-
1
-
-
0001584969
-
The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species
-
DOI 10.1002/bies.1062
-
Smith C, Islam T, Mattsson P, Mohamed A, Nore B, Vihinen M. The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays. 2001;23:436-446. (Pubitemid 32453973)
-
(2001)
BioEssays
, vol.23
, Issue.5
, pp. 436-446
-
-
Smith, C.I.E.1
Islam, T.C.2
Mattsson, P.T.3
Mohamed, A.J.4
Nore, B.F.5
Vihinen, M.6
-
3
-
-
61849142482
-
The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development
-
Prince AL, Yin CC, Enos ME, Felices M, Berg LJ.The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development. Immunol Rev. 2009;228:115-131.
-
(2009)
Immunol Rev.
, vol.228
, pp. 115-131
-
-
Prince, A.L.1
Yin, C.C.2
Enos, M.E.3
Felices, M.4
Berg, L.J.5
-
4
-
-
61849110214
-
Tec kinases regulate Tlymphocyte development and function: New insights into the roles of Itk and Rlk/Txk
-
Readinger JA, Mueller KL, Venegas AM, Horai R, Schwartzberg PL. 2009. Tec kinases regulate Tlymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev. 228:93-114.
-
(2009)
Immunol Rev.
, vol.228
, pp. 93-114
-
-
Readinger, J.A.1
Mueller, K.L.2
Venegas, A.M.3
Horai, R.4
Schwartzberg, P.L.5
-
5
-
-
49149113472
-
The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival
-
Felices M, Berg LJ. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol. 2008;180:3007-3018.
-
(2008)
J Immunol.
, vol.180
, pp. 3007-3018
-
-
Felices, M.1
Berg, L.J.2
-
6
-
-
0027441332
-
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
-
DOI 10.1038/361226a0
-
Vetrie D, Vorechovský I, Sideras P, et al.The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature. 1993;361:226-233. (Pubitemid 23034471)
-
(1993)
Nature
, vol.361
, Issue.6409
, pp. 226-233
-
-
Vetrie, D.1
Vorechovsky, I.2
Sideras, P.3
Holland, J.4
Davies, A.5
Flinter, F.6
Hammarstrom, L.7
Kinnon, C.8
Levinsky, R.9
Bobrow, M.10
Smith, C.I.E.11
Bentley, D.R.12
-
7
-
-
84860429556
-
Erratum
-
1993 Jul
-
Erratum in: Nature. 1993 Jul 1922;1364(6435):1362.
-
(1922)
Nature
, vol.1364
, Issue.6435
, pp. 1362
-
-
-
8
-
-
0001584969
-
The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species
-
DOI 10.1002/bies.1062
-
Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, Vihinen M. The Tec family of cytoplasmic tyrosine kinases:mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays. 2001;23:436-446. (Pubitemid 32453973)
-
(2001)
BioEssays
, vol.23
, Issue.5
, pp. 436-446
-
-
Smith, C.I.E.1
Islam, T.C.2
Mattsson, P.T.3
Mohamed, A.J.4
Nore, B.F.5
Vihinen, M.6
-
9
-
-
0030826662
-
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase
-
DOI 10.1073/pnas.94.21.11227
-
August A, Sadra A, Dupont B, Hanafusa H. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. Proc Natl Acad Sci U S A. 1997;94:11227-11232. (Pubitemid 27450980)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.21
, pp. 11227-11232
-
-
August, A.1
Sadra, A.2
Dupont, B.O.3
Hanafusa, H.4
-
10
-
-
0033486066
-
Emt/Itk associates with activated TCR complexes: Role of the pleckstrin homology domain
-
Ching K, Kawakami Y, Kawakami T, Tsoukas C. Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain. J Immunol. 1999;163:6006-6013.
-
(1999)
J Immunol.
, vol.163
, pp. 6006-6013
-
-
Ching, K.1
Kawakami, Y.2
Kawakami, T.3
Tsoukas, C.4
-
11
-
-
0035868761
-
A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor
-
DOI 10.1093/emboj/20.6.1232
-
Woods M, Kivens W, Adelsman M, Qiu Y, August A, Shimizu Y. A novel function for the Tec family tyrosine kinase Itk in activation of beta1 integrins by the T-cell receptor. EMBOJ. 2001;20:1232-1244. (Pubitemid 32233964)
-
(2001)
EMBO Journal
, vol.20
, Issue.6
, pp. 1232-1244
-
-
Woods, M.L.1
Kivens, W.J.2
Adelsman, M.A.3
Qiu, Y.4
August, A.5
Shimizu, Y.6
-
12
-
-
0029165836
-
Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells
-
Kawakami Y, Yao L, Tashiro M, Gibson S,Mills G, Kawakami T. Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells. J Immunol. 1995;155:3556-3562.
-
(1995)
J Immunol.
