cis-Diamminedichloroplatinum(II)-induced cell death through apoptosis in sensitive and resistant human ovarian carcinoma cell lines

Cancer Chemotherapy and Pharmacology

Volumn 37, Issue 5, 1996, Pages 463-471

  Ormerod, Michael G ^a,b   O'Neill, Ciaran ^a   Robertson, David ^a   Kelland, Lloyd R ^a   Harrap, Kenneth R ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

Apoptosis; Cisplatin; Flow cytometry; Ovarian carcinoma

Indexed keywords

CISPLATIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DNA BINDING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA L 1210; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 0030038389     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050413     Document Type: Article

References (66)

1. Andrews PA, Howell SB (1990) Cellular pharmacology of cis-platin, perspectives on mechanisms of acquired resistance. Cancer Cells 2:35
2. Arends MJ, Wyllie AH (1991) Apoptosis, mechanisms, role in pathology. Int Rev Exp Pathol 32:223
3. Arends MJ, Morris RG, Wyllie AH (1990) Apoptosis. The role of endonuclease. Am J Pathol 136:595
4. Barry MA, Behnke CA, Eastman A (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol 40:2353
5. Boe R, Gjersten BT, Vintermyr OK, Houge H, Lanotte M, Doskeland SO (1991) The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 195:237
6. Bramson J, Panasci LC (1993) Effect of ERCC-1 over-expression on sensitivity of Chinese hamster ovary cells to DNA damaging agents. Cancer Res 53:3237
7. Brown DG, Sun X-M Cohen GM (1993) Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J Biol Chem 268:3037
8. Cohen GM, Sun X-M, Snowden RT, Dinsdale D, Skilleter DN (1992) Morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem J 286:331
9. Collins RJ, Harmon BV, Gobé GC, Kerr JF (1992) Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Radiat Biol 61:451
10. Compton MM (1992) A biochemical hallmark of apoptosis, internucleosomal degradation of the genome. Cancer Metastasis Rev 11:105
11. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, Traganos F (1992) Features of apoptotic cells measured by flow cytometry. Cytometry 13:795
12. De Graeff A, Slebos RJ, Rodenhuis S (1988) Resistance to cisplatin, analogues: mechanisms, potential clinical implications. Cancer Chemother Pharmacol. 22:325
13. Demarcq C, Bastian B, Remvikos Y (1992) BrdUrd DNA flow cytometry analysis demonstrates cis-diamminedichloroplatinum(II)-induced multiple cell-cycle modifications on human lung carcinoma cells. Cytometry 13:416
14. Dive C, Hickman JA (1991) Drug-target interactions, only the first step in the commitment to a programmed cell death? Br J Cancer 64:192
15. Evan G, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119
16. Evans DL, Dive C (1993) Effects of cisplatin on the induction apoptosis in proliferating hepatoma cells, non proliferating immature thymocytes. Cancer Res. 53:2133
17. Evans DL, Tilby M, Dive C (1994) Differential sensitivity to the induction of apoptosis by cisplatin in proliferating, quiescent immature rat thymocytes is independent of the levels of drug accumulation. DNA adduct formation. Cancer Res 54:1596
18. Fearnhead HO, Chwalinski M, Snowden RT, Ormerod MG, Cohen GM (1984) Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle. Biochem Pharmacol 48:1073
19. Fogh J, Fogh JM, Orfeo T (1977) One hundred twenty-seven cultured tumour cell lines producing tumours in nude mice. J Natl Cancer Inst 59:221
20. Fraval HNA, Roberts JJ (1978) Effects of cis-platinumdiamminedichloride on survival, the rate of DNA synthesis in synchronously growing Chinese hamster V79-379A cells in the absence presence of caffeine inhibited post replication repair, evidence for an inducible repair mechanism. Chem Biol Interact 23:99-110
