Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells

Bioscience, Biotechnology and Biochemistry

Volumn 71, Issue 4, 2007, Pages 935-945

  Eguchi, Ai ^a   Kaneko, Yuki ^a   Murakami, Akira ^a   Ohigashi, Hajime ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Caco 2; Lectin like ox LDL receptor 1 (LOX 1); Oxidized low density lipoprotein (ox LDL); Scavenger receptor; Zerumbone

Indexed keywords

INTESTINES; OXIDIZED LOW-DENSITY LIPOPROTEIN (OX-LDL); SCAVENGER RECEPTORS; ZERUMBONE;

CELLS; ESTERS; GENE EXPRESSION; HUMAN ENGINEERING; PLANTS (BOTANY); PROTEINS;

DRUG PRODUCTS;

CELL ADHESION MOLECULE; HUMULENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOXL1 PROTEIN, HUMAN; MESSENGER RNA; OXIDOREDUCTASE; PHORBOL 13 ACETATE 12 MYRISTATE; SCAVENGER RECEPTOR; SESQUITERPENE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; ZERUMBONE;

ARTICLE; BIOSYNTHESIS; BLOOD; CELL STRAIN CACO 2; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MONOCYTE; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID OXIDOREDUCTASES; CACO-2 CELLS; CELL ADHESION MOLECULES; CHOLESTEROL, LDL; GENES, REPORTER; HUMANS; LIPOPROTEINS, LDL; MONOCYTES; NF-KAPPA B; RECEPTORS, SCAVENGER; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SESQUITERPENES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

CURCUMA AROMATICA; CURCUMA LONGA; ZINGIBER OFFICINALE; ZINGIBER ZERUMBET; ZINGIBERACEAE;

EID: 34247547489     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60596     Document Type: Article

References (59)

