Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology

Pancreas

Volumn 35, Issue 3, 2007, Pages 249-255

  Szabolcs, Annamária ^a,c   Tiszlavicz, László ^a   Kaszaki, József ^a   Pósa, Anikó ^a   Berkó, Anikó ^a   Varga, Ilona S ^b   Boros, Imre ^b   Szüts, Viktória ^a   Lonovics, János ^a   Takács, Tamás ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c NONE   (Hungary)

Author keywords

Pancreatitis; Rat; Zerumbone

Indexed keywords

2,6,9,9 TETRAMETHYLCYCLOUNDECA 2,6,10 TRIEN 1 ONE; AMYLASE; ANTIINFLAMMATORY AGENT; CHOLECYSTOKININ OCTAPEPTIDE; COPPER ZINC SUPEROXIDE DISMUTASE; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; MANGANESE; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOLOGY; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL LIPASE BLOOD LEVEL;

ACUTE DISEASE; AMYLASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CALCIUM; DRUG EVALUATION, PRECLINICAL; I-KAPPA B PROTEINS; INTERLEUKIN-6; LIPASE; MALE; NITRIC OXIDE SYNTHASE TYPE II; ORGAN SIZE; PANCREATITIS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SESQUITERPENES; SINCALIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34748873851     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/mpa.0b013e318070d791     Document Type: Article

References (44)

