SBF-1, a synthetic steroidal glycoside, inhibits melanoma growth and metastasis through blocking interaction between PDK1 and AKT3

Biochemical Pharmacology

Volumn 84, Issue 2, 2012, Pages 172-181

  Li, Wanshuai ^a   Song, Ran ^a   Fang, Xianying ^a   Wang, Lu ^a   Chen, Wei ^a   Tang, Pingping ^b   Yu, Biao ^b   Sun, Yang ^a   Xu, Qiang ^a  

^a NANJING UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

AKT3; Melanoma; Metastasis; PDK 1; SBF 1

Indexed keywords

ALPHA4 INTEGRIN; ANTINEOPLASTIC AGENT; CISPLATIN; FIBRONECTIN; ISOENZYME; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN AKT 3; PROTEIN KINASE B; SBF 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL ADHESION; CELL CYCLE ARREST; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LYMPH NODE; MELANOMA; MELANOMA CELL; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CHOLESTENONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; INTEGRIN ALPHA4; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SAPONINS;

EID: 84861235279     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.04.006     Document Type: Article

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