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Volumn 22, Issue 2, 2010, Pages 112-120

Epidermal growth factor receptor tyrosine kinase inhibitors as first-line treatment in advanced nonsmall-cell lung cancer

Author keywords

Epidermal growth factor receptor mutations; Nonsmall cell lung cancer; Serum DNA; Threonine at position 790

Indexed keywords

CARBOPLATIN; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PACLITAXEL; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C RECEPTOR;

EID: 76749137179     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e32833500d2     Document Type: Review
Times cited : (42)

References (48)
  • 1
    • 69949126786 scopus 로고    scopus 로고
    • Personalized medicine and inhibition of EGFR signaling in lung cancer
    • Gazdar AF. Personalized medicine and inhibition of EGFR signaling in lung cancer. N Engl J Med 2009; 361:1018-1020.
    • (2009) N Engl J Med , vol.361 , pp. 1018-1020
    • Gazdar, A.F.1
  • 2
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate antiapoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate antiapoptotic pathways. Science 2004; 305:1163-1167.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 3
    • 63049132774 scopus 로고    scopus 로고
    • First-line gefitinib for patients with advanced nonsmall-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
    • Inoue A, Kobayashi K, Usui K, et al. First-line gefitinib for patients with advanced nonsmall-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol 2009; 27:1394-1400.
    • (2009) J Clin Oncol , vol.27 , pp. 1394-1400
    • Inoue, A.1    Kobayashi, K.2    Usui, K.3
  • 4
    • 68549140332 scopus 로고    scopus 로고
    • Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC
    • Linardou H, Dahabreh IJ, Bafaloukos D, et al. Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC. Nat Rev Clin Oncol 2009; 6:352-366.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 352-366
    • Linardou, H.1    Dahabreh, I.J.2    Bafaloukos, D.3
  • 5
    • 66849091226 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV nonsmall-cell lung cancer
    • Bai H, Mao L, Wang HS, et al. Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV nonsmall-cell lung cancer. J Clin Oncol 2009; 27:2653-2659.
    • (2009) J Clin Oncol , vol.27 , pp. 2653-2659
    • Bai, H.1    Mao, L.2    Wang, H.S.3
  • 6
    • 68849105058 scopus 로고    scopus 로고
    • Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations
    • Tam IY, Leung EL, Tin VP, et al. Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations. Mol Cancer Ther 2009; 8:2142-2151.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2142-2151
    • Tam, I.Y.1    Leung, E.L.2    Tin, V.P.3
  • 7
    • 68349139723 scopus 로고    scopus 로고
    • An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors
    • Chitale D, Gong Y, Taylor BS, et al. An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. Oncogene 2009; 28:2773-2783.
    • (2009) Oncogene , vol.28 , pp. 2773-2783
    • Chitale, D.1    Gong, Y.2    Taylor, B.S.3
  • 8
    • 68049088934 scopus 로고    scopus 로고
    • EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases
    • Schmid K, Oehl N, Wrba F, et al. EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases. Clin Cancer Res 2009; 15:4554-4560.
    • (2009) Clin Cancer Res , vol.15 , pp. 4554-4560
    • Schmid, K.1    Oehl, N.2    Wrba, F.3
  • 9
    • 58149234399 scopus 로고    scopus 로고
    • Effects of erlotinib in EGFR mutated nonsmall cell lung cancers with resistance to gefitinib
    • Costa DB, Nguyen KS, Cho BC, et al. Effects of erlotinib in EGFR mutated nonsmall cell lung cancers with resistance to gefitinib. Clin Cancer Res 2008; 14:7060-7067.
    • (2008) Clin Cancer Res , vol.14 , pp. 7060-7067
    • Costa, D.B.1    Nguyen, K.S.2    Cho, B.C.3
  • 10
    • 67449138855 scopus 로고    scopus 로고
    • Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo
    • Ichihara E, Ohashi K, Takigawa N, et al. Effects of vandetanib on lung adenocarcinoma cells harboring epidermal growth factor receptor T790M mutation in vivo. Cancer Res 2009; 69:5091-5098.
    • (2009) Cancer Res , vol.69 , pp. 5091-5098
    • Ichihara, E.1    Ohashi, K.2    Takigawa, N.3
  • 11