1. Gorelick FS, Otani T. Mechanisms of intracellular zymogen activation. Baillieres Best Pract Res Clin Gastroenterol. 1999;13:227-240.
2. Raraty MG, Murphy JA, McLoughlin E, et al. Mechanisms of acinar cell injury in acute pancreatitis. Scand J Surg. 2005;94:89-96.
3. Bhatia M, Wong FL, Cao Y, et al. Pathophysiology of acute pancreatitis. Pancreatology. 2005;5:132-144.
4. Meng Y, Ma QY, Kou XP, et al. Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis. World J Gastroenterol. 2005;11:525-528.
5. Rakonczay Z Jr, Jarmay K, Kaszaki J, et al. NF-kappaB activation is detrimental in arginine-induced acute pancreatitis. Free Radic Biol Med. 2003;34:696-709.
6. Yagci G, Gul H, Simsek A, et al. Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats. J Gastroenterol. 2004;39:268-276.
7. Araki Y, Andoh A, Yokono T, et al. The free radical scavenger edaravone suppresses experimental closed duodenal loop-induced acute pancreatitis in rats. Int J Mol Med. 2003;12:121-124.
8. Czako L, Takacs T, Varga IS, et al. Oxidative stress in distant organs and the effects of allopurinol during experimental acute pancreatitis. Int J Pancreatol. 2000;27:209-216.
9. Letoha T, Somlai C, Takacs T, et al. A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis. World J Gastroenterol. 2005;11:990-999.
10. Li ZD, Ma QY, Wang CA. Effect of resveratrol on pancreatic oxygen free radicals in rats with severe acute pancreatitis. World J Gastroenterol. 2006;12:137-140.
11. Szabolcs A, Varga IS, Varga C, et al. Beneficial effect of resveratrol on cholecystokinin-induced experimental pancreatitis. Eur J Pharmacol. 2006;532:187-193.
12. Takacs T, Czako L, Jarmay K, et al. Time-course changes in pancreatic laboratory and morphologic parameters in two different acute pancreatitis models in rats. Acta Med Hung. 1994;50:117-130.
13. Takacs T, Farkas G Jr, Czako L, et al. Time-course changes in serum cytokine levels in two experimental acute pancreatitis models in rats. Res Exp Med (Berl). 1996;196:153-161.
14. Willemer S, Elsasser HP, Adler G. Hormone-induced pancreatitis. Eur Surg Res. 1992;24(suppl 1):29-39.
15. Jungermann J, Lerch MM, Weidenbach H, et al. Disassembly of rat pancreatic acinar cell cytoskeleton during supramaximal secretagogue stimulation. Am J Physiol. 1995;268:G328-G338.
16. Niederau C, Luthen R, Klonowski-Stumpe H, et al. The role of calcium in pancreatitis. Hepatogastroenterology. 1999;46:2723-2730.
17. Chen X, Ji B, Han B, et al. NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology. 2002;122:448-457.
18. Gukovsky I, Gukovskaya AS, Blinman TA, et al. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol. 1998;275:G1402-G1414.
19. Kirana C, McIntosh GH, Record IR, et al. Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr Cancer. 2003;45:218-225.
20. Takada Y, Murakami A, Aggarwal BB. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene. 2005;24:6957-6969.
21. Murakami A, Ohigashi H. Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells. Biol Chem. 2006;387:387-392.
22. Murakami A, Shigemori T, Ohigashi H. Zingiberaceous and citrus constituents, 1′-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action. J Nutr. 2005;135:2987S-2992S.
23. Murakami A, Takahashi D, Kinoshita T, et al. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite. Carcinogenesis. 2002;23:795-802.
24. Murakami A, Hayashi R, Tanaka T, et al. Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem Pharmacol. 2003;66:1253-1261.
25. Penke B, Hajnal F, Lonovics J, et al. Synthesis of potent heptapeptide analogues of cholecystokinin. J Med Chem. 1984;27:845-849.
26. Knowles RG, Salter M. Measurement of NOS activity by conversion of radiolabeled arginine to citrulline using ion-exchange separation. Methods Mol Biol. 1998;100:67-73.
27. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170-3175.
28. Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem. 1971;44:276-287.
29. Goa J. A micro biuret method for protein determination; determination of total protein in cerebrospinal fluid. Scand J Clin Lab Invest. 1953;5:218-222.
30. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983;11:1475-1489.
31. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
32. Hoffman A, Spetner LM, Burke M. Redox-regulated mechanism may account for zerumbone's ability to suppress cancer-cell proliferation. Carcinogenesis. 2002;23:1961.
33. Liao YH, Houghton PJ, Hoult JR. Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod. 1999;62:1241-1245.
34. Ozaki Y, Kawahara N, Harada M. Anti-inflammatory effect of Zingiber cassumunar Roxb. and its active principles. Chem Pharm Bull (Tokyo). 1991;39:2353-2356.
35. Nhareet Somchit M, Nur Shukriyah MH. Antiinflammatory property of ethanol and water extracts of Zingiber zerumbet. Indian J Pharmacol. 2003;35:181-182.
36. Huang GC, Chien TY, Chen LG, et al. Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo. Planta Med. 2005;71:219-224.
37. Szabolcs A, Reiter RJ, Letoha T, et al. Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats. World J Gastroenterol. 2006;12:251-258.
38. Letoha T, Somlai C, Takacs T, et al. The proteasome inhibitor MG132 protects against acute pancreatitis. Free Radic Biol Med. 2005;39:1142-1151.
39. Al-Mufti RA, Williamson RC, Mathie RT. Increased nitric oxide activity in a rat model of acute pancreatitis. Gut. 1998;43:564-570.
40. Um SH, Kwon YD, Kim CD, et al. The role of nitric oxide in experimental cerulein induced pancreatitis. J Korean Med Sci. 2003;18:520-526.
41. Schulz HU, Niederau C, Klonowski-Stumpe H, et al. Oxidative stress in acute pancreatitis. Hepatogastroenterology. 1999;46:2736-2750.
42. Borrelli E, Roux-Lombard P, Grau GE, et al. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit Care Med. 1996;24:392-397.
43. Brady M, Christmas S, Sutton R, et al. Cytokines and acute pancreatitis. Baillieres Best Pract Res Clin Gastroenterol. 1999;13:265-289.
44. Geiger T, Andus T, Klapproth J, et al. Induction of rat acute-phase proteins by interleukin 6 in vivo. Eur J Immunol. 1988;18:717-721