21. Hickman JA (1992) Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11:121
22. Hill BT, Shellard SA, Fichtinger-Schepman AM, Schmoll HJ, Harstrick A (1994) Differential formation and enhanced removal of specific cisplatin-DNA adducts in two cisplatin-selected resistant human testicular teratoma sublines. Anticancer Drugs 5:321
23. Hills CA, Kelland LR, Abel G, Siracky J, Wilson AP, Harrap KR (1989) Biological properties of ten human ovarian carcinoma cell lines, calibration in vitro against four platinum complexes. Br J Cancer 59:527
24. Hromas RA, Andrews PA, Murphy MP, Burns CP (1987) Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells. Cancer Lett 34:9
25. Kanter P, Leister KJ, Tomei LD, Wenner PA, Wenner CE (1992) Epidermal growth factor, tumour promoters prevent DNA fragmentation by different mechanisms. Biochem Biophys Res Commun 11:392
26. Karran P, Bignami M (1994) DNA damage tolerance, mismatch repair and genome instability. Bioessays 16:833
27. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304
28. Kellund LR, Mistry P, Abel G, Lob SY, O'Neill CF, Murrer BA, Harrap KR (1992) Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine amine plutinum(IV) dicarboxylates. Cancer Res 52:3857
29. Kerr JFR, Harmon BV (1991) Definition, incidence of apoptosis, an historical perspective. In: Tomei LD, Cope FO (eds) Apoptosis, the molecular basis of cell death. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York pp. 5-29
30. Lane DP (1992) p53, guardian of the genome. Nature 358:15
31. Loehrer PJ, Einhorn LH (1984) Cisplatin, diagnosis, treatment. Ann Intern Med 100:704
32. Lowe SW, Rutley HE, Jacks T, Housman DE. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957
33. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Tyler J (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847
34. Modrich P (1991) Mechanisms and biological effects of mismatch repair. Annu Rev Genet 25:229
35. Nicolson MC, Orr RM, O'Neill CF, Harrap KR (1992) The role of platinum uptake, glutathione levels in L1210 cells sensitive, resistant to cisplatin, tetraplatin or carboplatin. Neoplasma 39:189
36. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Shulte-Hermann R (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-β1. Proc Natl Acad Sci USA 89:5408
37. Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE, Walker PR, Sikorska M (1993) Apoptotic death in epithelial cells, cleavage of DNA to 300 and or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12:3679
38. O'Neill CF, Orr RM, Kelland LR, Harrap KR (1992a) Studies of Pt DNA interactions in human ovarian carcinoma cell lines sensitive, resistant to cisplatin (abstract). Br J Cancer 65 [Suppl XVI]:64
39. O'Neill CF, Orr RM, Kelland LR, Harrap KR (1992b) Formation, removal of platinum DNA adducts in human ovarian carcinoma cell lines sensitive, resistant to cisplatin (abstract). Proc Am Assoc Cancer Res 33:535
40. O'Neill CF, Orr RM, Kelland LR, Harrap KR (1995) Comparison of platinum (Pt) binding to DNA, and removal of total Pt adducts and inter-strand cross-links in three human ovarian carcinoma cell lines sensitive and resistant to cisplatin. Cell Pharmacol 2:1
41. Ormerod MG (1994a) Analysis of DNA. General methods. In: Ormerod MG (ed) Flow cytometry. A practical approach, 2nd edn. IRL Press Oxford University Press, Oxford, pp 119-135
42. Ormerod MG (1994b) Further applications to cell biology. In: Ormerod MG (ed) Flow cytometry. A practical approach, 2nd ed. IRL Press Oxford University Press, Oxford pp 261-273
43. Ormerod MG (1994c) Flow cytometry. Bios, Oxford
44. Ormerod MG, Payne AWR, Watson JV (1987) Improved program for the analysis of DNA histograms. Cytometry 8:637
