Oxidative stress and mitochondrial dysfunction in Down's syndrome: Relevance to aging and dementia

Current Gerontology and Geriatrics Research

Volumn 2012, Issue , 2012, Pages

  Coskun, Pinar E ^a   Busciglio, Jorge ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84861091417     PISSN: 16877063     EISSN: 16877071     Source Type: Journal    
DOI: 10.1155/2012/383170     Document Type: Review

References (62)

1. Pritchard M. A., Kola I., The gene dosage effect hypothesis versus the amplified developmental instability hypothesis in Down syndrome Journal of Neural Transmission, Supplement 1999 57 293 303
2. Leporrier N., Herrou M., Morello R., Leymarie P., Fetuses with Down's syndrome detected by prenatal screening are more likely to abort spontaneously than fetuses with Down's syndrome not detected by prenatal screening Journal of Obstetrics and Gynaecology 2003 110 1 18 21 (Pubitemid 36034288)
3. Bittles A. H., Bower C., Hussain R., Glasson E. J., The four ages of Down syndrome European Journal of Public Health 2007 17 2 221 225 (Pubitemid 46536733)
4. Coppus A., Evenhuis H., Verberne G. J., Visser F., Van Gool P., Eikelenboom P., Van Duijin C., Dementia and mortality in persons with Down's syndrome Journal of Intellectual Disability Research 2006 50 10 768 777 (Pubitemid 44336413)
5. Martin G. M., Genetic syndromes in man with potential relevance to the pathobiology of aging Birth Defects 1978 14 1 5 39 (Pubitemid 8277253)
6. Colvin L., Jurenka S. B., Van Allen M. I., Down Syndrome 2003 New York, NY, USA Marcel Dekker
7. Pallard F. V., Lloret A., Lebel M., d'Ischia M., Cogger V. C., Le Couteur D. G., Gadaleta M. N., Castello G., Pagano G., Mitochondrial dysfunction in some oxidative stress-related genetic diseases: ataxia-telangiectasia, Down syndrome, fanconi anaemia and werner syndrome Biogerontology 2010 11 4 401 419
8. Harman D., Free radical theory of aging: dietary implications American Journal of Clinical Nutrition 1972 25 8 839 843
9. Harman D., The biologic clock: the mitochondria? Journal of the American Geriatrics Society 1972 20 4 145 147
10. Miquel J., Fleming J. E., A two-step hypothesis on the mechanisms of in vitro cell aging: cell differentiation followed by intrinsic mitochondrial mutagenesis Experimental Gerontology 1984 19 1 31 36 (Pubitemid 14164826)
11. Cenini G., Dowling A. L., Beckett T. L., Barone E., Mancuso C., Murphy M. P., LeVine H., Lott I. T., Schmitt F. A., Butterfield D. A., Head E., Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome Biochimica et Biophysica Acta 2012 1822 2 130 138
12. Perluigi M., Butterfield D. A., The identification of protein biomarkers for oxidative stress in Down syndrome Expert Review of Proteomics 2011 8 4 427 429
13. Busciglio J., Pelsman A., Wong C., Pigino G., Yuan M., Mori H., Yankner B. A., Altered metabolism of the amyloid precursor protein is associated with mitochondrial dysfunction in Down's syndrome Neuron 2002 33 5 677 688 (Pubitemid 34219240)
14. Shukkur E. A., Shimohata A., Akagi T., Yu W., Yamaguchi M., Murayama M., Chui D., Takeuchi T., Amano K., Subramhanya K. H., Hashikawa T., Sago H., Epstein C. J., Takashima A., Yamakawa K., Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome Human Molecular Genetics 2006 15 18 2752 2762 (Pubitemid 44400402)
15. Lott I. T., Head E., Doran E., Busciglio J., Beta-amyloid, oxidative stress and down syndrome Current Alzheimer Research 2006 3 5 521 528 (Pubitemid 46066428)
16. Tiano L., Busciglio J., Mitochondrial dysfunction and Down's syndrome: is there a role for CoQ 10 ? BioFactors 2011 37 5 386 392
17. Porta S., Serra S. A., Huch M., Valverde M. A., Llorens F., Estivill X., Arbonés M. L., Mart E., RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: apotential pathogenic process in neurodegeneration Human Molecular Genetics 2007 16 9 1039 1050 (Pubitemid 47062725)
18. Wallace D. C., A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annual Review of Genetics 2005 39 359 407 (Pubitemid 43011120)
