Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet

Pakistan Journal of Pharmaceutical Sciences

Volumn 23, Issue 1, 2010, Pages 75-82

  Keong, Yeap Swee ^a   Alitheen, Noorjahan Banu ^a   Mustafa, Shuhaimi ^a   Aziz, Suraini Abdul ^a   Rahman, Mashitoh Abdul ^a   Ali, Abdul Manaf ^a  

^a NONE

Author keywords

Immunomodulation; Interleukin 2; Zerumbone; Zingiber zerumbet

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 12; INTERLEUKIN 2; UNCLASSIFIED DRUG; ZERUMBONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; GINGER; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MITOGENESIS; MOUSE; NONHUMAN; PLANT ROOT; PROTEIN INDUCTION; UPREGULATION; ZINGIBER ZERUMBET;

ANIMALS; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-12; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MICE; MICE, INBRED ICR; PLANT ROOTS; SESQUITERPENES; SPLEEN; THYMUS GLAND; ZINGIBERALES;

EID: 75649121142     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Ahmdad, MS (2006). Chemical study of zerumbone from Zingiber Zerumbet, Smith. Master Thesis, UKM, http://eprints.utm.my/5325/.
2. Akmal S, Henrik S, Lars B, Kirsten F, Swanne L, Ninna A and Hans VDM (2005). A phase 11 trial of low-dose total body irradiation and subcutaneous Interleukin-2 in matastatic melanoma. Radiother. Oncol., 77: 143-147.
3. Cerqueira F, Cordeiro-Da-Silva A, Gaspar-Marques C, Simoes F, Pinto MMM and Nascimento MSJ (2004). Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocytes proliferation. Bioorg. Med. Chem., 12: 217-223.
4. Dai JR, Cardellina JH, McMohan JB and Boyd MR (1997). Zerumbone, an HIV-Inhibitory and Cytotoxic Sesquiterpene of Zingiber aromaticum and Zingiber zerumbet. Nat. Prod. Lett., 10: 115-118.
5. Elliot S and Brimacombe J (1987). The Medicinal Plants of Gunung Leusar National Park, Indonesia. J. Ethnopharmacol., 19: 285-317.
6. Huang GC, Chien TY, Chen LG and Wang CC (2005). Antitumor effects of Zerumbone from Zingiber zerumbet in P-388D cells in vitro and in vivo. Plant Med., 71: 219-24
7. Kirana C, McIntosh GH, Record IR and Jones GP (2003). Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr. Cancer, 45: 218-225.
8. Kitayama T, Furuya A, Moriyama C, Masuda T, Fushimi S, Yonekura Y, Kubo H and Sawada S (2006). Elucidation of the sharpless epoxidation of zerumbol. Tetrehedron Asymmetry, 17: 2311-2316
9. Lechat-Vahirua I, Francois P, Menut C, Lamaty G and Bessiere JM (1993). Aromatic Plants of French Polynesia. I. Constituents of the Essential Oils of Rhizomes of Three Zingiberaceae: Zingiber zerumbet Smith, Hedychium coronarium Koening and Etlingera cevuga Smithd. J. Essential Oil Res., 5: 55-59.
10. Loken MR (1980). Simultaneous quantitation of Hoechst 33342 and immunofluorescence on viable cells using a fluorescence activated cell sorter. Cytometry, 1: 136.
11. Metthes HWD, Luu B and Ourison G (1980). Cytotoxic components of Zingiber zerumbet, Curcuma zedoaria and Curcuma domestica. Phytochemistry, 19: 2643-2650.
12. Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assay. J. Immunol. Methods, 65: 55-63.
13. Murado MA and Vazquez JA (2007). The notion of hormesis and the dose-response theory: A unified approach. J. Theor. Biol., 224: 489-499.
14. Murakami A, Ohigashi H, Hayashi R, Takana T, Kwon KH and Safitri R (2003a). Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical sesquiterpene, and nimesulide: separately and in combination. Biochem. Pharmacol., 66: 1253-1261.
15. Murakami A, Takahashi D, Koshimizu K and Ohigashi H (2003b). Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors. Mutat. Res., 523-524: 151-161.
16. Murakami A, Takahashi M, Jiwajinda S, Koshimizu K and Ohigashi H (1999). Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradeconyolphorbol-13-acetate-induced Epstein-Barr Virus activation. Biosci. Biotechnol. Biochem., 63: 1811-1812.
17. Murakami A, Takahashita D, Kinoshita T, Koshimizu K, Kim HW, Yoshihiro A Nakamura Y, Jiwajinda S, Tereo J and Ohigashi H (2002). Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppress free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis. Carcinogenesis, 23(11): 1961-1963.
18. Nakamura Y, Yoshida C, Murakami A, Ohigashi H, Osawa T and Uchida K (2004). Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett., 572: 245-250.
19. Takada Y, Murakami A and Aggarwal BB (2005). Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis and down regulation of invasion. Oncogene, 17: 122-130
20. Tanaka T, Shimizu M, Kohno H, Yoshitani S and Hideki M (2001). Chemopreventive of azoxymethane-induced rat abberant crypt foci by dietary zerumbone isolated from Zingiber zerumbet Life Sci., 69: 1935-1945.
21. Vimala S, Norhanom AW and Yadav M (1999). Antitumor promoter activity in Malaysian ginger rhizobia used in traditional medicine. Br. J. Cancer, 80: 110-116.
22. Wagner H (1999). Immunomodulatory agent from plants. Germany: Birkhauser Verlag, pp.1-2.