-
1
-
-
34248204234
-
Uncommon tumors and exceptional therapies: Paradox or paradigm?
-
DOI 10.1158/1535-7163.MCT-06-0674
-
Braiteh F, Kurzrock R. Uncommon tumors and exceptional therapies: Paradox or paradigm? Mol Cancer Ther 2007;6:1175-1179. (Pubitemid 46711980)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.4
, pp. 1175-1179
-
-
Braiteh, F.1
Kurzrock, R.2
-
2
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441401
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-1037. (Pubitemid 32267972)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
3
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
DOI 10.1056/NEJMoa020461
-
Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472-480. (Pubitemid 34879334)
-
(2002)
New England Journal of Medicine
, vol.347
, Issue.7
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
Van Den Abbeele, A.D.4
Eisenberg, B.5
Roberts, P.J.6
Heinrich, M.C.7
Tuveson, D.A.8
Singer, S.9
Janicek, M.10
Fletcher, J.A.11
Silverman, S.G.12
Silberman, S.L.13
Capdeville, R.14
Kiese, B.15
Peng, B.16
Dimitrijevic, S.17
Druker, B.J.18
Corless, C.19
Fletcher, C.D.M.20
Joensuu, H.21
more..
-
4
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809-819.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
5
-
-
79952690921
-
PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors
-
Janku F, Tsimberidou AM, Garrido-Laguna I, et al. PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors. Mol Cancer Ther 2011;10:558-565.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 558-565
-
-
Janku, F.1
Tsimberidou, A.M.2
Garrido-Laguna, I.3
-
6
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
DOI 10.1056/NEJMoa050753
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353: 123-132. (Pubitemid 41058344)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Pereira, J.R.2
Ciuleanu, T.3
Eng, H.T.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
7
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-2550. (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
9
-
-
79960042770
-
Targeted therapy in non-smallcell lung cancer-is it becoming a reality?
-
Janku F, Stewart DJ, Kurzrock R. Targeted therapy in non-smallcell lung cancer-is it becoming a reality? Nat Rev Clin Oncol 2010;7:401-414.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 401-414
-
-
Janku, F.1
Stewart, D.J.2
Kurzrock, R.3
-
10
-
-
79951862254
-
The evolving role of histology in the management of advanced non-small-cell lung cancer
-
Langer CJ, Besse B, Gualberto A, et al. The evolving role of histology in the management of advanced non-small-cell lung cancer. J Clin Oncol 2010;28:5311-5320.
-
(2010)
J Clin Oncol
, vol.28
, pp. 5311-5320
-
-
Langer, C.J.1
Besse, B.2
Gualberto, A.3
-
11
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
DOI 10.1038/nature06358, PII NATURE06358
-
Weir BA, Woo MS, Getz G, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007;450:893-898. (Pubitemid 350231325)
-
(2007)
Nature
, vol.450
, Issue.7171
, pp. 893-898
-
-
Weir, B.A.1
Woo, M.S.2
Getz, G.3
Perner, S.4
Ding, L.5
Beroukhim, R.6
Lin, W.M.7
Province, M.A.8
Kraja, A.9
Johnson, L.A.10
Shah, K.11
Sato, M.12
Thomas, R.K.13
Barletta, J.A.14
Borecki, I.B.15
Broderick, S.16
Chang, A.C.17
Chiang, D.Y.18
Chirieac, L.R.19
Cho, J.20
Fujii, Y.21
Gazdar, A.F.22
Giordano, T.23
Greulich, H.24
Hanna, M.25
Johnson, B.E.26
Kris, M.G.27
Lash, A.28
Lin, L.29
Lindeman, N.30
Mardis, E.R.31
McPherson, J.D.32
Minna, J.D.33
Morgan, M.B.34
Nadel, M.35
Orringer, M.B.36
Osborne, J.R.37
Ozenberger, B.38
Ramos, A.H.39
Robinson, J.40
Roth, J.A.41
Rusch, V.42
Sasaki, H.43
Shepherd, F.44
Sougnez, C.45
Spitz, M.R.46
Tsao, M.-S.47
Twomey, D.48
Verhaak, R.G.W.49
Weinstock, G.M.50
Wheeler, D.A.51
Winckler, W.52
Yoshizawa, A.53
Yu, S.54
Zakowski, M.F.55
Zhang, Q.56
Beer, D.G.57
Wistuba, I.I.58
Watson, M.A.59
Garraway, L.A.60
Ladanyi, M.61
Travis, W.D.62
Pao, W.63
Rubin, M.A.64
Gabriel, S.B.65
Gibbs, R.A.66
Varmus, H.E.67
Wilson, R.K.68
Lander, E.S.69
Meyerson, M.70
more..
-
12
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008;455:1069-1075.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
-
13
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
DOI 10.1038/nature04869, PII NATURE04869
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006;441:424-430. (Pubitemid 44050136)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
14
-
-
33750962024
-
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
-
DOI 10.1200/JCO.2006.06.3958
-
Hirsch FR, Varella-Garcia M, Bunn PA Jr, et al. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol 2006;24:5034-5042. (Pubitemid 46631407)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.31
, pp. 5034-5042
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn Jr., P.A.3
Franklin, W.A.4
Dziadziuszko, R.5
Thatcher, N.6
Chang, A.7
Parikh, P.8
Pereira, J.R.9
Ciuleanu, T.10
Von Pawel, J.11
Watkins, C.12
Flannery, A.13
Ellison, G.14
Donald, E.15
Knight, L.16
Parums, D.17
Botwood, N.18
Holloway, B.19
-
15
-
-
49149127726
-
Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy
-
Hirsch FR, Herbst RS, Olsen C, et al. Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol 2008;26:3351-3357.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3351-3357
-
-
Hirsch, F.R.1
Herbst, R.S.2
Olsen, C.3
-
16
-
-
68949124435
-
Molecular and clinical predictors of outcome for cetuximab in non-small cell lung cancer (NSCLC): Data from the FLEX study
-
abstract 8007
-
O'Byrne KJ, Bondarenko I, Barrios C, et al. Molecular and clinical predictors of outcome for cetuximab in non-small cell lung cancer (NSCLC): Data from the FLEX study. J Clin Oncol 2009;27:abstract 8007.