, vol.155
, pp. 3556-3562
-
-
Kawakami, Y.1
Yao, L.2
Tashiro, M.3
Gibson Smills, G.4
Kawakami, T.5
-
13
-
-
0034695633
-
Biochemical interactions integrating Itk with the T cell receptor- initiated signaling cascade
-
DOI 10.1074/jbc.275.3.2219
-
Bunnell S, Diehn M, Yaffe M, Findell P, Cantley L, Berg L. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000;275:2219-2230. (Pubitemid 30060853)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.3
, pp. 2219-2230
-
-
Bunnell, S.C.1
Diehn, M.2
Yaffe, M.B.3
Findell, P.R.4
Cantley, L.C.5
Berg, L.J.6
-
14
-
-
0032701019
-
Interaction of SLP adaptors with the SH2 domain of Tec family kinases
-
DOI 10.1002/(SICI)1521-4141(199911)29:11<3702::AID-IMMU3702>3.0. CO;2-R
-
Su YW, Zhang Y, Schweikert J, Koretzky GA, Reth M, Wienands J. Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur J Immunol. 1999;29:3702-3711. (Pubitemid 29527819)
-
(1999)
European Journal of Immunology
, vol.29
, Issue.11
, pp. 3702-3711
-
-
Su, Y.-W.1
Zhang, Y.2
Schwelkert, J.3
Koretzky, G.A.4
Reth, M.5
Wienands, J.6
-
15
-
-
77949312475
-
Development of promyelocytic zinc finger and ThPOKexpressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3
-
Alonzo E, Gottschalk R, Das J, et al. Development of promyelocytic zinc finger and ThPOKexpressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol. 2010;184:1268-1279. .
-
(2010)
J Immunol.
, vol.184
, pp. 1268-1268
-
-
Alonzo, E.1
Gottschalk, R.2
Das, J.3
-
16
-
-
0031034930
-
Crystal structure of the Src family tyrosine kinase Hck
-
DOI 10.1038/385602a0
-
Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature. 1997;385:602-609. PMID: 9024658. (Pubitemid 27087567)
-
(1997)
Nature
, vol.385
, Issue.6617
, pp. 602-609
-
-
Sicheri, F.1
Moarefi, I.2
Kuriyan, J.3
-
17
-
-
0033001789
-
Crystal structures of c-Src reveal features of its autoinhibitory mechanism
-
DOI 10.1016/S1097-2765(00)80356-1
-
Xu W, Doshi A, Lei M, Eck M, Harrison S. Crystal structures of c-Src reveal features of its autoinhibitory mechanism.Mol Cell. 1999;3:629-638. (Pubitemid 29268446)
-
(1999)
Molecular Cell
, vol.3
, Issue.5
, pp. 629-638
-
-
Xu, W.1
Doshi, A.2
Lei, M.3
Eck, M.J.4
Harrison, S.C.5
-
18
-
-
0344626926
-
Structural basis for the autoinhibition of c-Abl tyrosine kinase
-
DOI 10.1016/S0092-8674(03)00194-6
-
Nagar B,Hantschel O, YoungM, et al. Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell. 2003;112:859-871. (Pubitemid 36378887)
-
(2003)
Cell
, vol.112
, Issue.6
, pp. 859-871
-
-
Nagar, B.1
Hantschel, O.2
Young, M.A.3
Scheffzek, K.4
Veach, D.5
Bornmann, W.6
Clarkson, B.7
Superti-Furga, G.8
Kuriyan, J.9
-
19
-
-
0034072765
-
Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src
-
DOI 10.1038/74041
-
Gonfloni S, Weijland A, Kretzschmar J, and Superti-Furga G. Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src. Nat Struct Biol. 2000; 281-286. (Pubitemid 30194450)
-
(2000)
Nature Structural Biology
, vol.7
, Issue.4
, pp. 281-286
-
-
Gonfloni, S.1
Weijland, A.2
Kretzschmar, J.3
Superti-Furga, G.4
-
20
-
-
0031029781
-
Regulatory intramolecular association in a tyrosine kinase of the tec family
-
DOI 10.1038/385093a0
-
Andreotti A, Bunnell S, Feng S, Berg L, Schreiber S. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature. 1997;385:93-97. (Pubitemid 27024562)
-
(1997)
Nature
, vol.385
, Issue.6611
, pp. 93-97
-
-
Andreotti, A.H.1
Bunnell, S.C.2
Feng, S.3
Berg, L.J.4
Schreiber, S.L.5
-
21
-
-
70350351223
-
The Tec family kinase Itk exists as a folded monomer in vivo
-
Epub 22009 Aug 29828
-
Qi Q, August A. The Tec family kinase Itk exists as a folded monomer in vivo. J Biol Chem. 2009;284:29882-29892. Epub 22009 Aug 29828.
-
(2009)
J Biol Chem.
, vol.284
, pp. 29882-29892
-
-
Qi, Q.1
August, A.2
-
22
-
-
0034703379
-
A specific intermolecular association between the regulatory domains of a Tec family kinase
-
Brazin K, Fulton D, Andreotti A. A specific intermolecular association between the regulatory domains of a Tec family kinase. JMol Biol. 2000;302:607-623.
