No evidence for heritability of Parkinson disease in Swedish twins

Neurology

Volumn 63, Issue 2, 2004, Pages 305-311

  Wirdefeldt, Karin ^a   Gatz, Margaret ^a,b   Schalling, Martin ^a   Pedersen, Nancy L ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; DEGENERATIVE DISEASE; DIZYGOTIC TWINS; FEMALE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; NEUROLOGIC DISEASE; PARKINSON DISEASE; PREVALENCE; PRIORITY JOURNAL; SWEDEN;

EID: 3242807321     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000129841.30587.9D     Document Type: Article

References (47)

1. Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alphasynuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
2. Kitada T, Asakawa S, Hattori N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998;392:605-608.
3. Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinson's disease. Nature 1998;395:451-452.
4. Bonifati V, Rizzu P, van Baren MJ, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003;299:256-259.
5. Le WD, Xu P, Jankovic J, et al. Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet 2003;33:85-89.
6. Gasser T, Muller-Myhsok B, Wszolek ZK, et al. A susceptibility locus for Parkinson's disease maps to chromosome 2pl3. Nat Genet 1998;18:262-265.
7. Farrer M, Gwinn-Hardy K, Muenter M, et al. A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. Hum Mol Genet 1999;8:81-85.
8. Valente EM, Bentivoglio AR, Dixon PH, et al. Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome lp35-p36. Am J Hum Genet 2001;68:895-900.
9. Funayama M, Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F. A new locus for Parkinson's disease (PARK8) maps to chromosome 12pll.2-ql3.1. Ann Neurol 2002;51:296-301.
10. Hicks AA, Petursson H, Jonsson T, et al. A susceptibility gene for late-onset idiopathic Parkinson's disease. Ann Neurol 2002;52:549-555.
11. Pankratz N, Nichols WC, Uniacke SK, et al. Significant linkage of Parkinson disease to chromosome 2q36-37. Am J Hum Genet 2003;72:1053-1057.
12. Ward CD, Duvoisin RC, Ince SE, Nutt JD, Eldridge R, Calne DB. Parkinson's disease in 65 pairs of twins and in a set of quadruplets. Neurology 1983;33:815-824.
13. Marsden CD. Parkinson's disease in twins. J Neurol Neurosurg Psychiatry 1987;50:105-106.
14. Marttila RJ, Kaprio J, Koskenvuo M, Rinne UK. Parkinson's disease in a nationwide twin cohort. Neurology 1988;38:1217-1219.
15. Vieregge P, Schiffke KA, Friedrich HJ, Muller B, Ludin HP. Parkinson's disease in twins. Neurology 1992;42:1453-1461.
16. Vieregge P, Hagenah J, Heberlein I, Klein C, Ludin HP. Parkinson's disease in twins: a follow-up study. Neurology 1999;53:566-572.
17. Tanner CM, Ottman R, Goldman SM, et al. Parkinson disease in twins: an etiologic study. JAMA 1999;281:341-346.
18. Lichtenstein P, De Faire U, Floderus B, Svartengren M, Svedberg P, Pedersen NL. The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. J Intern Med 2002;252:184-205.
19. Gatz M, Pedersen NL, Berg S, et al. Study of dementia in the Swedish Twin Registry. Neurobiol Aging 2002;23(suppl 1):S309. Abstract.
20. National Board of Health and Welfare, Stockholm, Sweden (www.sos.se/epc)
21. World Health Organization. Manual of the International Classification of Diseases, injuries and causes of death. 7th rev. Geneva: World Health Organization, 1955.
22. Langston JW, Widner H, Goetz CG, et al. Core Assessment Program for Intracerebral Transplantations (CAPIT). Mov Disord 1992;7:2-13.
23. Rocca WA, Maraganore DM, McDonnell SK, Schaid DJ. Validation of a telephone questionnaire for Parkinson's disease. J Clin Epidemiol 1998;51:517-523.
24. Efron B, Tibshirani R. Introduction to the bootstrap. New York: Chapman and Hall, 1993.
25. McGue M. When assessing twin concordance, use the probandwise not the pairwise rate. Schizophr Bull 1992;18:171-176.
26. SAS Institute. The SAS system for Windows. Release 8.02. Cary, NC: SAS Institute.
27. Neale MC. MX: statistical modeling. Richmond: Department of Psychiatry, Virginia Commonwealth University, 1994.
28. Pedersen NL, Gatz M, Berg S, Johansson B. How heritable is Alzheimer's disease late in life? Findings from Swedish twins. Ann Neurol 2004;55:180-185.
29. Gatz M, Pedersen NL, Berg S, et al. Heritability for Alzheimer's disease: the study of dementia in Swedish twins. J Gerontol A Biol Sci Med Sci 1997;52:MI17-MI25.
30. MacGregor AJ, Snieder H, Schork NJ, Spector TD. Twins. Novel uses to study complex traits and genetic diseases. Trends Genet 2000;16:131-134.
31. Risch N. The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol Biomarkers Prev 2001;10:733-741.
32. Dekker MC, Bonifati V, van Duijn CM. Parkinson's disease: piecing together a genetic jigsaw. Brain 2003;126:1722-1733.
33. DeStefano AL, Golbe LI, Mark MH, et al. Genome-wide scan for Parkinson's disease: the GenePD Study. Neurology 2001;57:1124-1126.
34. Scott WK, Nance MA, Watts RL, et al. Complete genomic screen in Parkinson disease: evidence for multiple genes. JAMA 2001;286:2239-2244.
35. Pankratz N, Nichols WC, Uniacke SK, et al. Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations. Am J Hum Genet 2002;71:124-135.
36. Checkoway H, Franklin GM, Costa-Mallen P, et al. A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease. Neurology 1998;50:1458-1461.
37. Kendler KS, Karkowski-Shuman L. Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychol Med 1997;27:539-547.
38. Legrand LN, McGue M, Iacono WG. Searching for interactive effects in the etiology of early-onset substance use. Behav Genet 1999;29:433-444.
39. Martin N. Gene-environment interaction and twin studies. In: Spector TD, Snieder H, MacGregor AJ, eds. Advances in twin and sib-pair analysis. London: Greenwich Medical Media, 2000:143-150.
40. Morrish PK, Rakshi JS, Bailey DL, Sawle GV, Brooks DJ. Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET. J Neurol Neurosurg Psychiatry 1998;64:314-319.
41. Burn DJ, Mark MH, Playford ED, et al. Parkinson's disease in twins studied with 18F-dopa and positron emission tomography. Neurology 1992;42:1894-1900.
42. Piccini P, Burn DJ, Ceravolo R, Maraganore D, Brooks DJ. The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann Neurol 1999;45:577-582.
43. Pramstaller PP, Falk M, Schoenhuber R, Poewe W. Validation of a mail questionnaire for parkinsonism in two languages (German and Italian). J Neurol 1999;246:79-86.
44. Melcon MO, Anderson DW, Vergara RH, Rocca WA. Prevalence of Parkinson's disease in Junin, Buenos Aires Province, Argentina. Mov Disord 1997;12:197-205.
45. de Rijk MC, Tzourio C, Breteler MM, et al. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's Disease. J Neurol Neurosurg Psychiatry 1997;62:10-15.
46. Raiha I, Kaprio J, Koskenvuo M, Rajala T, Sourander L. Alzheimer's disease in Finnish twins. Lancet 1996;347:573-578.
47. Gatz M, Pedersen NL. Use of twin samples to estimate the heritability of Alzheimer's disease: a methodological note. Alzheimers Res 1996;2:229-232.