-
(2009)
J Clin Oncol
, vol.27
-
-
O'Byrne, K.J.1
Bondarenko, I.2
Barrios, C.3
-
17
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
DOI 10.1093/jnci/dji055
-
Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005;97:339-346. (Pubitemid 40425952)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.5
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
Nomura, M.4
Suzuki, M.5
Wistuba, I.I.6
Fong, K.M.7
Lee, H.8
Toyooka, S.9
Shimizu, N.10
Fujisawa, T.11
Feng, Z.12
Roth, J.A.13
Herz, J.14
Minna, J.D.15
Gazdar, A.F.16
-
18
-
-
69949186250
-
Screening for epidermal growth factor receptor mutations in lung cancer
-
Rosell R, Moran T, Queralt C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009;361:958-967.
-
(2009)
N Engl J Med
, vol.361
, pp. 958-967
-
-
Rosell, R.1
Moran, T.2
Queralt, C.3
-
19
-
-
20244388126
-
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
-
DOI 10.1200/JCO.2005.00.992
-
Mitsudomi T, Kosaka T, Endoh H, et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 2005;23:2513-2520. (Pubitemid 47050841)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.11
, pp. 2513-2520
-
-
Mitsudomi, T.1
Kosaka, T.2
Endoh, H.3
Horio, Y.4
Hida, T.5
Mori, S.6
Hatooka, S.7
Shinoda, M.8
Takahashi, T.9
Yatabe, Y.10
-
20
-
-
22044453790
-
Erlotinib in lung cancer - Molecular and clinical predictors of outcome
-
DOI 10.1056/NEJMoa050736
-
Tsao MS, Sakurada A, Cutz JC, et al. Erlotinib in lung cancer- molecular and clinical predictors of outcome. N Engl J Med 2005;353: 133-144. (Pubitemid 41058345)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 133-144
-
-
Tsao, M.-S.1
Sakurada, A.2
Cutz, J.-C.3
Zhu, C.-Q.4
Kamel-Reid, S.5
Squire, J.6
Lorimer, I.7
Zhang, T.8
Liu, N.9
Daneshmand, M.10
Marrano, P.11
Da Cunha Santos, G.12
Lagarde, A.13
Richardson, F.14
Seymour, L.15
Whitehead, M.16
Ding, K.17
Pater, J.18
Shepherd, F.A.19
-
21
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008;26:2442-2449.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
-
22
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011;3:75ra26.
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
23
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007;104: 20932-20937.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
24
-
-
63849163410
-
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
-
Cappuzzo F, Marchetti A, Skokan M, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 2009;27:1667-1674.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1667-1674
-
-
Cappuzzo, F.1
Marchetti, A.2
Skokan, M.3
-
25
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
DOI 10.1126/science.1141478
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-1043. (Pubitemid 46799492)
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Joon, O.P.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
26
-
-
75549087826
-
COSMIC (the catalogue of somatic mutations in cancer): A resource to investigate acquired mutations in human cancer
-
Forbes SA, Tang G, Bindal N, et al. COSMIC (the catalogue of somatic mutations in cancer): A resource to investigate acquired mutations in human cancer. Nucleic Acids Res 2010;38:D652-D657.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Forbes, S.A.1
Tang, G.2
Bindal, N.3
-
27
-
-
33745651593
-
A transforming MET mutation discovered in non-small cell lung cancer using microarray-based resequencing
-
DOI 10.1016/j.canlet.2005.08.007, PII S0304383505007482
-
Tengs T, Lee JC, Paez JG, et al. A transforming MET mutation discovered in non-small cell lung cancer using microarray-based resequencing. Cancer Lett 2006;239:227-233. (Pubitemid 43974865)
-
(2006)
Cancer Letters
, vol.239
, Issue.2
, pp. 227-233
-
-
Tengs, T.1
Lee, J.C.2
Guillermo Paez, J.3
Zhao, X.4
LaFramboise, T.5
Giannoukos, G.6
Thomas, R.K.7
-
28
-
-
61549138135
-
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
-
Onozato R, Kosaka T, Kuwano H, et al. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol 2009;4:5-11.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 5-11
-
-
Onozato, R.1
Kosaka, T.2
Kuwano, H.3
-
29
-
-
65249095599
-
The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
-
Wong DW, Leung EL, So KK, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer 2009;115:1723-1733.
-
(2009)
Cancer
, vol.115
, pp. 1723-1733
-
-
Wong, D.W.1
Leung, E.L.2
So, K.K.3
-
30
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
DOI 10.1038/nature05945, PII NATURE05945
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007; 448:561-566. (Pubitemid 47206930)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.-I.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
Ishikawa, Y.13
Aburatani, H.14
Niki, T.15
Sohara, Y.16
Sugiyama, Y.17
Mano, H.18
-
31
-
-
77649222572
-
Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-smallcell lung cancer: Data from the randomized phase III INTEREST trial
-
Douillard JY, Shepherd FA, Hirsh V, et al. Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-smallcell lung cancer: Data from the randomized phase III INTEREST trial. J Clin Oncol 2010;28:744-752.