-
(2000)
JMol Biol.
, vol.302
, pp. 607-623
-
-
Brazin, K.1
Fulton, D.2
Andreotti, A.3
-
23
-
-
77958191732
-
T-cell signaling regulated by the Tec family kinase, Itk
-
Epub 002010 Jun 002282
-
Andreotti A, Schwartzberg P, Joseph R, Berg L. T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol. 2010;2:a002287. Epub 002010 Jun 002282.
-
(2010)
Cold Spring Harb Perspect Biol.
, vol.2
-
-
Andreotti, A.1
Schwartzberg, P.2
Joseph, R.3
Berg, L.4
-
24
-
-
0035986609
-
The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
-
DOI 10.1016/S1357-2725(02)00068-7, PII S1357272502000687
-
August A, FischerA,Hao S,MuellerC,RaginM.TheTec family of tyrosine kinases inTcells, amplifiers of T cell receptor signals. Int J Biochem Cell Biol. 2002;34:1184-1189. (Pubitemid 34804354)
-
(2002)
International Journal of Biochemistry and Cell Biology
, vol.34
, Issue.10
, pp. 1184-1189
-
-
August, A.1
Fischer, A.2
Hao, S.3
Mueller, C.4
Ragin, M.5
-
25
-
-
84859868110
-
Itk: The rheostat of the T cell response
-
Epub 292011 Apr 297867
-
Grasis J, Tsoukas C. Itk: the rheostat of the T cell response. J Signal Transduct. 2011;297868. Epub 292011 Apr 297867.
-
(2011)
J Signal Transduct.
, pp. 297868
-
-
Grasis, J.1
Tsoukas, C.2
-
26
-
-
0032878516
-
Itk/Emt/Tsk Activation in Response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment
-
Shan X, Wange RL. Itk/Emt/Tsk Activation in Response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment. J Biol Chem. 1999;274: 29323-29330.
-
(1999)
J Biol Chem.
, vol.274
, pp. 29323-29330
-
-
Shan, X.1
Wange, R.L.2
-
27
-
-
34249854024
-
SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK
-
DOI 10.1073/pnas.0609771104
-
Bogin Y, Ainey C, Beach D, Yablonski D. SLP-76 mediates andmaintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Proc Natl Acad Sci U S A. 2007;104:6638-6643. Epub 2007 Apr 6639. (Pubitemid 47175553)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.16
, pp. 6638-6643
-
-
Bogin, Y.1
Ainey, C.2
Beach, D.3
Yablonski, D.4
-
28
-
-
33846030497
-
Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors
-
DOI 10.1074/jbc.M609180200
-
Qi Q, Sahu N, August A. Tec kinase Itk formsmembrane clusters specifically in the vicinity of recruiting receptors. J Biol Chem. 2006;281:38529-38534. (Pubitemid 46041977)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.50
, pp. 38529-38534
-
-
Qi, Q.1
Sahu, N.2
August, A.3
-
29
-
-
34248566789
-
4
-
DOI 10.1126/science.1138684
-
Huang Y, Grasis J, Miller A, et al. Positive regulation of Itk PH domain function by soluble IP4. Science. 2007;316:886-889. Epub 2007 Apr 2005. (Pubitemid 46764278)
-
(2007)
Science
, vol.316
, Issue.5826
, pp. 886-889
-
-
Huang, Y.H.1
Grasis, J.A.2
Miller, A.T.3
Xu, R.4
Soonthornvacharin, S.5
Andreotti, A.H.6
Tsoukas, C.D.7
Cooke, M.P.8
Sauer, K.9
-
30
-
-
33846030497
-
Tec kinase Itk formsmembrane clusters specifically in the vicinity of recruiting receptors
-
Qi Q, Sahu N, August A. Tec kinase Itk formsmembrane clusters specifically in the vicinity of recruiting receptors. J Biol Chem. 2006;281:38529-38534. .
-
(2006)
J Biol Chem.
