A comparison of the effects of L-NAME, 7-NI and L-NIL on caurageenan-induced hindpaw oedema and NOS activity

British Journal of Pharmacology

Volumn 123, Issue 6, 1998, Pages 1119-1126

  Handy, Rachel L C ^a   Moore, Philip K ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

7 Nitro indazole; Hindpaw oedema; Inflammation; L NAME; Nitric oxide; Nitric oxide synthase

Indexed keywords

7 NITROINDAZOLE; ARGININE METHYL ESTER; CARRAGEENAN; CITRULLINE; CYCLIC GMP; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; HINDLIMB; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT;

ANIMALS; CARRAGEENAN; CYCLIC GMP; EDEMA; ENZYME INHIBITORS; HINDLIMB; INDAZOLES; LYSINE; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR;

EID: 0031952104     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701735     Document Type: Article

References (36)

1. BABBEDGE, R.C., BLAND-WARD, P.A., HART, S.L. & MOORE, P.K. (1993). Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br. J. Pharmacol., 110, 225-228.
2. BELVISI, M., BARNES, P.J., LARKIN, S., YACOUB, M., TADJKARIMI, S., WILLIAMS, T.J. & MITCHELL, J.A. (1995). Nitric oxide synthase activity is elevated in inflammatory lung disease in humans. Eur. J. Pharmacol., 283, 255-258.
3. BIRCH, P.J., HARRISON, S.M., HAYES, A.C., ROGERS, H. & TYERS, M.B. (1992). The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345 produces antinociceptive and anti-oedema effects in the rat. Br. J. Pharmacol., 105, 508-510.
4. BLAND-WARD, P.A. (1996). Inhibition of Nitric Oxide Synthase by Indazole Derivatives: An Evaluation of the Pharmacological Effects of 7-Nitro Indazole in the Cardiovascular and Central Nervous Systems, PhD thesis, University of London.
5. BLAND-WARD, P.A. & MOORE, P.K. (1995). 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci., 57, 131-135.
6. DIROSA, M., GIROUD, J.P. & WILLOUGHBY, D.A (1971). Studies of mediators of the acute inflammatory response in rats in different sites by carrageenan and turpentine. J. Pathol., 104, 15-29.
7. FORSTERMANN, U. & KLEINERT, H. (1995). Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn-Schmiederberg's Arch. Pharmacol., 352, 351-364.
8. GARDINER, S.M., COMPTON, A.M., BENNETT, T., PALMER, R.M.J. & MONCADA, S. (1990). Regional haemodynamic changes following prolonged infusion of N(G) monomethyl-L-arginine methyl ester in conscious Brattleboro rats. Eur. J. Pharmacol., 213, 449-451.
9. GIRALDELO, C.M.M., ZAPPELLINI, A., MUSCARA, M.N., DELUCA, I.M.S., HYSLOP, S., CIRINO, G., ZATZ, R., DENUCCI, G. & ANTUNES, E. (1994). Effect of arginine analogues on rat hind paw edema and mast cell activation in vitro. Eur. J. Pharmacol., 257, 87-93.
10. HANDY, R.L.C. & MOORE, P.K. (1996). The nitric oxide synthase inhibitor, 7-nitro indazole, inhibits carrageenan-induced hindpaw oedema in the rat. Br. J. Pharmacol., 119, 157P.
11. HOKFELT, T., CECCATELLI, S., GUSTAFSSON, L., HLLTING, A.L., VERGE, V., VILLAR, M., XU, X.J., WIESENFELD-HALLIN, Z & ZHANG, X. (1994). Plasticity of NO synthase expression in the nervous and endocrine systems. Neuropharmacology, 33, 1221-1227.
12. HUGHES, S.R., WILLIAMS, T.J. & BRAIN, S.D. (1990). Evidence that endogenous nitric oxide modulates oedema formation induced by substance P. Eur. J. Pharmacol., 191, 481-484.
13. HUKKANEN, M., HUGHES, F.J., BUTTERY, L.D.K., GROSS, S.S., EVANS, T.J., SEDDON, S., RIVEROS-MORENI, V., MACINTYRE, I. & POLAK, J.M. (1995). Cytokine stimulated expression of inducible nitric oxide synthase by mouse, rat and human osteoblast-like cells and its functional role in osteoblast metabolic activity. Endocrinology, 136, 5445-5453.
14. IALENTI, A., IANARO, A., MONCADA, S. & DIROSA, M. (1992). Modulation of acute inflammation by endogenous nitric oxide. Eur. J. Pharmacol., 211, 177-182.
15. KAJEKAR, R., MOORE, P.K. & BRAIN, S.D. (1995). An essential role of nitric oxide in neurogenic inflammation: evidence for an endothelial-independent mechanism. Circ. Res., 76, 441 447.