-
(2010)
J Clin Oncol
, vol.28
, pp. 744-752
-
-
Douillard, J.Y.1
Shepherd, F.A.2
Hirsh, V.3
-
32
-
-
77949886293
-
Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-smallcell lung cancer
-
Khambata-Ford S, Harbison CT, Hart LL, et al. Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-smallcell lung cancer. J Clin Oncol 2010;28:918-927.
-
(2010)
J Clin Oncol
, vol.28
, pp. 918-927
-
-
Khambata-Ford, S.1
Harbison, C.T.2
Hart, L.L.3
-
33
-
-
0023271954
-
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung
-
Rodenhuis S, van de Wetering ML, Mooi WJ, et al. Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. N Engl J Med 1987;317:929-935. (Pubitemid 17147935)
-
(1987)
New England Journal of Medicine
, vol.317
, Issue.15
, pp. 929-935
-
-
Rodenhuis, S.1
Van De Wetering, M.L.2
Mooi, W.J.3
-
34
-
-
0026425629
-
Ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent
-
Mitsudomi T, Steinberg SM, Oie HK, et al. ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. Cancer Res 1991;51:4999-5002.
-
(1991)
Cancer Res
, vol.51
, pp. 4999-5002
-
-
Mitsudomi, T.1
Steinberg, S.M.2
Oie, H.K.3
-
35
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
Stephens P, Hunter C, Bignell G, et al. Lung cancer: Intragenic ERBB2 kinase mutations in tumours. Nature 2004;431:525-526.
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
-
36
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
DOI 10.1158/0008-5472.CAN-04-4235
-
Shigematsu H, Takahashi T, Nomura M, et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 2005;65: 1642-1646. (Pubitemid 40478587)
-
(2005)
Cancer Research
, vol.65
, Issue.5
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
Majmudar, K.4
Suzuki, M.5
Lee, H.6
Wistuba, I.I.7
Fong, K.M.8
Toyooka, S.9
Shimizu, N.10
Fujisawa, T.11
Minna, J.D.12
Gazdar, A.F.13
-
37
-
-
34548485621
-
PIK3CA gene amplification in Japanese non-small cell lung cancer
-
DOI 10.1016/j.lungcan.2007.06.020, PII S0169500207003960
-
Kawano O, Sasaki H, Okuda K, et al. PIK3CA gene amplification in Japanese non-small cell lung cancer. Lung Cancer 2007;58:159-160. (Pubitemid 47379973)
-
(2007)
Lung Cancer
, vol.58
, Issue.1
, pp. 159-160
-
-
Kawano, O.1
Sasaki, H.2
Okuda, K.3
Yukiue, H.4
Yokoyama, T.5
Yano, M.6
Fujii, Y.7
-
38
-
-
52049099853
-
PIK3CA mutations and copy number gains in human lung cancers
-
Yamamoto H, Shigematsu H, Nomura M, et al. PIK3CA mutations and copy number gains in human lung cancers. Cancer Res 2008;68:6913-6921.
-
(2008)
Cancer Res
, vol.68
, pp. 6913-6921
-
-
Yamamoto, H.1
Shigematsu, H.2
Nomura, M.3
-
39
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
DOI 10.1016/j.lungcan.2006.07.006, PII S0169500206003576
-
Kawano O, Sasaki H, Endo K, et al. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 2006;54:209-215. (Pubitemid 44764916)
-
(2006)
Lung Cancer
, vol.54
, Issue.2
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
Suzuki, E.4
Haneda, H.5
Yukiue, H.6
Kobayashi, Y.7
Yano, M.8
Fujii, Y.9
-
40
-
-
79955040269
-
PIK3CA, KRAS, and BRAF mutations in patients with advanced cancers treated with PI3K/ AKT/mTOR axis inhibitors
-
abstract 2583
-
Janku F, Tsimberidou A, Garrido-Laguna I, et al. PIK3CA, KRAS, and BRAF mutations in patients with advanced cancers treated with PI3K/ AKT/mTOR axis inhibitors. J Clin Oncol 2010;28:abstract 2583.
-
(2010)
J Clin Oncol
, vol.28
-
-
Janku, F.1
Tsimberidou, A.2
Garrido-Laguna, I.3
-
41
-
-
79956316170
-
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
-
Paik PK, Arcila ME, Fara M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 2011;29:2046-2051.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2046-2051
-
-
Paik, P.K.1
Arcila, M.E.2
Fara, M.3
-
42
-
-
77952309862
-
Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: A comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression
-
Dziadziuszko R, Merrick DT, Witta SE, et al. Insulin-like growth factor receptor 1 (IGF1R) gene copy number is associated with survival in operable non-small-cell lung cancer: A comparison between IGF1R fluorescent in situ hybridization, protein expression, and mRNA expression. J Clin Oncol 2010;28:2174-2180.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2174-2180
-
-
Dziadziuszko, R.1
Merrick, D.T.2
Witta, S.E.3
-
43
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
DOI 10.1016/S0140-6736(05)67625-8, PII S0140673605676258
-
Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-smallcell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-1537. (Pubitemid 41540110)
-
(2005)
Lancet
, vol.366
, Issue.9496
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Pereira, J.R.4
Ciuleanu, T.5
Von Pawel, J.6
Thongprasert, S.7
Tan, E.H.8
Pemberton, K.9
Archer, V.10
Carroll, K.11
-
44
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
DOI 10.1200/JCO.2004.08.001
-
Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1. J Clin Oncol 2004;22:777-784. (Pubitemid 41103588)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
Natale, R.B.7
Schiller, J.H.8
Von Pawel, J.9
Pluzanska, A.10
Gatzemeier, U.11
Grous, J.12
Ochs, J.S.13
Averbuch, S.D.14
Wolf, M.K.15
Rennie, P.16
Fandi, A.17
Johnson, D.H.18
-
45
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
DOI 10.1200/JCO.2004.07.215
-
Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2. J Clin Oncol 2004;22:785-794. (Pubitemid 41103589)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
Scagliotti, G.7
Rosell, R.8
Oliff, I.9
Reeves, J.A.10
Wolf, M.K.11
Krebs, A.D.12
Averbuch, S.D.13
Ochs, J.S.14
Grous, J.15
Fandi, A.16
Johnson, D.H.17
-
46
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva lung cancer investigation trial
-
DOI 10.1200/JCO.2005.05.1474
-
Gatzemeier U, Pluzanska A, Szczesna A, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva Lung Cancer Investigation Trial. J Clin Oncol 2007;25:1545-1552. (Pubitemid 46733081)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.12
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
Kaukel, E.4
Roubec, J.5
De Rosa, F.6
Milanowski, J.7
Karnicka-Mlodkowski, H.8
Pesek, M.9
Serwatowski, P.10
Ramlau, R.11
Janaskova, T.12
Vansteenkiste, J.13
Strausz, J.14
Manikhas, G.M.15
Von Pawel, J.16
-
47
-
-
24944440830
-
TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
Herbst RS, Prager D, Hermann R, et al. TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5892-5899.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
-
48
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
49
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362:2380-2388.
