The identification of protein biomarkers for oxidative stress in Down syndrome

Expert Review of Proteomics

Volumn 8, Issue 4, 2011, Pages 427-429

  Perluigi, Marzia ^a   Butterfield, D Allan ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimers disease; Down syndrome; oxidative stress; protein oxidation; redox proteomics

Indexed keywords

BIOLOGICAL MARKER;

AGING; ALZHEIMER DISEASE; CANCER RISK; CHROMOSOME ABERRATION; COGNITIVE DEFECT; DOWN SYNDROME; EDITORIAL; ENVIRONMENTAL FACTOR; IMMUNE DEFICIENCY; OXIDATION; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; BIOLOGICAL MARKERS; DOWN SYNDROME; HUMANS; OXIDATIVE STRESS; PROTEINS;

EID: 80051723535     PISSN: 14789450     EISSN: 17448387     Source Type: Journal    
DOI: 10.1586/epr.11.36     Document Type: Editorial

References (20)

1. Hayes A, Batshaw ML. Down syndrome. Pediatr. Clin. North Am. 40(3), 523-535 (1993). (Pubitemid 23159435)
2. Roper RJ, Reeves RH. Understanding the basis for Down syndrome phenotypes. PLoS Genet. 2(3), e50 (2006).
3. Contestabile A, Benfenati F, Gasparini L. Communication breaks-down: From neurodevelopment defects to cognitive disabilities in Down syndrome. Prog. Neurobiol. 91(1), 1-22 (2010).
4. Iannello RC, Crack PJ, de Haan JB et al. Oxidative stress and neural dysfunction in Down syndrome. J. Neural Transm. Suppl. 57257-57267 (1999).
5. Zana M, Janka Z, Kalman J. Oxidative stress: A bridge between Down's syndrome and Alzheimer's disease. Neurobiol. Aging 28(5), 648-676 (2007). (Pubitemid 46349350)
6. Jovanovic SV, Clements D, MacLeod K. Biomarkers of oxidative stress are significantly elevated in Down syndrome. Free Radic. Biol. Med. 25(9), 1044-1048 (1998). (Pubitemid 28558330)
7. Head E, Lott IT. Down syndrome and b-amyloid deposition. Curr. Opin. Neurol. 17(2), 95-100 (2004).
8. Butterfield DA, Boyd-Kimball D. Amyloid b-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain. Brain Pathol. 14(4), 426-432 (2004). (Pubitemid 39524972)
9. Butterfield DA, Drake J, Pocernich C et al. Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid b-peptide. Trends Mol. Med. 7(12), 548-554 (2001). (Pubitemid 33127140)
10. Butterfield DA, Galvan V, Lange MB et al. In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid b-peptide of APP. Free Radic. Biol. Med. 48(1), 136-144 (2010).
11. Odetti P, Angelini G, Dapino D et al. Early glycoxidation damage in brains from Down's syndrome. Biochem. Biophys. Res. Commun. 243(3), 849-851 (1998). (Pubitemid 28414171)
12. Nunomura A, Perry G, Pappolla MA et al. Neuronal oxidative stress precedes amyloid-b deposition in Down syndrome. J. Neuropathol. Exp. Neurol. 59(11), 1011-1017 (2000).
13. Pratico D, Iuliano L, Amerio G et al. Down's syndrome is associated with increased 8,12-iso-iPF2a-VI levels: Evidence for enhanced lipid peroxidation in vivo. Ann. Neurol. 48(5), 795-798 (2000).
14. Campos C, Guzman R, Lopez-Fernandez E et al. Urinary biomarkers of oxidative/nitrosative stress in healthy smokers. Inhal. Toxicol. 23(3), 148-156 (2011).
15. Ishihara K, Amano K, Takaki E et al. Increased lipid peroxidation in Down's syndrome mouse models. J. Neurochem. 110(6), 1965-1976 (2009).
16. Butterfield DA, Bader Lange ML, Sultana R. Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease. Biochim. Biophys. Acta. 1801(8), 924-929 (2010).
17. Reed T, Perluigi M, Sultana R et al. Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease. Neurobiol. Dis. 30(1), 107-120 (2008).
18. Perluigi M, Sultana R, Cenini G et al. Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis. Proteomics Clin. Appl. 3(6), 682-693 (2009).
19. Perluigi M, di Domenico F, Fiorini A et al. Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid. Proteomics Clin. Appl. 5(3-4), 167-178 (2011).
20. Perrone S, Longini M, Bellieni CV et al. Early oxidative stress in amniotic fluid of pregnancies with Down syndrome. Clin. Biochem. 40(3-4), 177-180 (2007). (Pubitemid 46108711)