16. LOWRY, O.J., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with Folin-phenol reagent. J. Biol. Chem., 193, 265-269.
17. LYONS, C.R. (1995). The role of nitric oxide in inflammation. Adv. Immunol, 60, 323-371.
18. MARCINKIEWICZ, J., GRABOWSKA, A. & CHAIN, B. (1995). Nitric oxide up-regulates the release of inflammatory mediators by mouse macrophages. Eur. J. Immunol., 25, 947-951.
19. MCCARTNEY-FRANCIS, N., ALLEN, J.B., MIZEL, D.E., ALBINA, J.E., XIE, Q.W., NATHAN, C.F. & WAHL, S.M. (1993). Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med., 178, 749-754.
20. MEDEIROS, M.V., BINHARA, I.M., MORENO, H., ZATZ, R., DENUCCI, G. & ANTUNES, E. (1995). Effect of chronic nitric oxide synthesis inhibition on the inflammatory responses induced by carrageenan in rats. Eur. J. Pharmacol., 285, 109-114.
21. MILLER, M.U.S. & GRISHAM, M.B. (1995). Nitric oxide as a mediator of inflammation - you had better believe it. Mediators Inflammation, 4, 387-396.
22. MOORE, P.K., WALLACE, P, GAFFEN, Z.A., HART, S.L. & BABBEDGE, R.C. (1993). 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol., 108, 296-297.
23. MOORE, W.M., WEBBER, R.K., JEROME, G.M., TJOENG, F.S., MISKO, T.P. & CURRIE, M.G. (1994). L-N6-(1-Iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase. J. Med. Schem., 37, 3886-3888.
24. NUSSLER, A.K. & BILLIAR, T.R. (1993). Inflammation, immunoregulation and inducible nitric oxide synthase. J. Leukocyte Biol., 2, 171-178.
25. OGDEN, J.E. & MOORE, P.K. (1995). Inhibition of nitric oxide synthase - potential for a novel class of therapeutic agent? Trends Biotechnol., 13, 70-78.
26. PALMER, R.M.J., ASHTON, D.S. & MONCADA, S. (1988). Vascular endothelial cells synthesise nitric oxide from L-arginine. Nature, 333, 664-666.
27. PARKS, D.J., CHEUNG, M.K., CHAN, C.C. & ROBERGE, F.G. (1994). The role of nitric oxide in uveitis. Arch. Opthalmol., 112, 544-546.
28. RUAN, E., OTTERSON, M.F., TELFORD, G.L., STRYKER, S.J., ALEXANDER, C., RAO, S. & KOCH, T.R. (1995). Increased neuronal nitric oxide synthase activity in IBD apepars to be related to inflammation. Gastroenterology, 108, A1002.
29. SALVEMINI, D., WANG, Z.-Q., WYATT, P.A., BOURDON, D.M., MARINO, M.H., MANNING, P.T. & CURRIE, M.G. (1996). Nitric oxide: a key mediator in the early and late phase of carrageenaninduced rat paw inflammation. Br. J. Pharmacol., 118, 829-838.
30. SAUTEBIN, I., IALENTI, A., IANARO, A. & DIROSA, M. (1995). Modulation by nitric oxide of prostaglandin biosynthesis in the rat. Br. J. Pharmacol., 114, 323-328.
31. STEFANOVICRACIC, M., MEYERS, K., MESCHTER, C., COFFEY, J.W., HUFFMAN, R.A. & EVANS, C.H. (1995). Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis. J. Rheumatol., 22, 1922-1928.
32. SUSCHEK, C., FEHSEL, K., KRONCKE, K.D. & SOMMER, A.V.K.-B. (1994). Primary cultures of rat islet capillary endothelial cells. Constitutive and cytokine-inducible macrophage-like nitric oxide synthases are expressed and activities regulated by glucose concentration. Am. J. Pathol., 145, 685-695.
33. TOMLINSON, A., APPLETON, I., MOORE, A.R., GILROY, D.W., WILLIS, D., MITCHELL, J.A. & WILLOUGHBY, D.A. (1994). Cycloooxygenase and nitric oxide synthase isoforms in rat carrageenan-induced pleurisy. Br. J. Pharmacol., 113, 693-698.
34. TRACEY, W.R., NAKANE, M., KIK, J., BUDZIK, G., KLINGHOFER, V., HARRIS, R. & CARTER, G. (1995). The nitric oxide synthase inhibitor, L-N-G-monomethylarginine, reduces carrageenaninduced pleurisy in the rat. J. Pharmacol. Exp. Ther., 273, 1295-1299.
35. VANE, J.R., MITCHELL, J.A., APPLETON, I., TOMLINSON, A., BISHOP-BAILEY, D, CROXTALL, J. & WILLOUGHBY, D.A. (1994). Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation. Proc. Natl. Acad. Sci. U.S.A., 91, 2046-2050.
36. WEINER, C.P., LIZASOAIN, I., BAYLIS, S.A., KNOWLES, R.G., CHARLES, I.G. & MONCADA, S (1994). Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc. Natl. Acad. Sci. U.S.A., 91, 5213-5216.