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
50
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
51
-
-
79954606282
-
Efficacy results from the randomised phase III Optimal (CTONG 0802) study comparing first-line erlotinib versus carboplatin (CBDCA) plus gemcitabine (GEM), in Chinese advanced non-small-cell lung cancer (NSCLC) patients (PTS) with EGFR activating mutations
-
abstract LBA13
-
Zhou C, Wu Y-L, Chen G, et al. Efficacy results from the randomised phase III Optimal (CTONG 0802) study comparing first-line erlotinib versus carboplatin (CBDCA) plus gemcitabine (GEM), in Chinese advanced non-small-cell lung cancer (NSCLC) patients (PTS) with EGFR activating mutations. Ann Oncol 2010;21:viii6, abstract LBA13.
-
(2010)
Ann Oncol
, vol.21
-
-
Zhou, C.1
Wu, Y-.L.2
Chen, G.3
-
52
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F, Ciuleanu T, Stelmakh L, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 2010;11: 521-529.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
-
53
-
-
70349477817
-
A randomized, doubleblind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
-
abstract LBA8002
-
Miller VA, O'Connor P, Soh C, Kabbinavar F. A randomized, doubleblind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2009;27:abstract LBA8002.
-
(2009)
J Clin Oncol
, vol.27
-
-
Miller, V.A.1
O'Connor, P.2
Soh, C.3
Kabbinavar, F.4
-
54
-
-
78650429490
-
Phase IIB/III double-blind randomized trial of afatinib (BIBW 2992, an irreversible inhibitor of EGFR/HER1 and HER2) + best supportive care (BSC) versus placebo + BSC in patients with NSCLC failing 1-2 lines of chemotherapy and erlotinib or gefitinib (LUX-LUNG 1)
-
abstract LBA1
-
Miller VA, Hirsh V, Cadranel J, et al. Phase IIB/III double-blind randomized trial of afatinib (BIBW 2992, an irreversible inhibitor of EGFR/HER1 and HER2) + best supportive care (BSC) versus placebo + BSC in patients with NSCLC failing 1-2 lines of chemotherapy and erlotinib or gefitinib (LUX-LUNG 1). Ann Oncol 2010;21:abstract LBA1.
-
(2010)
Ann Oncol
, vol.21
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
55
-
-
77958011527
-
Efficacy and safety of PF299804 versus erlotinib (E): A global, randomized phase II trial in patients (pts) with advanced non-small cell lung cancer (NSCLC) after failure of chemotherapy (CT)
-
abstract LBA7523
-
Boyer MJ, Blackhall FH, Park K, et al. Efficacy and safety of PF299804 versus erlotinib (E): A global, randomized phase II trial in patients (pts) with advanced non-small cell lung cancer (NSCLC) after failure of chemotherapy (CT). J Clin Oncol 2010;28:abstract LBA7523.
-
(2010)
J Clin Oncol
, vol.28
-
-
Boyer, M.J.1
Blackhall, F.H.2
Park, K.3
-
56
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
-
Pirker R, Pereira JR, Szczesna A, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial. Lancet 2009;373:1525-1531.
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
-
57
-
-
77949891126
-
Cetuximab and first-line taxane/ carboplatin chemotherapy in advanced non-small-cell lung cancer: Results of the randomized multicenter phase III trial BMS099
-
Lynch TJ, Patel T, Dreisbach L, et al. Cetuximab and first-line taxane/ carboplatin chemotherapy in advanced non-small-cell lung cancer: Results of the randomized multicenter phase III trial BMS099. J Clin Oncol 2010;28:911-917.
-
(2010)
J Clin Oncol
, vol.28
, pp. 911-917
-
-
Lynch, T.J.1
Patel, T.2
Dreisbach, L.3
-
58
-
-
62449124416
-
Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
-
Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009;27:1227-1234.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1227-1234
-
-
Reck, M.1
Von Pawel, J.2
Zatloukal, P.3
-
59
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL)
-
Reck M, von Pawel J, Zatloukal P, et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL). Ann Oncol 2010;21:1804 -1809.
-
(2010)
Ann Oncol
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
Von Pawel, J.2
Zatloukal, P.3
-
60
-
-
77951639655
-
Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced nonsmall- cell lung cancer
-
Scagliotti G, Novello S, von Pawel J, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced nonsmall- cell lung cancer. J Clin Oncol 2010;28:1835-1842.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1835-1842
-
-
Scagliotti, G.1
Novello, S.2
Von Pawel, J.3
-
61
-
-
65349161533
-
A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501
-
abstract 8014
-
Schiller JH, Lee JW, Hanna NH, et al. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501. J Clin Oncol 2008;26:abstract 8014.
