-
1
-
-
70349438994
-
Tumor suppression by p53: A role for the DNA damage response?
-
D.W. Meek Tumor suppression by p53: a role for the DNA damage response? Nat. Rev. Cancer 9 2009 714 723
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 714-723
-
-
Meek, D.W.1
-
3
-
-
34547935761
-
Living with p53, Dying of p53
-
DOI 10.1016/j.cell.2007.08.005, PII S0092867407010276
-
Y. Aylon, and M. Oren Living with p53, dying of p53 Cell 130 2007 597 600 (Pubitemid 47268063)
-
(2007)
Cell
, vol.130
, Issue.4
, pp. 597-600
-
-
Aylon, Y.1
Oren, M.2
-
4
-
-
67649424560
-
P21 in cancer: Intricate networks and multiple activities
-
T. Abbas, and A. Dutta p21 in cancer: intricate networks and multiple activities Nat. Rev. Cancer 9 2009 400 414
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 400-414
-
-
Abbas, T.1
Dutta, A.2
-
5
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene
-
T. Miyashita, and J.C. Reed Tumor suppressor p53 is a direct transcriptional activator of the human Bax gene Cell 80 1995 293 299
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
6
-
-
33846148980
-
Outcomes of p53 activation - Spoilt for choice
-
DOI 10.1242/jcs.03293
-
K.H. Vousden Outcomes of p53 activation - spoilt for choice J. Cell Sci. 119 2006 5015 5020 (Pubitemid 46085181)
-
(2006)
Journal of Cell Science
, vol.119
, Issue.24
, pp. 5015-5020
-
-
Vousden, K.H.1
-
7
-
-
50149097809
-
A complex barcode underlies the heterogeneous response of p53 to stress
-
F. Murray-Zmijewski, E.A. Slee, and X. Lu A complex barcode underlies the heterogeneous response of p53 to stress Nat. Rev. Mol. Cell Biol. 9 2008 702 712
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 702-712
-
-
Murray-Zmijewski, F.1
Slee, E.A.2
Lu, X.3
-
9
-
-
34548014527
-
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
-
DOI 10.1038/sj.cdd.4402196, PII 4402196
-
A. Olsson, and C. Manzl A. Villunger How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumor suppression? Cell Death Differ. 14 2007 1561 1575 (Pubitemid 47278842)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.9
, pp. 1561-1575
-
-
Olsson, A.1
Manzl, C.2
Strasser, A.3
Villunger, A.4
-
10
-
-
0034664733
-
P53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
-
K. Oda, and H. Arakawa Y. Taya p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 Cell 102 2000 849 862
-
(2000)
Cell
, vol.102
, pp. 849-862
-
-
Oda, K.1
Arakawa, H.2
Taya, Y.3
-
11
-
-
17944379798
-
ASPP proteins specifically stimulate the apoptotic function of p53
-
DOI 10.1016/S1097-2765(01)00367-7
-
Y. Samuels-Lev, and D.J. O'Connor X. Lu ASPP proteins specifically stimulate the apoptotic function of p53 Mol. Cell 8 2001 781 794 (Pubitemid 33030212)
-
(2001)
Molecular Cell
, vol.8
, Issue.4
, pp. 781-794
-
-
Samuels-Lev, Y.1
O'Connor, D.J.2
Bergamaschi, D.3
Trigiante, G.4
Hsieh, J.-K.5
Zhong, S.6
Campargue, I.7
Naumovski, L.8
Crook, T.9
Lu, X.10
-
12
-
-
34548049032
-
Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation
-
DOI 10.1016/j.cell.2007.06.013, PII S0092867407007799
-
S. Das, and L. Raj S.W. Lee Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation Cell 130 2007 624 637 (Pubitemid 47277418)
-
(2007)
Cell
, vol.130
, Issue.4
, pp. 624-637
-
-
Das, S.1
Raj, L.2
Zhao, B.3
Kimura, Y.4
Bernstein, A.5
Aaronson, S.A.6
Lee, S.W.7
-
13
-
-