, vol.281
, pp. 38529-38529
-
-
Qi, Q.1
Sahu, N.2
August, A.3
-
31
-
-
0030826662
-
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase
-
DOI 10.1073/pnas.94.21.11227
-
August A, Sadra A, Dupont B, Hanafusa H. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase. Proc Natl Acad Sci U S A. 1997;94:11227-11232. (Pubitemid 27450980)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.21
, pp. 11227-11232
-
-
August, A.1
Sadra, A.2
Dupont, B.O.3
Hanafusa, H.4
-
32
-
-
0033213484
-
+ T cells
-
DOI 10.1016/S1074-7613(00)80115-6
-
Fowell D, Shinkai K, Liao X, et al. Impaired NFATc Translocation and Failure ofTh2Development in Itk Deficient CD4 T Cells. Immunity. 1999;11:399-409. (Pubitemid 29504195)
-
(1999)
Immunity
, vol.11
, Issue.4
, pp. 399-409
-
-
Fowell, D.J.1
Shinkai, K.2
Liao, X.C.3
Beebe, A.M.4
Coffman, R.L.5
Littman, D.R.6
Locksley, R.M.7
-
33
-
-
0033597440
-
Requirement for Tec kinases Rlk and ltk in T cell receptor signaling and immunity
-
DOI 10.1126/science.284.5414.638
-
Schaeffer E,Debnath J, Yap G, et al. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 1999;284:638-641. (Pubitemid 29289587)
-
(1999)
Science
, vol.284
, Issue.5414
, pp. 638-641
-
-
Schaeffer, E.M.1
Debnath, J.2
Yap, G.3
McVicar, D.4
Liao, X.C.5
Littman, D.R.6
Sher, A.7
Varmus, H.E.8
Lenardo, M.J.9
Schwartzberg, P.L.10
-
34
-
-
0032543221
-
T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
-
DOI 10.1084/jem.187.10.1721
-
Liu K, Bunnell S, Gurniak C, Berg L. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J ExpMed. 1998;187:1721-1727. (Pubitemid 28235113)
-
(1998)
Journal of Experimental Medicine
, vol.187
, Issue.10
, pp. 1721-1727
-
-
Liu, K.-Q.1
Bunnell, S.C.2
Gurniak, C.B.3
Berg, L.J.4
-
35
-
-
0030888186
-
2+ response amplitude and duration
-
Dolmetsch R, Lewis R, Goodnow C, Healy J. Differential activation of transcription factors induced by Ca2 +response amplitude and duration. Nature. 1997;386:855-858. (Pubitemid 27181262)
-
(1997)
Nature
, vol.386
, Issue.6627
, pp. 855-858
-
-
Dolmetsch, R.E.1
Lewis, R.S.2
Goodnow, C.C.3
Healy, J.I.4
-
36
-
-
0032580202
-
Calcium oscillations increase the efficiency and specificity of gene expression
-
DOI 10.1038/31960
-
Dolmetsch R, Xu K, Lewis R. Calcium oscillations increase the efficiency and specificity of gene expression. Nature. 1998;392:933-936. (Pubitemid 28232066)
-
(1998)
Nature
, vol.392
, Issue.6679
, pp. 933-936
-
-
Dolmetsch, R.E.1
Xu, K.2
Lewis, R.S.3
-
37
-
-
0035194916
-
Mutation of Tec family kinases alters T helper cell differentiation
-
DOI 10.1038/ni734
-
Schaeffer E, Yap G, Lewis C, et al.Mutation of Tec family kinases alters T helper cell differentiation. Nat Immunol. 2001;2:1183-1188. (Pubitemid 33130154)
-
(2001)
Nature Immunology
, vol.2
, Issue.12
, pp. 1183-1188
-
-
Schaeffer, E.M.1
Yap, G.S.2
Lewis, C.M.3
Czar, M.J.4
McVicar, D.W.5
Cheever, A.W.6
Sher, A.7
Schwartzberg, P.L.8
-
38
-
-
0036499182
-
Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase
-
Miller AT, Berg LJ. Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J Immunol. 2002;168:2163-2172. (Pubitemid 34171815)
-
(2002)
Journal of Immunology
, vol.168
, Issue.5
, pp. 2163-2172
-
-
Miller, A.T.1
Berg, L.J.2
-
39
-
-
75849121661
-
Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1
-
Min L, Joseph RE, Fulton DB, Andreotti AH. Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1. Proc Natl Acad Sci U S A. 2009;106:21143-21148.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, pp. 21143-21148
-
-
Min, L.1
Joseph, R.E.2
Fulton, D.B.3
Andreotti, A.H.4
-
40
-
-
19944431032
-
Kinase-independent functions for Itk in TCRinduced regulation of Vav and the actin cytoskeleton
-
Dombroski D, Houghtling RA, Labno CM, et al. Kinase-independent functions for Itk in TCRinduced regulation of Vav and the actin cytoskeleton. J Immunol. 2005;174:1385-1392.
-
(2005)
J Immunol.
, vol.174
, pp. 1385-1392
-
-
Dombroski, D.1
Houghtling, R.A.2
Labno, C.M.3
-
41
-
-
0037029653
-
Vav1 transduces T cell receptor signals to the activation of phospholipase C-γ1 via phosphoinositide 3-kinase-dependent and -independent pathways
-
DOI 10.1084/jem.20011663
-
Reynolds L,Smyth L,Norton T, et al. Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J Exp Med. 2002;195:1103-1114. (Pubitemid 34517137)
-
(2002)
Journal of Experimental Medicine
, vol.195
, Issue.9
, pp. 1103-1114
-
-
Reynolds, L.F.1
Smyth, L.A.2
Norton, T.3
Freshney, N.4
Downward, J.5
Kioussis, D.6
Tybulewicz, V.L.J.7
-
42
-
-
78650964326
-
Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell
-
Epub 2010 Oct 2029
-
Qi Q, Xia M, Bai Y, Yu S, Cantorna M, August A. Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell. J Biol Chem. 2011;286:138-146. Epub 2010 Oct 2029.
-
(2011)
J Biol Chem.