-
(2008)
J Clin Oncol
, vol.26
-
-
Schiller, J.H.1
Lee, J.W.2
Hanna, N.H.3
-
62
-
-
77954035012
-
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
-
Herbst RS, Sun Y, Eberhardt WE, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial. Lancet Oncol 2010;11:619-626.
-
(2010)
Lancet Oncol
, vol.11
, pp. 619-626
-
-
Herbst, R.S.1
Sun, Y.2
Eberhardt, W.E.3
-
63
-
-
79952742483
-
Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial
-
de Boer RH, Arrieta O, Yang CH, et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial. J Clin Oncol 2011;29:1067-1074.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1067-1074
-
-
De Boer, R.H.1
Arrieta, O.2
Yang, C.H.3
-
64
-
-
79952748468
-
Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
-
Natale RB, Thongprasert S, Greco FA, et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011;29:1059-1066.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1059-1066
-
-
Natale, R.B.1
Thongprasert, S.2
Greco, F.A.3
-
65
-
-
56749102822
-
Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
-
Heymach JV, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008;26:5407-5415.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5407-5415
-
-
Heymach, J.V.1
Paz-Ares, L.2
De Braud, F.3
-
66
-
-
66349091290
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Karp DD, Paz-Ares LG, Novello S, et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 2009;27:2516-2522.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
-
67
-
-
77956227862
-
Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
-
abstract 7500
-
Jassem J, Langer CJ, Karp DD, et al. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28:abstract 7500.
-
(2010)
J Clin Oncol
, vol.28
-
-
Jassem, J.1
Langer, C.J.2
Karp, D.D.3
-
68
-
-
77957031745
-
Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
-
Abstract LBA7502
-
Schiller JH, Akerley WL, Brugger W, et al. Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28: Abstract LBA7502.
-
(2010)
J Clin Oncol
, vol.28
-
-
Schiller, J.H.1
Akerley, W.L.2
Brugger, W.3
-
69
-
-
63049132774
-
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
-
Inoue A, Kobayashi K, Usui K, et al. First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol 2009;27:1394-1400.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1394-1400
-
-
Inoue, A.1
Kobayashi, K.2
Usui, K.3
-
70
-
-
33746789922
-
Prospective phase II study of gefitinib for chemotherapy-naïve patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
-
DOI 10.1200/JCO.2005.05.4692
-
Inoue A, Suzuki T, Fukuhara T, et al. Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 2006;24:3340-3346. (Pubitemid 46638887)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.21
, pp. 3340-3346
-
-
Inoue, A.1
Suzuki, T.2
Fukuhara, T.3
Maemondo, M.4
Kimura, Y.5
Morikawa, N.6
Watanabe, H.7
Saijo, Y.8
Nukiwa, T.9
-
71
-
-
45749120442
-
Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy
-
Yang CH, Yu CJ, Shih JY, et al. Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy. J Clin Oncol 2008;26:2745-2753.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2745-2753
-
-
Yang, C.H.1
Yu, C.J.2
Shih, J.Y.3
-
72
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-5909.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
-
73
-
-
71549143528
-
Detecting an overall survival benefit that is derived from progression-free survival
-
Broglio KR, Berry DA. Detecting an overall survival benefit that is derived from progression-free survival. J Natl Cancer Inst 2009;101: 1642-1649.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 1642-1649
-
-
Broglio, K.R.1
Berry, D.A.2
-
74
-
-
2342471392
-
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib
-
DOI 10.1056/NEJMoa040938
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of nonsmall- cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-2139. (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
75
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
DOI 10.1158/0008-5472.CAN-04-2818
-
Kosaka T, Yatabe Y, Endoh H, et al. Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications. Cancer Res 2004;64:8919-8923. (Pubitemid 39665498)
-
(2004)
Cancer Research
, vol.64
, Issue.24
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
Kuwano, H.4
Takahashi, T.5
Mitsudomi, T.6
-
76
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa044238
-
Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005;352:786-792. (Pubitemid 40271173)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.8
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
Johnson, B.E.7
Eck, M.J.8
Tenen, D.G.9
Halmos, B.10
-
77
-
-
28844501639
-
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
-
DOI 10.1002/ijc.21496
-
Shigematsu H, Gazdar AF. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 2006; 118:257-262. (Pubitemid 41779062)
-
(2006)
International Journal of Cancer
, vol.118
, Issue.2
, pp. 257-262
-
-
Shigematsu, H.1
Gazdar, A.F.2
-
78
-
-
75249090732
-
Clinical outcome of patients with different types of epidermal growth factor receptor mutations in IPASS
-
abstract B9.5
-
Mok T, To K, Wu YL, et al. Clinical outcome of patients with different types of epidermal growth factor receptor mutations in IPASS. J Thorac Oncol 2009;4:abstract B9.5.