33746685694
-
Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death
-
DOI 10.1529/biophysj.105.077693
-
K.B. Wee, and B.D. Aguda Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death Biophys. J. 91 2006 857 865 (Pubitemid 44161917)
-
(2006)
Biophysical Journal
, vol.91
, Issue.3
, pp. 857-865
-
-
Keng, B.W.1
Aguda, B.D.2
-
14
-
-
33846594408
-
Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis
-
T. Zhang, P. Brazhnik, and J.J. Tyson Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis Cell Cycle 6 2007 85 94 (Pubitemid 46178023)
-
(2007)
Cell Cycle
, vol.6
, Issue.1
, pp. 85-94
-
-
Zhang, T.1
Brazhnik, P.2
Tyson, J.J.3
-
16
-
-
79959343390
-
Two-phase dynamics of p53 in the DNA damage response
-
X.P. Zhang, F. Liu, and W. Wang Two-phase dynamics of p53 in the DNA damage response Proc. Natl. Acad. Sci. USA 108 2011 8990 8995
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 8990-8995
-
-
Zhang, X.P.1
Liu, F.2
Wang, W.3
-
17
-
-
77957767333
-
Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage
-
X.P. Zhang, F. Liu, and W. Wang Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage J. Biol. Chem. 285 2010 31571 31580
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 31571-31580
-
-
Zhang, X.P.1
Liu, F.2
Wang, W.3
-
19
-
-
26444583906
-
A plausible model for the digital response of p53 to DNA damage
-
DOI 10.1073/pnas.0501352102
-
L. Ma, and J. Wagner G.A. Stolovitzky A plausible model for the digital response of p53 to DNA damage Proc. Natl. Acad. Sci. USA 102 2005 14266 14271 (Pubitemid 41429687)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.40
, pp. 14266-14271
-
-
Ma, L.1
Wagner, J.2
Rice, J.J.3
Hu, W.4
Levine, A.J.5
Stolovitzky, G.A.6
-
20
-
-
0034807357
-
Two-lesion kinetic model of double-strand break rejoining and cell killing
-
R.D. Stewart Two-lesion kinetic model of double-strand break rejoining and cell killing Radiat. Res. 156 2001 365 378 (Pubitemid 32904990)
-
(2001)
Radiation Research
, vol.156
, Issue.4
, pp. 365-378
-
-
Stewart, R.D.1
-
21
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
DOI 10.1038/nature01368
-
C.J. Bakkenist, and M.B. Kastan DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 421 2003 499 506 (Pubitemid 36168436)
-
(2003)
Nature
, vol.421
, Issue.6922
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
22
-
-
33644524741
-
Cell-signaling dynamics in time and space
-
B.N. Kholodenko Cell-signaling dynamics in time and space Nat. Rev. Mol. Cell Biol. 7 2006 165 176
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 165-176
-
-
Kholodenko, B.N.1
-
23
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
DOI 10.1126/science.281.5383.1677
-
C.E. Canman, and D.S. Lim J.D. Siliciano Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 Science 281 1998 1677 1679 (Pubitemid 28435584)
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.-S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
24
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
DOI 10.1038/sj.emboj.7600145
-
J.M. Stommel, and G.M. Wahl Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation EMBO J. 23 2004 1547 1556 (Pubitemid 38579515)
-
(2004)
EMBO Journal
, vol.23
, Issue.7
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
27
-
-
22544433198
-
Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified
-
DOI 10.1074/jbc.M503026200
-
L.D. Mayo, and Y.R. Seo D.B. Donner Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified J. Biol. Chem. 280 2005 25953 25959 (Pubitemid 41022185)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.28
, pp. 25953-25959
-
-
Mayo, L.D.1
Seo, Y.R.2
Jackson, M.W.3
Smith, M.L.4
Guzman, J.R.5
Korgaonkar, C.K.6
Donner, D.B.7
-
28
-
-
33847365838
-
MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
-
DOI 10.1016/j.molcel.2007.02.008, PII S1097276507000883
-
46 phosphorylation and DNA damage-induced apoptosis Mol. Cell 25 2007 739 750 (Pubitemid 46341925)
-
(2007)
Molecular Cell
, vol.25
, Issue.5
, pp. 739-750
-
-
Rinaldo, C.1
Prodosmo, A.2
Mancini, F.3
Iacovelli, S.4
Sacchi, A.5
Moretti, F.6
Soddu, S.7
-
29
-
-
65949083750
-
Cytoplasmic functions of the tumor suppressor p53
-
D.R. Green, and G. Kroemer Cytoplasmic functions of the tumor suppressor p53 Nature 458 2009 1127 1130
-
(2009)
Nature
, vol.458
, pp. 1127-1130
-
-
Green, D.R.1
Kroemer, G.2
-
30
-
-
34250788809
-
AKT/PKB Signaling: Navigating Downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274 (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
31
-
-
85047699328
-
Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis
-
DOI 10.1038/sj/onc/1205181
-
T.M. Gottlieb, and J.F. Leal M. Oren Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis Oncogene 21 2002 1299 1303 (Pubitemid 34185247)
-
(2002)
Oncogene
, vol.21
, Issue.8
, pp. 1299-1303
-
-
Gottlieb, T.M.1
Martinez Leal, J.F.2
Seger, R.3
Taya, Y.4
Oren, M.5
-
32
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
DOI 10.1073/pnas.96.8.4240
-
L.C. Cantley, and B.G. Neel New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Proc. Natl. Acad. Sci. USA 96 1999 4240 4245 (Pubitemid 29190320)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.8
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
33
-
-
0842332406
-
Dynamics of the p53-Mdm2 feedback loop in individual cells
-
DOI 10.1038/ng1293
-
G. Lahav, and N. Rosenfeld U. Alon Dynamics of the p53-Mdm2 feedback loop in individual cells Nat. Genet. 36 2004 147 150 (Pubitemid 38174372)
-
(2004)
Nature Genetics
, vol.36
, Issue.2
, pp. 147-150
-
-
Lahav, G.1
Rosenfeld, N.2
Sigal, A.3
Geva-Zatorsky, N.4
Levine, A.J.5
Elowitz, M.B.6
Alon, U.7
-
34
-
-
42949171936
-
Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage
-
DOI 10.1016/j.molcel.2008.03.016, PII S1097276508002402
-
E. Batchelor, and C.S. Mock G. Lahav Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage Mol. Cell 30 2008 277 289 (Pubitemid 351615316)
-
(2008)
Molecular Cell
, vol.30
, Issue.3
, pp. 277-289
-
-
Batchelor, E.1
Mock, C.S.2
Bhan, I.3
Loewer, A.4
Lahav, G.5
-
35
-
-
17144404587
-
ASPP1 and ASPP2 are new transcriptional targets of E2F
-
DOI 10.1038/sj.cdd.4401562
-
V. Fogal, and N.N. Kartasheva X. Lu ASPP1 and ASPP2 are new transcriptional targets of E2F Cell Death Differ. 12 2005 369 376 (Pubitemid 40520688)
-
(2005)
Cell Death and Differentiation
, vol.12
, Issue.4
, pp. 369-376
-
-
Fogal, V.1
Kartasheva, N.N.2
Trigiante, G.3
Llanos, S.4
Yap, D.5
Vousden, K.H.6
Lu, X.7
-
36
-
-
0036716281
-
The BCL2 family: Regulators of the cellular life-or-death switch
-
DOI 10.1038/nrc883
-