    • 69349088824 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated nonsmall cell lung cancer patients: Results of an online tumor registry of clinical trials
    • Jackman DM, Miller VA, Cioffredi LA, et al. Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated nonsmall cell lung cancer patients: results of an online tumor registry of clinical trials. Clin Cancer Res 2009; 15:5267-5273.
    • (2009) Clin Cancer Res , vol.15 , pp. 5267-5273
    • Jackman, D.M.1    Miller, V.A.2    Cioffredi, L.A.3
  • 12
    • 45149084723 scopus 로고    scopus 로고
    • First-line gefitinib in patients with advanced nonsmall-cell lung cancer harboring somatic EGFR mutations
    • Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced nonsmall-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008; 26:2442-2449.
    • (2008) J Clin Oncol , vol.26 , pp. 2442-2449
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 13
    • 32944481596 scopus 로고    scopus 로고
    • Clinical course of patients with nonsmall cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
    • Riely GJ, Pao W, Pham D, et al. Clinical course of patients with nonsmall cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 2006; 12:839-844.
    • (2006) Clin Cancer Res , vol.12 , pp. 839-844
    • Riely, G.J.1    Pao, W.2    Pham, D.3
  • 14
    • 67650378948 scopus 로고    scopus 로고
    • Combined survival analysis of prospective clinical trials of gefitinib for nonsmall cell lung cancer with EGFR mutations
    • Morita S, Okamoto I, Kobayashi K, et al. Combined survival analysis of prospective clinical trials of gefitinib for nonsmall cell lung cancer with EGFR mutations. Clin Cancer Res 2009; 15:4493-4498.
    • (2009) Clin Cancer Res , vol.15 , pp. 4493-4498
    • Morita, S.1    Okamoto, I.2    Kobayashi, K.3
  • 15
    • 84887212361 scopus 로고    scopus 로고
    • Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
    • Gandhi J, Zhang J, Xie Y, et al. Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS ONE 2009; 4:e4576.
    • (2009) PLoS ONE , vol.4
    • Gandhi, J.1    Zhang, J.2    Xie, Y.3
  • 16
    • 34250837538 scopus 로고    scopus 로고
    • Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in nonsmall cell lung cancers in relation to smoking history
    • Mounawar M, Mukeria A, Le Calvez F, et al. Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in nonsmall cell lung cancers in relation to smoking history. Cancer Res 2007; 67:5667-5672.
    • (2007) Cancer Res , vol.67 , pp. 5667-5672
    • Mounawar, M.1    Mukeria, A.2    Le Calvez, F.3
  • 17
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009; 361:958-967.
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 18
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • MokTS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 19
    • 67749110399 scopus 로고    scopus 로고
    • MiR-21 is an EGFR-regulated antiapoptotic factor in lung cancer in never-smokers
    • Seike M, Goto A, OkanoT, et al. MiR-21 is an EGFR-regulated antiapoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci USA 2009; 106:12085-12090.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12085-12090
    • Seike, M.1    Okanot, G.A.2
  • 20
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • Meng F, Henson R, Wehbe-JanekH, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133:647-658.
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Wehbe-Janekh, H.R.2
  • 21
    • 65249127504 scopus 로고    scopus 로고
    • Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant nonsmall cell lung cancer
    • Kuang Y, Rogers A, Yeap BY, et al. Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant nonsmall cell lung cancer. Clin Cancer Res 2009; 15:2630-2636.
    • (2009) Clin Cancer Res , vol.15 , pp. 2630-2636
    • Kuang, Y.1    Rogers, A.2    Yeap, B.Y.3
  • 22
    • 58149218582 scopus 로고    scopus 로고
    • Reduced erlotinib sensitivity of epidermal growth factor receptor-mutant nonsmall cell lung cancer following cisplatin exposure: A cell culture model of second-line erlotinib treatment
    • Chin TM, Quinlan MP, Singh A, et al. Reduced erlotinib sensitivity of epidermal growth factor receptor-mutant nonsmall cell lung cancer following cisplatin exposure: a cell culture model of second-line erlotinib treatment. Clin Cancer Res 2008; 14:6867-6876.
