Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats

Toxicological Sciences

Volumn 54, Issue 1, 2000, Pages 110-120

  Waalkes, Michael P ^a   Rehm, Sabine ^a,c   Cherian, M George ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Cadmium; Carcinogenesis; Rats; Sarcoma; Tumor invasion; Tumor metastasis; Tumor progression

Indexed keywords

BINDING PROTEIN; CADMIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CARCINOGENESIS; DRUG EXPOSURE; IMMUNOHISTOCHEMISTRY; LETHALITY; METASTASIS; NONHUMAN; RAT; SARCOMA; TUMOR GROWTH;

ANIMALIA; NICOTIANA TABACUM;

EID: 0034020620     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/54.1.110     Document Type: Article

References (40)

1. Abshire, M. K., Devor, D. E., Diwan, B. A., Shaughnessy, J. D., Jr., and Waalkes, M. P. (1996). In vitro exposure to cadmium in rat L6 myoblasts can result in both enhancement and suppression of malignant progression in vivo. Carcinogenesis 17, 1349-1356.
2. Banerjee, D., Onosaka, S., and Cherian, M. G. (1982). Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney. Toxicology 24, 95-105.
3. Cherian, M. G. (1993). Nuclear and cytoplasmic localization of metallothionein in human liver during development and in tumor cells. In Metallothionein III, (K. T. Suzuki, N. Imura, and M. Kimura, Eds.), pp. 175-187. Birkhäuser Verlag, Basel.
4. Deng, D. X., Chakrabarti, S., Waalkes, M. P., and Cherian, M. G. (1998). Metallothionein and apoptosis in primary human hepatocellular carcinoma and metastatic adenocarcinoma. Histopathology 32, 340-347.
5. Douglas-Jones, A. G., Navabi, H., Morgan, J. M., and Jasani, B. (1997). Immunoreactive p53 and metallothionein expression in duct carcinoma in situ of the breast: No correlation. Virchows Archives 430, 373-379.
6. Elinder, C.-G. (1985). Normal values for cadmium in human tissue, blood, and urine in different countries. In Cadmium and Health: A Toxicological und Epidemiological Appraisal (L. Friberg, C.-G. Elinder, T. Kjellström, and G. F. Nordberg, Eds.), Vol. 1, pp. 81-102. CRC Press, Boca Raton, FL.
7. Goering, P. L., Waalkes, M. P., and Klaassen, C. D. (1994). Toxicology of cadmium. In Handbook of Experimental Pharmacology; Toxicology of Metals, Biochemical Effects, (R. A. Goyer, and M. G. Cherian, Eds.), Vol. 115, pp. 189-214. Springer-Verlag, New York.
8. Gunn, S. A., Gould, T. C., and Anderson, W. A. D. (1963). Cadmium-induced interstitial cell tumors in rats and mice and their prevention by zinc. J. Natl. Cancer Inst. 31, 745-753.
9. Gunn, S. A., Gould, T. C., and Anderson, W. A. D. (1964). Effect of zinc on cancerogenesis by cadmium. Proc. Soc. Exp. Biol. Med. 115, 653-657.
10. Gunn, S. A., Gould, T. C., and Anderson, W. A. D. (1967). Specific response of mesenchymal tissue to cancerogenesis by cadmium. Arch. Pathol. 83, 493-499.
11. Haerslev, T., Jacobsen, K., Nedergaard, L., and Zedeler, K. (1994). Immunohistochemical detection of metallothionein in primary breast carcinomas and their auxiliary lymph node metastises. Pathology Res. Practice 190, 675-681.
12. Haga, A., Nagase, H., Kito, H., and Sato, T. (1996). Enhanced invasiveness of tumour cells after host exposure to heavy metals. Europ. J. Cancer 32A, 2342-2347.
13. Haga, A., Nagase, H., Kito, H., and Sato, T. (1997). Invasive properties of cadmium-resistant human fibrosarcoma HT-1080 cells. Cancer Biochem. Biophys. 15, 275-284.
14. Haga, A., Nagase, H., Kito, H., and Sato, T. (1998). Inhibition effect of propargylglycine on human HT-1080 cell invasivevess. Cancer Biochem. Biophys. 16, 31-43.
15. Heath, J. C., and Webb, M. (1967). Content and intracellular distribution of the inducing metal in the primary rhabdomyosarcomata induced in the rat by cobalt, nickel and cadmium, Br. J. Cancer 21, 768-779.
16. Heath, J. C., Daniel, I. R., Dingle, J. T., and Webb, M. (1962). Cadmium as a carcinogen. Nature 193, 592-593.
17. IARC (1993). International Agency for Research on Cancer Monographs, Vol 58. Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry, pp. 119-238. IARC Press, Lyon.
18. Kasprzak, K. S., and Poirier, L. A. (1985). Effects of calcium and magnesium actetates on tissue distribution of carcinogenic doses of cadmium chloride in Wistar rats. Toxicology 34, 221-230.
19. Klaassen, C. D., Liu, J., and Choudhuri, S. (1999). Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 39, 267-294.
20. Kuester, R. K., Waalkes, M., Goering, P. L., Li, G., Fisher, B., Younis, H., and Sipes, I. G. (1999). Differential induction of metallothionein and heat shock protein 72 by cadmium in the livers of the male Fischer-344 and the Sprague-Dawley rat. Toxicologist 48, 355.
