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Volumn 5, Issue 3, 2012, Pages 211-223

Deciphering the key features of malignant tumor microenvironment for anti-cancer therapy

Author keywords

Angiogenesis; Metabolism; Niche; Oncogene; Stem cell; Stromal cells

Indexed keywords

ANTINEOPLASTIC AGENT; MEMBRANE RECEPTOR; PROTEIN KINASE; TRANSCRIPTION FACTOR;

EID: 84860897302     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-012-0108-9     Document Type: Review
Times cited : (11)

References (101)
  • 1
    • 78649997911 scopus 로고    scopus 로고
    • Jekyll and Hyde: The role of the microenvironment on the progression of cancer
    • Allen M, Louise Jones J (2011) Jekyll and Hyde: the role of the microenvironment on the progression of cancer. J Pathol 223:162-176. doi:10.1002/path.2803, LID
    • (2011) J Pathol , vol.223 , pp. 162-176
    • Allen, M.1    Louise Jones, J.2
  • 4
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S (1989) The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev 8:98-101
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 5
    • 0020456385 scopus 로고
    • How does the extracellular matrix direct gene expression?
    • Bissell MJ, Hall HG, Parry G (1982) How does the extracellular matrix direct gene expression? J Theor Biol 99:31-68
    • (1982) J Theor Biol , vol.99 , pp. 31-68
    • Bissell, M.J.1    Hall, H.G.2    Parry, G.3
  • 7
    • 38749114995 scopus 로고    scopus 로고
    • Oncogenes and cancer
    • Croce CM (2008) Oncogenes and cancer. N Engl J Med 358:502-511
    • (2008) N Engl J Med , vol.358 , pp. 502-511
    • Croce, C.M.1
  • 9
    • 77956503422 scopus 로고    scopus 로고
    • Cancer stem cells: A stride towards cancer cure?
    • Sengupta A, Cancelas JA (2010) Cancer stem cells: a stride towards cancer cure? J Cell Physiol 225:7-14
    • (2010) J Cell Physiol , vol.225 , pp. 7-14
    • Sengupta, A.1    Cancelas, J.A.2
  • 10
    • 80053030114 scopus 로고    scopus 로고
    • The cancer stem cell niche—there goes the neighborhood
    • Cabarcas SM, Mathews LA, Farrar WL (2011) The cancer stem cell niche—there goes the neighborhood? Int J Cancer 129:2315-27 LID, doi:10.1002/ijc.26312
    • (2011) Int J Cancer , vol.129 , pp. 2315-2327
    • Cabarcas, S.M.1    Mathews, L.A.2    Farrar, W.L.3
  • 12
    • 79959238013 scopus 로고    scopus 로고
    • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
    • Medema JP, Vermeulen L (2011) Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 474:318-26 LID—doi:10.1038/nature10212
    • (2011) Nature , vol.474 , pp. 318-326
    • Medema, J.P.1    Vermeulen, L.2
  • 14
    • 84859410313 scopus 로고    scopus 로고
    • Induced pluripotent stem cell consensus genes: Implication for the risk of tumorigenesis and cancers in induced pluripotent stem cell therapy
    • Zhang G, Shang B, Yang P, Cao Z, Pan Y, Zhou Q (2012) Induced pluripotent stem cell consensus genes: implication for the risk of tumorigenesis and cancers in induced pluripotent stem cell therapy. Stem Cells Dev 21(6):955-964
    • (2012) Stem Cells Dev , vol.21 , Issue.6 , pp. 955-964
    • Zhang, G.1    Shang, B.2    Yang, P.3    Cao, Z.4    Pan, Y.5    Zhou, Q.6
  • 15
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinibsensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • New York, NY
    • Sordella R, Bell DW, Haber DA, Settleman J (2004) Gefitinibsensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science (New York, NY) 305:1163-1167
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 16
    • 77956926560 scopus 로고    scopus 로고
    • Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal
    • Aguirre A, Rubio ME, Gallo V (2010) Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature 467:323-327
    • (2010) Nature , vol.467 , pp. 323-327
    • Aguirre, A.1    Rubio, M.E.2    Gallo, V.3
  • 25
    • 0023133732 scopus 로고
    • Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL
    • New York, NY
    • Clark SS, McLaughlin J, Crist WM, Champlin R, Witte ON (1987) Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL. Science (New York, NY) 235:85-88
    • (1987) Science , vol.235 , pp. 85-88
    • Clark, S.S.1    McLaughlin, J.2    Crist, W.M.3    Champlin, R.4    Witte, O.N.5
  • 28
    • 26844520965 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H 3
    • New York, NY
    • Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC (2005) Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H 3. Science (New York, NY) 310:306-310
    • (2005) Science , vol.310 , pp. 306-310
    • Cha, T.L.1    Zhou, B.P.2    Xia, W.3    Wu, Y.4    Yang, C.C.5    Chen, C.T.6    Ping, B.7    Otte, A.P.8    Hung, M.C.9
  • 29
    • 79953312648 scopus 로고    scopus 로고
    • BRAF(V600E) and microenvironment in thyroid cancer: A functional link to drive cancer progression
    • Nucera C, Lawler J, Parangi S (2011) BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res 71:2417-2422
    • (2011) Cancer Res , vol.71 , pp. 2417-2422
    • Nucera, C.1    Lawler, J.2    Parangi, S.3
  • 32
    • 0021362206 scopus 로고
    • Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient
    • New York, NY
    • Santos E, Martin-Zanca D, Reddy EP, Pierotti MA, Della Porta G, Barbacid M (1984) Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science (New York, NY) 223:661-664
    • (1984) Science , vol.223 , pp. 661-664
    • Santos, E.1    Martin-Zanca, D.2    Reddy, E.P.3    Pierotti, M.A.4    Della Porta, G.5    Barbacid, M.6
  • 35
    • 0038724937 scopus 로고    scopus 로고
    • Role of Raf in vascular protection from distinct apoptotic stimuli
    • New York, NY
    • Alavi A, Hood JD, Frausto R, Stupack DG, Cheresh DA (2003) Role of Raf in vascular protection from distinct apoptotic stimuli. Science (New York, NY) 301:94-96
    • (2003) Science , vol.301 , pp. 94-96
    • Alavi, A.1    Hood, J.D.2    Frausto, R.3    Stupack, D.G.4    Cheresh, D.A.5
  • 37
    • 0027275755 scopus 로고
    • Point mutations in the c-Myc transactivation domain are common in Burkitt’s lymphoma and mouse plasmacytomas
    • Bhatia K, Huppi K, Spangler G, Siwarski D, Iyer R, Magrath I (1993) Point mutations in the c-Myc transactivation domain are common in Burkitt’s lymphoma and mouse plasmacytomas. Nat Genet 5:56-61
    • (1993) Nat Genet , vol.5 , pp. 56-61
    • Bhatia, K.1    Huppi, K.2    Spangler, G.3    Siwarski, D.4    Iyer, R.5    Magrath, I.6
  • 38
    • 0023947487 scopus 로고
    • Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma
    • Morse B, Rotherg PG, South VJ, Spandorfer JM, Astrin SM (1988) Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature 333:87-90
    • (1988) Nature , vol.333 , pp. 87-90
    • Morse, B.1    Rotherg, P.G.2    South, V.J.3    Spandorfer, J.M.4    Astrin, S.M.5
  • 39
    • 84857648310 scopus 로고    scopus 로고
    • Tumor microenvironment: Becoming sick of Myc
    • Whitfield JR, Soucek L (2012) Tumor microenvironment: becoming sick of Myc. Cell Mol Life Sci 69:931-934
    • (2012) Cell Mol Life Sci , vol.69 , pp. 931-934
    • Whitfield, J.R.1    Soucek, L.2
  • 44
    • 82755192941 scopus 로고    scopus 로고
    • Induction of a regenerative microenvironment in skeletal muscle is sufficient to induce embryonal rhabdomyosarcoma in p53-deficient mice
    • Camboni M, Hammond S, Martin LT, Martin PT (2012) Induction of a regenerative microenvironment in skeletal muscle is sufficient to induce embryonal rhabdomyosarcoma in p53-deficient mice. J Pathol 226:40-9 LID—doi:10.1002/path.2996
    • (2012) J Pathol , vol.226 , pp. 40-49
    • Camboni, M.1    Hammond, S.2    Martin, L.T.3    Martin, P.T.4
  • 45
    • 83355173203 scopus 로고    scopus 로고
    • Prisoner’s dilemma in cancer metabolism
