-
1
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
2
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
3
-
-
33846244217
-
Epidermal growth factor receptor activation: How exon 19 and 21 mutations changed our understanding of the pathway
-
Rosell R, Taron M, Reguart N, Isla D, Moran T. Epidermal growth factor receptor activation: how exon 19 and 21 mutations changed our understanding of the pathway. Clin Cancer Res 2006;12:7222-31.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7222-7231
-
-
Rosell, R.1
Taron, M.2
Reguart, N.3
Isla, D.4
Moran, T.5
-
4
-
-
34250161814
-
Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL trial
-
Cappuzzo F, Ligorio C, Janne PA, et al. Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial. J Clin Oncol 2007;25:2248-55.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2248-2255
-
-
Cappuzzo, F.1
Ligorio, C.2
Janne, P.A.3
-
5
-
-
33750962024
-
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
-
Hirsch FR, Varella-Garcia M, Bunn PA, Jr., et al. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol 2006;24:5034-42.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5034-5042
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn Jr., P.A.3
-
6
-
-
27244443759
-
Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
-
Hirsch FR, Varella-Garcia M, McCoy J, et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol 2005;23:6838-45.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6838-6845
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
McCoy, J.3
-
7
-
-
22044453790
-
Erlotinib in lung cancer - molecular and clinical predictors of outcome
-
Tsao MS, Sakurada A, Cutz JC, et al. Erlotinib in lung cancer - molecular and clinical predictors of outcome. N Engl J Med 2005;353:133-44.
-
(2005)
N Engl J Med
, vol.353
, pp. 133-144
-
-
Tsao, M.S.1
Sakurada, A.2
Cutz, J.C.3
-
8
-
-
27244451321
-
Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
-
Takano T, Ohe Y, Sakamoto H, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23:6829-37.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6829-6837
-
-
Takano, T.1
Ohe, Y.2
Sakamoto, H.3
-
9
-
-
20444498630
-
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
-
Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005;97:643-55.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 643-655
-
-
Cappuzzo, F.1
Hirsch, F.R.2
Rossi, E.3
-
10
-
-
17344381429
-
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt L, Duh FM, Chen F, et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet 1997;16:68-73.
-
(1997)
Nat Genet
, vol.16
, pp. 68-73
-
-
Schmidt, L.1
Duh, F.M.2
Chen, F.3
-
11
-
-
17344373892
-
-
Zhuang Z, Park WS, Pack S, et al. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet 1998;20:66-9.
-
Zhuang Z, Park WS, Pack S, et al. Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet 1998;20:66-9.
-
-
-
-
12
-
-
33947224133
-
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification
-
Okabe T, Okamoto I, Tamura K, et al. Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification. Cancer Res 2007;67:2046-53.
-
(2007)
Cancer Res
, vol.67
, pp. 2046-2053
-
-
Okabe, T.1
Okamoto, I.2
Tamura, K.3
-
13
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005;97:339-46.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
-
14
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
15
-
-
33947122693
-
Amplification, mutation and loss of heterozygosity of the EGFR gene in metastatic lung cancer
-
author reply 32-3
-
Ma ES, Wong CL, Siu D, Chan WK. Amplification, mutation and loss of heterozygosity of the EGFR gene in metastatic lung cancer. Int J Cancer 2007;120:1828-31; author reply 32-3.
-
(2007)
Int J Cancer
, vol.120
, pp. 1828-1831
-
-
Ma, E.S.1
Wong, C.L.2
Siu, D.3
Chan, W.K.4
-
16
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 2004;64:8919-23.
-
(2004)
Cancer Res
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Kuwano, H.4
Takahashi, T.5
Mitsudomi, T.6
-
17
-
-
9444260917
-
Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype
-
Marchetti A, Buttitta F, Pellegrini S, et al. Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype. J Pathol 1996;179:254-9.
-
(1996)
J Pathol
, vol.179
, pp. 254-259
-
-
Marchetti, A.1
Buttitta, F.2
Pellegrini, S.3
-
18
-
-
34347363140
-
Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas
-
Sakamoto H, Shimizu J, Horio Y, et al. Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas. J Pathol 2007;212:287-94.
-
(2007)
J Pathol
, vol.212
, pp. 287-294
-
-
Sakamoto, H.1
Shimizu, J.2
Horio, Y.3
-
19
-
-
33745985181
-
A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer
-
Yatabe Y, Hida T, Horio Y, Kosaka T, Takahashi T, Mitsudomi T. A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer. J Mol Diagn 2006;8:335-41.
-
(2006)
J Mol Diagn
, vol.8
, pp. 335-341
-
-
Yatabe, Y.1
Hida, T.2
Horio, Y.3
Kosaka, T.4
Takahashi, T.5
Mitsudomi, T.6
-
20
-
-
28844449401
-
Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: Molecular analysis of the IDEAL/INTACT gefitinib trials
-
Bell DW, Lynch TJ, Haserlat SM, et al. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol 2005;23:8081-92.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8081-8092
-
-
Bell, D.W.1
Lynch, T.J.2
Haserlat, S.M.3
-
21
-
-
20044364933
-
EGFR mutations in non-small-cell lung cancer: Analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
-
Marchetti A, Martella C, Felicioni L, et al. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol 2005;23:857-65.
-
(2005)
J Clin Oncol
, vol.23
, pp. 857-865
-
-
Marchetti, A.1
Martella, C.2
Felicioni, L.3
-
22
-
-
33750346939
-
Gains of COL1A1-PDGFB genomic copies occur in fibrosarcomatous transformation of dermatofibrosarcoma protuberans
-
Abbott JJ, Erickson-Johnson M, Wang X, Nascimento AG, Oliveira AM. Gains of COL1A1-PDGFB genomic copies occur in fibrosarcomatous transformation of dermatofibrosarcoma protuberans. Mod Pathol 2006;19:1512-8.
-
(2006)
Mod Pathol
, vol.19
, pp. 1512-1518
-
-
Abbott, J.J.1
Erickson-Johnson, M.2
Wang, X.3
Nascimento, A.G.4
Oliveira, A.M.5
-
23
-
-
33845267265
-
Molecular classification of tumors with special reference to EGFR mutation in lung cancer
-
Yatabe Y. Molecular classification of tumors with special reference to EGFR mutation in lung cancer. Cancer Chemother Pharmacol 2006;58 Suppl 1:17-23.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, Issue.SUPPL. 1
, pp. 17-23
-
-
Yatabe, Y.1
-
24
-
-
34247172606
-
Epidermal growth factor receptor mutations in lung cancers
-
Yatabe Y, Mitsudomi T. Epidermal growth factor receptor mutations in lung cancers. Pathol Int 2007;57:233-44.
-
(2007)
Pathol Int
, vol.57
, pp. 233-244
-
-
Yatabe, Y.1
Mitsudomi, T.2
-
25
-
-
34447131535
-
Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1
-
Tanaka H, Yanagisawa K, Shinjo K, et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res 2007;67:6007-11.
-
(2007)
Cancer Res
, vol.67
, pp. 6007-6011
-
-
Tanaka, H.1
Yanagisawa, K.2
Shinjo, K.3
-
26
-
-
33645804773
-
Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors
-
Takeuchi T, Tomida S, Yatabe Y, et al. Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Clin Oncol 2006;24:1679-88.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1679-1688
-
-
Takeuchi, T.1
Tomida, S.2
Yatabe, Y.3
-
27
-
-
33750966349
-
Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts
-
Hayes DN, Monti S, Parmigiani G, et al. Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. J Clin Oncol 2006;24:5079-90.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5079-5090
-
-
Hayes, D.N.1
Monti, S.2
Parmigiani, G.3
-
28
-
-
0142151074
-
Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathways
-
Borczuk AC, Gorenstein L, Walter KL, Assaad AA, Wang L, Powell CA. Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathways. Am J Pathol 2003;163:1949-60.
-
(2003)
Am J Pathol
, vol.163
, pp. 1949-1960
-
-
Borczuk, A.C.1
Gorenstein, L.2
Walter, K.L.3
Assaad, A.A.4
Wang, L.5
Powell, C.A.6
-
29
-
-
24344435084
-
Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: Its association with clinicopathologic features
-
Shibata T, Uryu S, Kokubu A, et al. Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features. Clin Cancer Res 2005;11:6177-85.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6177-6185
-
-
Shibata, T.1
Uryu, S.2
Kokubu, A.3
-
30
-
-
0035503076
-
Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma
-
Aoyagi Y, Yokose T, Minami Y, et al. Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma. Cancer Res 2001;61:7950-4.
-
(2001)
Cancer Res
, vol.61
, pp. 7950-7954
-
-
Aoyagi, Y.1
Yokose, T.2
Minami, Y.3
-
31
-
-
0034494225
-
Topographical distributions of allelic loss in individual non-small- cell lung cancers
-
Yatabe Y, Konishi H, Mitsudomi T, Nakamura S, Takahashi T. Topographical distributions of allelic loss in individual non-small- cell lung cancers. Am J Pathol 2000;157:985-93.
-
(2000)
Am J Pathol
, vol.157
, pp. 985-993
-
-
Yatabe, Y.1
Konishi, H.2
Mitsudomi, T.3
Nakamura, S.4
Takahashi, T.5
-
32
-
-
24744443517
-
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung
-
Yoshida Y, Shibata T, Kokubu A, et al. Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung. Lung Cancer 2005;50:1-8.
-
(2005)
Lung Cancer
, vol.50
, pp. 1-8
-
-
Yoshida, Y.1
Shibata, T.2
Kokubu, A.3
-
33
-
-
0038488950
-
A multigenic program mediating breast cancer metastasis to bone
-
Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49.
-
(2003)
Cancer Cell
, vol.3
, pp. 537-549
-
-
Kang, Y.1
Siegel, P.M.2
Shu, W.3
-
34
-
-
34447123918
-
Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach
-
Tomida S, Yanagisawa K, Koshikawa K, et al. Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. Oncogene 2007;26:4600-8.
-
(2007)
Oncogene
, vol.26
, pp. 4600-4608
-
-
Tomida, S.1
Yanagisawa, K.2
Koshikawa, K.3
|