-
1
-
-
9444287030
-
Common and distinct elements in cellular signaling via EGF and FGF receptors
-
Schlessinger J: Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 306:1506-1507, 2004
-
(2004)
Science
, vol.306
, pp. 1506-1507
-
-
Schlessinger, J.1
-
3
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500, 2004
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
4
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139, 2004
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
5
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 101:13306-13311, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
6
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
Stephens P, Hunter C, Bignell G, et al: Lung cancer: Intragenic ERBB2 kinase mutations in tumours. Nature 431:525-526, 2004
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
-
7
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T: Oncogenic kinase signalling. Nature 411:355-365, 2001
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
8
-
-
28844501639
-
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
-
Shigematsu H, Gazdar AF: Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer 118:257-262, 2006
-
(2006)
Int J Cancer
, vol.118
, pp. 257-262
-
-
Shigematsu, H.1
Gazdar, A.F.2
-
9
-
-
2442701289
-
The ErbB/HER receptor protein-tyrosine kinases and cancer
-
Roskoski R Jr: The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 319:1-11, 2004
-
(2004)
Biochem Biophys Res Commun
, vol.319
, pp. 1-11
-
-
Roskoski Jr, R.1
-
10
-
-
12944271053
-
Cancer statistics, 2005
-
Jemal A, Murray T, Ward E, et al: Cancer statistics, 2005. CA Cancer J Clin 55:10-30, 2005
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 10-30
-
-
Jemal, A.1
Murray, T.2
Ward, E.3
-
11
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller JH, Harrington D, Belani CP, et al: Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346:92-98, 2002
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
12
-
-
5644296647
-
Gefitinib ('Iressa', ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer in IDEAL 1 and 2: Tumor response is not clinically relevantly predictable from tumor EGFR membrane staining alone
-
Bailey R, Kris M, Wolf M, et al: Gefitinib ('Iressa', ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer in IDEAL 1 and 2: Tumor response is not clinically relevantly predictable from tumor EGFR membrane staining alone. Lung Cancer 41:S71, 2003
-
(2003)
Lung Cancer
, vol.41
-
-
Bailey, R.1
Kris, M.2
Wolf, M.3
-
13
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al: Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353:123-132, 2005
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
14
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu H, Lin L, Takahashi T, et al: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:339-346, 2005
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
-
15
-
-
19944426858
-
High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan
-
Huang SF, Liu HP, Li LH, et al: High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clin Cancer Res 10:8195-8203, 2004
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8195-8203
-
-
Huang, S.F.1
Liu, H.P.2
Li, L.H.3
-
16
-
-
10844231985
-
Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
-
Kosaka T, Yatabe Y, Endoh H, et al: Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications. Cancer Res 64:8919-8923, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 8919-8923
-
-
Kosaka, T.1
Yatabe, Y.2
Endoh, H.3
-
17
-
-
33744814638
-
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
-
Politi K, Zakowski MF, Fan PD, et al: Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes Dev 20:1496-1510, 2006
-
(2006)
Genes Dev
, vol.20
, pp. 1496-1510
-
-
Politi, K.1
Zakowski, M.F.2
Fan, P.D.3
-
18
-
-
33744788136
-
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
-
Ji H, Li D, Chen L, et al: The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 9:485-495, 2006
-
(2006)
Cancer Cell
, vol.9
, pp. 485-495
-
-
Ji, H.1
Li, D.2
Chen, L.3
-
19
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Sordella R, Bell DW, Haber DA, et al: Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305:1163-1167, 2004