    • (2008) Clin Cancer Res , vol.14 , pp. 6867-6876
    • Chin, T.M.1    Quinlan, M.P.2    Singh, A.3
  • 23
    • 33750339641 scopus 로고    scopus 로고
    • Nonsmall-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation
    • Das AK, Sato M, Story MD, et al. Nonsmall-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Res 2006; 66:9601-9608.
    • (2006) Cancer Res , vol.66 , pp. 9601-9608
    • Das, A.K.1    Sato, M.2    Story, M.D.3
  • 24
    • 34347223656 scopus 로고    scopus 로고
    • Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in nonsmall cell lung carcinoma
    • Das AK, Chen BP, Story MD, et al. Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in nonsmall cell lung carcinoma. Cancer Res 2007; 67:5267-5274.
    • (2007) Cancer Res , vol.67 , pp. 5267-5274
    • Das, A.K.1    Chen, B.P.2    Story, M.D.3
  • 25
    • 67649431893 scopus 로고    scopus 로고
    • Customized treatment in nonsmall-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression
    • Rosell R, Perez-Roca L, Sanchez JJ, et al. Customized treatment in nonsmall-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS ONE 2009; 4:e5133.
    • (2009) PLoS ONE , vol.4
    • Rosell, R.1    Perez-Roca, L.2    Sanchez, J.J.3
  • 26
    • 70349464846 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall-cell lung cancers dependent on the epidermal growth factor receptor pathway
    • Nguyen KS, Kobayashi S, Costa DB. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in nonsmall-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer 2009; 10:281-289.
    • (2009) Clin Lung Cancer , vol.10 , pp. 281-289
    • Nguyen, K.S.1    Kobayashi, S.2    Costa, D.B.3
  • 27
    • 47949114668 scopus 로고    scopus 로고
    • Detection of mutations in EGFR in circulating lung-cancer cells
    • Maheswaran S, Sequist LV, Nagrath S, et al. Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 2008; 359:366-377
    • (2008) N Engl J Med , vol.359 , pp. 366-377
    • Maheswaran, S.1    Sequist, L.V.2    Nagrath, S.3
  • 28
    • 33748074447 scopus 로고    scopus 로고
    • Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in nonsmall cell lung cancer
    • Inukai M, Toyooka S, Ito S, et al. Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in nonsmall cell lung cancer. Cancer Res 2006; 66:7854-7858.
    • (2006) Cancer Res , vol.66 , pp. 7854-7858
    • Inukai, M.1    Toyooka, S.2    Ito, S.3
  • 29
    • 34249946686 scopus 로고    scopus 로고
    • Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    • Wang B, Matsuoka S, Ballif BA, et al. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 2007; 316:1194-1198.
    • (2007) Science , vol.316 , pp. 1194-1198
    • Wang, B.1    Matsuoka, S.2    Ballif, B.A.3
  • 30
    • 67650458507 scopus 로고    scopus 로고
    • Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair
    • Wu X, Mondal G, Wang X, et al. Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res 2009; 69:5531-5536.
    • (2009) Cancer Res , vol.69 , pp. 5531-5536
    • Wu, X.1    Mondal, G.2    Wang, X.3
  • 31
    • 65549153625 scopus 로고    scopus 로고
    • Cancer. Complicated supercomplexes
    • Livingston DM. Cancer. Complicated supercomplexes. Science 2009; 324:602-603.
    • (2009) Science , vol.324 , pp. 602-603
    • Livingston, D.M.1
  • 32
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-Ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-Ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361:123-134.
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 33
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992,an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D, Ambrogio L, Shimamura T, et al. BIBW2992,an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008; 27:4702-4711.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3
  • 34
    • 46749156706 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    • Guix M, Faber AC, Wang SE, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 2008; 118:2609-2619.
    • (2008) J Clin Invest , vol.118 , pp. 2609-2619
    • Guix, M.1    Faber, A.C.2    Wang, S.E.3
  • 35
    • 58149229326 scopus 로고    scopus 로고
    • Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