-
(2009)
J Thorac Oncol
, vol.4
-
-
Mok, T.1
To, K.2
Wu, Y.L.3
-
79
-
-
33750302365
-
Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
-
Kosaka T, Yatabe Y, Endoh H, et al. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 2006;12: 5764-5749.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5764-5749
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
-
80
-
-
33751292685
-
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
-
DOI 10.1158/1078-0432.CCR-06-1570
-
Balak MN, Gong Y, Riely GJ, et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptormutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res 2006;12:6494-6501. (Pubitemid 44799723)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.21
, pp. 6494-6501
-
-
Balak, M.N.1
Gong, Y.2
Riely, G.J.3
Somwar, R.4
Li, A.R.5
Zakowski, M.F.6
Chiang, A.7
Yang, G.8
Ouerfelli, O.9
Kris, M.G.10
Ladanyi, M.11
Miller, V.A.12
Pao, W.13
-
81
-
-
21144439000
-
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
-
DOI 10.1073/pnas.0502860102
-
Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci USA 2005;102:7665-7670. (Pubitemid 40741028)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.21
, pp. 7665-7670
-
-
Kwak, E.L.1
Sordella, R.2
Bell, D.W.3
Godin-Heymann, N.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Driscoll, D.R.8
Fidias, P.9
Lynch, T.J.10
Rabindran, S.K.11
McGinnis, J.P.12
Wissner, A.13
Sharma, S.V.14
Isselbacher, K.J.15
Settleman, J.16
Haber, D.A.17
-
82
-
-
37549061078
-
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
-
Engelman JA, Zejnullahu K, Gale CM, et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 2007;67:11924-11932.
-
(2007)
Cancer Res
, vol.67
, pp. 11924-11932
-
-
Engelman, J.A.1
Zejnullahu, K.2
Gale, C.M.3
-
83
-
-
38849114239
-
Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced non-small-cell lung cancer
-
DOI 10.1093/annonc/mdm474
-
Rosell R, Robinet G, Szczesna A, et al. Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced nonsmall- cell lung cancer. Ann Oncol 2008;19:362-369. (Pubitemid 351201721)
-
(2008)
Annals of Oncology
, vol.19
, Issue.2
, pp. 362-369
-
-
Rosell, R.1
Robinet, G.2
Szczesna, A.3
Ramlau, R.4
Constenla, M.5
Mennecier, B.C.6
Pfeifer, W.7
O'byrne, K.J.8
Welte, T.9
Kolb, R.10
Pirker, R.11
Chemaissani, A.12
Perol, M.13
Ranson, M.R.14
Ellis, P.A.15
Pilz, K.16
Reck, M.17
-
84
-
-
78650694719
-
First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with first-line chemotherapy: A subgroup analysis of data from the FLEX phase 3 study
-
Gatzemeier U, von Pawel J, Vynnychenko I, et al. First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with first-line chemotherapy: A subgroup analysis of data from the FLEX phase 3 study. Lancet Oncol 2011;12: 30-37.
-
(2011)
Lancet Oncol
, vol.12
, pp. 30-37
-
-
Gatzemeier, U.1
Von Pawel, J.2
Vynnychenko, I.3
-
85
-
-
42949176742
-
Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity
-
DOI 10.1016/j.ccr.2008.03.015, PII S1535610808001207
-
Weihua Z, Tsan R, Huang WC, et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008;13:385-393. (Pubitemid 351609444)
-
(2008)
Cancer Cell
, vol.13
, Issue.5
, pp. 385-393
-
-
Weihua, Z.1
Tsan, R.2
Huang, W.-C.3
Wu, Q.4
Chiu, C.-H.5
Fidler, I.J.6
Hung, M.-C.7
-
86
-
-
0021241398
-
Molecular cloning of a new transforming gene from a chemically transformed human cell line
-
Cooper CS, Park M, Blair DG, et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 1984;311:29-33. (Pubitemid 14065275)
-
(1984)
Nature
, vol.311
, Issue.5981
, pp. 29-33
-
-
Cooper, C.S.1
Park, M.2
Blair, D.G.3
-
87
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15:220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
88
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
DOI 10.1016/S1535-6108(03)00085-0, PII S1535610803000850
-
Pennacchietti S, Michieli P, Galluzzo M, et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003;3:347-361. (Pubitemid 38340304)
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
89
-
-
77951760333
-
A phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors
-
Rosen PJ, Sweeney CJ, Park DJ, et al. A phase Ib study of AMG 102 in combination with bevacizumab or motesanib in patients with advanced solid tumors. Clin Cancer Res 2010;16:2677-2687.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2677-2687
-
-
Rosen, P.J.1
Sweeney, C.J.2
Park, D.J.3
-
90
-
-
78650509347
-
Randomized multicenter double-blind placebo-controlled phase II study evaluating Metmab, an antibody to MET receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer
-
abstract LBA 15
-
Spigel D, Ervin T, Ramlau R, et al. Randomized multicenter double-blind placebo-controlled phase II study evaluating Metmab, an antibody to MET receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer. Ann Oncol 2010;21:viii7, abstract LBA 15.
-
(2010)
Ann Oncol
, vol.21
-
-
Spigel, D.1
Ervin, T.2
Ramlau, R.3
-
91
-
-
79959195227
-
A phase Ib/II study of XL184 (BMS 907351) with and without erlotinib (E) in patients (pts) with non-small cell lung cancer (NSCLC)
-
Abstract 3017
-
Wakelee HA, Gettinger SN, Engelman JA, et al. A phase Ib/II study of XL184 (BMS 907351) with and without erlotinib (E) in patients (pts) with non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28: Abstract 3017.
-
(2010)
J Clin Oncol
, vol.28
-
-
Wakelee, H.A.1
Gettinger, S.N.2
Engelman, J.A.3
-
92
-
-
77949894217
-
Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599
-
Dahlberg SE, Sandler AB, Brahmer JR, et al. Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599. J Clin Oncol 2010;28:949-954.
-
(2010)
J Clin Oncol
, vol.28
, pp. 949-954
-
-
Dahlberg, S.E.1
Sandler, A.B.2
Brahmer, J.R.3
-
93
-
-
33845297206
-
Efficacy and safety of sunitinib in previously treated, advanced non-small cell lung cancer (NSCLC): Preliminary results of a multicenter phase II trial
-
abstract 7001
-
Socinski MA, Novello S, Sanchez JM, et al. Efficacy and safety of sunitinib in previously treated, advanced non-small cell lung cancer (NSCLC): Preliminary results of a multicenter phase II trial. J Clin Oncol 2006;24:abstract 7001.