-
(2004)
Science
, vol.305
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
-
20
-
-
32944481596
-
Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
-
Riely GJ, Pao W, Pham D, et al: Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 12:839-844, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 839-844
-
-
Riely, G.J.1
Pao, W.2
Pham, D.3
-
21
-
-
33746034167
-
Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
-
Jackman DM, Yeap BY, Sequist LV, et al: Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 12:3908-3914, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3908-3914
-
-
Jackman, D.M.1
Yeap, B.Y.2
Sequist, L.V.3
-
22
-
-
33846187218
-
Update on epidermal growth factor receptor mutations in non-small cell lung cancer
-
Riely GJ, Politi KA, Miller VA, et al: Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 12:7232-7241, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7232-7241
-
-
Riely, G.J.1
Politi, K.A.2
Miller, V.A.3
-
23
-
-
19844375720
-
Epidermal growth factor receptor mutations in non-small-cell lung cancer: Implications for treatment and tumor biology
-
Jänne PA, Engelman JA, Johnson BE: Epidermal growth factor receptor mutations in non-small-cell lung cancer: Implications for treatment and tumor biology. J Clin Oncol 23:3227-3234, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 3227-3234
-
-
Jänne, P.A.1
Engelman, J.A.2
Johnson, B.E.3
-
24
-
-
33750205340
-
A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
-
Asahina H, Yamazaki K, Kinoshita I, et al: A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br J Cancer 95:998-1004, 2006
-
(2006)
Br J Cancer
, vol.95
, pp. 998-1004
-
-
Asahina, H.1
Yamazaki, K.2
Kinoshita, I.3
-
25
-
-
33746789922
-
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
-
Inoue A, Suzuki T, Fukuhara T, et al: Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 24:3340-3346, 2006
-
(2006)
J Clin Oncol
, vol.24
, pp. 3340-3346
-
-
Inoue, A.1
Suzuki, T.2
Fukuhara, T.3
-
26
-
-
33845262077
-
Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp
-
Sutani A, Nagai Y, Udagawa K, et al: Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp. Br J Cancer 95:1483-1489, 2006
-
(2006)
Br J Cancer
, vol.95
, pp. 1483-1489
-
-
Sutani, A.1
Nagai, Y.2
Udagawa, K.3
-
27
-
-
17144411518
-
Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer
-
Hirsch FR, Witta S: Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer. Curr Opin Oncol 17:118-122, 2005
-
(2005)
Curr Opin Oncol
, vol.17
, pp. 118-122
-
-
Hirsch, F.R.1
Witta, S.2
-
28
-
-
22044453790
-
Erlotinib in lung cancer: Molecular and clinical predictors of outcome
-
Tsao MS, Sakurada A, Cutz JC, et al: Erlotinib in lung cancer: Molecular and clinical predictors of outcome. N Engl J Med 353:133-144, 2005
-
(2005)
N Engl J Med
, vol.353
, pp. 133-144
-
-
Tsao, M.S.1
Sakurada, A.2
Cutz, J.C.3
-
29
-
-
28444478439
-
Oncogenic transformation by inhibitor-sensitive and- resistant EGFR mutants
-
Greulich H, Chen TH, Feng W, et al: Oncogenic transformation by inhibitor-sensitive and- resistant EGFR mutants. PLoS Med 2:e313, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Greulich, H.1
Chen, T.H.2
Feng, W.3
-
30
-
-
25444505624
-
Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression
-
Jiang J, Greulich H, Janne PA, et al: Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib-sensitive cell cycle progression. Cancer Res 65:8968-8974, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 8968-8974
-
-
Jiang, J.1
Greulich, H.2
Janne, P.A.3
-
31
-
-
33746420974
-
Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors
-
Thomas RK, Greulich H, Yuza Y, et al: Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors. Cold Spring Harb Symp Quant Biol 70:73-81, 2005
-
(2005)
Cold Spring Harb Symp Quant Biol
, vol.70
, pp. 73-81
-
-
Thomas, R.K.1
Greulich, H.2
Yuza, Y.3
-
32
-
-
30944434263
-
Gefitinib response of erlotinib-refractory lung cancer involving meninges: Role of EGFR mutation
-
Choong NW, Dietrich S, Seiwert TY, et al: Gefitinib response of erlotinib-refractory lung cancer involving meninges: Role of EGFR mutation. Nat Clin Pract Oncol 3:50-57, 2006
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 50-57
