ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

Nature

Volumn 467, Issue 7317, 2010, Pages 849-853

  Chi, Ping ^a,b   Chen, Yu ^a   Zhang, Lei ^a   Guo, Xingyi ^c   Wongvipat, John ^a   Shamu, Tambudzai ^a   Fletcher, Jonathan A ^d   Dewell, Scott ^b   Maki, Robert G ^a   Zheng, Deyou ^c   Antonescu, Cristina R ^a   Allis, C David ^b   Sawyers, Charles L ^a,e  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; STEM CELL FACTOR; TRANSCRIPTION FACTOR ER81; TRANSCRIPTOME;

CYTOGENETICS; DIGESTIVE SYSTEM DISORDER; MUTATION; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CARCINOGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; ENHANCER REGION; GASTROINTESTINAL STROMAL TUMOR; GENE ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE TARGETING; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GENOMICS; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERSTITIAL CELL OF CAJAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; CELL LINEAGE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; DNA-BINDING PROTEINS; ENHANCER ELEMENTS, GENETIC; GASTROINTESTINAL STROMAL TUMORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERSTITIAL CELLS OF CAJAL; MICE; MUTANT PROTEINS; MUTATION; NIH 3T3 CELLS; ONCOGENES; PIPERAZINES; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

MUS;

EID: 77957943127     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09409     Document Type: Article

References (33)

1. Heinrich, M. C. et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299, 708-710 (2003).
2. Hirota, S. et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279, 577-580 (1998). (Pubitemid 28067289)
3. Kindblom, L. G., Remotti, H. E., Aldenborg, F. & Meis-Kindblom, J. M. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am. J. Pathol. 152, 1259-1269 (1998).
4. Antonescu, C. R. Gastrointestinal stromal tumor (GIST) pathogenesis, Familial GIST, and animal models. Semin. Diagn. Pathol. 23, 63-69 (2006).
5. Nakai, N. et al. A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. J. Pathol. 214, 302-311 (2008).
6. Rubin, B. P. et al. A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E. Cancer Res 65, 6631-6639 (2005).
7. Sommer, G. et al. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proc. Natl Acad. Sci. USA 100, 6706-6711 (2003).
8. Kwon, J. G. et al. Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors. Gastroenterology 136, 630-639 (2009).
9. Tomlins, S. A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644-648 (2005).
10. Mertens, F. et al. Translocation-related sarcomas. Semin. Oncol. 36, 312-323 (2009).
11. Jane-Valbuena, J. et al. An oncogenic role for ETV1 in melanoma. Cancer Res 70, 2075-2084 (2010).
12. Nielsen, T. O. et al. Molecular characterisation of soft tissue tumours: a gene expression study. Lancet 359, 1301-1307 (2002).
13. Segal, N. H. et al. Classification and subtype prediction ofadult soft tissue sarcoma by functional genomics. Am. J. Pathol. 163, 691-700 (2003).
14. Tomlins, S. A. et al. Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature 448, 595-599 (2007).
15. Beroukhim, R. et al. The landscape of somatic copy-number alteration across human cancers. Nature 463, 899-905 (2010).
16. Ward, S. M. & Sanders, K. M. Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G602-G611 (2001).
17. Chen, H. et al. Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine. Physiol. Genomics 31, 492-509 (2007). (Pubitemid 350127789)
18. Arber, S., Ladle, D. R., Lin, J. H., Frank, E. & Jessell, T. M. ETS gene Er81 controls the formationoffunctionalconnections between group Iasensoryafferentsand motor neurons. Cell 101, 485-498 (2000).
19. Gomez-Pinilla, P.J. et al. Ano1 is a selective marker of interstitial cells of Cajal inthe human and mouse gastrointestinal tract. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1370-G1381 (2009).
20. Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
21. Heintzman, N. D. et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459, 108-112 (2009).
22. Visel, A. et al. ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457, 854-858 (2009).
23. Miettinen, M. & Lasota, J. Gastrointestinal stromal tumors: review on morphology, Molecular pathology, Prognosis, and differential diagnosis. Arch. Pathol. Lab. Med. 130, 1466-1478 (2006).
24. Andersen, R. J. et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 17, 535-546 (2010).
25. Moellering, R. E. et al. Direct inhibition of the NOTCH transcription factor complex. Nature 462, 182-188 (2009).
26. Bauer, S., Yu, L. K., Demetri, G.D. &Fletcher, J.A. Heat shock protein90inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res. 66, 9153-9161 (2006).
27. Yamaguchi, U. et al. Distinct gene expression-defined classes of gastrointestinal stromal tumor. J. Clin. Oncol. 26, 4100-4108 (2008).
28. Ostrowski, J. et al. Functional features of gene expression profiles differentiating gastrointestinalstromaltumours accordingtoKITmutationsandexpression. BMC Cancer 9, 413 (2009).
29. De Jonge, H.J. et al. Evidence based selectionofhousekeeping genes. PLoS ONE2, E898 (2007).
30. Sarbassov, D. D., Guertin, D. A., Ali, S. M. & Sabatini, D. M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
31. Goldberg, A. D. et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell 140, 678-691 (2010).
32. Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).
33. Bailey, T. L., Williams, N., Misleh, C. & Li, W. W. MEME: discovering and analyzing DNA and protein sequence motifs. Nucleic Acids Res. 34, W369-W373 (2006).