A novel COL1A1 exon 14/PDGFB fusion gene in dermatofibrosarcoma protuberans

European Journal of Dermatology

Volumn 20, Issue 3, 2010, Pages 390-391

  Muchemwa, Faith C ^a   Jinnin, Masatoshi ^a   Wakasugi, Shoji ^a   Sakamoto, Maki ^a   Inoue, Yuji ^a   Ishihara, Tsuyoshi ^a   Ihn, Hironobu ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGAR GEL ELECTROPHORESIS; CANCER SURGERY; CASE REPORT; COL1A1 GENE; DERMATOFIBROSARCOMA PROTUBERANS; DNA SEQUENCE; EXON; FUSION GENE; GENE; HUMAN; LETTER; MALE; PDGFB GENE; PHYSICAL EXAMINATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; DERMATOFIBROSARCOMA; DIAGNOSIS, DIFFERENTIAL; EXONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SKIN; SKIN NEOPLASMS; TRANSLOCATION, GENETIC;

EID: 77952819636     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2010.0906     Document Type: Letter

References (6)

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2. Shimizu A, O'Brien K, Sjoblom T, et al. The dermatofibrosarcoma protuberans-associated collagen type 1alpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res 1999; 59: 3719-3723 (Pubitemid 29381878)
3. Saeki H, Hoashi T, Tada Y, et al. Analysis of gene mutations in three cases of dermatofibrosarcoma protuberans (DFSP): ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung metastasis of DFSP-FS. J Dermatol Sci 2003; 33: 161-167 (Pubitemid 37485697)
4. O'Brien KP, Seroussi E, Dal Cin P, et al. Various regions within the α-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer 1998; 23: 187-193 (Pubitemid 28402346)
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6. Muchemwa FC, Wakasugi S, Ihn H. PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases. Clin Exp Derm 2009 (in press).