Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt

Cancer Research

Volumn 67, Issue 12, 2007, Pages 5779-5788

  Yamasaki, Fumiyuki ^a,b   Johansen, Mary J ^a   Zhang, Dongwei ^a   Krishnamurthy, Savitri ^a   Felix, Edward ^a   Bartholomeusz, Chandra ^a   Aguilar, Richard J ^a   Kurisu, Kaoru ^b   Mills, Gordon B ^a   Hortobagyi, Gabriel N ^a   Ueno, Naoto T ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERLOTINIB; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTYROSINE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SERINE;

ADVANCED CANCER; ANTIBODY DETECTION; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME REPRESSION; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA; TANDEM MASS SPECTROMETRY; UPREGULATION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GENE DOSAGE; HUMANS; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION, FLUORESCENCE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFECTION; UP-REGULATION;

EID: 34250898667     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-3020     Document Type: Article

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