1. Cockerham, W. C., Hattori, H., and Yamori, Y., The social gradient in life expectancy: the contrary case of Okinawa in Japan. Soc. Sci. Med., 51, 115-122 (2000).
2. Kimura, Y., Takishita, S., Muratani, H., Kinjo, K., Shinzato, Y., Muratani, A., and Fukiyama, K., Demographic study of first-ever stroke and acute myocardial infarction in Okinawa, Japan. Intern. Med., 37, 736-745 (1998).
3. Fukiyama, K., Kimura, Y., Wakugami, K., and Muratani, H., Incidence and long-term prognosis of initial stroke and acute myocardial infarction in Okinawa, Japan. Hypertens. Res., 23, 127-135 (2000).
4. Tatsukawa, M., Sawayama, Y., Maeda, N., Okada, K., Furusyo, N., Kashiwagi, S., and Hayashi, J., Carotid atherosclerosis and cardiovascular risk factors: a comparison of residents of a rural area of Okinawa with residents of a typical suburban area of Fukuoka, Japan. Atherosclerosis, 172, 337-343 (2004).
5. Hosaki, S., Kishimoto, T., Yamauchi, M., and Shiina, S., Serum lipoproteins in Japanese rural community with low cardiovascular mortality. Atherosclerosis, 54, 43-47 (1985).
6. Suzuki, M., Wilcox, B. J., and Wilcox, C. D., Implications from and for food cultures for cardiovascular disease: longevity. Asia. Pac. J. Clin. Nutr., 10, 165-171 (2001).
7. Alfthan, G., Aro, A., and Gey, K. F., Plasma homocysteine and cardiovascular disease mortality. Lancet, 349, 397 (1997).
8. Cockerham, W. C., and Yamori, Y., Okinawa: an exception to the social gradient of life expectancy in Japan. Asia. Pac. J. Clin. Nutr., 10, 154-158 (2001).
9. Yamori, Y., Miura, A., and Taira, K., Implications from and for food cultures for cardiovascular diseases: Japanese food, particularly Okinawan diets. Asia. Pac. J. Clin. Nutr., 10, 144-145 (2001).
10. Murakami, A., Ishida, H., Kubo, K., Furukawa, I., Ikeda, Y., Yonaha, M., Aniya, Y., and Ohigashi, H., Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis. Asian Pac. J. Cancer Prev., 6, 437-448 (2005).
11. Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., and Witztum, J. L., Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med., 320, 915-924 (1989).
12. Steinberg, D., Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem., 272, 20963-20966 (1997).
13. Stemme, S., Faber, B., Holm, J., Wiklund, O., Witztum, J. L., and Hansson, G. K., T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA, 92, 3893-3897 (1995).
14. Gerrity, R. G., The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am. J. Pathol., 103, 181-190 (1981).
15. Berliner, J. A., Navab, M., Fogelman, A. M., Frank, J. S., Demer, L. L., Edwards, P. A., Watson, A. D., and Lusis, A. J., Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation, 91, 2488-2496 (1995).
16. van Berkel, T. J., Out, R., Hoekstra, M., Kuiper, J., Biessen, E., and van Eck, M., Scavenger receptors: friend or foe in atherosclerosis? Curr. Opin. Lipidol., 16, 525-535 (2005).
17. Chiba, Y., Ogita, T., Ando, K., and Fujita, T., PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells. Biochem. Biophys. Res. Commun., 286, 541-546 (2001).
18. Furukawa, K., Hori, M., Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y., Miyazaki, A., Nakayama, H., and Horiuchi, S., Adiponectin down-regulates acyl-coenzyme A:cholesterol acyltransferase-1 in cultured human monocyte-derived macrophages. Biochem. Biophys. Res. Commun., 317, 831-836 (2004).
19. Fuhrman, B., Koren, L., Volkova, N., Keidar, S., Hayek, T., and Aviram, M., Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes. Atherosclerosis, 164, 179-185 (2002).
20. Mehta, J. L., Chen, J., Yu, F., and Li, D. Y., Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells. Cardiovasc. Res., 64, 243-249 (2004).
21. Miles, E. A., Wallace, F. A., and Calder, P. C., Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages. Atherosclerosis, 152, 43-50 (2000).
22. Ricciarelli, R., Zingg, J. M., and Azzi, A., Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation, 102, 82-87 (2000).
23. Devaraj, S., Hugou, I., and Jialal, I., Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages. J. Lipid Res., 42, 521-527 (2001).
24. Ide, N., Keller, C., and Weiss, N., Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages. J. Nutr., 136, 755S-758S (2006).
25. Eguchi, A., Murakami, A., and Ohigashi, H., Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. FEBS Lett., 580, 3321-3328 (2006).
26. Eguchi, A., Murakami, A., and Ohigashi, H., Novel bioassay system for evaluating anti-oxidative activities of food items: use of basolateral media from differentiated Caco-2 cells. Free Radic. Res., 39, 1367-1375 (2005).
27. Tanaka, T., Shimizu, M., Kohno, H., Yoshitani, S., Tsukio, Y., Murakami, A., Safitri, R., Takahashi, D., Yamamoto, K., Koshimizu, K., Ohigashi, H., and Mori, H., Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. Life Sci., 69, 1935-1945 (2001).
28. Sladowski, D., Steer, S. J., Clothier, R. H., and Balls, M., An improved MTT assay. J. Immunol. Methods, 157, 203-207 (1993).
29. Dev, S., Studies in sesquiterpenes. XVI. Zerumbone, a monocyclic sesquiterpene ketone. Tetrahedron, 8, 171-180 (1960).
30. Yamanaka, S., Zhang, X. Y., Miura, K., Kim, S., and Iwao, H., The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile. Genomics, 54, 191-199 (1998).
31. Murakami, A., Takahashi, D., Koshimizu, K., and Ohigashi, H., Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors. Mutat. Res., 523-524, 151-161 (2003).
32. Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., Takashima, Y., Kawabe, Y., Cynshi, O., Wada, Y., Honda, M., Kurihara, H., Aburatani, H., Doi, T., Matsumoto, A., Azuma, S., Noda, T., Toyoda, Y., Itakura, H., Yazaki, Y., and Kodama, T., A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature, 386, 292-296 (1997).