-
-
Choong, N.W.1
Dietrich, S.2
Seiwert, T.Y.3
-
33
-
-
84889120137
-
Improved methods for building protein models in electron density maps and the location of errors in these models
-
Jones TA, Zhou JY, Cowan SW, et al: Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47:110-119, 1991
-
(1991)
Acta Crystallogr A
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zhou, J.Y.2
Cowan, S.W.3
-
34
-
-
0141599428
-
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
-
Stamos J, Sliwkowski MX, Eigenbrot C: Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J Biol Chem 277: 46265-46272, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 46265-46272
-
-
Stamos, J.1
Sliwkowski, M.X.2
Eigenbrot, C.3
-
35
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
Wood ER, Truesdale AT, McDonald OB, et al: A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res 64:6652-6659, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
McDonald, O.B.3
-
36
-
-
33745002702
-
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
-
Zhang X, Gureasko J, Shen K, et al: An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125: 1137-1149, 2006
-
(2006)
Cell
, vol.125
, pp. 1137-1149
-
-
Zhang, X.1
Gureasko, J.2
Shen, K.3
-
37
-
-
33847406095
-
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity
-
Yun CH, Boggon TJ, Li Y, et al: Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell 11: 217-227, 2007
-
(2007)
Cancer Cell
, vol.11
, pp. 217-227
-
-
Yun, C.H.1
Boggon, T.J.2
Li, Y.3
-
38
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M, Kuriyan J: The conformational plasticity of protein kinases. Cell 109:275-282, 2002
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
39
-
-
4444353636
-
Regulation of protein kinases; Controlling activity through activation segment conformation
-
Nolen B, Taylor S, Ghosh G: Regulation of protein kinases; Controlling activity through activation segment conformation. Mol Cell 15:661-675, 2004
-
(2004)
Mol Cell
, vol.15
, pp. 661-675
-
-
Nolen, B.1
Taylor, S.2
Ghosh, G.3
-
40
-
-
0033573921
-
Mechanism of biological synergy between cellular Src and epidermal growth factor receptor
-
Tice DA, Biscardi JS, Nickles AL, et al: Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci U S A 96:1415-1420, 1999
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 1415-1420
-
-
Tice, D.A.1
Biscardi, J.S.2
Nickles, A.L.3
-
41
-
-
0037459341
-
Variation on an Src-like theme
-
Harrison SC: Variation on an Src-like theme. Cell 112:737-740, 2003
-
(2003)
Cell
, vol.112
, pp. 737-740
-
-
Harrison, S.C.1
-
42
-
-
0033001789
-
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
-
Xu W, Doshi A, Lei M, et al: Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol Cell 3:629-638, 1999
-
(1999)
Mol Cell
, vol.3
, pp. 629-638
-
-
Xu, W.1
Doshi, A.2
Lei, M.3
-
43
-
-
0032541623
-
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
-
Russo AA, Tong L, Lee JO, et al: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395:237-243, 1998
-
(1998)
Nature
, vol.395
, pp. 237-243
-
-
Russo, A.A.1
Tong, L.2
Lee, J.O.3
-
44
-
-
0029665852
-
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
-
Russo AA, Jeffrey PD, Patten AK, et al: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382:325-331, 1996
-
(1996)
Nature
, vol.382
, pp. 325-331
-
-
Russo, A.A.1
Jeffrey, P.D.2
Patten, A.K.3
-
45
-
-
27844454552
-
Preliminary safety results of a phase II trial comparing two schedules of lapatinib (GW572016) as first line therapy for advanced or metastatic non-small cell lung cancer
-
abstr 7099, 645s
-
Ross HJ, Blumenschein GR, Dowlati A, et al: Preliminary safety results of a phase II trial comparing two schedules of lapatinib (GW572016) as first line therapy for advanced or metastatic non-small cell lung cancer. Proc Am Soc Clin Oncol 23:645s, 2005 (abstr 7099)
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
-
-
Ross, H.J.1
Blumenschein, G.R.2
Dowlati, A.3
-
46
-
-
33845886440
-
Lapatinib plus capecitabine for HER-2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, et al: Lapatinib plus capecitabine for HER-2-positive advanced breast cancer. N Engl J Med 355:2733-2743, 2006
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