    • Kareva I (2011) Prisoner’s dilemma in cancer metabolism. PLoS One 6:e28576
    • (2011) Plos One , pp. 6
    • Kareva, I.1
  • 47
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang CV, Le A, Gao P (2009) MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 15:6479-6483
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 49
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • New York, NY
    • Levine AJ, Puzio-Kuter AM (2010) The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science (New York, NY) 330:1340-1344
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 53
    • 79251502952 scopus 로고    scopus 로고
    • ATP consumption promotes cancer metabolism
    • Israelsen WJ, Vander Heiden MG (2010) ATP consumption promotes cancer metabolism. Cell 143:669-671
    • (2010) Cell , vol.143 , pp. 669-671
    • Israelsen, W.J.1    Vander Heiden, M.G.2
  • 54
    • 78149341677 scopus 로고    scopus 로고
    • Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1alpha and HIF-2alpha target genes
    • Chun SY, Johnson C, Washburn JG, Cruz-Correa MR, Dang DT, Dang LH (2010) Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1alpha and HIF-2alpha target genes. Mol Cancer 9:293
    • (2010) Mol Cancer , vol.9 , pp. 293
    • Chun, S.Y.1    Johnson, C.2    Washburn, J.G.3    Cruz-Correa, M.R.4    Dang, D.T.5    Dang, L.H.6
  • 55
    • 84856913587 scopus 로고    scopus 로고
    • Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
    • Goldberg MS, Sharp PA (2012) Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med 209:217-224
    • (2012) J Exp Med , vol.209 , pp. 217-224
    • Goldberg, M.S.1    Sharp, P.A.2
  • 57
    • 82855167795 scopus 로고    scopus 로고
    • Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment
    • Sotgia F, Martinez-Outschoorn UE, Pavlides S, Howell A, Pestell RG, Lisanti MP (2011) Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment. Breast Cancer Res 13:213
    • (2011) Breast Cancer Res , vol.13 , pp. 213
    • Sotgia, F.1    Martinez-Outschoorn, U.E.2    Pavlides, S.3    Howell, A.4    Pestell, R.G.5    Lisanti, M.P.6
  • 60
    • 41149129199 scopus 로고    scopus 로고
    • Cancer stem cells: The lessons from pre-cancerous stem cells
    • Gao JX (2008) Cancer stem cells: the lessons from pre-cancerous stem cells. J Cell Mol Med 12:67-96
    • (2008) J Cell Mol Med , vol.12 , pp. 67-96
    • Gao, J.X.1
  • 64
    • 79953331014 scopus 로고    scopus 로고
    • Origin and maintenance of the intestinal cancer stem cell
    • Davies EJ, Marsh V, Clarke AR (2011) Origin and maintenance of the intestinal cancer stem cell. Mol Carcinog 50:254-63 LID—doi:10.1002/mc.20631
    • (2011) Mol Carcinog , vol.50 , pp. 254-263
    • Davies, E.J.1    Marsh, V.2    Clarke, A.R.3
  • 65
    • 81255168182 scopus 로고    scopus 로고
    • Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: Distinct, overlapping or same populations
    • Floor S, van Staveren WC, Larsimont D, Dumont JE, Maenhaut C (2011) Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations. Oncogene 30:4609-21 LID—doi:10.1038/onc.2011.184
    • (2011) Oncogene , vol.30 , pp. 4609-4621
    • Floor, S.1    Van Staveren, W.C.2    Larsimont, D.3    Dumont, J.E.4    Maenhaut, C.5
  • 66
    • 79954576652 scopus 로고    scopus 로고
    • EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells
    • Tellez CS, Juri DE, Do K, Bernauer AM, Thomas CL, Damiani LA, Tessema M, Leng S, Belinsky SA (2011) EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res 71:3087-3097
    • (2011) Cancer Res , vol.71 , pp. 3087-3097
    • Tellez, C.S.1    Juri, D.E.2    Do, K.3    Bernauer, A.M.4    Thomas, C.L.5    Damiani, L.A.6    Tessema, M.7    Leng, S.8    Belinsky, S.A.9
  • 67
    • 79958093458 scopus 로고    scopus 로고
    • Genes associated with epithelial-mesenchymal transition: Possible therapeutic targets in ductal pancreatic adenocarcinoma?
