Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-κB, STAT3 and C/EBP signaling pathways

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 22, 2009, Pages 10990-10998

  Lai, Ching Shu ^a,e   Lee, Jong Hun ^b   Ho, Chi Tang ^b   Liu, Cheng Bin ^c   Wang, Ju Ming ^d   Wang, Ying Jan ^a   Pan, Min Hsiung ^e  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b RUTGERS UNIVERSITY   (United States)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

Author keywords

Cyclooxygenase 2 (COX 2); Inducible no synthase (iNOS); Lipopolysaccharide (LPS); NF B; RAW 264.7 monocyte macrophages; Rosmanol

Indexed keywords

ANTIINFLAMMATORY AGENT; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; CYCLOOXYGENASE 2; DITERPENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; ROSMANOL; STAT3 PROTEIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME INDUCTION; GENETICS; MACROPHAGE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; DITERPENES; DOWN-REGULATION; ENZYME INDUCTION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

ROSMARINUS OFFICINALIS;

EID: 72449121371     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf9025713     Document Type: Article

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