-
(2006)
J Clin Oncol
, vol.24
-
-
Socinski, M.A.1
Novello, S.2
Sanchez, J.M.3
-
94
-
-
33748913369
-
Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma
-
abstract 7002
-
Gatzemeier U, Blumenschein G, Fosella F. Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma. J Clin Oncol 2006;24:abstract 7002.
-
(2006)
J Clin Oncol
, vol.24
-
-
Gatzemeier, U.1
Blumenschein, G.2
Fosella, F.3
-
95
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009;27:4247-4253.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
96
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-1703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
97
-
-
0035883542
-
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung
-
DOI 10.1002/1097-0142(20010915)92: 6<1525::AID-CNCR1478>3.0.CO;2-H
-
Ahrendt SA, Decker PA, Alawi EA, et al. Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Cancer 2001;92:1525-1530. (Pubitemid 32947838)
-
(2001)
Cancer
, vol.92
, Issue.6
, pp. 1525-1530
-
-
Ahrendt, S.A.1
Anthony Decker, P.2
Alawi, E.A.3
Zhu, Y.-R.4
Sanchez-Cespedes, M.5
Yang, S.C.6
Haasler, G.B.7
Kajdacsy-Balla, A.8
Demeure, M.J.9
Sidransky, D.10
-
98
-
-
69349088824
-
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials
-
Jackman DM, Miller VA, Cioffredi LA, et al. Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials. Clin Cancer Res 2009;15:5267-5273.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5267-5273
-
-
Jackman, D.M.1
Miller, V.A.2
Cioffredi, L.A.3
-
99
-
-
52049090365
-
Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR. 21
-
Zhu CQ, da Cunha Santos G, Ding K, et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR. 21. J Clin Oncol 2008;26: 4268-4375.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4268-4375
-
-
Zhu, C.Q.1
Da Cunha Santos, G.2
Ding, K.3
-
100
-
-
79957857433
-
The BATTLE trial: Personalizing therapy for lung cancer
-
Kim ES, Herbst RS, Wistuba II, et al. The BATTLE trial: Personalizing therapy for lung cancer. Cancer Discovery 2011;1:43-51.
-
(2011)
Cancer Discovery
, vol.1
, pp. 43-51
-
-
Kim, E.S.1
Herbst, R.S.2
Wistuba, I.I.3
-
101
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman JA, Chen L, Tan X, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008;14:1351-1356.
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
-
102
-
-
80052189045
-
The oral MEK 1/2 inhibitor GSK 1120212 demonstrates early efficacy signals
-
abstract 495O
-
Falchook GS, Infante JR, Fecher LA, et al. The oral MEK 1/2 inhibitor GSK 1120212 demonstrates early efficacy signals. Ann Oncol 2010; 21:abstract 495O.
-
(2010)
Ann Oncol
, vol.21
-
-
Falchook, G.S.1
Infante, J.R.2
Fecher, L.A.3
-
104
-
-
0037291226
-
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors
-
DOI 10.1016/S1097-2765(03)00048-0
-
Garrett TP, McKern NM, Lou M, et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol Cell 2003;11:495-505. (Pubitemid 36293841)
-
(2003)
Molecular Cell
, vol.11
, Issue.2
, pp. 495-505
-
-
Garrett, T.P.J.1
McKern, N.M.2
Lou, M.3
Elleman, T.C.4
Adams, T.E.5
Lovrecz, G.O.6
Kofler, M.7
Jorissen, R.N.8
Nice, E.C.9
Burgess, A.W.10
Ward, C.W.11
-
105
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2
-
DOI 10.1056/NEJM200103153441101
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-792. (Pubitemid 32222155)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
106
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-697.
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
107
-
-
24644445676
-
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients
-
DOI 10.1200/JCO.2005.09.111
-
Cappuzzo F, Varella-Garcia M, Shigematsu H, et al. Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J Clin Oncol 2005;23:5007-5018. (Pubitemid 46224007)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.22
, pp. 5007-5018
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Shigematsu, H.3
Domenichini, I.4
Bartolini, S.5
Ceresoli, G.L.6
Rossi, E.7
Ludovini, V.8
Gregorc, V.9
Toschi, L.10
Franklin, W.A.11
Crino, L.12
Gazdar, A.F.13
Bunn Jr., P.A.14
Hirsch, F.R.15
-
108
-
-
10744231647
-
HER-2/neu Protein Expression and Gene Alteration in Stage I-IIIA Non-Small-Cell Lung Cancer: A Study of 140 Cases Using a Combination of High Throughput Tissue Microarray, Immunohistochemistry, and Fluorescent In Situ Hybridization
-
DOI 10.1097/00019606-200312000-00004
-
Tan D, Deeb G, Wang J, et al. HER-2/neu protein expression and gene alteration in stage I-IIIA non-small-cell lung cancer: A study of 140 cases using a combination of high throughput tissue microarray, immunohistochemistry, and fluorescent in situ hybridization. Diagn Mol Pathol 2003;12:201-211. (Pubitemid 37475228)
-
(2003)
Diagnostic Molecular Pathology
, vol.12
, Issue.4
, pp. 201-211
-
-
Tan, D.1
Deeb, G.2
Wang, J.3
Slocum, H.K.4
Winston, J.5
Wiseman, S.6
Beck, A.7
Sait, S.8
Anderson, T.9
Nwogu, C.10
Ramnath, N.11
Loewen, G.12
-
109
-
-
0141456467
-
HER-2/Neu alterations in non-small cell lung cancer: A comprehensive evaluation by real time reverse transcription-PCR, fluorescence in situ hybridization, and immunohistochemistry
-
Pellegrini C, Falleni M, Marchetti A, et al. HER-2/Neu alterations in non-small cell lung cancer: A comprehensive evaluation by real time reverse transcription-PCR, fluorescence in situ hybridization, and immunohistochemistry. Clin Cancer Res 2003;9:3645-3652. (Pubitemid 37169230)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.10
, pp. 3645-3652
-
-
Pellegrini, C.1
Falleni, M.2
Marchetti, A.3
Cassani, B.4
Miozzo, M.5
Buttitta, F.6
Roncalli, M.7
Coggi, G.8
Bosari, S.9
-
110
-
-
77949694139
-
Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer
-
Ross HJ, Blumenschein GR Jr, Aisner J, et al. Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer. Clin Cancer Res 2010;16:1938 -1949.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1938-1949
-
-
Ross, H.J.1
Blumenschein Jr., G.R.2
Aisner, J.3
-
111
-
-
33745727112
-
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
-
Wang SE, Narasanna A, Perez-Torres M, et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell 2006;10:25-38.
