Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression

Journal of Cell Science

Volumn 125, Issue 4, 2012, Pages 1027-1038

  Kaspar, James W ^a   Niture, Suryakant K ^a   Jaiswal, Anil K ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidant; Cul3 Rbx1; INrf2 (Keap1); NQO1; Nrf2; Nuclear export and degradation; Tyrosine phosphorylation

Indexed keywords

ANTIOXIDANT; CULLIN; CULLIN 3; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN; RING BOX PROTEIN 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; GENE MUTATION; GENE REPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIOXIDANTS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CULLIN PROTEINS; CYTOSKELETAL PROTEINS; CYTOSOL; HUMANS; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KARYOPHERINS; MUTANT PROTEINS; MUTATION; NF-E2-RELATED FACTOR 2; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84861204399     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.097295     Document Type: Article

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