33. Babaev, V. R., Gleaves, L. A., Carter, K. J., Suzuki, H., Kodama, T., Fazio, S., and Linton, M. F., Reduced atherosclerotic lesions in mice deficient for total or macrophage-specific expression of scavenger receptor-A. Arterioscler. Thromb. Vasc. Biol., 20, 2593-2599 (2000).
34. Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., and Silverstein, R. L., Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J. Clin. Invest., 105, 1049-1056 (2000).
35. Kamada, N., Kodama, T., and Suzuki, H., Macrophage scavenger receptor (SR-A I/II) deficiency reduced diet-induced atherosclerosis in C57BL/6J mice. J. Atheroscler. Thromb., 8, 1-6 (2001).
36. Kunjathoor, V. V., Febbraio, M., Podrez, E. A., Moore, K. J., Andersson, L., Koehn, S., Rhee, J. S., Silverstein, R., Hoff, H. F., and Freeman, M. W., Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem., 277, 49982-49988 (2002).
37. Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., and Silverstein, R. L., Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J. Clin. Invest., 105, 1049-1056 (2000).
38. Moore, K. J., Kunjathoor, V. V., Koehn, S. L., Manning, J. J., Tseng, A. A., Silver, J. M., McKee, M., and Freeman, M. W., Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J. Clin. Invest., 115, 2192-2201 (2005).
39. Olszanecki, R., Jawien, J., Gajda, M., Mateuszuk, L., Gebska, A., Korabiowska, M., Chlopicki, S., and Korbut, R., Effect of curcumin on atherosclerosis in apoE/ LDLR-double knockout mice. J. Physiol. Pharmacol., 56, 627-635 (2005).
40. Li, L., Sawamura, T., and Renier, G., Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation. Circ. Res., 94, 892-901 (2004).
41. Webb, N. R., Connell, P. M., Graf, G. A., Smart, E. J., de Villiers, W. J., de Beer, F. C., and van der Westhuyzen, D. R., SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. J. Biol. Chem., 273, 15241-15248 (1998).
42. Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., and Krieger, M., Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science, 271, 518-520 (1996).
43. Rigotti, A., Trigatti, B. L., Penman, M., Rayburn, H., Herz, J., and Krieger, M., A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc. Natl. Acad. Sci. USA, 94, 12610-12615 (1997).
44. Braun, A., Trigatti, B. L., Post, M. J., Sato, K., Simons, M., Edelberg, J. M., Rosenberg, R. D., Schrenzel, M., and Krieger, M., Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ. Res., 90, 270-276 (2002).
45. Ji, Y., Jian, B., Wang, N., Sun, Y., Moya, M. L., Phillips, M. C., Rothblat, G. H., Swaney, J. B., and Tall, A. R., Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J. Biol. Chem., 272, 20982-20985 (1997).
46. Moulton, K. S., Wu, H., Barnett, J., Parthasarathy, S., and Glass, C. K., Regulated expression of the human acetylated low density lipoprotein receptor gene and isolation of promoter sequences. Proc. Natl. Acad. Sci. USA, 89, 8102-8106 (1992).
47. Tsukamoto, K., Kinoshita, M., Kojima, K., Mikuni, Y., Kudo, M., Mori, M., Fujita, M., Horie, E., Shimazu, N., and Teramoto, T., Synergically increased expression of CD36, CLA-1 and CD68, but not of SR-A and LOX-1, with the progression to foam cells from macrophages. J. Atheroscler. Thromb., 9, 57-64 (2002).
48. Hass, R., Meinhardt, G., Hadam, M., and Bartels, H., Characterization of human TUR leukemia cells: continued cell cycle progression in the presence of phorbol ester is associated with resistance to apoptosis. Eur. J. Cell Biol., 65, 408-416 (1994).
49. Moulton, K. S., Semple, K., Wu, H., and Glass, C. K., Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif. Mol. Cell. Biol., 14, 4408-4418 (1994).
50. Wu, H., Moulton, K., Horvai, A., Parik, S., and Glass, C. K., Combinatorial interactions between AP-1 and ets domain proteins contribute to the developmental regulation of the macrophage scavenger receptor gene. Mol. Cell. Biol., 14, 2129-2139 (1994).
51. Chandrasekar, B., Mummidi, S., Valente, A. J., Patel, D. N., Bailey, S. R., Freeman, G. L., Hatano, M., Tokuhisa, T., and Jensen, L. E., The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling. J. Biol. Chem., 280, 26263-26277 (2005).
52. Krappmann, D., Patke, A., Heissmeyer, V., and Scheidereit, C., B-cell receptor- and phorbol ester-induced NF-kappaB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's. Mol. Cell. Biol., 21, 6640-6650 (2001).
53. Murakami, A., Takahashi, D., Kinoshita, T., Koshimizu, K., Kim, H. W., Yoshihiro, A., Nakamura, Y., Jiwajinda, S., Terao, J., and Ohigashi, H., Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite. Carcinogenesis, 23, 795-802 (2002).
54. Murakami, A., Hayashi, R., Tanaka, T., Kwon, K. H., Ohigashi, H., and Safitri, R., Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem. Pharmacol., 66, 1253-1261 (2003).
55. Takada, Y., Murakami, A., and Aggarwal, B. B., Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene, 24, 6957-6969 (2005).
56. de Nooijer, R., Verkleij, G. J., von der Thusen, J. H., Jukema, J. W., van der wall, E. E., van Berkel, T. J., Baker, A. H., and Biessen, E. A., Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis. Arterioscler. Thromb. Vasc. Biol., 26, 340-346 (2006).
57. Blankenberg, S., Barbaux, S., and Tiret, L., Adhesion molecules and atherosclerosis. Atherosclerosis, 170, 191-203 (2003).
58. Ohta, H., Wada, H., Niwa, T., Kirii, H., Iwamoto, N., Fujii, H., Saito, K., Sekikawa, K., and Seishima, M., Disruption of tumor necrosis factor-alpha gene diminishes the development of atherosclerosis in ApoE-deficient mice. Atherosclerosis, 180, 11-17 (2005).
59. Murakami, A., Takahashi, M., Jiwajinda, S., Koshimizu, K., and Ohigashi, H., Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci. Biotechnol. Biochem., 63, 1811-1812 (1999).