Chinese herb constituent β-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices

Neuroscience Letters

Volumn 231, Issue 3, 1997, Pages 171-174

  Chiou, Lih Chu ^a   Ling, Jeng Yi ^a   Chang, Chuan Chiung ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Eudesmol; Chinese herb; Hippocampus; Phenytoin; Seizures

Indexed keywords

BETA EUDESMOL; PHENYTOIN;

ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CHINESE HERB; CONTROLLED STUDY; DOSE RESPONSE; ELECTRIC SHOCK; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; LETHALITY; MALE; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; TONIC SEIZURE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; DRUGS, CHINESE HERBAL; ELECTROSHOCK; HIPPOCAMPUS; MALE; MICE; MICE, INBRED ICR; PENTYLENETETRAZOLE; PHENYTOIN; PICROTOXIN; POTASSIUM; RATS; SEIZURES; SESQUITERPENES, EUDESMANE; TERPENES;

EID: 0030770498     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00557-0     Document Type: Article

References (14)

1. Albuquerque, E.X., Costa, A.C., Alkondon, M., Shaw, K.P., Ramoa, A.S. and Aracava, Y., Functional properties of the nicotinic and glutamatergic receptors, J. Rec. Res., 11 (1991) 603-625.
2. Amador, M. and Dani, J.A., MK-801 inhibition on nicotinic acetylcholine receptor channels, Synapse, 7 (1991) 207-215.
3. Arora, C.K., Arora, R.B., Mesta, C.K., Shanbag, S.N., Seshari, R., Maheshwarei, M.L. and Bhattacharya, S.C., Hypotensive activity of β-eudesmol and some related sesquiterpenes, Ind. J. Med. Res., 55 (1967) 463-472.
4. Chiou, L.C. and Chang, C.C., Antagonism by β-eudesmol of neostigmine-induced neuromuscular failure in mouse diaphragm, Eur. J. Pharmacol., 216 (1992) 199-206.
5. Chiou, L.C., Ling, J.Y. and Chang, C.C., β-Eudesmol as an antidote for intoxication from organophosphorus anticholinesterase agents, Eur. J. Pharmacol., 292 (1995) 151-156.
6. Jensen, M.S. and Yaari, Y., The relationship between interictal and ictal paroxysms in an in vitro model of focal hippocampal epilepsy, Ann. Neurol., 24 (1988) 591-598.
7. Kimura, M., Nojima, H., Muroi, M. and Kimura, I., Mechanism of the blocking action of β-eudesmol on the nicotinic acetylcholine receptor channel in mouse skeletal muscles, Neuropharmacology, 30 (1991) 835-841.
8. 2+ concentration in rat hippocampal slices, Exp. Brain Res., 96 (1993) 230-240.
9. Matsumoto, H. and Ajmone-Marsan, C., Cortical cellular phenomena in experimental epilepsy: ictal manifestations, Exp. Neurol., 9 (1964) 305-326.
10. Swinyard, E.A., Laboratory evaluation of antiepileptic drugs, Epilepsia, 10 (1969) 107-119.
11. Swinyard, E.A., Electrically induced convulsions. In D.P. Purpura, J.K. Penry, D.M. Woodbury, D.B. Tower and R.D. Walter (Eds.), Experimental Models of Epilepsy - A Manual for the Laboratory Worker, Raven Press, New York, 1972, pp. 433-458.
12. Tamai, H. and Yamahara, J., β-Eudesmol for treatment of colon disease, Jpn. Kokai. Tokyo Koho, JP04-13629 (1992) 201.
13. Traynelis, S.F. and Dingledine, R., Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice, J. Neurophysiol., 59 (1988) 259-276.
14. Woodbury, D.M., Applications to drug evaluations. In D.P. Purpura, J.K. Penry, D.M. Woodbury, D.B. Tower and R.D. Walter (Eds.), Experimental Models of Epilepsy - A Manual for the Laboratory Worker, Raven Press, New York, 1972, pp. 557-583.