19. Wallace D. C., Fan W., Energetics, epigenetics, mitochondrial genetics Mitochondrion 2010 10 1 12 31
20. Sjodin B., Hellsten Westing Y., Apple F. S., Biochemical mechanisms for oxygen free radical formation during exercise Sports Medicine 1990 10 4 236 254 (Pubitemid 20304380)
21. Wallace D. C., Why do we still have a maternally inherited mitochondrial DNA? insights from evolutionary medicine Annual Review of Biochemistry 2007 76 781 821
22. Helguera P., Pelsman A., Pigino G., Wolvetang E., Head E., Busciglio J., ets-2 promotes the activation of a mitochondrial death pathway in down's syndrome neurons Journal of Neuroscience 2005 25 9 2295 2303 (Pubitemid 40322270)
23. Schon E. A., Kim S. H., Ferreira J. C., Magalhaes P., Grace M., Warburton D., Gross S. J., Chromosomal non-disjunction in human oocytes: is there a mitochondrial connection? Human Reproduction 2000 15 2 160 172
24. Koga Y., Akita Y., Takane N., Sato Y., Kato H., Heterogeneous presentation in A3243G mutation in the mitochondrial tRNA Leu(UUR) gene Archives of Disease in Childhood 2000 82 5 407 411 (Pubitemid 30307773)
25. Arbuzova S., Cuckle H., Mueller R., Sehmi I., Familial down syndrome: evidence supporting cytoplasmic inheritance Clinical Genetics 2001 60 6 456 462 (Pubitemid 34083262)
26. Arbuzova S., Hutchin T., Cuckle H., Mitochondrial dysfunction and Down's syndrome BioEssays 2002 24 8 681 684 (Pubitemid 34850322)
27. Eichenlaub-Ritter U., Wieczorek M., Lke S., Seidel T., Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions Mitochondrion 2011 11 783 796
28. Eichenlaub-Ritter U., Reproductive semi-cloning respecting biparental origin. Reconstitution of gametes for assisted reproduction Human Reproduction 2003 18 3 473 475
29. Coskun P. E., Wyrembak J., Derbereva O., Melkonian G., Doran E., Lott I. T., Head E., Cotman C. W., Wallace D. C., Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia Journal of Alzheimer's Disease 2010 20 supplement 2 S293 S310
30. Coskun P. E., Beal M. F., Wallace D. C., Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication Proceedings of the National Academy of Sciences of the United States of America 2004 101 29 10726 10731 (Pubitemid 38955810)
31. Druzhyna N., Nair R. G., Ledoux S. P., Wilson G. L., Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome Mutation Research 1998 409 2 81 89 (Pubitemid 28522174)
32. Nagy Z., Esiri M. M., LeGris M., Matthews P. M., Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology Acta Neuropathologica 1999 97 4 346 354 (Pubitemid 29134514)
33. Kim S. H., Vlkolinsky R., Cairns N., Fountoulakis M., Lubec G., The reduction of NADHubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease Life Sciences 2001 68 24 2741 2750 (Pubitemid 32455678)
34. Lee S. H., Lee S., Jun H. S., Jeong H. J., Cha W. T., Cho Y. S., Kim J. H., Ku S. Y., Cha K. Y., Expression of the mitochondrial ATPase6 gene and Tfam in down syndrome Molecules and Cells 2003 15 2 181 185 (Pubitemid 41582921)
35. Valenti D., Manente G. A., Moro L., Marra E., Vacca R. A., Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway Biochemical Journal 2011 435 3 679 688
36. Bozner P., Wilson G. L., Druzhyna N. M., Bryant-Thomas T. K., LeDoux S. P., Wilson G. L., Pappolla M. A., Deficiency of chaperonin 60 in Down's syndrome Journal of Alzheimer's Disease 2002 4 6 479 486 (Pubitemid 36142837)
37. Martin J., Horwich A. L., Hartl F. U., Prevention of protein denaturation under heat stress by the chaperonin Hsp60 Science 1992 258 5084 995 998
38. Bajo M., Fruehauf J., Kim S. H., Fountoulakis M., Lubec G., Proteomic evaluation of intermediary metabolism enzyme proteins in fetal down's syndrome cerebral cortex Proteomics 2002 2 11 1539 1546 (Pubitemid 35424502)
39. Shin J. H., Weitzdoerfer R., Fountoulakis M., Lubec G., Expression of cystathionine -synthase, pyridoxal kinase, and ES1 protein homolog (mitochondrial precursor) in fetal Down syndrome brain Neurochemistry International 2004 45 1 73 79 (Pubitemid 38479566)