    • Hotz HG, Hotz B, Buhr HJ (2011) Genes associated with epithelial-mesenchymal transition: possible therapeutic targets in ductal pancreatic adenocarcinoma? Anticancer Agents Med Chem 11:448-454
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 448-454
    • Hotz, H.G.1    Hotz, B.2    Buhr, H.J.3
  • 68
    • 78650510303 scopus 로고    scopus 로고
    • Growth factors in induction of epithelial-mesenchymal transition and metastasis
    • Said NA, Williams ED (2011) Growth factors in induction of epithelial-mesenchymal transition and metastasis. Cells Tissues Organs 193:85-97
    • (2011) Cells Tissues Organs , vol.193 , pp. 85-97
    • Said, N.A.1    Williams, E.D.2
  • 70
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente M, Gerhardt H, Carmeliet P (2011) Basic and therapeutic aspects of angiogenesis. Cell 146:873-887
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 73
    • 0038143145 scopus 로고    scopus 로고
    • Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma
    • Hendrix MJ, Seftor EA, Hess AR, Seftor RE (2003) Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer 3:411-421
    • (2003) Nat Rev Cancer , vol.3 , pp. 411-421
    • Hendrix, M.J.1    Seftor, E.A.2    Hess, A.R.3    Seftor, R.E.4
  • 77
    • 68949114117 scopus 로고    scopus 로고
    • Tumor-associated macrophages: Effectors of angiogenesis and tumor progression
    • Coffelt SB, Hughes R, Lewis CE (2009) Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta 1796:11-18
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 11-18
    • Coffelt, S.B.1    Hughes, R.2    Lewis, C.E.3
  • 78
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298-307
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 79
    • 84894905968 scopus 로고    scopus 로고
    • The molecular and celluar progress of tumor-cell-mediated angiogenesis and vasculogenesis
    • Zhou Q, Cao Z, Shang B, Zhang G, Pan Y, Guo P (2011) The molecular and celluar progress of tumor-cell-mediated angiogenesis and vasculogenesis. Blood 118(21):1405-1406
    • (2011) Blood , vol.118 , Issue.21 , pp. 1405-1406
    • Zhou, Q.1    Cao, Z.2    Shang, B.3    Zhang, G.4    Pan, Y.5    Guo, P.6
  • 80
    • 38649085329 scopus 로고    scopus 로고
    • Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine
    • San Diego, Calif
    • Zhou Q, Kiosses WB, Liu J, Schimmel P (2008) Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine. Methods (San Diego, Calif) 44:190-195
    • (2008) Methods , vol.44 , pp. 190-195
    • Zhou, Q.1    Kiosses, W.B.2    Liu, J.3    Schimmel, P.4
  • 82
    • 79952129849 scopus 로고    scopus 로고
    • Concise review: Vascular stem cells and tumor angiogenesis
    • Dayton, Ohio
    • Melero-Martin JM, Dudley AC (2011) Concise review: vascular stem cells and tumor angiogenesis. Stem Cells (Dayton, Ohio) 29:163-8 LID—doi:10.1002/stem.583
    • (2011) Stem Cells , vol.29 , pp. 163-168
    • Melero-Martin, J.M.1    Dudley, A.C.2
  • 84
    • 77956803700 scopus 로고    scopus 로고
    • The perivascular niche microenvironment in brain tumor progression
    • Georgetown, Tex
    • Charles N, Holland EC (2010) The perivascular niche microenvironment in brain tumor progression. Cell Cycle (Georgetown, Tex) 9:3012-3021
