Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: Role of cellular calcium and reactive oxygen species

Toxicological Sciences

Volumn 61, Issue 2, 2001, Pages 295-303

  Joseph, Pius ^a   Muchnok, Timothy K ^a   Klishis, Michelle L ^a   Roberts, Jenny R ^a   Antonini, James M ^a   Whong, Wen Zong ^a   Ong, Tong Man ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Cadmium; Calcium; Carcinogenesis; Cell transformation; Gene expression; Immediate early response genes; Reactive oxygen species

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CADMIUM CHLORIDE; CALCIUM; CATALASE; DACTINOMYCIN; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FLUORESCENT DYE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CARCINOGENESIS; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; EXPOSURE; GENE ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; INHIBITION KINETICS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUDE MOUSE; PROTO ONCOGENE; STAINING; TUMOR CELL LINE;

3T3 CELLS; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, NORTHERN; CADMIUM; CALCIUM; CELL TRANSFORMATION, NEOPLASTIC; DACTINOMYCIN; EGTAZIC ACID; FLAVONOIDS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, FOS; GENES, JUN; GENES, MYC; INDOLES; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TUMOR CELLS, CULTURED;

ANIMALIA; LETHRINIDAE; MUS MUSCULUS;

EID: 0034989784     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/61.2.295     Document Type: Article

References (37)

1. Redox regulation of fos and jun DNA-binding activity in vitro
2. In vitro exposure to cadmium in rat L6 myoblasts can result in both enhancement and suppression of malignant progression
3. Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis
4. The Chemistry, Biochemistry and Biology of Cadmium
5. Use of cell transformation system for carcinogenicity testing and mechanistic studies of carcinogens
6. Cadmium, gene regulation, and cellular signalling in mammalian cells
7. Role of oxygen free radicals in cancer development
8. A synthetic inhibitor of the mitogen-activated protein kinase cascade
9. Heavy metals induce expression of the TPA-inducible sequence (TIS) genes
10. Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database
11. Metallothionein
12. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
13. Role of DNA repair inhibition in lead- and cadmium-induced genotoxicity: A review
14. Investigation on the carcinogenic effects of various cadmium compounds after inhalation exposure in hamsters and mice
15. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry
16. Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts
17. Redox regulation of cellular signaling
18. Transforming and carcinogenic potential of cadmium chloride in BALB/c-3T3 cells
19. Linking protein kinase C to cell-cycle control
20. 2+]i in induction of c-fos, c-jun, and c-myc mRNA in rat PTE after oxidative stress
21. Mitochondrial permeability transition is a central coordinating event of apoptosis
22. Cadmium-induced expression of immediate early genes in LLC-PK1 cells
23. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores
24. Nucleotide sequence and organization of the rat heme oxygenase gene
25. Untersuchungen zur Induktion der proto-onkogene c-fos und c-jun durch cadmium
26. 2+ transport in brain microsomes
27. Metal carcinogenesis: Mechanistic implications
28. 2+-induced c-myc mRNA accumulation in NRK-49F cells is blocked by the protein kinase inhibitor H7 but not by HA1004, indicating that protein kinase C is a mediator of the response
29. Cadmium and calcium-dependent c-fos expression in mesangial cells
30. The oncogene jun and nuclear signaling
31. Cadmium carcinogenesis in review
32. Toxicological principles of metal carcinogenesis with special emphasis on cadmium
33. Induction of c-fos proto-oncogene in mesangial cells by cadmium
34. Role of reactive oxygen species and p53 in chromium (VI)-induced apoptosis
35. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo