-
1
-
-
0034176798
-
DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
-
Baylin SB, Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16:168-174
-
(2000)
Trends Genet
, vol.16
, pp. 168-174
-
-
Baylin, S.B.1
Herman, J.G.2
-
2
-
-
0032960181
-
Cancer epigenetics comes of age
-
Jones PA, Laird PW (1999) Cancer epigenetics comes of age. Nat Genet 21:163-167
-
(1999)
Nat Genet
, vol.21
, pp. 163-167
-
-
Jones, P.A.1
Laird, P.W.2
-
3
-
-
0030840954
-
Cytosine methylation and the ecology of intragenomic parasites
-
Yoder JA, Walsh CP, Bestor TH (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13:335-340
-
(1997)
Trends Genet
, vol.13
, pp. 335-340
-
-
Yoder, J.A.1
Walsh, C.P.2
Bestor, T.H.3
-
4
-
-
0033601096
-
Putting boundaries on silence
-
Sun FL, Elgin SC (1999) Putting boundaries on silence. Cell 99:459-462
-
(1999)
Cell
, vol.99
, pp. 459-462
-
-
Sun, F.L.1
Elgin, S.C.2
-
5
-
-
0036144048
-
DNA methylation patterns and epigenetic memory
-
Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6-21
-
(2002)
Genes Dev
, vol.16
, pp. 6-21
-
-
Bird, A.1
-
6
-
-
0030868694
-
Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation
-
Graff JR, Herman JG, Myohanen S, Baylin SB, Vertino PM (1997) Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem 272:22322-22329
-
(1997)
J Biol Chem
, vol.272
, pp. 22322-22329
-
-
Graff, J.R.1
Herman, J.G.2
Myohanen, S.3
Baylin, S.B.4
Vertino, P.M.5
-
7
-
-
0033215453
-
p15 (INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
-
Cameron EE, Baylin SB, Herman JG (1999) p15 (INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood 94:2445-24451
-
(1999)
Blood
, vol.94
, pp. 2445-24451
-
-
Cameron, E.E.1
Baylin, S.B.2
Herman, J.G.3
-
8
-
-
0034723255
-
Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression
-
Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG (2000) Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 275:2727-2732
-
(2000)
J Biol Chem
, vol.275
, pp. 2727-2732
-
-
Graff, J.R.1
Gabrielson, E.2
Fujii, H.3
Baylin, S.B.4
Herman, J.G.5
-
9
-
-
0032756518
-
The establishment and maintenance of DNA methylation patterns in mouse somatic cells
-
Turker MS (1999) The establishment and maintenance of DNA methylation patterns in mouse somatic cells. Semin Cancer Biol 9:329-337
-
(1999)
Semin Cancer Biol
, vol.9
, pp. 329-337
-
-
Turker, M.S.1
-
10
-
-
0034720284
-
CpG methylation is maintained in human cancer cells lacking DNMT1
-
Rhee I, Jair KW, Yen RW et al. (2000) CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404:1003-1007
-
(2000)
Nature
, vol.404
, pp. 1003-1007
-
-
Rhee, I.1
Jair, K.W.2
Yen, R.W.3
-
11
-
-
0033607147
-
In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
-
Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG (1999) In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc Natl Acad Sci USA 96:12754-12759
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 12754-12759
-
-
Nuovo, G.J.1
Plaia, T.W.2
Belinsky, S.A.3
Baylin, S.B.4
Herman, J.G.5
-
12
-
-
0028849277
-
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
-
Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davidson NE, Baylin SB (1995) E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55:5195-5199
-
(1995)
Cancer Res
, vol.55
, pp. 5195-5199
-
-
Graff, J.R.1
Herman, J.G.2
Lapidus, R.G.3
Chopra, H.4
Xu, R.5
Jarrard, D.F.6
Isaacs, W.B.7
Pitha, P.M.8
Davidson, N.E.9
Baylin, S.B.10
-
13
-
-
0027770015
-
Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas
-
Moll R, Mitze M, Frixen UH, Birchmeier W (1993) Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol 143:1731-1742
-
(1993)
Am J Pathol
, vol.143
, pp. 1731-1742
-
-
Moll, R.1
Mitze, M.2
Frixen, U.H.3
Birchmeier, W.4
-
14
-
-
0033601073
-
Methylation-induced repression - Belts, braces, and chromatin
-
Bird AP, Wolffe AP (1999) Methylation-induced repression - belts, braces, and chromatin. Cell 99:451-454
-
(1999)
Cell
, vol.99
, pp. 451-454
-
-
Bird, A.P.1
Wolffe, A.P.2
-
15
-
-
0035542555
-
Transcriptional regulation in the context of chromatin structure
-
Wolffe AP (2001) Transcriptional regulation in the context of chromatin structure. Essays Biochem 37:45-57
-
(2001)
Essays Biochem
, vol.37
, pp. 45-57
-
-
Wolffe, A.P.1
-
16
-
-
0032948005
-
Synergy of demethylation SB histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
Cameron EE, Bachman KE, Myohanen S, Herman JG, Synergy of demethylation SB (1999) histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21:103-107
-
(1999)
Nat Genet
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
-
17
-
-
0035942170
-
Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia
-
Magdinier F, Wolffe AP (2001) Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. Proc Natl Acad Sci USA 98:4990-4995
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4990-4995
-
-
Magdinier, F.1
Wolffe, A.P.2
-
18
-
-
0035890665
-
Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: Correlation of accessibility, methylation MeCP2 binding and acetylation
-
Nguyen CT, Gonzales FA, Jones PA (2001) Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Res 29:4598-4606
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 4598-4606
-
-
Nguyen, C.T.1
Gonzales, F.A.2
Jones, P.A.3
-
19
-
-
0033119780
-
DNA methylation and chromatin modification
-
Ng HH, Bird A (1999) DNA methylation and chromatin modification. Curr Opin Genet Dev 9:158-163
-
(1999)
Curr Opin Genet Dev
, vol.9
, pp. 158-163
-
-
Ng, H.H.1
Bird, A.2
-
20
-
-
0031837109
-
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
-
Jones PL, Veenstra GJ, Wade PA et al. (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19:187-191
-
(1998)
Nat Genet
, vol.19
, pp. 187-191
-
-
Jones, P.L.1
Veenstra, G.J.2
Wade, P.A.3
-
21
-
-
0032574977
-
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
-
Nan X, Ng HH, Johnson CA et al. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389
-
(1998)
Nature
, vol.393
, pp. 386-389
-
-
Nan, X.1
Ng, H.H.2
Johnson, C.A.3
-
22
-
-
0032845039
-
Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
-
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999) Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet 23:62-66
-
(1999)
Nat Genet
, vol.23
, pp. 62-66
-
-
Wade, P.A.1
Gegonne, A.2
Jones, P.L.3
Ballestar, E.4
Aubry, F.5
Wolffe, A.P.6
-
23
-
-
0036182132
-
Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation
-
El-Osta A, Kantharidis P, Zalcberg JR, Wolffe AP (2002) Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation. Mol Cell Biol 22:1844-1857
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1844-1857
-
-
El-Osta, A.1
Kantharidis, P.2
Zalcberg, J.R.3
Wolffe, A.P.4
-
24
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
25
-
-
0010730989
-
DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian development
-
Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian development. Cell 9:9247-9257
-
(1999)
Cell
, vol.9
, pp. 9247-9257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
26
-
-
0033988813
-
DNA methyltransferase DNMT1 associates with histone deacetylase activity
-
Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T (2000) DNA methyltransferase DNMT1 associates with histone deacetylase activity. Nat Genet 24:88-91
-
(2000)
Nat Genet
, vol.24
, pp. 88-91
-
-
Fuks, F.1
Burgers, W.A.2
Brehm, A.3
Hughes-Davies, L.4
