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Volumn 30, Issue 4, 2012, Pages

Novel Platelet ADP P2Y12 Inhibitors in the Treatment of Acute Coronary Syndrome

Author keywords

Acute coronary syndrome; ADP P2Y12 Inhibitors; Antiplatelet therapy; Cangrelor; Clop Dorel; Elinogrel; Prasugrel; Ticagrelor

Indexed keywords

CANGRELOR; CLOPIDOGREL; ELINOGREL; PRASUGREL; TICAGRELOR;

EID: 84863481144     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2011.00262.x     Document Type: Review
Times cited : (11)

References (52)
  • 1
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996;348:1329-1339.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 2
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • CURE Trial Investigators
    • Yusuf S, Zhao F, Mehta SR, et al. CURE Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345:494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3
  • 3
    • 33748039103 scopus 로고    scopus 로고
    • Usefulness of clopidogrel in abolishing the increased risk of reinfarction associated with higher platelet counts in patients with ST-elevation myocardial infarction (results from CLARITY-TIMI 28)
    • Gibson CM, Ly HQ, Murphy SA, et al. Usefulness of clopidogrel in abolishing the increased risk of reinfarction associated with higher platelet counts in patients with ST-elevation myocardial infarction (results from CLARITY-TIMI 28). Am J Cardiol 2006;98:761-763.
    • (2006) Am J Cardiol , vol.98 , pp. 761-763
    • Gibson, C.M.1    Ly, H.Q.2    Murphy, S.A.3
  • 4
    • 34547655744 scopus 로고    scopus 로고
    • ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction
    • Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction. J Am Coll Cardiol 2007;50:e1-e157.
    • (2007) J Am Coll Cardiol , vol.50
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 5
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner AR, O'Connell JR, Bliden KP, et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 2009;302:849-857.
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3
  • 6
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    • Trenk D, Hochholzer W, Fromm MF, et al. Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents. J Am Coll Cardiol 2008;51:1925-1934.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1925-1934
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3
  • 7
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 2009;360:354-362.
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 8
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009;360:363-375.
    • (2009) N Engl J Med , vol.360 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 9
  • 10
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega JL, Simon T, Collet JP, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis. JAMA 2010;304:1821-1830.
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 11
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard M, Arnaud B, Cornily JC, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J Am Coll Cardiol 2008;51:256-260.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3
  • 12
    • 57149104093 scopus 로고    scopus 로고
    • Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel
    • Siller-Matula JM, Spiel AO, Lang IM, et al. Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am Heart J 2009;157:148.e1-148.e5.
    • (2009) Am Heart J , vol.157
    • Siller-Matula, J.M.1    Spiel, A.O.2    Lang, I.M.3
  • 13
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomised trials
    • O'Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomised trials. Lancet 2009;374:989-997.
    • (2009) Lancet , vol.374 , pp. 989-997
    • O'Donoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 14
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without omeprazole in coronary artery disease
    • COGENT Investigators
    • Bhatt DL, Cryer BL, Contant CF, et al; COGENT Investigators. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med 2010;363:1909-1917.
    • (2010) N Engl J Med , vol.363 , pp. 1909-1917
    • Bhatt, D.L.1    Cryer, B.L.2    Contant, C.F.3
  • 15
    • 0032814002 scopus 로고    scopus 로고
    • Clopidogrel loading dose regimens: Kinetic profile of pharmacodynamic response in healthy subjects
    • Savcic M, Hauert J, Bachmann F, et al. Clopidogrel loading dose regimens: Kinetic profile of pharmacodynamic response in healthy subjects. Semin Thromb Hemost 1999;25(Suppl 2):15-19.
    • (1999) Semin Thromb Hemost , vol.25 , Issue.SUPPL. 2 , pp. 15-19
    • Savcic, M.1    Hauert, J.2    Bachmann, F.3
  • 16
    • 23044505564 scopus 로고    scopus 로고
    • Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients
    • Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
    • Schulman S, Kearon C. Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 2005;3:692-694.
    • (2005) J Thromb Haemost , vol.3 , pp. 692-694
