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone
    • Kirana C, McIntosh GH, Record IR, Jones GP (2003) Antitumour activity of extracts of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr Cancer 45:218-225 (Pubitemid 37022796)
    • (2003) Nutrition and Cancer , vol.45 , Issue.2 , pp. 218-225
    • Kirana, C.1    McIntosh, G.H.2    Record, I.R.3    Jones, G.P.4
  • 56
    • 0033574390 scopus 로고    scopus 로고
    • Chemistry of Zerumbone Simplified isolation, conjugate addition reactions, and a unique ring contracting transannular reaction of its dibromide
    • Kitayama T, Okamoto T, Hill RK, Kawai Y, Takahashi S, Yonemori S, Yamamoto Y, Ohe K, Uemura S, Sawada S (1999) Chemistry of Zerumbone Simplified isolation, conjugate addition reactions, and a unique ring contracting transannular reaction of its dibromide. J Org Chem 64: 2667-2672
    • (1999) J Org Chem , vol.64 , pp. 2667-2672
    • Kitayama, T.1    Okamoto, T.2    Hill, R.K.3    Kawai, Y.4    Takahashi, S.5    Yonemori, S.6    Yamamoto, Y.7    Ohe, K.8    Uemura, S.9    Sawada, S.10
  • 63
    • 44949286405 scopus 로고
    • Acetylated flavonol glycosides from Zingiber zerumbet
    • Masuda T, Akiko J, Shigeru K, Nobuji N (1991) Acetylated flavonol glycosides from Zingiber zerumbet. Phytochemistry 30(7):2391-2392
    • (1991) Phytochemistry , vol.30 , Issue.7 , pp. 2391-2392
    • Masuda, T.1    Akiko, J.2    Shigeru, K.3    Nobuji, N.4
  • 64
    • 0033202940 scopus 로고    scopus 로고
    • Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation
    • Murakami A, Takahashi M, Jiwajinda S, Koshimizu K, Ohigashi H (1999) Identification of Zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol- 13-acetate-induced Epstein-Barr virus activation. Biosci Biotechnol Biochem 63(10):1811-1812 (Pubitemid 129548415)
    • (1999) Bioscience, Biotechnology and Biochemistry , vol.63 , Issue.10 , pp. 1811-1812
    • Murakami, A.1    Takahashi, M.2    Jiwajinda, S.3    Koshimizu, K.4    Ohigashi, H.5
  • 65
    • 0036258778 scopus 로고    scopus 로고
    • Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The α,β-unsaturated carbonyl group is a prerequisite
    • Murakami A, Takahashi D, Kinoshita T et al (2002) Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the a, b-unsaturated carbonyl group is a prerequisite. Carcinogenesis 23:795-802 (Pubitemid 34567518)
    • (2002) Carcinogenesis , vol.23 , Issue.5 , pp. 795-802
    • Murakami, A.1    Takahashi, D.2    Kinoshita, T.3    Koshimizu, K.4    Kim, H.W.5    Yoshihiro, A.6    Nakamura, Y.7    Jiwajinda, S.8    Terao, J.9    Ohigashi, H.10
  • 66
    • 0141852339 scopus 로고    scopus 로고
    • Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: Separately and in combination
    • DOI 10.1016/S0006-2952(03)00446-5
    • Murakami A, Hayashi R, Tanaka T, Kwon KH, Ohigashi H, Safitri R (2003) Suppression of dextran sodium sulfateinduced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem Pharmacol 66:1253-1261 (Pubitemid 37130300)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.7 , pp. 1253-1261
    • Murakami, A.1    Hayashi, R.2    Takana, T.3    Kwon, K.H.4    Ohigashi, H.5    Safitri, R.6
  • 68
    • 4143081630 scopus 로고    scopus 로고
    • Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes
    • DOI 10.1016/j.febslet.2004.07.042, PII S0014579304009068
    • Nakamura Y, Yoshida C, Murakami A, Ohigashi H, Osawa T, Uchida K (2004) Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett 572(1-3):245-250 (Pubitemid 39092543)
    • (2004) FEBS Letters , vol.572 , Issue.1-3 , pp. 245-250
    • Nakamura, Y.1    Yoshida, C.2    Murakami, A.3    Ohigashi, H.4    Osawa, T.5    Uchida, K.6
  • 70
    • 67649983452 scopus 로고    scopus 로고
    • Hedgehog-Gli signaling pathway inhibitors as anticancer
    • Neeraj M, Chandanamali P, Naoaki F (2009) Hedgehog-Gli signaling pathway inhibitors as anticancer. Agents J Med Chem 52(13):3829-3845
    • (2009) Agents J Med Chem , vol.52 , Issue.13 , pp. 3829-3845
    • Neeraj, M.1    Chandanamali, P.2    Naoaki, F.3
  • 71
    • 0242357944 scopus 로고
    • Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL 12-induced i NVASION of breast and pancreatic tumor cells
    • Nigam LC, Levi L (1963a) Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL 12-induced I NVASION of breast and pancreatic tumor cells. Can J Chem 41:1726-1730
    • (1963) Can J Chem , vol.41 , pp. 1726-1730
    • Nigam, L.C.1    Levi, L.2
  • 72
    • 0023732557 scopus 로고
    • Inhibition of the tumour promoting action of 12-O-tetradecanoylphorbol- 13-asetate by some oleane-type triterpenoid compounds
    • Nishino H, Nishino A, Takayasu J, Hasegawa T, Iwashima A, Hirabayashi K, Iwata S, Shibata S (1988) Inhibition of the tumour promoting action of 12-O-tetradecanoylphorbol- 13-asetate by some oleane-type triterpenoid compounds. Cancer Res 48:5210
    • (1988) Cancer Res , vol.48 , pp. 5210
    • Nishino, H.1    Nishino, A.2    Takayasu, J.3    Hasegawa, T.4    Iwashima, A.5    Hirabayashi, K.6    Iwata, S.7    Shibata, S.8
  • 74
    • 33748483259 scopus 로고    scopus 로고
    • Development of anti-dementia drugs related to neurotrophic factors
    • DOI 10.1248/yakushi.126.747
    • Obara Y (2006) Development of antidementia drugs related to neurotrophic factors. Yakugaku Zasshi 126:747-755 (Pubitemid 44358774)
    • (2006) Yakugaku Zasshi , vol.126 , Issue.9 , pp. 747-755
    • Obara, Y.1
  • 75
    • 0036849565 scopus 로고    scopus 로고
    • Redox-regulated mechanism may account for zerumbone's ability to suppress cancer cell proliferation
    • Ohigashi H, Murakami A (2002) Redox-regulated mechanism may account for zerumbone's ability to suppress cancer cell proliferation. Carcinogenesis 23(12):1963
    • (2002) Carcinogenesis , vol.23 , Issue.12 , pp. 1963
    • Ohigashi, H.1    Murakami, A.2
  • 76
    • 73349099843 scopus 로고
    • Isolation, purification and characterization of antimicrobial principle from Zingiber zerumbet
    • Oliveros MB, Cantoria MC (1982) Isolation, purification and characterization of antimicrobial principle from Zingiber zerumbet. Smith Int J Crude Drug Res 203:141-153
    • (1982) Smith Int J Crude Drug Res , vol.203 , pp. 141-153
    • Oliveros, M.B.1    Cantoria, M.C.2
  • 77
    • 0030038389 scopus 로고    scopus 로고
    • Cisdiaminedichloroplatinum-induced cell dead through apoptosis in sensitive and resistant human ovarian carcinoma cell lines
    • Ormerod MG, Neill CO, Robertson D, Kelland LR, Harrap KR (1996) Cisdiaminedichloroplatinum-induced cell dead through apoptosis in sensitive and resistant human ovarian carcinoma cell lines. Cancer Chemother Pharmacol 37: 463-471