, vol.286
, pp. 138-146
-
-
Qi, Q.1
Xia, M.2
Bai, Y.3
Yu, S.4
Cantorna, M.5
August, A.6
-
43
-
-
0037446773
-
Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor
-
Grasis J, Browne C, Tsoukas C. Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor. J Immunol. 2003;170:3971-3976. (Pubitemid 36428157)
-
(2003)
Journal of Immunology
, vol.170
, Issue.8
, pp. 3971-3976
-
-
Grasis, J.A.1
Browne, C.D.2
Tsoukas, C.D.3
-
44
-
-
19944431032
-
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton
-
Dombroski D, Houghtling R, Labno C, et al. Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol. 2005;174:1385-1392. .
-
(2005)
J Immunol.
, vol.174
, pp. 1385-1385
-
-
Dombroski, D.1
Houghtling, R.2
Labno, C.3
-
45
-
-
33646197502
-
A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation
-
Epub 2006 Apr 2619.PMID: 16631752
-
Hao S, Qi Q, Hu J, August A. A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation. FEBS Lett. 2006;580:2691-2697. Epub 2006 Apr 2619.PMID: 16631752.
-
(2006)
FEBS Lett.
, vol.580
, pp. 2691-2697
-
-
Hao, S.1
Qi, Q.2
Hu, J.3
August, A.4
-
46
-
-
33646197502
-
A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation
-
Hao S, Qi Q, Hu J, August A. A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation. FEBS Lett. 2006;580:2691-2697.
-
(2006)
FEBS Lett.
, vol.580
, pp. 2691-2697
-
-
Hao, S.1
Qi, Q.2
Hu, J.3
August, A.4
-
47
-
-
0034596946
-
Tec family kinasesmodulate thresholds for thymocytedevelopment andselection
-
Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, Schwartzberg PL. Tec family kinasesmodulate thresholds for thymocytedevelopment andselection. JExpMed. 2000;192:987-1000.
-
(2000)
JExpMed.
, vol.192
, pp. 987-1000
-
-
Schaeffer, E.M.1
Broussard, C.2
Debnath, J.3
Anderson, S.4
McVicar, D.W.5
Schwartzberg, P.L.6
-
48
-
-
13344270890
-
Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk
-
DOI 10.1016/1074-7613(95)90065-9
-
Liao X, LittmanD. Altered T cell receptor signaling and disrupted T cell development inmice lacking Itk. Immunity. 1995;3:757-769. (Pubitemid 26091149)
-
(1995)
Immunity
, vol.3
, Issue.6
, pp. 757-769
-
-
Chartern Liao, X.1
Littman, D.R.2
-
49
-
-
34249693078
-
+ T-cell development
-
DOI 10.1038/nri2091, PII NRI2091
-
Berg, LJ. Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat Rev Immunol. 2007;7:479-485. (Pubitemid 46834846)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.6
, pp. 479-485
-
-
Berg, L.J.1
-
50
-
-
33745986018
-
+ T cell lineages in mice deficient for the tec kinases itk and rlk
-
DOI 10.1016/j.immuni.2006.05.011, PII S1074761306003062
-
Broussard C, Fleischacker C, Horai R, et al. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 2006;25:93-104. (Pubitemid 44066833)
-
(2006)
Immunity
, vol.25
, Issue.1
, pp. 93-104
-
-
Broussard, C.1
Fleischecker, C.2
Horai, R.3
Chetana, M.4
Venegas, A.M.5
Sharp, L.L.6
Hedrick, S.M.7
Fowlkes, B.J.8
Schwartzberg, P.L.9
-
52
-
-
35348835445
-
+ T cells with innate function selectively develop in the absence of active Itk
-
DOI 10.1002/eji.200737311
-
Hu J, Sahu N, Walsh E, August A. Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk. Eur J Immunol. 2007;37:2892-2899. (Pubitemid 47578308)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.10
, pp. 2892-2899
-
-
Hu, J.1
Sahu, N.2
Walsh, E.3
August, A.4
-
53
-
-
36048946331
-
Requirements for Selection of Conventional and Innate T Lymphocyte Lineages
-
DOI 10.1016/j.immuni.2007.09.012, PII S1074761307005006
-
Horai R, Mueller KL, Handon RA, et al. Requirements for selection of conventional and innate T lymphocyte lineages. Immunity. 2007;27:775-785. (Pubitemid 350102265)
-
(2007)
Immunity
, vol.27
, Issue.5
, pp. 775-785
-
-
Horai, R.1
Mueller, K.L.2
Handon, R.A.3
Cannons, J.L.4
Anderson, S.M.5
Kirby, M.R.6
Schwartzberg, P.L.7
-
54
-
-
45549105834
-
Naive and innate memory phenotype CD4 +T cells have different requirements for active Itk for their development
-
Hu J, August A. Naive and innate memory phenotype CD4 +T cells have different requirements for active Itk for their development. J Immunol. 2008;180:6544-6552.
-
(2008)
J Immunol.