S. Cory, and J.M. Adams The Bcl2 family: regulators of the cellular life-or-death switch Nat. Rev. Cancer 2 2002 647 656 (Pubitemid 37328916)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.9
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
37
-
-
0033597785
-
Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
-
D.G. Kirsch, and A. Doseff J.M. Hardwick Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c J. Biol. Chem. 274 1999 21155 21161
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21155-21161
-
-
Kirsch, D.G.1
Doseff, A.2
Hardwick, J.M.3
-
39
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
R.J. Youle, and A. Strasser The BCL-2 protein family: opposing activities that mediate cell death Nat. Rev. Mol. Cell Biol. 9 2008 47 59
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
40
-
-
34247345833
-
The apoptosome: Signalling platform of cell death
-
DOI 10.1038/nrm2153, PII NRM2153
-
S.J. Riedl, and G.S. Salvesen The apoptosome: signaling platform of cell death Nat. Rev. Mol. Cell Biol. 8 2007 405 413 (Pubitemid 46643237)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.5
, pp. 405-413
-
-
Riedl, S.J.1
Salvesen, G.S.2
-
41
-
-
43149108161
-
A bistable Rb-E2F switch underlies the restriction point
-
G. Yao, and T.J. Lee L. You A bistable Rb-E2F switch underlies the restriction point Nat. Cell Biol. 10 2008 476 482
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 476-482
-
-
Yao, G.1
Lee, T.J.2
You, L.3
-
42
-
-
68949136900
-
Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death
-
T. Zhang, P. Brazhnik, and J.J. Tyson Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death Biophys. J. 97 2009 415 434
-
(2009)
Biophys. J.
, vol.97
, pp. 415-434
-
-
Zhang, T.1
Brazhnik, P.2
Tyson, J.J.3
-
43
-
-
0035936113
-
The E2F1-3 transcription factors are essential for cellular proliferation
-
DOI 10.1038/35106593
-
L. Wu, and C. Timmers G. Leone The E2F1-3 transcription factors are essential for cellular proliferation Nature 414 2001 457 462 (Pubitemid 34173728)
-
(2001)
Nature
, vol.414
, Issue.6862
, pp. 457-462
-
-
Wu, L.1
Timmers, C.2
Malti, B.3
Saavedra, H.I.4
Sang, L.5
Chong, G.T.6
Nuckolls, F.7
Giangrande, P.8
Wright, F.A.9
Field, S.J.10
Greenberg, M.E.11
Orkin, S.12
Nevins, J.R.13
Robinson, M.L.14
Leone, G.15
-
44
-
-
33646356739
-
F-box protein Skp2: A novel transcriptional target of E2F
-
L. Zhang, and C. Wang F-box protein Skp2: a novel transcriptional target of E2F Oncogene 25 2006 2615 2627
-
(2006)
Oncogene
, vol.25
, pp. 2615-2627
-
-
Zhang, L.1
Wang, C.2
-
45
-
-
0037459377
-
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
-
DOI 10.1016/S0092-8674(03)00193-4
-
R.P. Leng, and Y. Lin S. Benchimol Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation Cell 112 2003 779 791 (Pubitemid 36378882)
-
(2003)
Cell
, vol.112
, Issue.6
, pp. 779-791
-
-
Leng, R.P.1
Lin, Y.2
Ma, W.3
Wu, H.4
Lemmers, B.5
Chung, S.6
Parant, J.M.7
Lozano, G.8
Hakem, R.9
Benchimol, S.10
-
46
-
-
2342447397
-
The ubiquitin ligase COP1 is a critical negative regulator of p53
-
DOI 10.1038/nature02514
-
D. Dornan, and I. Wertz V.M. Dixit The ubiquitin ligase COP1 is a critical negative regulator of p53 Nature 429 2004 86 92 (Pubitemid 38620556)
-
(2004)
Nature
, vol.429
, Issue.6987
, pp. 86-92
-
-
Dornan, D.1
Wertz, I.2
Shimizu, H.3
Arnott, D.4
Frantz, G.D.5
Dowd, P.6
O'Rourke, K.7
Koeppen, H.8
Dixit, V.M.9
|