    • Schulman, S.1    Kearon, C.2
  • 17
    • 33847022346 scopus 로고    scopus 로고
    • Antiplatelet therapy preceding coronary artery surgery: Implications for bleeding, transfusion requirements and outcome
    • Picker SM, Kaleta T, Hekmat K, et al. Antiplatelet therapy preceding coronary artery surgery: Implications for bleeding, transfusion requirements and outcome. Eur J Anaesthesiol 2007;24:332-339.
    • (2007) Eur J Anaesthesiol , vol.24 , pp. 332-339
    • Picker, S.M.1    Kaleta, T.2    Hekmat, K.3
  • 18
    • 18044398749 scopus 로고    scopus 로고
    • Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity
    • Niitsu Y, Jakubowski JA, Sugidachi A, et al. Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity. Semin Thromb Hemost 2005;31:184-194.
    • (2005) Semin Thromb Hemost , vol.31 , pp. 184-194
    • Niitsu, Y.1    Jakubowski, J.A.2    Sugidachi, A.3
  • 19
    • 34249053105 scopus 로고    scopus 로고
    • The disposition of prasugrel, a novel thienopyridine, in humans
    • Farid NA, Smith RL, Gillespie TA, et al. The disposition of prasugrel, a novel thienopyridine, in humans. Drug Metab Dispos 2007;35:1096-1104.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1096-1104
    • Farid, N.A.1    Smith, R.L.2    Gillespie, T.A.3
  • 20
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation
    • Brandt JT, Payne CD, Wiviott SD, et al. A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation. Am Heart J 2007;153:66.e9-66.e16.
    • (2007) Am Heart J , vol.153
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3
  • 21
    • 0034068625 scopus 로고    scopus 로고
    • The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties
    • Sugidachi A, Asai F, Ogawa T, et al. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br J Pharmacol 2000;129:1439-1446.
    • (2000) Br J Pharmacol , vol.129 , pp. 1439-1446
    • Sugidachi, A.1    Asai, F.2    Ogawa, T.3
  • 22
    • 33947284488 scopus 로고    scopus 로고
    • A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans
    • Jakubowski JA, Matsushima N, Asai F, et al. A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans. Br J Clin Pharm 2006;63:421-430.
    • (2006) Br J Clin Pharm , vol.63 , pp. 421-430
    • Jakubowski, J.A.1    Matsushima, N.2    Asai, F.3
  • 23
    • 36348977461 scopus 로고    scopus 로고
    • Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel
    • Payne CD, Li YG, Small DS, et al. Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel. J Cardiovasc Pharmacol 2007;50:555-562.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 555-562
    • Payne, C.D.1    Li, Y.G.2    Small, D.S.3
  • 24
    • 33646732608 scopus 로고    scopus 로고
    • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
    • Jernberg T, Payne CD, Winters KJ, et al. Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J 2006;27:1166-1173.
    • (2006) Eur Heart J , vol.27 , pp. 1166-1173
    • Jernberg, T.1    Payne, C.D.2    Winters, K.J.3
  • 25
    • 21644448736 scopus 로고    scopus 로고
    • Randomized comparison of prasugrel (CS-747,LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilizationì of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial
    • Wiviott SD, Antman EM, Winters KJ, et al. Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilizationì of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial. Circulation 2005;111:3366-3373.
    • (2005) Circulation , vol.111 , pp. 3366-3373
    • Wiviott, S.D.1    Antman, E.M.2    Winters, K.J.3
  • 26
    • 37349111065 scopus 로고    scopus 로고
    • Prasugrel compared with high loading and maintenance dose clopidogrel in patients with planned percutaneous coronary intervention: The Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial
    • PRINCIPLE-TIMI 44 Investigators
    • Wiviott SD, Trenk D, Frelinger AL, et al. PRINCIPLE-TIMI 44 Investigators. Prasugrel compared with high loading and maintenance dose clopidogrel in patients with planned percutaneous coronary intervention: The Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial. Circulation 2007;116:2923-2932.
    • (2007) Circulation , vol.116 , pp. 2923-2932
    • Wiviott, S.D.1    Trenk, D.2    Frelinger, A.L.3
  • 27
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • TRITON-TIMI 38 Investigators
    • Wiviott SD, Braunwald E, McCabe CH, et al. TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357:2001-2015.
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 28
    • 69949163560 scopus 로고    scopus 로고
    • Weighing benefits and risks-The FDA's review of prasugrel
    • Unger EF. Weighing benefits and risks-The FDA's review of prasugrel. N Engl J Med 2009;361:942-945.
    • (2009) N Engl J Med , vol.361 , pp. 942-945
    • Unger, E.F.1
  • 29
    • 5344257562 scopus 로고    scopus 로고
    • ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels
    • Wihlborg AK, Wang L, Braun OO, et al. ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels. Arterioscler Thromb Vasc Biol 2004;24:1810-1815.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1810-1815
    • Wihlborg, A.K.1    Wang, L.2    Braun, O.O.3
  • 30
    • 71849097646 scopus 로고    scopus 로고
    • AZD6140 inhibits adenosine uptake into erythrocytes and enhances coronary blood flow after local ischemia or intracoronary adenosine infusion (abstract 245)
    • Bjorkman JA, Kirk I, van Giezen JJ. AZD6140 inhibits adenosine uptake into erythrocytes and enhances coronary blood flow after local ischemia or intracoronary adenosine infusion (abstract 245). Circulation 2007;116:II_28.
    • (2007) Circulation , vol.116
    • Bjorkman, J.A.1    Kirk, I.2    van Giezen, J.J.3
  • 31
    • 23044461331 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and pharmacodynamics of AZD6140-An oral reversible ADP receptor antagonist (abstract)
    • Peters G, Robbie G. Single-dose pharmacokinetics and pharmacodynamics of AZD6140-An oral reversible ADP receptor antagonist (abstract). Haematologica 2004;989(suppl 7):14.
    • (2004) Haematologica , vol.989 , Issue.SUPPL. 7 , pp. 14
    • Peters, G.1    Robbie, G.2
  • 32
    • 77749345735 scopus 로고    scopus 로고
    • Efficacy and safety of ticagrelor: A reversible P2Y12 receptor antagonist
    • Anderson SD, Shah NK, Yim J, Epstein BJ. Efficacy and safety of ticagrelor: A reversible P2Y12 receptor antagonist. Ann Pharmacother 2010;44:524-537.
    • (2010) Ann Pharmacother , vol.44 , pp. 524-537
    • Anderson, S.D.1    Shah, N.K.2    Yim, J.3    Epstein, B.J.4
  • 33
    • 70349865565 scopus 로고    scopus 로고
    • Multiple dose pharmacokinetics and pharmacodynamics of the reversible, orally active ADP receptor antagonist AZD6140 (abstract P4556)
    • Peters G, Buter K, Winter HE, et al. Multiple dose pharmacokinetics and pharmacodynamics of the reversible, orally active ADP receptor antagonist AZD6140 (abstract P4556). Eur Heart J 2006;27(suppl 1):758.
    • (2006) Eur Heart J , vol.27 , Issue.SUPPL. 1 , pp. 758
    • Peters, G.1    Buter, K.2    Winter, H.E.3
  • 34
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, et al. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin. Eur Heart J 2006;27:1038-1047.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3
  • 35
    • 35548995394 scopus 로고    scopus 로고
    • Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: Primary results of the DISPERSE-2 trial
    • Cannon CP, Husted S, Harrington RA, et al. Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: Primary results of the DISPERSE-2 trial. J Am Coll Cardiol 2007;50:1844-1851.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1844-1851
    • Cannon, C.P.1    Husted, S.2    Harrington, R.A.3
  • 36
    • 35548933800 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes
    • Storey RF, Husted S, Harrington RA, et al. Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes. J Am Coll Cardiol 2007;50:1852-1856.
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1852-1856
    • Storey, R.F.1    Husted, S.2    Harrington, R.A.3
  • 37
    • 33847050871 scopus 로고    scopus 로고
    • Dyspnoea after antiplatelet agents: The AZD6140 controversy
    • Serebruany VL, Stebbing J, Atar D. Dyspnoea after antiplatelet agents: The AZD6140 controversy. Int J Clin Pract 2007;61:529-533.
    • (2007) Int J Clin Pract , vol.61 , pp. 529-533
    • Serebruany, V.L.1    Stebbing, J.2    Atar, D.3
  • 38
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study
    • Gurbel PA, Bliden KP, Butler K, et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study. Circulation 2009;120:2577-2585.
    • (2009) Circulation , vol.120 , pp. 2577-2585
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3
  • 39
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • et PLATO Investigators
    • Wallentin L, Becker RC, Budaj A, et PLATO Investigators. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009;361:1045-1057.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 40
    • 74649085430 scopus 로고    scopus 로고
    • Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): A randomised double-blind study
    • et PLATO Investigators
    • Cannon CP, Harrington RA, James S, et PLATO Investigators. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): A randomised double-blind study. Lancet 2010;375:283-293.
    • (2010) Lancet , vol.375 , pp. 283-293
    • Cannon, C.P.1    Harrington, R.A.2    James, S.3
  • 41
    • 0000540934 scopus 로고    scopus 로고
    • Sustained coronary artery recanalization with adjunctive infusion of a novel P2T-receptor antagonist AR-C69931 in a canine model
    • Wang K, Zhou X, Zhou Z, et al. Sustained coronary artery recanalization with adjunctive infusion of a novel P2T-receptor antagonist AR-C69931 in a canine model. J Am Coll Cardiol 2000;35(suppl):281A-282A.