, vol.180
, pp. 6544-6552
-
-
Hu, J.1
August, A.2
-
55
-
-
66449085077
-
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation
-
Huck K, Feyen O, Niehues T, et al. Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest. 2009;119:1350-1358.
-
(2009)
J Clin Invest.
, vol.119
, pp. 1350-1358
-
-
Huck, K.1
Feyen, O.2
Niehues, T.3
-
56
-
-
68249134207
-
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors
-
Weinreich M, Takada K, Skon C, Reiner S, Jameson S, Hogquist K. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009;31:122-130.
-
(2009)
Immunity.
, vol.31
, pp. 122-130
-
-
Weinreich, M.1
Takada, K.2
Skon, C.3
Reiner, S.4
Jameson, S.5
Hogquist, K.6
-
57
-
-
77954954319
-
T cells expressing the transcription factor PLZF regulate the development ofmemory-like CD8+ T cells
-
Epub 2010 Jul 2014
-
Weinreich M, Odumade O, Jameson S, Hogquist K. T cells expressing the transcription factor PLZF regulate the development ofmemory-like CD8+ T cells. Nat Immunol. 2010;11:709-716. Epub 2010 Jul 2014.
-
(2010)
Nat Immunol.
, vol.11
, pp. 709-716
-
-
Weinreich, M.1
Odumade, O.2
Jameson, S.3
Hogquist, K.4
-
58
-
-
79956133739
-
KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells
-
Epub 2011 Apr 1011
-
Lai D, Zhu J, Wang T, et al. KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells. J ExpMed. 2011;1093-1103. Epub 2011 Apr 1011.
-
(2011)
J ExpMed.
, pp. 1093-1103
-
-
Lai, D.1
Zhu, J.2
Wang, T.3
-
59
-
-
70149110081
-
Enhanced development of CD4 +gammadelta T cells in the absence of Itk results in elevated IgE production
-
Qi Q, Xia M, Hu J, et al. Enhanced development of CD4 +gammadelta T cells in the absence of Itk results in elevated IgE production. Blood. 2009;114:564-571.
-
(2009)
Blood.
, vol.114
, pp. 564-571
-
-
Qi, Q.1
Xia, M.2
Hu, J.3
-
60
-
-
66249138887
-
Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo
-
Felices M, Yin CC, Kosaka Y, Kang J, Berg LJ. Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proc Natl Acad Sci U S A. 2009;106:8308-8313.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, pp. 8308-8313
-
-
Felices, M.1
Yin, C.C.2
Kosaka, Y.3
Kang, J.4
Berg, L.J.5
-
61
-
-
79954990281
-
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells
-
Epub 2011 Mar 4577
-
Gordon S, Carty S, Kim J, et al. Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. J Immunol. 2011;186:4573-4578. Epub 2011 Mar 4577.
-
(2011)
J Immunol.
, vol.186
, pp. 4573-4578
-
-
Gordon, S.1
Carty, S.2
Kim, J.3
-
62
-
-
70349741015
-
Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functionalmaturation Notch independent
-
Lauritsen J, Wong G, Lee S, et al. Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functionalmaturation Notch independent. Immunity. 2009;31:565-575.
-
(2009)
Immunity.
, vol.31
, pp. 565-575
-
-
Lauritsen, J.1
Wong, G.2
Lee, S.3
-
63
-
-
77953637652
-
Differential roles of IL-2-inducible T cell kinasemediated TCR signals in tissue-specific localization andmaintenance of skin intraepithelial T cells
-
Xia M, Qi Q, Jin Y, Wiest D, August A, Xiong N. Differential roles of IL-2-inducible T cell kinasemediated TCR signals in tissue-specific localization andmaintenance of skin intraepithelial T cells. J Immunol. 2010;184:6807-6814.
-
(2010)
J Immunol.
, vol.184
, pp. 6807-6814
-
-
Xia, M.1
Qi, Q.2
Jin, Y.3
Wiest, D.4
August, A.5
Xiong, N.6
-
64
-
-
34250862012
-
A key role for Itk in both IFNγ and IL-4 production by NKT cells
-
Au-Yeung B, Fowell D. A key role for Itk in both IFN gamma and IL-4 production by NKT cells. J Immunol. 2007;179:111-119. (Pubitemid 46986524)
-
(2007)
Journal of Immunology
, vol.179
, Issue.1
, pp. 111-119
-
-
Au-Yeung, B.B.1
Fowell, D.J.2
-
65
-
-
49149113472
-
The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival
-
Felices M, Berg L. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol. 2008;180:3007-3018.
-
(2008)
J Immunol.
, vol.180
, pp. 3007-3018
-
-
Felices, M.1
Berg, L.2
-
66
-
-
77958611660
-
Peripheral CD4 +T-cell differentiation regulated by networks of cytokines and transcription factors
-
Zhu J, PaulWE. Peripheral CD4 +T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev. 2010;238:247-262.
-
(2010)
Immunol Rev.