47
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
Konecny GE, Pegram MD, Venkatesan N, et al: Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res 66:1630-1639, 2006
-
(2006)
Cancer Res
, vol.66
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
Venkatesan, N.3
-
48
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, et al: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2:117-125, 2002
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
49
-
-
30644462841
-
Targeted CML therapy: Controlling drug resistance, seeking cure
-
O'Hare T, Corbin AS, Druker BJ: Targeted CML therapy: Controlling drug resistance, seeking cure. Curr Opin Genet Dev 16:92-99, 2006
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 92-99
-
-
O'Hare, T.1
Corbin, A.S.2
Druker, B.J.3
-
50
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jorgensen HG, Allan E, et al: Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 99:319-325, 2002
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
51
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T, et al: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352:786-792, 2005
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
52
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, et al: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2:e73, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
53
-
-
33751292685
-
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
-
Balak MN, Gong Y, Riely GJ, et al: Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res 12:6494-6501, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6494-6501
-
-
Balak, M.N.1
Gong, Y.2
Riely, G.J.3
-
54
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
Branford S, Rudzki Z, Walsh S, et al: High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99:3472-3475, 2002
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
-
55
-
-
20844448396
-
A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient
-
Tamborini E, Bonadiman L, Greco A, et al: A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. Gastroenterology 127:294-299, 2004
-
(2004)
Gastroenterology
, vol.127
, pp. 294-299
-
-
Tamborini, E.1
Bonadiman, L.2
Greco, A.3
-
56
-
-
18244396069
-
EGFR inhibition in non-small cell lung cancer: Resistance, once again, rears its ugly head
-
Clark J, Cools J, Gilliland DG: EGFR inhibition in non-small cell lung cancer: Resistance, once again, rears its ugly head. PLoS Med 2:e75, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Clark, J.1
Cools, J.2
Gilliland, D.G.3
-
57
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
Yun CH, Mengwasser KE, Toms AV, et al: The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 105:2070-2075, 2008
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2070-2075
-
-
Yun, C.H.1
Mengwasser, K.E.2
Toms, A.V.3
-
58
-
-
33847323129
-
Epidermal growth factor receptor mutations in lung cancer
-
Sharma SV, Bell DW, Settleman J, et al: Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 7:169-181, 2007
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 169-181
-
-
Sharma, S.V.1
Bell, D.W.2
Settleman, J.3
-
59
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al: MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316:1039-1043, 2007
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
60
-
-
35948977282
-
Predictive model of resistance mechanisms against irreversible EGFR inhibitors reveals novel treatment strategies
-
Yu Z, Jin C, Kobayashi S, et al: Predictive model of resistance mechanisms against irreversible EGFR inhibitors reveals novel treatment strategies. Cancer Res 67:10417-10427, 2007
-
(2007)
Cancer Res
, vol.67
, pp. 10417-10427
-
-
Yu, Z.1
Jin, C.2
Kobayashi, S.3
-
61
-
-
35648949422
-
Bim mediates EGFR tyrosine kinase inhibitor induced apoptosis in non-small cell lung cancers and is linked to the resistance conferred by secondary EGFR mutations, T790M and the novel L747S
-
Costa DB, Kobayashi S, Halmos B, et al: Bim mediates EGFR tyrosine kinase inhibitor induced apoptosis in non-small cell lung cancers and is linked to the resistance conferred by secondary EGFR mutations, T790M and the novel L747S. PLOS Med 4:1669-1680, 2007