Kouzarides, T.5
-
27
-
-
0033945861
-
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
-
Rountree MR, Bachman KE, Baylin SB (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet 25:269-277
-
(2000)
Nat Genet
, vol.25
, pp. 269-277
-
-
Rountree, M.R.1
Bachman, K.E.2
Baylin, S.B.3
-
28
-
-
0033919595
-
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
-
Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP (2000) DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25:338-342
-
(2000)
Nat Genet
, vol.25
, pp. 338-342
-
-
Robertson, K.D.1
Ait-Si-Ali, S.2
Yokochi, T.3
Wade, P.A.4
Jones, P.L.5
Wolffe, A.P.6
-
29
-
-
0035873225
-
DNMT3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
-
Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T (2001) DNMT3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 20:2536-2544
-
(2001)
EMBO J
, vol.20
, pp. 2536-2544
-
-
Fuks, F.1
Burgers, W.A.2
Godin, N.3
Kasai, M.4
Kouzarides, T.5
-
30
-
-
0035943709
-
DNMT3a and DNMT3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
-
Bachman KE, Rountree MR, Baylin SB (2001) DNMT3a and DNMT3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem 276:32282-32287
-
(2001)
J Biol Chem
, vol.276
, pp. 32282-32287
-
-
Bachman, K.E.1
Rountree, M.R.2
Baylin, S.B.3
-
31
-
-
0033552604
-
Duplication and maintenance of heterochromatin domains
-
Taddei A, Roche D, Sibarita JB, Turner BM, Almouzni G (1999) Duplication and maintenance of heterochromatin domains. J Cell Biol 147:1153-1166
-
(1999)
J Cell Biol
, vol.147
, pp. 1153-1166
-
-
Taddei, A.1
Roche, D.2
Sibarita, J.B.3
Turner, B.M.4
Almouzni, G.5
-
32
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee I, Bachman KE, Park B, Jair K, Yen RC, Schuebel KM, Cui H, Feinberg AP, Lengauer C, Kinzler KW et al. (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416:552-556
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.3
Jair, K.4
Yen, R.C.5
Schuebel, K.M.6
Cui, H.7
Feinberg, A.P.8
Lengauer, C.9
Kinzler, K.W.10
-
33
-
-
0036135014
-
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
-
Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA (2002) Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol 22:480-491
-
(2002)
Mol Cell Biol
, vol.22
, pp. 480-491
-
-
Liang, G.1
Chan, M.F.2
Tomigahara, Y.3
Tsai, Y.C.4
Gonzales, F.A.5
Li, E.6
Laird, P.W.7
Jones, P.A.8
-
34
-
-
0032907728
-
Maintenance of genomic methylation requires an SW12/SNF2-like protein
-
Jeddeloh JA, Stokes TL, Richards EJ (1999) Maintenance of genomic methylation requires an SW12/SNF2-like protein. Nat Genet 22:94-97
-
(1999)
Nat Genet
, vol.22
, pp. 94-97
-
-
Jeddeloh, J.A.1
Stokes, T.L.2
Richards, E.J.3
-
35
-
-
0035890090
-
Lsh, a member of the SNF2 family, is required for genome-wide methylation
-
Dennis K, Fan T, Geiman T, Yan Q, Muegge K (2001) Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev 15:2940-2944
-
(2001)
Genes Dev
, vol.15
, pp. 2940-2944
-
-
Dennis, K.1
Fan, T.2
Geiman, T.3
Yan, Q.4
Muegge, K.5
-
36
-
-
0035891265
-
A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
-
Tamaru H, Selker EU (2001) A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414:277-283
-
(2001)
Nature
, vol.414
, pp. 277-283
-
-
Tamaru, H.1
Selker, E.U.2
-
37
-
-
0038527642
-
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
-
Di Croce L, Raker VA, Corsaro M, Fazi F, Fanelli M, Faretta M, Fuks F, Lo Coco F, Kouzarides T, Nervi C et al. (2002) Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 295:1079-1082
-
(2002)
Science
, vol.295
, pp. 1079-1082
-
-
Di Croce, L.1
Raker, V.A.2
Corsaro, M.3
Fazi, F.4
Fanelli, M.5
Faretta, M.6
Fuks, F.7
Lo Coco, F.8
Kouzarides, T.9
Nervi, C.10
|