-
(2006)
Cancer Cell
, vol.10
, pp. 25-38
-
-
Wang, S.E.1
Narasanna, A.2
Perez-Torres, M.3
-
112
-
-
34250161814
-
Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-akt-positive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL trial
-
DOI 10.1200/JCO.2006.09.4300
-
Cappuzzo F, Ligorio C, Janne PA, et al. Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/ phospho-Akt-positive or never smoker patients with advanced nonsmall- cell lung cancer: The ONCOBELL trial. J Clin Oncol 2007;25:2248-2255. (Pubitemid 46954651)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.16
, pp. 2248-2255
-
-
Cappuzzo, F.1
Ligorio, C.2
Janne, P.A.3
Toschi, L.4
Rossi, E.5
Trisolini, R.6
Paioli, D.7
Holmes, A.J.8
Magrini, E.9
Finocchiaro, G.10
Bartolini, S.11
Cancellieri, A.12
Ciardiello, F.13
Patelli, M.14
Crino, L.15
Varella-Garcia, M.16
-
113
-
-
1642434133
-
Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3′-Kinase/Akt Pathway in Vitro and in Vivo
-
DOI 10.1158/0008-5472.CAN-03-3241
-
West KA, Linnoila IR, Belinsky SA, et al. Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. Cancer Res 2004;64:446-451. (Pubitemid 38120880)
-
(2004)
Cancer Research
, vol.64
, Issue.2
, pp. 446-451
-
-
West, K.A.1
Linnoila, I.R.2
Belinsky, S.A.3
Harris, C.C.4
Dennis, P.A.5
-
114
-
-
58249120506
-
Mutations in the phosphatidylinositol- 3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
-
Ihle NT, Lemos R Jr, Wipf P, et al. Mutations in the phosphatidylinositol- 3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res 2009;69:143-150.
-
(2009)
Cancer Res
, vol.69
, pp. 143-150
-
-
Ihle, N.T.1
Lemos Jr., R.2
Wipf, P.3
-
115
-
-
78651330430
-
COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer
-
Forbes SA, Bindal N, Bamford S, et al. COSMIC: Mining complete cancer genomes in the catalogue of somatic mutations in cancer. Nucleic Acids Res 2011;39:D945-D950.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Forbes, S.A.1
Bindal, N.2
Bamford, S.3
-
116
-
-
33644685228
-
The phosphatidylinositol- 3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts
-
Ihle NT, Paine-Murrieta G, Berggren MI, et al. The phosphatidylinositol- 3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther 2005;4: 1349-1357.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1349-1357
-
-
Ihle, N.T.1
Paine-Murrieta, G.2
Berggren, M.I.3
-
117
-
-
55949097252
-
Genetic predictors of MEK dependence in non-small cell lung cancer
-
Pratilas CA, Hanrahan AJ, Halilovic E, et al. Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res 2008;68: 9375-9383.
-
(2008)
Cancer Res
, vol.68
, pp. 9375-9383
-
-
Pratilas, C.A.1
Hanrahan, A.J.2
Halilovic, E.3
-
118
-
-
0042889104
-
Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas
-
DOI 10.1016/S0046-8177(03)00291-0
-
Ouban A, Muraca P, Yeatman T, et al. Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas. Hum Pathol 2003;34:803-808. (Pubitemid 37040618)
-
(2003)
Human Pathology
, vol.34
, Issue.8
, pp. 803-808
-
-
Ouban, A.1
Muraca, P.2
Yeatman, T.3
Coppola, D.4
-
119
-
-
0033911567
-
New concepts in regulation and function of the insulin-like growth factors: Implications for understanding normal growth and neoplasia
-
Werner H, Le Roith D. New concepts in regulation and function of the insulin-like growth factors: Implications for understanding normal growth and neoplasia. Cell Mol Life Sci 2000;57:932-942. (Pubitemid 30461834)
-
(2000)
Cellular and Molecular Life Sciences
, vol.57
, Issue.6
, pp. 932-942
-
-
Werner, H.1
Le Roith, D.2
-
120
-
-
33751076856
-
The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer
-
DOI 10.1016/j.lungcan.2006.07.014, PII S0169500206003643
-
Han JY, Choi BG, Choi JY, et al. The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer. Lung Cancer 2006;54:227-234. (Pubitemid 44764920)
-
(2006)
Lung Cancer
, vol.54
, Issue.2
, pp. 227-234
-
-
Han, J.-Y.1
Choi, B.G.2
Choi, J.Y.3
Lee, S.Y.4
Ju, S.Y.5
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