-
(2007)
PLOS Med
, vol.4
, pp. 1669-1680
-
-
Costa, D.B.1
Kobayashi, S.2
Halmos, B.3
-
62
-
-
0037085373
-
The single transmembrane domains of ErbB receptors self-associate in cell membranes
-
Mendrola JM, Berger MB, King MC, et al: The single transmembrane domains of ErbB receptors self-associate in cell membranes. J Biol Chem 277: 4704-4712, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 4704-4712
-
-
Mendrola, J.M.1
Berger, M.B.2
King, M.C.3
-
63
-
-
34247470836
-
Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
-
Weisberg E, Manley PW, Cowan-Jacob SW, et al: Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat Rev Cancer 7:345-356, 2007
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 345-356
-
-
Weisberg, E.1
Manley, P.W.2
Cowan-Jacob, S.W.3
-
64
-
-
5444227865
-
Guilty as charged: B-RAF is a human oncogene
-
Garnett MJ, Marais R: Guilty as charged: B-RAF is a human oncogene. Cancer Cell 6:313-319, 2004
-
(2004)
Cancer Cell
, vol.6
, pp. 313-319
-
-
Garnett, M.J.1
Marais, R.2
-
65
-
-
33845730781
-
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
-
King AJ, Patrick DR, Batorsky RS, et al: Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res 66:11100-11105, 2006
-
(2006)
Cancer Res
, vol.66
, pp. 11100-11105
-
-
King, A.J.1
Patrick, D.R.2
Batorsky, R.S.3
-
66
-
-
33748413525
-
Cancer and kinases: Reports from the front line
-
Burley SK: Cancer and kinases: Reports from the front line. Genome Biol 7:314, 2006
-
(2006)
Genome Biol
, vol.7
, pp. 314
-
-
Burley, S.K.1
-
67
-
-
7944238044
-
Somatic alterations in the human cancer genome
-
Weir B, Zhao X, Meyerson M: Somatic alterations in the human cancer genome. Cancer Cell 6:433-438, 2004
-
(2004)
Cancer Cell
, vol.6
, pp. 433-438
-
-
Weir, B.1
Zhao, X.2
Meyerson, M.3
-
68
-
-
33749435816
-
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
-
Engelman JA, Mukohara T, Zejnullahu K, et al: Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J Clin Invest 116:2695-2706, 2006
-
(2006)
J Clin Invest
, vol.116
, pp. 2695-2706
-
-
Engelman, J.A.1
Mukohara, T.2
Zejnullahu, K.3
-
69
-
-
33745926178
-
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
-
Thomas RK, Nickerson E, Simons JF, et al: Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing. Nat Med 12:852-855, 2006
-
(2006)
Nat Med
, vol.12
, pp. 852-855
-
-
Thomas, R.K.1
Nickerson, E.2
Simons, J.F.3
-
70
-
-
17444380497
-
EGF receptor inhibition: Attacks on multiple fronts
-
Hubbard SR: EGF receptor inhibition: Attacks on multiple fronts. Cancer Cell 7:287-288, 2005
-
(2005)
Cancer Cell
, vol.7
, pp. 287-288
-
-
Hubbard, S.R.1
-
71
-
-
0027182223
-
Crystal structure of cyclin-dependent kinase 2
-
De Bondt HL, Rosenblatt J, Jancarik J, et al: Crystal structure of cyclin-dependent kinase 2. Nature 363:595-602, 1993
-
(1993)
Nature
, vol.363
, pp. 595-602
-
-
De Bondt, H.L.1
Rosenblatt, J.2
Jancarik, J.3
-
72
-
-
0029029617
-
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
-
Jeffrey PD, Russo AA, Polyak K, et al: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376: 313-320, 1995
-
(1995)
Nature
, vol.376
, pp. 313-320
-
-
Jeffrey, P.D.1
Russo, A.A.2
Polyak, K.3
-
73
-
-
0028103275
-
The CCP4 suite: Programs for protein crystallography. Acta Cryst
-
4
-
CCP4: The CCP4 suite: Programs for protein crystallography. Acta Cryst D50:760-776, 1994
-
(1994)
, vol.D50
, pp. 760-776
-
-
CCP1
-
74
-
-
0028582185
-
Crystal structure of the tyrosine kinase domain of the human insulin receptor
-
Hubbard SR, Wei L, Ellis L, et al: Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372:746-754, 1994
-
(1994)
Nature
, vol.372
, pp. 746-754
-
-
Hubbard, S.R.1
Wei, L.2
Ellis, L.3
-
75
-
-
33947317223
-
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
-
Blair JA, Rauh D, Kung C, et al: Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol 3:229-238, 2007
-
(2007)
Nat Chem Biol
, vol.3
, pp. 229-238
-
-
Blair, J.A.1
Rauh, D.2
Kung, C.3
-
76
-
-
36749011864
-
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
-
Zhang X, Pickin KA, Bose R, et al: Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature 450: 741-744, 2007
-
(2007)
Nature
, vol.450
, pp. 741-744
-
-
Zhang, X.1
Pickin, K.A.2
Bose, R.3
|