The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1α in neurons and astrocytes

Journal of Neuroscience

Volumn 28, Issue 8, 2008, Pages 1988-1993

  Vangeison, Grace ^a   Carr, Dan ^a   Federoff, Howard J ^b   Rempe, David A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Astrocyte; HIF 1; Hypoxia; Ischemia; Neuron; Neurotoxicity

Indexed keywords

AMINOGUANIDINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CELL DEATH; CELL SURVIVAL; CELL TYPE; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; COCULTURE TECHNIQUES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, TRANSGENIC; NEURONS; NITRIC OXIDE SYNTHASE TYPE II;

EID: 39749188133     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5323-07.2008     Document Type: Article

References (19)

1. Aminova LR, Chavez JC, Lee J, Ryu H, Kung A, Lamanna JC, Ratan RR (2004) Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. J Biol Chem 280:3996-4003.
2. Anderson CM, Swanson RA (2000) Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32:1-14.
3. Andrews NC, Faller DV (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucl Acids Res 19:2499.
4. Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC (2007) Neuron-specific inactivation of the hypoxia inducible factor 1α increases brain injury in a mouse model of transient focal cerebral ischemia. J Neurosci 27:6320-6332.
5. Bruick R (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 97:9082-9087.
6. Bruick RK, McKnight SL (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337-1340.
7. Chavez JC, Baranova O, Lin J, Pichiule P (2006) The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci 26:9471-9481.
8. Chen Y, Swanson RA (2003) Astrocytes and brain injury. J Cereb Blood Flow Metab 23:137-149.
9. Halterman MW, Miller CC, Federoff HJ (1999) Hypoxia-inducible factor 1a mediates hypoxia induced delayed neuronal death that involves p53. J Neurosci 19:6818-6824.
10. Hayashi S, McMahon AP (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244:305-318.
11. Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson RS, Lipton SA, Barlow C (2005) Brainspecific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxic-ischemic damage. J Neurosci 25:4099-4107.
12. Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468-472.
13. Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S (2007) Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 10:615-622.
14. Nedergaard M, Ransom B, Goldman SA (2003) New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 26:523-530.
15. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y (1997) "Green mice" as a source of ubiquitous green cells. FEBS Lett 407:313-319.
16. Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff HJ (2007) In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1(alpha) function regardless of the presence of DNA damage. J Biol Chem 282:16187-16201.
17. Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, Johnson RS (2000) Hypoxia-inducible factor-1a is a positive factor in solid tumor growth. Cancer Res 60:4010-4015.
18. Semenza GL (2000) HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88:1474-1480.
19. Swanson RA (1992) Astrocyte glutamate uptake during chemical hypoxia in vitro. Neurosci Lett 147:143-146.