    • (1996) Cancer Chemother Pharmacol , vol.37 , pp. 463-471
    • Ormerod, M.G.1    Neill, C.O.2    Robertson, D.3    Kelland, L.R.4    Harrap, K.R.5
  • 78
    • 0025992016 scopus 로고
    • Anti-inflammatory effect of Zingiber cassumunar Roxb and its active principles
    • Ozaki Y, Kawahara N, Harada M (1991) Anti-inflammatory effect of Zingiber cassumunar Roxb and its active principles. Chem Pharm Bull 39:2353-2356
    • (1991) Chem Pharm Bull , vol.39 , pp. 2353-2356
    • Ozaki, Y.1    Kawahara, N.2    Harada, M.3
  • 80
    • 10544249810 scopus 로고
    • Terpenoids - XXXI: Isolation of humulene monoxide and humulenedioxide
    • Ramaswami SK, Bhattacharyya SC (1962) Terpenoids - XXXI: Isolation of humulene monoxide and humulenedioxide. Tetrahedron 18:5575-5579
    • (1962) Tetrahedron , vol.18 , pp. 5575-5579
    • Ramaswami, S.K.1    Bhattacharyya, S.C.2
  • 81
    • 84861232547 scopus 로고    scopus 로고
    • Comparative study on the rhizomes essential oil of three Zingiber species from Manipur
    • Rana VS, Verdeguer M, Blazquez MA (2008) Comparative study on the rhizomes essential oil of three Zingiber species from Manipur. Indian perfumer 52:17-18
    • (2008) Indian Perfumer , vol.52 , pp. 17-18
    • Rana, V.S.1    Verdeguer, M.2    Blazquez, M.A.3
  • 82
    • 13944281987 scopus 로고    scopus 로고
    • Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2)
    • DOI 10.1021/jf0490798
    • Rasmos S, Alia M, Bravo L, Goya L (2005) Comparative effects of food derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). J Agric Food Chem 53:1271-1280 (Pubitemid 40270427)
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , Issue.4 , pp. 1271-1280
    • Ramos, S.1    Alia, M.2    Bravo, L.3    Goya, L.4
  • 84
    • 33749521888 scopus 로고    scopus 로고
    • Neuronal control of skin function: The skin as a neuroimmunoendocrine organ
    • DOI 10.1152/physrev.00026.2005
    • Roosterman D, Goerge T, Schneider SW, BunnettNW,Steinhoff M (2006) Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev 86:1309-1379 (Pubitemid 44523706)
    • (2006) Physiological Reviews , vol.86 , Issue.4 , pp. 1309-1379
    • Roosterman, D.1    Goerge, T.2    Schneider, S.W.3    Bunnett, N.W.4    Steinhoff, M.5
  • 85
    • 70349616803 scopus 로고    scopus 로고
    • Development and validation of an HPTLC method for analysis of Zerumbone, the anticancer marker from Zingiber zerumbe
    • Rout KK, Mishra SK, Sherma J (2009) Development and validation of an HPTLC method for analysis of Zerumbone, the anticancer marker from Zingiber zerumbe. Acta Chromatographica 3:443-452
    • (2009) Acta Chromatographica , vol.3 , pp. 443-452
    • Rout, K.K.1    Mishra, S.K.2    Sherma, J.3
  • 86
    • 34247218059 scopus 로고    scopus 로고
    • Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio
    • Sharifah S, Handayani ST, Hawariah LPA (2007) Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Cancer Cell Int 7:1-11
    • (2007) Cancer Cell Int , vol.7 , pp. 1-11
    • Sharifah, S.1    Handayani, S.T.2    Hawariah, L.P.A.3
  • 87
    • 77953603824 scopus 로고    scopus 로고
    • Planar chromatography
    • Sherma J (2010) Planar chromatography. Anal Chem 82: 4895-4910