    • (2010) Cell Cycle , vol.9 , pp. 3012-3021
    • Charles, N.1    Holland, E.C.2
  • 85
    • 84856731931 scopus 로고    scopus 로고
    • The vascular niche: Home for normal and malignant hematopoietic stem cells
    • Doan PL, Chute JP (2012) The vascular niche: home for normal and malignant hematopoietic stem cells. Leukemia 26:54-62 LID—doi:10.1038/leu.2011.236
    • (2012) Leukemia , vol.26 , pp. 54-62
    • Doan, P.L.1    Chute, J.P.2
  • 87
    • 67349168435 scopus 로고    scopus 로고
    • Role of macrophages in tumour progression
    • Siveen KS, Kuttan G (2009) Role of macrophages in tumour progression. Immunol Lett 123:97-102
    • (2009) Immunol Lett , vol.123 , pp. 97-102
    • Siveen, K.S.1    Kuttan, G.2
  • 88
    • 68949150545 scopus 로고    scopus 로고
    • Tie2-expressing monocytes (TEMs): Novel targets and vehicles of anticancer therapy?
    • De Palma M, Naldini L (2009) Tie2-expressing monocytes (TEMs): novel targets and vehicles of anticancer therapy? Biochim Biophys Acta 1796:5-10
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 5-10
    • De Palma, M.1    Naldini, L.2
  • 91
    • 79959959625 scopus 로고    scopus 로고
    • Niche contributions to oncogenesis: Emerging concepts and implications for the hematopoietic system
    • Raaijmakers MH (2011) Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system. Haematologica 96:1041-1048
    • (2011) Haematologica , vol.96 , pp. 1041-1048
    • Raaijmakers, M.H.1
  • 93
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell MJ, Hines WC (2011) Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 17:320-329
    • (2011) Nat Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 94
    • 80051770214 scopus 로고    scopus 로고
    • Yin-yang balance therapy on regulating cancer stem cells
    • Xu WR, Lin HS, Chen XY, Zhang Y (2011) Yin-yang balance therapy on regulating cancer stem cells. J Tradit Chin Med 31:158-160
    • (2011) J Tradit Chin Med , vol.31 , pp. 158-160
    • Xu, W.R.1    Lin, H.S.2    Chen, X.Y.3    Zhang, Y.4
  • 95
    • 84864879887 scopus 로고    scopus 로고
    • Progress in tumor vascular normalization for anticancer therapy: Challenges and perspectives
    • Shang B, Cao Z, Zhou Q (2012) Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives. Front Med 6(1):67-78
    • (2012) Front Med , vol.6 , Issue.1 , pp. 67-78
    • Shang, B.1    Cao, Z.2    Zhou, Q.3
  • 96
    • 79953244361 scopus 로고    scopus 로고
    • Antiangiogenic therapy: Impact on invasion, disease progression, and metastasis
    • Ebos JM, Kerbel RS (2011) Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 8:210-221
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 210-221
    • Ebos, J.M.1    Kerbel, R.S.2
  • 99
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK (2011) Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 10:417-427
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 101
    • 79959236558 scopus 로고    scopus 로고
    • Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy
    • Sato Y (2011) Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy. Cancer Sci 102:1253-1256
    • (2011) Cancer Sci , vol.102 , pp. 1253-1256
    • Sato, Y.1


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