40. Martin K. R., Barrett J. C., Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity Human and Experimental Toxicology 2002 21 2 71 75 (Pubitemid 34591267)
41. Birringer M., Hormetics: dietary triggers of an adaptive stress response Pharmaceutical Research 2011 28 11 2680 2694
42. Calabrese E. J., Baldwin L. A., Defining hormesis Human and Experimental Toxicology 2002 21 2 91 97 (Pubitemid 34591271)
43. Schriner S. E., Linford N. J., Martin G. M., Treuting P., Ogburn C. E., Emond M., Coskun P. E., Ladiges W., Wolf N., Van Remmen H., Wallace D. C., Rabinovitch P. S., Medecine: extension of murine life span by overexpression of catalase targeted to mitochondria Science 2005 308 5730 1909 1911 (Pubitemid 40941874)
44. Harrington L. A., Harley C. B., Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans Mechanisms of Ageing and Development 1988 43 1 71 78 (Pubitemid 18085924)
45. Orr W. C., Sohal R. S., Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster Science 1994 263 5150 1128 1130 (Pubitemid 24105957)
46. Melov S., Ravenscroft J., Malik S., Gill M. S., Walker D. W., Clayton P. E., Wallace D. C., Malfroy B., Doctrow S. R., Lithgow G. J., Extension of life-span with superoxide dismutase/catalase mimetics Science 2000 289 5484 1567 1569
47. Lott I. T., Doran E., Nguyen V. Q., Tournay A., Head E., Gillen D. L., Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation American Journal of Medical Genetics A 2011 155 8 1939 1948
48. Lapointe J., Hekimi S., When a theory of aging ages badly Cellular and Molecular Life Sciences 2010 67 1 1 8
49. Ristow M., Schmeisser S., Extending life span by increasing oxidative stress Free Radical Biology and Medicine 2011 51 2 327 336
50. Lott I. T., Antioxidants in Down syndrome Biochim Biophys Acta 2012 1822 5 657 663
51. Masoro E. J., Austad S. N., The evolution of the antiaging action of dietary restriction: a hypothesis Journals of Gerontology A 1996 51 6 B387 B391
52. Sharma P. K., Agrawal V., Roy N., Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae Age 2011 33 2 143 154
53. McMahon M., Thomas N., Itoh K., Yamamoto M., Hayes J. D., Dimerization of substrate adaptors can facilitate Cullin-mediated ubiquitylation of proteins by a tethering mechanism: a two-site interaction model for the Nrf2-Keap1 complex Journal of Biological Chemistry 2006 281 34 24756 24768 (Pubitemid 44274250)
54. Itoh K., Mimura J., Yamamoto M., Discovery of the negative regulator of Nrf2, keap1: a historical overview Antioxidants and Redox Signaling 2010 13 11 1665 1678
55. Kong A. N., Owuor E., Yu R., Hebbar V., Chen C., Hu R., Mandlekar S., Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE) Drug Metabolism Reviews 2001 33 3-4 255 271 (Pubitemid 33136265)
56. Helguera P., Seiglie J., Rodriguez J., Busciglio J., Adaptive downregulation of mitochondrial function in Downs syndrome. submitted
57. Swatton J. E., Sellers L. A., Faull R. L., Holland A., Iritani S., Bahn S., Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain European Journal of Neuroscience 2004 19 10 2711 2719 (Pubitemid 38746388)
58. Taguchi K., Motohashi H., Yamamoto M., Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution Genes to Cells 2011 16 2 123 140
59. Zhu H., Itoh K., Yamamoto M., Zweier J. L., Li Y., Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury FEBS Letters 2005 579 14 3029 3036 (Pubitemid 40797830)
60. Strydom A., Dickinson M. J., Shende S., Pratico D., Walker Z., Oxidative stress and cognitive ability in adults with Down syndrome Progress in Neuro-Psychopharmacology and Biological Psychiatry 2009 33 1 76 80
61. Wang X., Hai C. X., ROS acts as a double-edged sword in the pathogenesis of Type 2 diabetes mellitus: is Nrf2 a potential target for the treatment? Mini-Reviews in Medicinal Chemistry 2011 11 12 1082 1092
62. Ristow M., Zarse K., Oberbach A., Klting N., Birringer M., Kiehntopf M., Stumvoll M., Kahn C. R., Blher M., Antioxidants prevent health-promoting effects of physical exercise in humans Proceedings of the National Academy of Sciences of the United States of America 2009 106 21 8665 8670