45. Ormerod MG, Collins MKL, Rodriguez-Tarduchy G, Robertson D (1992) Apopltsis in interleukin-3-dependent haemopoietic cells. Quantification by two flow cytometric methods. J Immunol Methods 153:57
46. Ormerod MG, O'Neill CF, Orr RM, Robertson D, Titley JC, Kelland L, Harrap KR (1994) Cytotoxicity of platinum drugs: role of apoptosis (abstract). Cytometry [Suppl] 7:24
47. Ormerod MG, O'Neill CF, Robertson D, Harrap KR (1994) Cisplatin induces apoptosis in a human ovarian carcinoma cell line without concomitant internucleosomal degradation of DNA. Exp Cell Res 206:231
48. Ormerod MG, Orr RM, Peacock JH (1994) The role of apoptosis in cell killing by cisplatin, a flow cytometric study. Br J Cancer 69:93
49. Perez RP, Godwin AK, Handel LM, Hamilton TC (1993) A comparison of clonogenic, microtetrazolium and sulforhodamine B assays for determination of cisplatin cytotoxicity in human ovarian carcinoma cell lines. Eur J Cancer 29A:395
50. Piacentini M, Fesus L, Melino G (1993) Multiple cell cycle access to the apoptotic death programme in human neuroblastoma cells. FEBS Lett 320:150
51. Rampino NJ, Bohr VA (1994) Rapid gene-specific repair of cisplatin lesions at the human DUG/DHFR locus comprising the divergent upstream gene and dihydrofolate reductase gene during early G1 phase of the cell cycle assayed by using the exonucleolytic activity of T4 DNA polymerase. Proc Natl Acad Sci USA 91:10977
52. Richon VM, Schulte N, Eastman A (1987) Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) on murine leukemia L1210 cells. Cancer Res 47:2056
53. 2 inhibit DNA synthesis in cultured L1210 leukemia cells. Biochem Biophys Res Commum 112:555
54. Sheibani N, Jennerwein MM, Eastman A (1989) DNA repair in cells sensitive, resistant to cis-diamminedichloroplatinum(II); host cell reactivation of damaged plasmid DNA. Biochemistry 28:3120
55. Shellard SA, Hosking LK, Hill BT (1991) Anomalous relationship between cisplatin sensitivity and the formation and removal of platinum-DNA adducts in two human ovarian carcinoma cell lines in vitro. Cancer Res 51:455
56. Sorenson CM, Eastman A (1988) Influence of cis-diamminedichloroplatinum(II) on DNA synthesis, cell cycle progression in excision repair proficient, deficient Chinese hamster ovary cells. Cancer Res 48:6703
57. Sorenson CM, Barry MA, Eastman A (1990) Analysis of events associated with cell cycle arrest at G2 phase, cell death induced by cisplatin. J Natl Cancer Inst 82:749
58. Tomei LD, Shapiro JP, Cope FO (1993) Apoptosis in C3H/10T1/2_ mouse embryonic cells, evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc Natl Acad Sci USA 90:853
59. Walker PR, Smith C, Youdale T, Leblanc J, Whitfield JF, Sikorska M (1991) Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res 51:1078
60. Walton MI, Koshy P, Wu E, Kelland LR (1995) Molecular characterisation of a panel of human ovarian cancers with respect to p53 status and cis-platinum chemosensitivity (abstract 121). Proceedings, 7th international symposium on platinum and other metal co-ordination compounds in cancer chemotherapy. European Cancer Centre, Amsterdam, March 1-4
61. Wiltshaw E, Carr B (1984) cis-Platinumdiamminedichloride. In: Connors TA, Roberts JJ (eds) Platinum coordination complexes in cancer chemotherapy. Springer, Berlin Heidelberg New York, pp 178-182
62. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endonuclease activation. Nature 284:555
63. Wyllie AH (1988) Apoptosis. ISI Atlas Sci Immunol 1:192
64. Wyllie AH, Kerr JFR, Currie AR (1980) Cell death, the significance of apoptosis. Int Rev Cytol 68:251
65. Yaginuma Y, Westphal H (1992) Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res 52:4196
66. Zhen W, Link CJ, O'Connor PM, Reed E, Parker R, Howell SB, Bohr VA (1992) Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines. Mol Cell Biol 12:3689