    • (2010) Anal Chem , vol.82 , pp. 4895-4910
    • Sherma, J.1
  • 88
    • 77953215652 scopus 로고    scopus 로고
    • Screening of selected Zingiberaceae extracts for dengue-2 virus protease inhibitory activities
    • SiewKiat T, Richard P (2006) Screening of selected Zingiberaceae extracts for dengue-2 virus protease inhibitory activities. Sun Acad J 3:1-7
    • (2006) Sun Acad J , vol.3 , pp. 1-7
    • Siewkiat, T.1    Richard, P.2
  • 89
    • 0037983965 scopus 로고    scopus 로고
    • Anti-inflammatory property of ethanol and water extracts of Z. zerumbet
    • Somchit MN, Shukriyah MH (2005) Anti-inflammatory property of ethanol and water extracts of Z. zerumbet. Indian Pharmacol 35:181-182
    • (2005) Indian Pharmacol , vol.35 , pp. 181-182
    • Somchit, M.N.1    Shukriyah, M.H.2
  • 92
    • 69249083578 scopus 로고    scopus 로고
    • Zerumbone induces TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species
    • Supachai Y, Sung B, Pornngarm L, Bharat BA (2009) Zerumbone induces TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: evidence for an essential role of reactive oxygen species. Cancer Res 69(16):6581-6589
    • (2009) Cancer Res , vol.69 , Issue.16 , pp. 6581-6589
    • Supachai, Y.1    Sung, B.2    Pornngarm, L.3    Bharat, B.A.4
  • 93
    • 33845994041 scopus 로고    scopus 로고
    • Antiallergic activity of some selected plants in the zingiberaceae family
    • Supinya T, Sanan S (2007) Antiallergic activity of some selected plants in the zingiberaceae family. J Ethnopharmacol 109:535-538
    • (2007) J Ethnopharmacol , vol.109 , pp. 535-538
    • Supinya, T.1    Sanan, S.2
  • 94
    • 73349097062 scopus 로고    scopus 로고
    • Studies on the volatile oil components in Zingiber zerumbet smith rhizomes by gas chromatography
    • Supinya T, Sardsaengjun C, Itchayapruk J, Chaitongruk P (1997) Studies on the volatile oil components in Zingiber zerumbet smith rhizomes by gas chromatography. J Sci Technol (Thailand) 19(2):197-202
    • (1997) J Sci Technol (Thailand) , vol.19 , Issue.2 , pp. 197-202
    • Supinya, T.1    Sardsaengjun, C.2    Itchayapruk, J.3    Chaitongruk, P.4
  • 95
    • 34748873851 scopus 로고    scopus 로고
    • Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology
    • DOI 10.1097/mpa.0b013e318070d791, PII 0000667620071000000009
    • Szabolcs A, Tiszlavicz L, Kaszaki J, Posa A, Berko A, Varga IS, Boros I, Szuts V, Lonovics J (2007) Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology. Pancrease 35(30):249-255 (Pubitemid 47482518)
    • (2007) Pancreas , vol.35 , Issue.3 , pp. 249-255
    • Szabolcs, A.1    Tiszlavicz, L.2    Kaszaki, J.3    Posa, A.4    Berko, A.5    Varga, I.S.6    Boros, I.7    Szuts, V.8    Lonovics, J.9    Takacs, T.10
  • 96
    • 77954427466 scopus 로고    scopus 로고
    • Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene- promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)
    • Taha MME, Abdula BA, Abdullah R, Ibrahimc TAT, Abdelwahaba SI, Mohana S (2010) Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene- promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem Biol Interact 186(3):295-305
    • (2010) Chem Biol Interact , vol.186 , Issue.3 , pp. 295-305