, vol.238
, pp. 247-262
-
-
Zhu, J.1
Paul, W.E.2
-
67
-
-
33646053861
-
+ T cells to exert, but not gain, Th2 effector function
-
Au-Yeung B, Katzman S, Fowell D. Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain,Th2 effector function. J Immunol. 2006;176:3895-3899. (Pubitemid 44264364)
-
(2006)
Journal of Immunology
, vol.176
, Issue.7
, pp. 3895-3899
-
-
Au-Yeung, B.B.1
Katzman, S.D.2
Fowell, D.J.3
-
68
-
-
70349743977
-
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase
-
Gomez-Rodriguez J, Sahu N, Handon R, et al. Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity. 2009;31:587-597.
-
(2009)
Immunity.
, vol.31
, pp. 587-597
-
-
Gomez-Rodriguez, J.1
Sahu, N.2
Handon, R.3
-
69
-
-
3142686560
-
Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet
-
DOI 10.1016/j.immuni.2004.06.009, PII S1074761304001700
-
Miller A,Wilcox H, Lai Z, Berg L. 2004. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity. 2004;21:67-80. (Pubitemid 38925268)
-
(2004)
Immunity
, vol.21
, Issue.1
, pp. 67-80
-
-
Miller, A.T.1
Wilcox, H.M.2
Lai, Z.3
Berg, L.J.4
-
70
-
-
79954906546
-
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division
-
Epub 2011 Apr 2014
-
Chang J, Ciocca M, Kinjyo I, et al. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011;34:492-504. Epub 2011 Apr 2014.
-
(2011)
Immunity.
, vol.34
, pp. 492-504
-
-
Chang, J.1
Ciocca, M.2
Kinjyo, I.3
-
72
-
-
31144451318
-
+ T cell help
-
Atherly L, Brehm M,Welsh R, Berg L. Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. J Immunol. 2006;176:1571-1581. (Pubitemid 43134301)
-
(2006)
Journal of Immunology
, vol.176
, Issue.3
, pp. 1571-1581
-
-
Atherly, L.O.1
Brehm, M.A.2
Welsh, R.M.3
Berg, L.J.4
-
73
-
-
58749090768
-
Selective expression rather than specific function of Txk and Itk regulate Th1 andTh2 responses
-
Sahu N, Venegas A, JankovicD, et al. Selective expression rather than specific function of Txk and Itk regulate Th1 andTh2 responses. J Immunol. 2008;181:6125-6131.
-
(2008)
J Immunol.
, vol.181
, pp. 6125-6131
-
-
Sahu, N.1
Venegas, A.2
Jankovic, D.3
-
74
-
-
44349123838
-
Selective targeting of ITK blocks multiple steps of HIV replication
-
DOI 10.1073/pnas.0709659105
-
Readinger J, Schiralli G, Jiang J, et al. Selective targeting of ITK blocksmultiple steps of HIV replication. Proc Natl Acad Sci U S A. 2008;105:6684-6689. (Pubitemid 351754567)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.18
, pp. 6684-6689
-
-
Readinger, J.A.1
Schiralli, G.M.2
Jiang, J.-K.3
Thomas, C.J.4
August, A.5
Henderson, A.J.6
Schwartzberg, P.L.7
-
75
-
-
0038557038
-
Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK
-
Mueller C, August A. Attenuation of immunological symptoms of allergic asthma inmice lacking the tyrosine kinase ITK. J Immunol. 2003;170:5056-5063. (Pubitemid 36559524)
-
(2003)
Journal of Immunology
, vol.170
, Issue.10
, pp. 5056-5063
-
-
Mueller, C.1
August, A.2
-
76
-
-
33646017981
-
Reduced airway hyperresponsiveness and tracheal responses during allergic asthma inmice lacking tyrosine kinase inducible T-cell kinase
-
Epub 2006 Feb 2007
-
Ferrara T,Mueller C, Sahu N, Ben-Jebria, A, and AA. Reduced airway hyperresponsiveness and tracheal responses during allergic asthma inmice lacking tyrosine kinase inducible T-cell kinase. J Allergy Clin Immunol. 2006;117:780-786. Epub 2006 Feb 2007.
-
(2006)
J Allergy Clin Immunol.
, vol.117
, pp. 780-786
-
-
Ferrara Tmueller, C.1
Sahu, N.2
Ben-Jebria, A.3
-
77
-
-
77956194447
-
Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk
-
Sahu N,Morales JL, Fowell D, August A.Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk. PLoS ONE. 2010;5:e11348.
-
(2010)
PLoS ONE.
, vol.5
-
-
Sahu Nmorales, J.L.1
Fowell, D.2
August, A.3
-
78
-
-
44849086094
-
Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration
-
Sahu N, Mueller C, Fischer A, August A. Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration. J Immunol. 2008;180:3833-3838.
-
(2008)
J Immunol.
, vol.180
, pp. 3833-3838
-
-
Sahu, N.1
Mueller, C.2
Fischer, A.3
August, A.4
-
79
-
-
84860489837
-
Erratum
-
May 3815
-
Erratum in: J Immunol. 2008May 3815;3180(3810):7047-3838.
