The Association of a Single-Nucleotide Polymorphism of the IL-2 Inducible T-cell Kinase Gene with Asthma

Annals of Human Genetics

Volumn 75, Issue 3, 2011, Pages 359-369

  Lee, Shin Hwa ^a   Chang, Hun Soo ^a   Jang, An Soo ^a   Park, Sung Woo ^a   Park, Jong Sook ^a   Uh, Soo Taek ^a   Kim, Yong Hoon ^b   Oh, Bermseok ^c   Lee, Jong Keuk ^d   Park, Byung Lae ^e   Shin, Hyung Doo ^e,f   Park, Choon Sik ^a   Kimm, Kuchan ^g  

^a Soonchunhyang University College of Medicine   (South Korea)

^b Soonchunhyang University   (South Korea)

^c Kyung Hee University Hospital   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e SNP Genetics Inc   (South Korea)

^f Sogang University   (South Korea)

^g Korea National Institute of Health   (South Korea)

Author keywords

Asthma; ITK; SNPs; TIM

Indexed keywords

INTERLEUKIN 2 INDUCIBLE T CELL KINASE; LUCIFERASE; NUCLEAR FACTOR; NUCLEAR PROTEIN; OLIGONUCLEOTIDE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; ASTHMA; BINDING SITE; CHILD; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LEUKEMIA CELL LINE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASTHMA; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTEIN-TYROSINE KINASES; YOUNG ADULT;

EID: 79954495865     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2010.00637.x     Document Type: Article

References (25)

1. Bateman, E. D., Hurd, S. S., Barnes, P. J., Bousquet, J., Drazen, J. M., Fitzgerald, M., Gibson, P., Ohta, K., O'byrne, P., Pedersen, S. E., Pizzichini, E., Sullivan, S. D., Wenzel, S. E. & Zar, H. J. (2008) Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 31, 143-178.
2. Broide, D. H., Lotz, M., Cuomo, A. J., Coburn, D. A., Federman, E. C. & Wasserman, S. I. (1992) Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 89, 958-967.
3. Cohn, L., Elias, J. A. & Chupp, G. L. (2004) Asthma: Mechanisms of disease persistence and progression. Annu Rev Immunol 22, 789-815.
4. Ferris, B. G. (1978) Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 118, 1-120.
5. Graves, P. E., Siroux, V., Guerra, S., Klimecki, W. T. & Martinez, F. D. (2005) Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. J Allergy Clin Immunol 116, 650-656.
6. Hedrick, P. W. (1987) Gametic disequilibrium measures: Proceed with caution. Genetics 117, 331-341.
7. Holberg, C. J., Halonen, M., Solomon, S., Graves, P. E., Baldini, M., Erickson, R. P. & Martinez, F. D. (2001) Factor analysis of asthma and atopy traits shows 2 major components, one of which is linked to markers on chromosome 5q. J Allergy Clin Immunol 108, 772-780.
8. Holgate, S. T. (2010) A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis. Allergy Asthma Immunol Res 2, 165-171.
9. Kanner, S. B. & Perez-Villar, J. J. (2003) Altering T-cell activation by targeting the multidomain tyrosine kinase Itk. Trends Immunol 24, 249-253.
10. Kauffmann, F., Dizier, M. H., Annesi-Maesano, I., Bousquet, J., Charpin, D., Demenais, F., Ecochard, D., Feingold, J., Gormand, F., Grimfeld, A., Lathrop, M., Matran, R., Neukirch, F., Paty, E., Pin, I., Pison, C., Scheinmann, P., Vervloet, D. & Lockhart, A. (1999) EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)-Descriptive characteristics. Clin Exp Allergy 29(Suppl 4), 17-21.
11. Kuchroo, V. K., Umetsu, D. T., Dekruyff, R. H. & Freeman, G. J. (2003) The TIM gene family: Emerging roles in immunity and disease. Nat Rev Immunol 3, 454-462.
12. Mueller, C. & August, A. (2003) Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK. J Immunol 170, 5056-5063.
13. Nyholt, D. R. (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74, 765-769.
14. Ober, C., Cox, N. J., Abney, M., Di Rienzo, A., Lander, E. S., Changyaleket, B., Gidley, H., Kurtz, B., Lee, J., Nance, M., Pettersson, A., Prescott, J., Richardson, A., Schlenker, E., Summerhill, E., Willadsen, S. & Parry, R. (1998) Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet 7, 1393-1398.
15. Ober, C., Tsalenko, A., Parry, R. & Cox, N. J. (2000) A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 67, 1154-1162.
16. Oliphant, A., Barker, D. L., Stuelpnagel, J. R. & Chee, M. S. (2002) BeadArray technology: Enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques 56-58, 60-61..
17. Robinson, D. S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A. M., Corrigan, C., Durham, S. R. & Kay, A. B. (1992) Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326, 298-304.
18. Schaeffer, E. M., Yap, G. S., Lewis, C. M., Czar, M. J., Mcvicar, D. W., Cheever, A. W., Sher, A. & Schwartzberg, P. L. (2001) Mutation of Tec family kinases alters T helper cell differentiation. Nat Immunol 2, 1183-1188.
19. Schreiber, E., Matthias, P., Muller, M. M. & Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17, 6419.
20. Sengler, C., Lau, S., Wahn, U. & Nickel, R. (2002) Interactions between genes and environmental factors in asthma and atopy: New developments. Respir Res 3, 7.
21. Stephens, M., Smith, N. J. & Donnelly, P. (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68, 978-989.
22. The Collaborative Study on the Genetics of Asthma (CGSA) (1997) A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 15, 389-392.
23. Xu, J., Meyers, D. A., Ober, C., Blumenthal, M. N., Mellen, B., Barnes, K. C., King, R. A., Lester, L. A., Howard, T. D., Solway, J., Langefeld, C. D., Beaty, T. H., Rich, S. S., Bleecker, E. R. & Cox, N. J. (2001) Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: Collaborative study on the genetics of asthma. Am J Hum Genet 68, 1437-1446.
24. Yang, W.C., Ghiotto, M., Barbarat, B. & Olive, D. (1999) The role of Tec protein-tyrosine kinase in T cell signaling. J Biol Chem 274, 607-617.
25. Yokouchi, Y., Nukaga, Y., Shibasaki, M., Noguchi, E., Kimura, K., Ito, S., Nishihara, M., Yamakawa-Kobayashi, K., Takeda, K., Imoto, N., Ichikawa, K., Matsui, A., Hamaguchi, H. & Arinami, T. (2000) Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 66, 152-160.