    • Taha, M.M.E.1    Abdula, B.A.2    Abdullah, R.3    Ibrahimc, T.A.T.4    Abdelwahaba, S.I.5    Mohana, S.6
  • 97
    • 75649144324 scopus 로고    scopus 로고
    • Zerumbone abolishes NF-kappa B and i Kappa Balpha kinase activation leading to suppression of anti-apoptotic and metastatic gene expression, upregulation of apoptosis and down regulation of invasion
    • Takada Y, Murakami A, Agarwal BB (2005) Zerumbone abolishes NF-kappa B and I Kappa Balpha kinase activation leading to suppression of anti-apoptotic and metastatic gene expression, upregulation of apoptosis and down regulation of invasion. Oncogene 17:122-130
    • (2005) Oncogene , vol.17 , pp. 122-130
    • Takada, Y.1    Murakami, A.2    Agarwal, B.B.3
  • 99
    • 73349112387 scopus 로고
    • Zingiber Zerumbet (L)J.E. Smith from phathalung province Thailand
    • Thebpatiphat
    • Thebpatiphat (1984) Zingiber Zerumbet (L)J.E. Smith from phathalung province Thailand. J Sci Res 9(1):116-124
    • (1984) J Sci Res , vol.9 , Issue.1 , pp. 116-124
  • 100
    • 84861229531 scopus 로고
    • Chemical examination of the rhizomes of Zingiber zerumbet Smith
    • Varier NS (1944) Chemical examination of the rhizomes of Zingiber zerumbet Smith. Proc Math Sci 20(5):5257-5260
    • (1944) Proc Math Sci , vol.20 , Issue.5 , pp. 5257-5260
    • Varier, N.S.1
  • 101
    • 0032925799 scopus 로고    scopus 로고
    • Antitumour promoter activity in Malaysian ginger rhizobia used in traditional medicine
    • Vimala S, Norhanom AW, Yadav M (1999) Antitumour promoter activity in Malaysian ginger rhizobia used in traditional medicine. Br J Cancer 80:10-116
    • (1999) Br J Cancer , vol.80 , pp. 10-116
    • Vimala, S.1    Norhanom, A.W.2    Yadav, M.3
  • 102
    • 33749817742 scopus 로고    scopus 로고
    • Antibacterial activity of extracts from family Zingiberaceae against foodborne pathogens
    • DOI 10.1111/j.1745-4565.2006.00052.x
    • Voravuthikunchai VP, Limsuwan S, Suparol O, Subhadhirasakul S (2006) Antibacterial activity of extracts from family Zingiberaceae against food borne pathogens. J Food Safety 26:325-334 (Pubitemid 44564225)
    • (2006) Journal of Food Safety , vol.26 , Issue.4 , pp. 325-334
    • Voravuthikunchai, S.P.1    Limsuwan, S.2    Supapol, O.3    Subhadhirasakul, S.4
  • 104
    • 33751332527 scopus 로고    scopus 로고
    • Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway
    • DOI 10.1111/j.1349-7006.2006.00362.x
    • Xian M, Ito K, Nakazato T et al (2007) Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria mediated pathway. Cancer Sci 98:118-126 (Pubitemid 44803930)
    • (2007) Cancer Science , vol.98 , Issue.1 , pp. 118-126
    • Xian, M.1    Ito, K.2    Nakazato, T.3    Shimizu, T.4    Chen, C.-K.5    Yamato, K.6    Murakami, A.7    Ohigashi, H.8    Ikeda, Y.9    Kizaki, M.10
  • 105
    • 77953218946 scopus 로고    scopus 로고
    • Anti-inflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems
    • Zakaria Z, Mohamad AAS, Chear CT, Wong YY, Israf DA, Sulaiman MR (2010) Anti-inflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems. Med Princ Pract 19:287-294
    • (2010) Med Princ Pract , vol.19 , pp. 287-294
    • Zakaria, Z.1    Mohamad, A.A.S.2    Chear, C.T.3    Wong, Y.Y.4    Israf, D.A.5    Sulaiman, M.R.6


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