    • (2000) J Am Coll Cardiol , vol.35 , Issue.SUPPL.
    • Wang, K.1    Zhou, X.2    Zhou, Z.3
  • 42
    • 72749128296 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of a bolus and infusion of cangrelor: A direct, parenteral P2Y12 receptor antagonist
    • Akers WS, Oh JJ, Oestreich JH, Ferraris S, et al. Pharmacokinetics and pharmacodynamics of a bolus and infusion of cangrelor: A direct, parenteral P2Y12 receptor antagonist. J Clin Pharmacol 2010;50:27-35.
    • (2010) J Clin Pharmacol , vol.50 , pp. 27-35
    • Akers, W.S.1    Oh, J.J.2    Oestreich, J.H.3    Ferraris, S.4
  • 43
    • 0033781969 scopus 로고    scopus 로고
    • Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model
    • Huang J, Driscoll EM, Gonzales ML, et al. Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model. J Pharmacol Ex Ther 2000;295:492-499.
    • (2000) J Pharmacol Ex Ther , vol.295 , pp. 492-499
    • Huang, J.1    Driscoll, E.M.2    Gonzales, M.L.3
  • 44
    • 0035085132 scopus 로고    scopus 로고
    • Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndrome
    • Storey RF, Oldroyd KG, Wilcox RG. Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndrome. Thromb Haemost 2001;85:401-407.
    • (2001) Thromb Haemost , vol.85 , pp. 401-407
    • Storey, R.F.1    Oldroyd, K.G.2    Wilcox, R.G.3
  • 45
    • 0036848824 scopus 로고    scopus 로고
    • Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease
    • Storey RF, Wilcox RG, Heptinstall S. Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease. Platelets 2002;13:407-413.
    • (2002) Platelets , vol.13 , pp. 407-413
    • Storey, R.F.1    Wilcox, R.G.2    Heptinstall, S.3
  • 46
    • 33344464928 scopus 로고    scopus 로고
    • Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial
    • Greenbaum AB, Grines CL, Bittl JA, et al. Initial experience with an intravenous P2Y12 platelet receptor antagonist in patients undergoing percutaneous coronary intervention: results from a 2-part, phase II, multicenter, randomized, placebo- and active-controlled trial. Am Heart J 2006;151:689.e1-689.e10.
    • (2006) Am Heart J , vol.151
    • Greenbaum, A.B.1    Grines, C.L.2    Bittl, J.A.3
  • 47
    • 71849087338 scopus 로고    scopus 로고
    • Platelet inhibition with cangrelor in patients undergoing PCI
    • Harrington RA, Stone GW, McNulty S, et al. Platelet inhibition with cangrelor in patients undergoing PCI. N Engl J Med 2009;361:2318-2329.
    • (2009) N Engl J Med , vol.361 , pp. 2318-2329
    • Harrington, R.A.1    Stone, G.W.2    McNulty, S.3
  • 48
    • 71849119604 scopus 로고    scopus 로고
    • Intravenous platelet blockade with cangrelor during PCI
    • CHAMPION PLATFORM Investigators
    • Bhatt DL, Lincoff AM, Gibson CM, et al. CHAMPION PLATFORM Investigators. Intravenous platelet blockade with cangrelor during PCI. N Engl J Med 2009;361:2330-2341.
    • (2009) N Engl J Med , vol.361 , pp. 2330-2341
    • Bhatt, D.L.1    Lincoff, A.M.2    Gibson, C.M.3
  • 49
    • 47649131209 scopus 로고    scopus 로고
    • Initial intravenous experience with PRT060128 (PRT128), an orally-available, direct-acting, and reversible P2y12 inhibitor
    • Lieu HDCP, Andre P, Leese PT, et al. Initial intravenous experience with PRT060128 (PRT128), an orally-available, direct-acting, and reversible P2y12 inhibitor. J Thromb Haemost 2007;5(suppl 1):P-T-292.
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 1
    • Lieu, H.D.C.P.1    Andre, P.2    Leese, P.T.3
  • 50
    • 77954510334 scopus 로고    scopus 로고
    • Elinogrel: Pharmacological principles, preclinical and early phase clinical testing
    • Ueno M, Rao SV, Angiolillo DJ. Elinogrel: Pharmacological principles, preclinical and early phase clinical testing. Future Cardiol 2010;6:445-453.
    • (2010) Future Cardiol , vol.6 , pp. 445-453
    • Ueno, M.1    Rao, S.V.2    Angiolillo, D.J.3
  • 51
    • 73149118496 scopus 로고    scopus 로고
    • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: First experience in patients
    • Gurbel PA, Bliden KP, Antonino MJ, et al. The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: First experience in patients. J Thromb Haemost 2010;8:43-53.
    • (2010) J Thromb Haemost , vol.8 , pp. 43-53
    • Gurbel, P.A.1    Bliden, K.P.2    Antonino, M.J.3
  • 52
    • 70649090353 scopus 로고    scopus 로고
    • Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: The Early Rapid ReversAl of platelet thromboSis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial Infarction (ERASE MI) pilot trial
    • Berger JS, Roe MT, Gibson CM, et als. Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: The Early Rapid ReversAl of platelet thromboSis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial Infarction (ERASE MI) pilot trial. Am Heart J 2009;158:998-1004.e1.
    • (2009) Am Heart J , vol.158
    • Berger, J.S.1    Roe, M.T.2    Gibson, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.