-
(2008)
J Immunol.
, vol.3180
, Issue.3810
, pp. 7047-3838
-
-
-
80
-
-
4644237821
-
Selective Itk inhibitors block T-cell activation and murine lung inflammation
-
DOI 10.1021/bi049428r
-
Lin T,McIntyre K,Das J, et al. Selective itk inhibitors block T-cell activation andmurine lung inflammation. Biochemistry. 2004;43:11056-11062. (Pubitemid 39433694)
-
(2004)
Biochemistry
, vol.43
, Issue.34
, pp. 11056-11062
-
-
Lin, T.-A.1
McIntyre, K.W.2
Das, J.3
Liu, C.4
O'Day, K.D.5
Penhallow, B.6
Hung, C.-Y.7
Whitney, G.S.8
Shuster, D.J.9
Yang, X.10
Townsend, R.11
Postelnek, J.12
Spergel, S.H.13
Lin, J.14
Moquin, R.V.15
Furch, J.A.16
Kamath, A.V.17
Zhang, H.18
Marathe, P.H.19
Perez-Villar, J.J.20
Doweyko, A.21
Killar, L.22
Dodd, J.H.23
Barrish, J.C.24
Wityak, J.25
Kanner, S.B.26
more..
-
81
-
-
17344375403
-
Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis
-
Matsumoto Y, Oshida T, A, et al. Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis. Int Arch Allergy Immunol. 2002;129:327-340.
-
(2002)
Int Arch Allergy Immunol.
, vol.129
, pp. 327-340
-
-
Matsumoto, Y.1
Oshida, T.A.2
-
82
-
-
78650193349
-
Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: A new concept for the therapy of inflammatory skin diseases
-
doi: 10.1111/j.1600-0625.2010.01198.x
-
von Bonin A, Rausch A, Mengel A, et al. Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases. Exp Dermatol. 2011;20:41-47. doi: 10.1111/j.1600-0625.2010.01198. x.
-
(2011)
Exp Dermatol.
, vol.20
, pp. 41-47
-
-
Von Bonin, A.1
Rausch, A.2
Mengel, A.3
-
83
-
-
68949209328
-
A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis
-
Benson M, Mobini R, Barrenas F, et al. A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. Allergy. 2009;64:1286-1291.
-
(2009)
Allergy.
, vol.64
, pp. 1286-1291
-
-
Benson, M.1
Mobini, R.2
Barrenas, F.3
-
84
-
-
79954495865
-
The association of a single-nucleotide polymorphism of the IL-2 inducible T-cell kinase gene with asthma
-
doi: 310.1111/j.1469- 1809.2010.00637.x. Epub 02011 Feb 00615
-
Lee S, Chang H, Jang A, et al.The association of a single-nucleotide polymorphism of the IL-2 inducible T-cell kinase gene with asthma. Ann Hum Genet. 2011;75:359-369. doi: 310.1111/j.1469- 1809.2010.00637.x. Epub 02011 Feb 00615.
-
(2011)
Ann Hum Genet.
, vol.75
, pp. 359-369
-
-
Lee, S.1
Chang, H.2
Jang, A.3
-
85
-
-
24644514025
-
Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain - IL-2-inducible T-cell kinase gene cluster in chromosome 5q33
-
DOI 10.1016/j.jaci.2005.05.004, PII S0091674905012856
-
Graves P, Siroux V, Guerra S, Klimecki W, Martinez F. Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain andmucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. J Allergy Clin Immunol. 2005;116:650-656. (Pubitemid 41267142)
-
(2005)
Journal of Allergy and Clinical Immunology
, vol.116
, Issue.3
, pp. 650-656
-
-
Graves, P.E.1
Siroux, V.2
Guerra, S.3
Klimecki, W.T.4
Martinez, F.D.5
-
86
-
-
50949120676
-
The Tec family kinase, IL-2-inducible T cell kinase, differentially controlsmast cell responses
-
Iyer A, August A. The Tec family kinase, IL-2-inducible T cell kinase, differentially controlsmast cell responses. J Immunol. 2008;180:7869-7877.
-
(2008)
J Immunol.
, vol.180
, pp. 7869-7877
-
-
Iyer, A.1
August, A.2
-
87
-
-
79953228472
-
Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependentmast cell responses
-
Epub 2011 Jan 9506
-
Iyer A,Morales J, HuangW, et al. Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependentmast cell responses. J Biol Chem. 2011;286:9503-9513. Epub 2011 Jan 9506.
-
(2011)
J Biol Chem.
, vol.286
, pp. 9503-9513
-
-
Iyer, A.1
Morales, J.2
Huang, W.3
-
88
-
-
70350135638
-
ITK inhibitors in inflammation and immune-mediated disorders
-
Sahu N, August A. ITK inhibitors in inflammation and immune-mediated disorders. Curr Top Med Chem. 2009;9:690-703.
-
(2009)
Curr Top Med Chem.
, vol.9
, pp. 690-703
-
-
Sahu, N.1
August, A.2
|