Alpha-fetoprotein: A new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines

International Journal of Cancer

Volumn 128, Issue 3, 2011, Pages 524-532

  Li, Mengsen ^a,b   Li, Hui ^b   Li, Chaoying ^b   Wang, Shanshan ^b   Jiang, Wei ^b   Liu, Zhongmin ^b   Zhou, Sheng ^a   Liu, Xinhua ^b   McNutt, Michael A ^b   Li, Gang ^b  

^a HAINAN MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

AFP; AKT; hepatoma; PI3K; PTEN; signal molecule

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA FETOPROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RETINOIC ACID;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL GROWTH; CELL STIMULATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOPLASM; ENZYME REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; CELL ADHESION MOLECULES; CHROMOSOMES, HUMAN, PAIR 10; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE DELETION; HOMEOSTASIS; HUMANS; LIVER NEOPLASMS; MICROFILAMENT PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; TRETINOIN; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 78649883907     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25373     Document Type: Article

References (30)

1. Schütte K, Bornschein J, Malfertheiner P,. Hepatocellular carcinoma-epidemiological trends and risk factors. Dig Dis 2009; 27: 80-92.
2. Mizejewski GJ, MacColl R,. Alpha-fetoprotein growth inhibitory peptides: potential leads for cancer therapeutics. Mol Cancer Ther 2003; 2: 1243-55.
3. Vakharia D, Mizejewski GJ,. Human alpha-fetoprotein peptides bind estrogen receptor and estradiol, and suppress breast cancer. Breast Cancer Res Treat 2000; 63: 41-52.
4. Muehlemann M, Miller KD, Dauphinee M, Mizejewski GJ,. Review of growth inhibitory peptide as a biotherapeutic agent for tumor growth, adhesion, and metastasis. Cancer Metastasis Rev 2005; 24: 441-67.
5. Li MS, Li PF, Chen Q, Du GG, Li G,. Alpha-fetoprotein stimulated the expression of some oncogenes in human hepatocellular carcinoma Bel 7402 cells. World J Gastroenterol 2004; 10: 819-24.
6. Li MS, Liu XH, Zhou S, Li PF, Li G,. Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes. BMC Cancer 2005; 5: 96.
7. Li MS, Zhou S, Liu XH, Li PF, McNutt MA, Li G,. Alpha-fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand. Cancer Lett 2007; 249: 227-34.
8. Dauphinee MJ, Mizejewski GJ,. Human alpha-fetoprotein contains potential heterodimerization motifs capable of interaction with nuclear receptors and transcription/growth factors. Med Hypotheses 2002; 58: 453-61.
9. Li M, Li H, Li C, Guo L, Liu H, Zhou S, Liu X, Chen Z, Shi S, Wei J, McNutt MA, Li G,. Cytoplasmic alpha-fetoprotein functions as a co-repressor in RA-RAR signaling to promote the growth of human hepatoma Bel 7402 cells. Cancer Lett 2009; 285: 190-9.
10. Li M, Li H, Li C, Zhou S, Guo L, Liu H, Wei J, Liu X, Li P, McNutt MA, Li G,. Alpha fetoprotein is a novel protein-binding partner for caspase-3 and blocks the apoptotic signaling pathway in human hepatoma cells. Int J Cancer 2009; 124: 2845-54.
11. Yin Y, Shen WH,. PTEN: a new guardian of the genome. Oncogene 2008; 27: 5443-53.
12. Andrews S, Stephens LR, Hawkins PT,. PI3K class IB pathway in neutrophils. Sci STKE 2007; 2007: cm3.
13. Kandel ES, Hay N,. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 1999; 253: 210-29.
14. Downward J,. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004; 15: 177-82.
15. Vivanco I, Sawyers CL,. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
16. Datta SR, Brunet A, Greenberg ME,. Cellular survival: a play in three Akts. Genes Dev 1999; 13: 2905-27.
17. Liu H, Li H, Guo LY, Li MS, Li CY, Wang SS, Jiang W, Liu XH, McNutt MA, Li G,. Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes. Biochem Pharmacol 2010; 79: 516-23.
18. Li H, Liu H, Wang Z, Liu X, Guo L, Huang L, Gao L, McNutt MA, Li G,. The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes. J Cell Biochem 2008; 104: 237-50.
19. Xu J, Li PF, Liu XH, Li G,. Morphine aggravates the apoptosis of simian immunodeficiency virus infected CEM x174 cells in the prolonged culture in vitro. Int Immunopharmacol 2004; 4: 1805-16.
20. Mizejewski GJ, Dias JA, Hauer CR, Henrikson KP, Gierthy J,. Alpha-fetoprotein derived synthetic peptides: assay of an estrogen-modifying regulatory segment. Mol Cell Endocrinol 1996; 118: 15-23.
21. Mizejewski GJ,. Alpha-fetoprotein (AFP)-derived peptides as epitopes for hepatoma immunotherapy: a commentary. Cancer Immunol Immunother 2009; 58: 159-70.
22. Li MS, Li PF, Yang FY, He SP, Du GG, Li G,. The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells. Cell Res 2002; 12: 151-6.
23. Li MS, Li PF, He SP, Du GG, Li G,. The promoting molecular mechanism of alpha-fetoprotein on the growth of human hepatoma Bel7402 cell line. World J Gastroenterol 2002; 8: 469-75.
24. Li MS, Liu XH, Zhou S, Li G,. Inhibited the expression of alpha fetoprotein by all trans retinoic acid sensitize hepatoma cells to tumor necrosis factor-related apoptosis-induced ligand (Trail). Gastroenterology 2007; 132: A822-A823.
25. Wang XW, Xie H,. Alpha-fetoprotein enhances the proliferation of human hepatoma cells in vitro. Life Sci 1999; 64: 17-23.
26. Mizejewski G,. Hypothesis: an apparent dimerization motif in the third domain of alphafetoprotein: molecular mimicry of the steroid/thyroid nuclear receptor superfamily. Bioessays 1993; 15: 427-32.
27. Blanco-Aparicio C, Renner O, Leal JFM, Carnero A,. PTEN, more than the AKT pathway. Carcinogenesis 2007; 28: 1379-86.
28. Jiang B-H, Liu L-Z,. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 2009; 102: 19-65.
29. Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH, Evers BM,. Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci USA 2008; 105: 20315-20.
30. Lee YR, Yu HN, Noh EM, Kim JS, Song EK, Han MK, Kim BS, Lee SH, Park J,. Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells. Int J Hematol 2007; 85: 231-7.