21. Mulder, T. P., Janssens, A. R., Verspaget, H. W., van Hattum, J., and Lamers, C. B. (1992). Metallothionein concentration in the liver of patients with Wilson's disease, primary biliary cirrhosis, and liver metastasis of colorectal cancer. J. Hepatol. 16, 346-350.
22. Nartey, N., Cherian, M. G., and Banerjee, D. (1987). Immunohistochemical localization of metallothionein in human thyroid tumors. Am. J. Pathol. 129, 177-182.
23. Poirier, L. A., Kasprzak, K. S., Hoover, K., and Wenk, M. L. (1983). Effects of calcium and magnesium acetates on the carcinogenicity of cadmium chloride in Wistar rats. Cancer Res. 43, 4575-4581.
24. Roe, F. J. C., Dukes, C. E., Cameron, K. I., Pugh, R. C. B., and Mitchley, B. C. V. (1964). Cadmium neoplasia: Testicular atrophy and Leydig cell hyperplasia and neoplasia in rats and mice following subcutaneous injection of cadmium salts. Br. J. Cancer 18, 674-681.
25. Rossman, T. G., Goncharova, E. I., Nadas, A., and Dolzhanskaya, N. (1997). Chinese hamster cells expressing antisense to metallothionein become spontaneous mutators. Mutat. Res. 373, 75-85.
26. Shimada, H., Shiao, Y.-H., Shibata, M.-A., and Waalkes, M. P. (1998). Cadmium suppresses apoptosis induced by chromium. J. Toxicol. Environ. Health, 54, 159-168.
27. Takeda, A., Hisada, H., Okada, S., Mata, J. E., Iversen, P. L., and Ebadi, M. (1999). The suppression of metallothionein inhibits the growth of leukemia P388 cells. In Metallothionein IV, (C. D. Klaassen, Ed.), pp. 613-617. Birkhäuser Verlag, Basel.
28. Takiguchi, M., and Waalkes, M. P. (1999). Cyproterone acetate, the antiandrogen, induces a novel form of cellular tolerance to cadmium involving reduced cellular tolerance to cadmium involving reduced cellular accumulation. Toxicologist 48, 354.
29. Waalkes, M. P., Anver, M., and Diwan, B. (1999). Carcinogenic effects of cadmium in the Noble (NBL/Cr) rat: Induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions of the dorsolateral prostate. Toxicol. Sci. 52, 154-161.
30. Waalkes, M, P., Kovatch, R., and Rehm, S. (1991a). Effect of chronic dietary zinc deficiency on cadmium toxicity and carcinogenesis in the male Wistar [Hsd:(WI)BR] rat. Toxicol. Appl. Pharmacol. 108, 448-456.
31. Waalkes, M. P., and Misra, R. R. (1996). Cadmium carcinogenicity and genotoxicity. In Toxicology of Metals (L. W. Chang, Ed.), pp. 231-244. CRC Press, Boca Raton, FL.
32. Waalkes, M. P., and Perez-Olle, R. (1999). Role of metallothionein in metabolism, transport, and toxicity of metals. Molecular Biology and Toxicology of Metals, (D. J. Koropatnick and R. Zalups, Eds.), Taylor & Francis, London (in press).
33. Waalkes, M. P., and Rehm, S. (1994). Chronic toxic and carcinogenic effects of cadmium chloride in male DBA/2NCr and NFS/NCr mice: Strain-dependent association with tumors of the hematopoietic system, injection site, liver, and lung. Fundam. Appl. Toxicol. 23, 21-31.
34. Waalkes, M. P., and Rehm, S. (1998). Lack of carcinogenicity of cadmium chloride in female Syrian hamsters. Toxicology 126, 173-178.
35. Waalkes, M. P., Rehm, S., and Devor, D. E. (1997). The effects of continuous testosterone exposure on spontaneous and cadmium-induced tumors in the male Fischer (F344/NCr) rat: Loss of testicular response. Toxicol. Appl. Pharmacol. 142, 40-46.
36. Waalkes, M. P., Rehm, S., Riggs, C. W., Bare, R. M., Devor, D. E., Poirier, L. A., Wenk, M. L., and Henneman, J. R. (1989). Cadmium carcinogenesis in the male Wistar [Crl:(WI)BR] rat: Dose-response analysis of effects of zinc on tumor induction in the prostate and in the testes and at the injection site. Cancer Res. 49, 4282-4288.
37. Waalkes, M. P., Rehm, S., Riggs, C. W., Bare, R. M., Devor, D. E., Poirier, L. A., Wenk, M. L., Henneman, J. R., and Balaschak, M. S. (1988). Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: Dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res. 48, 4656-4663.
38. Waalkes, M. P., Rehm, S., Sass, B., Konishi, N., and Ward, J. M. (1991b). Chronic carcinogenic and toxic effects of a single subcutaneous dose of cadmium in the male Fischer rat. Environ. Res. 55, 40-50.
39. Woo, E. S., Monks, A., Watkins, S. C., Wang, A. S., and Lazo, J. S. (1997). Diversity of metallothionein content and subcellular localization in the National Cancer Institute tumor panel. Cancer Chemother. Pharmacol. 41, 61-68.
40. Yuan, C., Kadiiska, M. B., Mason, R., and Waalkes, M. P. (1999). Cadmium blocks apoptosis induced by chromium, hydromycin B, and actinomycin D: The role of caspase-3 inhibition. Toxicologist 48, 355.