    • Wolf I, Levanon-Cohen S, Bose S, et al. Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 2008; 27:7094-7105.
    • (2008) Oncogene , vol.27 , pp. 7094-7105
    • Wolf, I.1    Levanon-Cohen, S.2    Bose, S.3
  • 36
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007; 117:3846-3856.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3
  • 37
    • 66949122194 scopus 로고    scopus 로고
    • IL-6/gp130/STAT3 signaling axis in cancer and the presence of in-frame gp130 somatic deletions in inflammatory hepatocellular tumors
    • Rosell R, Bertran-Alamillo J, Molina MA, Taron M. IL-6/gp130/STAT3 signaling axis in cancer and the presence of in-frame gp130 somatic deletions in inflammatory hepatocellular tumors. Future Oncol 2009; 5:305-308.
    • (2009) Future Oncol , vol.5 , pp. 305-308
    • Rosell, R.1    Bertran-Alamillo, J.2    Molina, M.A.3    Taron, M.4
  • 38
    • 33750571170 scopus 로고    scopus 로고
    • Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
    • Morgillo F, Woo JK, Kim ES, et al. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res 2006; 66:10100-10111.
    • (2006) Cancer Res , vol.66 , pp. 10100-10111
    • Morgillo, F.1    Woo, J.K.2    Kim, E.S.3
  • 39
    • 67649500009 scopus 로고    scopus 로고
    • GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
    • Scott KL, Kabbarah O, Liang MC, et al. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature 2009; 459:1085-1090.
    • (2009) Nature , vol.459 , pp. 1085-1090
    • Scott, K.L.1    Kabbarah, O.2    Liang, M.C.3
  • 40
    • 38749089854 scopus 로고    scopus 로고
    • MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    • Schetter AJ, Leung SY, Sohn JJ, et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 2008; 299:425-436.
    • (2008) JAMA , vol.299 , pp. 425-436
    • Schetter, A.J.1    Leung, S.Y.2    Sohn, J.J.3
  • 41
    • 67649120071 scopus 로고    scopus 로고
    • MicroRNA identification in plasma and serum: A new tool to diagnose and monitor diseases
    • Cortez MA, Calin GA. MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases. Expert Opin Biol Ther 2009; 9:703-711.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 703-711
    • Cortez, M.A.1    Calin, G.A.2
  • 42
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall-cell lung cancer to gefitinib. N Engl J Med 2004; 350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 43
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 44
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptorgenemutations arecommon in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • PaoW,MillerV,ZakowskiM,etal. EGF receptorgenemutations arecommon in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004; 101:13306-13311.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 45
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • Taron M, Ichinose Y, Rosell R, et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res 2005; 11:5878-5885.
    • (2005) Clin Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3
  • 46
    • 65349165823 scopus 로고    scopus 로고
    • EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer
    • Smouse JH, Cibas ES, Janne PA, et al. EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer. Cancer Cytopathol 2009; 117:67-72.
    • (2009) Cancer Cytopathol , vol.117 , pp. 67-72
    • Smouse, J.H.1    Cibas, E.S.2    Janne, P.A.3
  • 47
    • 58949089105 scopus 로고    scopus 로고
    • A sensitive method for detecting EGFR mutations in nonsmall cell lung cancer samples with few tumor cells
    • Molina-Vila MA, Bertran-Alamillo J, Reguart N, et al. A sensitive method for detecting EGFR mutations in nonsmall cell lung cancer samples with few tumor cells. J Thorac Oncol 2008; 3:1224-1235.
    • (2008) J Thorac Oncol , vol.3 , pp. 1224-1235
    • Molina-Vila, M.A.1    Bertran-Alamillo, J.2    Reguart, N.3
  • 48
    • 38949177364 scopus 로고    scopus 로고
    • Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation
    • Miyazawa H, Tanaka T, Nagai Y, et al. Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation.Cancer Sci 2008; 99:595-600.
    • (2008) Cancer Sci , vol.99 , pp. 595-600
    • Miyazawa, H.1    Tanaka, T.2    Nagai, Y.3


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